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Journal of Liquid Chromatography Volume 17, 1994 - Issue 10
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Original Articles

Identification and Determination of Geniposide, Genipin, Gardenoside, and Geniposidic Acid from Herbs by HPLC/Photodiode-Array Detection

T.-H. Tsm National Research Institute of Chinese Medicine, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan
,
J. Westly Department of Zoology, University of Alberta Edmonton, Alberta, Canada
,
T.-F. Lee Department of Zoology, University of Alberta Edmonton, Alberta, Canada
&
C.-F. Chen National Research Institute of Chinese Medicine, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming Medical College, Taipei, 112, Taiwan
Pages 2199-2205 | Received 25 Sep 1993, Accepted 02 Nov 1993, Published online: 17 Feb 2007

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Jin Zhao, Yufang Yan, Yuezai Shang, Yang Du, Lixia Long, Xubo Yuan & Xin Hou. (2017) Thermosensitive elastin-derived polypeptide hydrogels crosslinked by genipin. International Journal of Polymeric Materials and Polymeric Biomaterials 66:8, pages 369-377.
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K. Chervenkova & B. Nikolova-Damyanova. (2000) THE ELUTION PATTERN OF IRIDOID GLUCOSIDES FROM GALIUM SPECIES ON C-18 REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. Journal of Liquid Chromatography & Related Technologies 23:5, pages 741-753.
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Hsing-Wen Sung, Rong-Nan Huang, Lynn L.H. Huang & Chen-Chi Tsai. (1999) In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation. Journal of Biomaterials Science, Polymer Edition 10:1, pages 63-78.
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S. Jason Lai, StevenR. Binder, Herbert Essien & Kuo-Ching Wen. (1995) Identification of Western Medicines as Adulterants in Chinese Herbal Medicines Using a Broad-Spectrum Drug Screening HPLC System. Journal of Liquid Chromatography 18:14, pages 2861-2875.
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Dong-Jin Lim. (2022) Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering. International Journal of Molecular Sciences 23:10, pages 5444.
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Tamara Birman & Dror Seliktar. (2021) Injectability of Biosynthetic Hydrogels: Consideration for Minimally Invasive Surgical Procedures and 3D Bioprinting. Advanced Functional Materials 31:29, pages 2100628.
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Lídia Cristina Alves Camêlo, Gabriela de Souza Dias Santos, Ranyere Lucena de Souza, Cleide Mara Faria Soares, Jorge Fernando Brandão Pereira & Álvaro Silva Lima. (2021) Pre-purification of genipin from genipap using aqueous-two-phase systems composed of protic ionic liquids + polymers + water at 298 K and atmospheric pressure. Separation and Purification Technology 256, pages 117843.
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Hamid Hamedi, Sara Moradi, Samuel M. Hudson & Alan E. Tonelli. (2018) Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. Carbohydrate Polymers 199, pages 445-460.
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Ying-Sui Sun, Chi-Ya Huang, Chiang-Sang Chen, Jean-Heng Chang, Wen-Tao Hou, Shu-Jun Li, Yu-Lin Hao, Haobo Pan & Her-Hsiung Huang. (2018) Bone cell responses to a low elastic modulus titanium alloy surface immobilized with the natural cross-linker genipin. Surface and Coatings Technology 350, pages 918-924.
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Lingyan Tao, Zhonglin Lin, Jiashan Chen, Yongjiang Wu & Xuesong Liu. (2017) Mid-infrared and near-infrared spectroscopy for rapid detection of Gardeniae Fructus by a liquid-liquid extraction process. Journal of Pharmaceutical and Biomedical Analysis 145, pages 1-9.
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Dawei Yu, Mengsong Shi, Jinwei Bao, Xinyan Yu, Yuhui Li & Wenbo Liu. (2016) Genipin ameliorates hypertension-induced renal damage via the angiotensin II-TLR/MyD88/MAPK pathway. Fitoterapia 112, pages 244-253.
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Ana Mayela Ramos-de-la-Peña, Catherine M. G. C. Renard, Julio Montañez, María de la Luz Reyes-Vega & Juan Carlos Contreras-Esquivel. (2014) A review through recovery, purification and identification of genipin. Phytochemistry Reviews 15:1, pages 37-49.
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Qingqing Yao, Wei Li, Shanshan Yu, Liwei Ma, Dayong Jin, Aldo R. Boccaccini & Yong Liu. (2015) Multifunctional chitosan/polyvinyl pyrrolidone/45S5 Bioglass® scaffolds for MC3T3-E1 cell stimulation and drug release. Materials Science and Engineering: C 56, pages 473-480.
