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Journal of Liquid Chromatography & Related Technologies Volume 29, 2006 - Issue 20
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Original Articles

Liquid Chromatography‐Electrospray Mass Spectrometry Determination of Imatinib and Its Main Metabolite, N‐Desmethyl‐Imatinib in Human Plasma

I. Solassol Onco‐pharmacology Department, Pharmacy Service, Val d'Aurelle Anticancer Centre, parc Euromédecine, Montpellier, France
,
Dr. F. Bressolle PhD Onco‐pharmacology Department, Pharmacy Service, Val d'Aurelle Anticancer Centre, parc Euromédecine, Montpellier, France; Clinical Pharmacokinetic Laboratory, Faculty of Pharmacy, University Montpellier I, Montpellier, FranceCorrespondence[email protected]
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L. Philibert Onco‐pharmacology Department, Pharmacy Service, Val d'Aurelle Anticancer Centre, parc Euromédecine, Montpellier, France; Clinical Pharmacokinetic Laboratory, Faculty of Pharmacy, University Montpellier I, Montpellier, France
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V. Charasson Onco‐pharmacology Department, Pharmacy Service, Val d'Aurelle Anticancer Centre, parc Euromédecine, Montpellier, France; Department of Medical Pharmacology and Toxicology, Lapeyronie Hospital, Montpellier, France
,
C. Astre Onco‐pharmacology Department, Pharmacy Service, Val d'Aurelle Anticancer Centre, parc Euromédecine, Montpellier, France
&
F. Pinguet Onco‐pharmacology Department, Pharmacy Service, Val d'Aurelle Anticancer Centre, parc Euromédecine, Montpellier, France
Pages 2957-2974 | Received 18 Jul 2006, Accepted 28 Aug 2006, Published online: 07 Feb 2007

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Vinicius Marcondes Rezende, Ariane Rivellis, Mafalda Megumi Yoshinaga Novaes, Dalton de Alencar Fisher Chamone & Israel Bendit. (2013) Quantification of imatinib in human serum: validation of a high-performance liquid chromatography-mass spectrometry method for therapeutic drug monitoring and pharmacokinetic assays. Drug Design, Development and Therapy 7, pages 699-710.
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Yong Chen, Peng Du, Fengmei Han & Huaixia Chen. (2007) Characterization of in vivo and in vitro Metabolic Pathway of Anisodamine by Liquid Chromatography‐Tandem Mass Spectrometry. Journal of Liquid Chromatography & Related Technologies 30:13, pages 1933-1949.
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Articles from other publishers (14)

Houli Li, Di Zhang, Xiaoliang Cheng, Qiaowei Zheng, Kai Cheng, Lilong Xiong, Maoyi Wang, Weihua Dong & Weiyi Feng. (2022) A Validated 2D-LC-UV Method for Simultaneous Determination of Imatinib and N-desmethylimatinib in Plasma and its Clinical Application for Therapeutic Drug Monitoring with GIST Patients. Current Pharmaceutical Analysis 18:1, pages 122-131.
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Tingting Zhao, Lingyu Wang & David Da Yong Chen. (2020) Quantification of imatinib and related compounds using capillary electrophoresis‐tandem mass spectrometry with field‐amplified sample stacking. ELECTROPHORESIS 41:21-22, pages 1843-1850.
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Dalia W. Zidan, Wafaa S. Hassan, Manal S. Elmasry & Abdalla A. Shalaby. (2018) A novel spectrofluorimetric method for determination of imatinib in pure, pharmaceutical preparation, human plasma, and human urine. Luminescence 33:1, pages 232-242.
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Wei Zhuang, Hai-Bo Qiu, Xin-Meng Chen, Xiu-Hong Yuan, Li-Fang Yang, Xiao-Wei Sun, Xiao-Jun Zhou, Min Huang, Xue-Ding Wang & Zhi-Wei Zhou. (2017) Simultaneous quantification of imatinib and its main metabolite N-demethyl-imatinib in human plasma by liquid chromatography-tandem mass spectrometry and its application to therapeutic drug monitoring in patients with gastrointestinal stromal tumor. Biomedical Chromatography 31:12, pages e4022.
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Dipanjan Goswami, Sanjay Gurule, Abhiroop Lahiry, Amit Anand, Arshad Khuroo & Tausif Monif. (2016) Clinical development of imatinib: an anticancer drug. Future Science OA 2:1.
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S. J. Kumari A. Ubhayasekera, Warunika Aluthgedara, Bo Ek & Jonas Bergquist. (2016) Simultaneous quantification of imatinib and CGP74588 in human plasma by liquid chromatography-time of flight mass spectrometry (LC-TOF-MS). Analytical Methods 8:15, pages 3046-3054.
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Emil Vinţeler, Nicoleta-Florina Stan, Raluca Luchian, Călin Căinap, João P. Prates Ramalho & Vasile Chiş. (2015) Conformational landscape and low lying excited states of imatinib. Journal of Molecular Modeling 21:4.
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Y. Zhang, S. Qiang, Z. Yu, W. Zhang, Z. Xu, L. Yang, A. Wen & T. Hang. (2013) LC-MS-MS Determination of Imatinib and N-Desmethyl Imatinib in Human Plasma. Journal of Chromatographic Science 52:4, pages 344-350.
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J. Rodríguez, G. Castañeda, L. Muñoz & S. López. (2014) Development and validation of a non-aqueous capillary electrophoresis method for the determination of imatinib, codeine and morphine in human urine. Analytical Methods 6:11, pages 3842.
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Jian Li, Yifei Huang, Lei Huang, Lei Ye, Zhou Zhou, Guangya Xiang & Li Xu. (2012) Determination of imatinib mesylate and related compounds by field amplified sample stacking with large volume sample injection capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 70, pages 26-31.
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Ka Liong Tan, Ravindran Ankathil & Siew Hua Gan. (2011) Method development and validation for the simultaneous determination of imatinib mesylate and N-desmethyl imatinib using rapid resolution high performance liquid chromatography coupled with UV-detection. Journal of Chromatography B 879:30, pages 3583-3591.
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Noelia Nebot, Severine Crettol, Fabrizio D'Esposito, Bruce Tattam, David E Hibbs & Michael Murray. (2010) Participation of CYP2C8 and CYP3A4 in the N‐demethylation of imatinib in human hepatic microsomes. British Journal of Pharmacology 161:5, pages 1059-1069.
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Andrea Davies, Alison K. Hayes, Katy Knight, Sarah J. Watmough, Munir Pirmohamed & Richard E. Clark. (2010) Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography. Leukemia Research 34:6, pages 702-707.
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. (2007) Current literature in mass spectrometry. Journal of Mass Spectrometry 42:6, pages 830-841.
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