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Original Articles

Preparative Isolation and Purification of Alkaloids from Corydalis yanhusuo W. T. Wang by High Speed Counter‐Current Chromatography

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Pages 2979-2989 | Received 12 Mar 2005, Accepted 12 Apr 2005, Published online: 06 Feb 2007

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Read on this site (5)

Bing Tian, Ming Tian & Shu-Ming Huang. (2020) Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis. Pharmaceutical Biology 58:1, pages 265-275.
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Hai-Tao Xiao, Jiao Peng, Yan Liang, Jie Yang, Xue Bai, Xiao-Yan Hao, Fu-Mei Yang & Qian-Yun Sun. (2011) Acetylcholinesterase inhibitors from Corydalis yanhusuo . Natural Product Research 25:15, pages 1418-1422.
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Xing-Ye Cheng, Yue Shi, Shun-Liang Zheng, Wen Jin & Hong Sun. (2008) Two new protoberberine quaternary alkaloids from Corydalis yanhusuo . Journal of Asian Natural Products Research 10:12, pages 1117-1121.
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Yuanjiang Pan & Yanbin Lu. (2007) Recent Progress in Countercurrent Chromatography. Journal of Liquid Chromatography & Related Technologies 30:5-7, pages 649-679.
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Articles from other publishers (38)