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Long Xu, Yun-An Huang, Qiu-Jin Zhu & Chun Ye. (2015) Chitosan in Molecularly-Imprinted Polymers: Current and Future Prospects. International Journal of Molecular Sciences 16:8, pages 18328-18347.
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A. K. Siddhanta, Naresh D. Sanandiya, Dharmesh R. Chejara & Stalin Kondaveeti. (2015) Functional modification mediated value addition of seaweed polysaccharides – a perspective. RSC Advances 5:73, pages 59226-59239.
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Michael S Reich, Vipuil Kishore, Rodrigo Iglesias & Ozan Akkus. (2013) Genipin as a sporicidal agent for the treatment of cortical bone allografts. Journal of Biomaterials Applications 28:9, pages 1336-1342.
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Michael S. Reich & Ozan Akkus. (2012) Sporicidal efficacy of genipin: a potential theoretical alternative for biomaterial and tissue graft sterilization. Cell and Tissue Banking 14:3, pages 381-393.
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Saeromi JeongEun Jung YoonHong Gook LimSi Chan SungYong Jin Kim. (2013) The Effect of Space Fillers in the Cross-Linking Processes of Bioprosthesis. BioResearch Open Access 2:2, pages 98-106.
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Ana Agustina Aldana, Agustín González, Miriam C. Strumia & Marisa Martinelli. (2012) Preparation and characterization of chitosan/genipin/poly(N-vinyl-2-pyrrolidone) films for controlled release drugs. Materials Chemistry and Physics 134:1, pages 317-324.
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Xia Zheng, Xiao-Tao Huang, Neng Li, Ying-Yi Li, Sui-Qing Mi, Ning-Sheng Wang & Chang-Hui Liu. (2012) Determination of geniposidic acid in rat plasma by LC–MS/MS and its application to in vivo pharmacokinetic studies. Journal of Chromatography B 887-888, pages 138-142.
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Yu Xi-xun, Liu Fei, Xu Yuan-ting & Wan Chang-xiu. (2009) In vitro study in the endothelial cell compatibility and endothelialization of genipin-crosslinked biological tissues for tissue-engineered vascular scaffolds. Journal of Materials Science: Materials in Medicine 21:2, pages 777-785.
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Bin Yang, Xuan Liu & Yanxiang Gao. (2009) Extraction optimization of bioactive compounds (crocin, geniposide and total phenolic compounds) from Gardenia (Gardenia jasminoides Ellis) fruits with response surface methodology. Innovative Food Science & Emerging Technologies 10:4, pages 610-615.
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Riccardo A.A. Muzzarelli. (2009) Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohydrate Polymers 77:1, pages 1-9.
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Chen-Jung Chang. (2009) The Effect of Pulse-Released Nerve Growth Factor from Genipin-Crosslinked Gelatin in Schwann Cell–Seeded Polycaprolactone Conduits on Large-Gap Peripheral Nerve Regeneration. Tissue Engineering Part A 15:3, pages 547-557.
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Lingling Ren, Xingya Xue, Feifang Zhang, Yongcan Wang, Yanfang Liu, Cunman Li & Xinmiao Liang. (2007) Studies of iridoid glycosides using liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 21:18, pages 3039-3050.
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Jeon -Heon Yang, Mi -Young Yun, Dae -Keun Kim, Mi -Jeong Kim, Young-ll Kim, Tae -Youl Kim, Kyu -Ho Yang & Sang -Chul Shin. (2007) Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases. Archives of Pharmacal Research 30:7, pages 871-875.
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Ana Karina B. Bedran-Russo, Patricia N. R. Pereira, Wagner R. Duarte, James L. Drummond & Mitsuo Yamauchi. (2007) Application of crosslinkers to dentin collagen enhances the ultimate tensile strength. Journal of Biomedical Materials Research Part B: Applied Biomaterials 80B:1, pages 268-272.
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Hongxia Liu, Lin Gao, Mian Liu, Qin Li, Yuyang Jiang & Shusheng Zhang. (2006) Characterization and determination of genipin-1-β-gentiobioside in gardenia fruit by high-performance liquid chromatography with ultraviolet detection following electrospray ionization mass spectrometry. Microchemical Journal 84:1-2, pages 38-43.
