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Pharmaceutical Development and Technology Volume 23, 2018 - Issue 10: Issue Theme: Drug stability testing and formulation strategies
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Research Article

Modeling and simulation of continuous powder blending applied to a continuous direct compression process

Shaun C. GalbraithDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USAView further author information
,
Huolong LiuDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USAView further author information
,
Bumjoon ChaDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USAView further author information
,
Seo-Young ParkDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USAView further author information
,
Zhuangrong HuangDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USAView further author information
&
Seongkyu YoonDepartment of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USACorrespondence[email protected]
View further author information
Pages 1097-1107 | Received 24 Aug 2017, Accepted 24 Dec 2017, Published online: 17 Jan 2018

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Zhuangrong Huang, Shaun C. Galbraith, Bumjoon Cha, Huolong Liu, Seoyoung Park, Matthew H. Flamm, Matt Metzger, Anthony Tantuccio & Seongkyu Yoon. (2020) Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models. Pharmaceutical Development and Technology 25:10, pages 1204-1215.
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Articles from other publishers (14)

Rute C. Dias, Ossi Korhonen, Jarkko Ketolainen, João A. Lopes & Tuomas Ervasti. (2023) Flowsheet modelling of a powder continuous feeder-mixer system. International Journal of Pharmaceutics 639, pages 122969.
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Maarten Jaspers, Sri Sharath Kulkarni, Florian Tegel, Timo P. Roelofs, Myrthe T.W. de Wit, Pauline H.M. Janssen, Bernhard Meir, Ralf Weinekötter & Bastiaan H.J. Dickhoff. (2022) Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures. International Journal of Pharmaceutics: X 4, pages 100111.
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Moritz Peterwitz, Simon Buchgeister, Robin Meier & Gerhard Schembecker. (2022) Tracking raw material flow through a continuous direct compression line. Part II of II: Predicting dynamic changes in quality attributes of tablets due to disturbances in raw material properties using an independent residence time distribution model. International Journal of Pharmaceutics 615, pages 121528.
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Pooja Bhalode, Huayu Tian, Shashwat Gupta, Sonia M. Razavi, Andres Roman-Ospino, Shahrzad Talebian, Ravendra Singh, James V. Scicolone, Fernando J. Muzzio & Marianthi Ierapetritou. (2021) Using residence time distribution in pharmaceutical solid dose manufacturing – A critical review. International Journal of Pharmaceutics 610, pages 121248.
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Pooja Bhalode & Marianthi Ierapetritou. (2021) Hybrid multi-zonal compartment modeling for continuous powder blending processes. International Journal of Pharmaceutics 602, pages 120643.
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James Holman, Anthony Tantuccio, John Palmer, Tom van Doninck & Robert Meyer. (2021) A very boring 120 h: 15 million tablets under a continuous state of control. Powder Technology 382, pages 208-231.
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Hervé Barjat, Stephen Checkley, Toma Chitu, Neil Dawson, Amin Farshchi, Ana Ferreira, John Gamble, Michael Leane, Andy Mitchell, Chris Morris, Kendal Pitt, Richard Storey, Furqan Tahir & Mike Tobyn. (2020) Demonstration of the Feasibility of Predicting the Flow of Pharmaceutically Relevant Powders from Particle and Bulk Physical Properties. Journal of Pharmaceutical Innovation 16:1, pages 181-196.
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Geng Tian, Abdollah Koolivand, Zongyu Gu, Michael Orella, Ryan Shaw & Thomas F. O’Connor. (2021) Development of an RTD-Based Flowsheet Modeling Framework for the Assessment of In-Process Control Strategies. AAPS PharmSciTech 22:1.
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Huolong Liu, Robert Meyer, Matthew Flamm, Laura Wareham, Matthew Metzger, Anthony Tantuccio & Seongkyu Yoon. (2021) Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data. AAPS PharmSciTech 22:1.
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Shinji Tanimura, Ravendra Singh, Andrés D. Román-Ospino & Marianthi Ierapetritou. (2021) Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones. International Journal of Pharmaceutics 592, pages 120048.
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Ryoichi Furukawa, Ravendra Singh & Marianthi Ierapetritou. (2020) Effect of material properties on the residence time distribution (RTD) of a tablet press feed frame. International Journal of Pharmaceutics 591, pages 119961.
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Lajos Madarász, Ákos Köte, Martin Gyürkés, Attila Farkas, Bence Hambalkó, Hajnalka Pataki, Gergő Fülöp, György Marosi, László Lengyel, Tibor Casian, Kristóf Csorba & Zsombor Kristóf Nagy. (2020) Videometric mass flow control: A new method for real-time measurement and feedback control of powder micro-feeding based on image analysis. International Journal of Pharmaceutics 580, pages 119223.
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Cheng Du, Jianlin Xu, Hangtian Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Michael C. Borys & Zheng Jian Li. (2019) Mechanisms of color formation in drug substance and mitigation strategies for the manufacture and storage of therapeutic proteins produced using mammalian cell culture. Process Biochemistry 86, pages 127-135.
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M. Sebastian Escotet-Espinoza, Sara Moghtadernejad, Sarang Oka, Yifan Wang, Andres Roman-Ospino, Elisabeth Schäfer, Philippe Cappuyns, Ivo Van Assche, Mauricio Futran, Marianthi Ierapetritou & Fernando Muzzio. (2019) Effect of tracer material properties on the residence time distribution (RTD) of continuous powder blending operations. Part I of II: Experimental evaluation. Powder Technology 342, pages 744-763.
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