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Anastasiia O. Whaley, Andrei K. Whaley, Valeria Toporkova, Ekaterina Fock, Natalia Rukoyatkina, Sergey N. Smirnov, Gayrat B. Satimov, Baxtiyar A. Abduraxmanov & Stepan Gambaryan. (2023) Bracteatinine and isogroenlandicine, two new isoquinoline alkaloids isolated from Corydalis bracteata and their effect on platelet function. Fitoterapia 171, pages 105697.
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Irem Kiris, Wirginia Kukula-Koch, Merve Karayel-Basar, Busra Gurel, Julide Coskun & Ahmet Tarik Baykal. (2023) Proteomic alterations in the cerebellum and hippocampus in an Alzheimer’s disease mouse model: Alleviating effect of palmatine. Biomedicine & Pharmacotherapy 158, pages 114111.
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V. I. Toporkova, A. O. Ponkratova, A. K. Whaley, V. G. Luzhanin & M. U. Goncharov. (2022) The Use of Spectroscopic Methods for Structural Elucidation of Individual Secondary Metabolites Isolated from the Aerial Parts of Corydalis bracteata. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. Regulatory Research and Medicine Evaluation 12:1, pages 56-64.
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C. Y. Chen, C. L. Kao, H. C. Yeh, H. T. Li & R. J. Lin. (2022) Secondary Metabolites of Mahonia bealei. Chemistry of Natural Compounds 58:1, pages 181-184.
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C. Y. Chen, C. L. Kao, H. C. Yeh, H. M. Wu & H. T. Li. (2021) Isoquinoline Alkaloids of Ilex latifolia. Chemistry of Natural Compounds 57:6, pages 1175-1176.
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Waraluck Chaichompoo, Pornchai Rojsitthisak, Wachirachai Pabuprapap, Yuttana Siriwattanasathien, Pathumwadee Yotmanee, Woraphot Haritakun & Apichart Suksamrarn. (2021) Stephapierrines A–H, new tetrahydroprotoberberine and aporphine alkaloids from the tubers of Stephania pierrei Diels and their anti-cholinesterase activities . RSC Advances 11:34, pages 21153-21169.
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Yongping Zhang, Zuhua Wang, Jian Xu, Fangfang Yang, Chuanyang Dai, Weijie Xie, Zhu Liang & Songbo Su. (2020) Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method. BMC Chemistry 14:1.
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Y. K. Hsieh, C. L. Kao, H. C. Yeh, Y. Y. Wan, Z. Y. Fang, W. J. Li & C. Y. Chen. (2020) Secondary Metabolites of the Leaves of Mahonia fortunei. Chemistry of Natural Compounds 56:6, pages 1178-1179.
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Cheng Tao, Sheng-quan Hu, Jian Chen, Yuan-ji Chen, Ke-huan Sun, Guo-zhen Cui, Min Ma & Zheng-zhi Wu. (2020) Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine. Neurochemistry International 139, pages 104807.
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Yan Lin, Hong-Cheng Guo, Yi Kuang, Zhan-Peng Shang, Bin Li, Kuan Chen, Lu-Lu Xu, Xue Qiao, Hong Liang & Min Ye. (2020) AChE inhibitory alkaloids from Coptis chinensis. Fitoterapia 141, pages 104464.
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Xiujie Guo, Zhenhua Gao, Jixia Wang, Zhimou Guo, Xiuli Zhang, Yanfang Liu, Lianzhi Wang, Chaoran Wang & Xinmiao Liang. (2019) Purification of tertiary and quaternary alkaloids from Rhizoma Corydalis using reversed-phase/weak cation-exchange mixed-mode class separation combined with preparative C18 and silica based strong cation-exchange chromatography. Journal of Chromatography B 1126-1127, pages 121742.
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Ah-Reum Han, Hyang Rim Kim, Yun Seo Kil, Unwoo Kang, Dae Sik Jang & Eun Kyoung Seo. (2018) Isoquinoline Alkaloids from Corydalis pallida. Chemistry of Natural Compounds 54:5, pages 1020-1022.
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C. Y. Chen, C. L. Kao, W. J. Li, H. C. Yeh, S. C. Huang & H. T. Li. (2018) Secondary Metabolites from the Stems of Ilex cornuta. Chemistry of Natural Compounds 54:3, pages 617-618.
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Dejan Gođevac, Ana Damjanović, Tatjana P. Stanojković, Boban Anđelković & Gordana Zdunić. (2018) Identification of cytotoxic metabolites from Mahonia aquifolium using 1H NMR-based metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis 150, pages 9-14.
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L. T. Yuan, C. L. Kao, S. C. Huang, C. T. Chen, H. T. Li & C. Y. Chen. (2017) Secondary Metabolites from the Stems of Mahonia oiwakensis. Chemistry of Natural Compounds 53:5, pages 997-998.
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Shiqiang Zhou & Rongbiao Tong. (2016) A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps. Chemistry - A European Journal 22:21, pages 7084-7089.
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Yang Li, Fanfan Cai, Min Zhang, Hongyang Zhang, Yuerong Wang & Ping Hu. (2015) Two-stage fractionation of polar alkaloids from Rhizoma coptidis by countercurrent chromatography considering the strategy of reactive extraction. Journal of Chromatography A 1378, pages 58-64.
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Alice E. Gatland, Ben S. Pilgrim, Panayiotis A. Procopiou & Timothy J. Donohoe. (2014) Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium‐Catalyzed Enolate Arylation. Angewandte Chemie International Edition 53:52, pages 14555-14558.