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Guan Ye, Hai-Yan Zhu, Hao-Long Zhao, Bo Xu & Cheng-Gang Huang. (2006) HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction. Biomedical Chromatography 20:8, pages 743-747.
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Mei-Chin Chen, Hsiang-Fa Liang, Ya-Ling Chiu, Yen Chang, Hao-Ji Wei & Hsing-Wen Sung. (2005) A novel drug-eluting stent spray-coated with multi-layers of collagen and sirolimus. Journal of Controlled Release 108:1, pages 178-189.
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Shau-Chun Wang, Ting-Yu Tseng, Chih-Min Huang & Tung-Hu Tsai. (2004) Gardenia herbal active constituents: applicable separation procedures. Journal of Chromatography B 812:1-2, pages 193-202.
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. (2004) Skin Permeation and Anti-inflammatory Effects of Hydrolyzed Products of Gardeniae Fructus Extracts. Journal of Korean Pharmaceutical Sciences 34:2, pages 115-123.
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Sung-Ching Chen, Yung-Chih Wu, Fwu-Long Mi, Yu-Hsin Lin, Lin-Chien Yu & Hsing-Wen Sung. (2004) A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. Journal of Controlled Release 96:2, pages 285-300.
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J. Jin, M. Song & D. J. Hourston. (2003) Novel Chitosan-Based Films Cross-Linked by Genipin with Improved Physical Properties. Biomacromolecules 5:1, pages 162-168.
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Fwu-Long Mi, Hsing-Wen Sung, Shin-Shing Shyu, Chia-Ching Su & Chih-Kang Peng. (2003) Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. Polymer 44:21, pages 6521-6530.
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Hsing‐Wen Sung, Wen‐Hisang Chang, Chiun‐Yuang Ma & Meng‐Horng Lee. (2003) Crosslinking of biological tissues using genipin and/or carbodiimide. Journal of Biomedical Materials Research Part A 64A:3, pages 427-438.
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Tong-Rong Tsai, Ting-Yu Tseng, Chieh-Fu Chen & Tung-Hu Tsai. (2002) Identification and determination of geniposide contained in Gardenia jasminoides and in two preparations of mixed traditional Chinese medicines. Journal of Chromatography A 961:1, pages 83-88.
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Fwu-Long Mi, Yu-Chiun Tan, Hsiang-Fa Liang & Hsing-Wen Sung. (2002) In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials 23:1, pages 181-191.
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Kimiko Ueno, Yoshie Takeda, Yoko Iwasaki & Fumihiko Yoshizaki. (2001) Simultaneous Estimation of Geniposide and Genipin in Mouse Plasma Using High-Performance Liquid Chromatography. Analytical Sciences 17:10, pages 1237-1239.
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Fwu‐Long Mi, Hsing‐Wen Sung & Shin‐Shing Shyu. (2001) Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: Examination of crosslinking and polycation–anionic drug interaction. Journal of Applied Polymer Science 81:7, pages 1700-1711.
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Chen-Chi Tsai, Rong-Nan Huang, Hsing-Wen Sung & Huang Chien Liang. (2000) In vitro evaluation of the genotoxicity of a naturally occurring crosslinking agent (genipin) for biologic tissue fixation. Journal of Biomedical Materials Research 52:1, pages 58-65.
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Hsing-Wen Sung, Yen Chang, Chi-Tung Chiu, Chiun-Nan Chen & Huang-Chien Liang. (1999) Crosslinking characteristics and mechanical properties of a bovine pericardium fixed with a naturally occurring crosslinking agent. Journal of Biomedical Materials Research 47:2, pages 116-126.
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Hsing-Wen Sung, Yen Chang, Chi-Tung Chiu, Chiun-Nan Chen & Huang-Chien Liang. (1999) Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent. Biomaterials 20:19, pages 1759-1772.
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Hsing-Wen Sung, Rong-Nan Huang, Lynn L. H. Huang, Chen-Chi Tsai & Chi-Tung Chiu. (1998) Feasibility study of a natural crosslinking reagent for biological tissue fixation. Journal of Biomedical Materials Research 42:4, pages 560-567.
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Shuenn-Jyi Sheu & Wen-Chi Hsin. (1998) HPLC Separation of the Major Constituents of Gardeniae Fructus. Journal of High Resolution Chromatography 21:9, pages 523-526.
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Famei Li, Suya Sun, Jin Wang & Dawei Wang. (1998) Chromatography of medicinal plants and chinese traditional medicines. Biomedical Chromatography 12:2, pages 78-85.
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