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Alice E. Gatland, Ben S. Pilgrim, Panayiotis A. Procopiou & Timothy J. Donohoe. (2014) Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium‐Catalyzed Enolate Arylation. Angewandte Chemie 126:52, pages 14783-14786.
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M. Iranshahy, R. J. Quinn & M. Iranshahi. (2014) Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis. RSC Advances 4:31, pages 15900.
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Zhanying Hong, Liang Zhao, Xiaoling Wang, Jian Le, Jing Jia, Yifeng Chai & Guoqing Zhang. (2012) High‐performance liquid chromatography–time‐of‐flight mass spectrometry with adjustment of fragmentor voltages for rapid identification of alkaloids in rat plasma after oral administration of R hizoma corydalis extracts . Journal of Separation Science 35:13, pages 1690-1696.
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Hai-yan Lu, Shi-sheng Wang, Rui Cai, Yu Meng, Xin Xie & Wei-jie Zhao. (2012) Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 59, pages 44-49.
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Lei Fang, Yuqin Liu, Bin Yang, Xiao Wang & Luqi Huang. (2011) Separation of alkaloids from herbs using high‐speed counter‐current chromatography. Journal of Separation Science 34:19, pages 2545-2558.
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Svetlana Ignatova, Neil Sumner, Nicola Colclough & Ian Sutherland. (2011) Gradient elution in counter-current chromatography: A new layout for an old path. Journal of Chromatography A 1218:36, pages 6053-6060.
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Qing Yu, Shengqiang Tong, Jizhong Yan, Chaoqun Hong, Wenfeng Zhai & Yaqin Li. (2011) Preparative separation of quaternary ammonium alkaloids from Corydalis yanhusuo W. T. Wang by pH-zone-refining counter-current chromatography . Journal of Separation Science 34:3, pages 278-285.
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Chaoran Wang, Zhimou Guo, Jing Zhang, Jing Zeng, Xiuli Zhang & Xinmiao Liang. (2010) High‐performance purification of quaternary alkaloids from Corydalis yanhusuo W. T. Wang using a new polar‐copolymerized stationary phase . Journal of Separation Science 34:1, pages 53-58.
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Tian Tian Hu, Xue Zhang, Shi Zhong Ma & Xin Sheng Yao. (2009) A new protoberberine alkaloid from Corydalis yanhusuo W. T. Wang. Chinese Chemical Letters 20:8, pages 955-957.
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Jing Zhang, Yu Jin, Yanfang Liu, Yuansheng Xiao, Jiatao Feng, Xingya Xue, Xiuli Zhang & Xinmiao Liang. (2009) Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2‐D HPLC . Journal of Separation Science 32:9, pages 1401-1406.
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Ian A. Sutherland & Derek Fisher. (2009) Role of counter-current chromatography in the modernisation of Chinese herbal medicines. Journal of Chromatography A 1216:4, pages 740-753.
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Zhong-Ze Ma, Wei Xu, Niels Jensen, Bryan Roth, Lee-Yuan Liu-Chen & David Lee. (2008) Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor. Molecules 13:9, pages 2303-2312.
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Hui‐Liang Li, Ting Han, Run‐Hui Liu, Chuan Zhang, Hai‐Sheng Chen & Wei‐Dong Zhang. (2008) Alkaloids from Corydalis saxicola and Their Anti‐Hepatitis B Virus Activity . Chemistry & Biodiversity 5:5, pages 777-783.
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Otto Sticher. (2008) Natural product isolation. Natural Product Reports 25:3, pages 517.
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Zhilan Liu, Yan Yu, Pingniang Shen, Juan Wang, Chengyun Wang & Yongjia Shen. (2008) Separation and purification of dl-tetrahydropalmatine from Corydalis yanhusuo by high-speed counter-current chromatography. Separation and Purification Technology 58:3, pages 343-346.
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Bo Ding, Tingting Zhou, Guorong Fan, Zhanying Hong & Yutian Wu. (2007) Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC–MS/MS and LC–DAD. Journal of Pharmaceutical and Biomedical Analysis 45:2, pages 219-226.
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Hui‐liang Li, Wei‐dong Zhang, Chuan Zhang, Ting Han, Run‐hui Liu, Jiang Hu & Hai‐sheng Chen. (2007) Comparative analysis of the chemical profile of wild and cultivated populations of Corydalis saxicola by high‐performance liquid chromatography . Phytochemical Analysis 18:5, pages 393-400.
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Hui-Liang Li, Wei-Dong Zhang, Chuan Zhang, Run-Hui Liu, Xiang-Wei Wang, Xiao-Lin Wang, Jian-Bao Zhu & Chun-Lin Chen. (2006) Bioavailabilty and pharmacokinetics of four active alkaloids of traditional Chinese medicine Yanhuanglian in rats following intravenous and oral administration. Journal of Pharmaceutical and Biomedical Analysis 41:4, pages 1342-1346.
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Hui-Liang Li, Wei-Dong Zhang, Run-Hui Liu, Chuan Zhang, Ting Han, Xiang-Wei Wang, Xiao-Lin Wang, Jian-Bao Zhu & Chun-Lin Chen. (2006) Simultaneous determination of four active alkaloids from a traditional chinese medicine Corydalis saxicola Bunting. (Yanhuanglian) in plasma and urine samples by LC–MS–MS. Journal of Chromatography B 831:1-2, pages 140-146.
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