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Pharmaceutical Development and Technology Volume 14, 2009 - Issue 3
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Research Article

Monitoring and end-point prediction of a small scale wet granulation process using acoustic emission

John F. GambleBiopharmaceutics R&D, Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, UKCorrespondence[email protected]
,
Andrew B. DennisBiopharmaceutics R&D, Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, UK
&
Mike TobynBiopharmaceutics R&D, Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, UK
Pages 299-304 | Received 09 Jul 2008, Accepted 29 Oct 2008, Published online: 01 Jun 2009

Citations (27)

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Read on this site (5)

Xingjun Wang, Ying Huang & Thomas M. Michelitsch. (2019) Acoustic emission detection of crystallization in two forms: monohydrate and anhydrous citric acid. Pharmaceutical Development and Technology 24:4, pages 419-426.
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Allison Crouter & Lauren Briens. (2015) Passive acoustic emissions from particulates in a V-blender. Drug Development and Industrial Pharmacy 41:11, pages 1809-1818.
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Smruti P. Chaudhari & Rutesh H. Dave. (2015) To prepare and characterize microcrystalline cellulose granules using water and isopropyl alcohol as granulating agents and determine its end-point by thermal and rheological tools. Drug Development and Industrial Pharmacy 41:5, pages 744-752.
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Erin M. Hansuld, Lauren Briens, Amyn Sayani & Joe A. B. McCann. (2013) The effect of process parameters on audible acoustic emissions from high-shear granulation. Drug Development and Industrial Pharmacy 39:2, pages 331-341.
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Rutesh H. Dave, Stephen H. Wu & Labdhi D. Contractor. (2012) To determine the end point of wet granulation by measuring powder energies and thermal properties. Drug Development and Industrial Pharmacy 38:4, pages 439-446.
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Articles from other publishers (22)

Selina Ramm, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey & Miriam Pein-Hackelbusch. (2022) Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics 14:11, pages 2303.
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Katherine Wilson & Lauren Briens. (2022) Investigation of passive acoustic emissions during powder mixing in a V-blender. Powder Technology 408, pages 117754.
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Keita Koyanagi, Akinori Ueno, Tetsuo Sasaki & Makoto Otsuka. (2022) Real-Time Monitoring of Critical Quality Attributes during High-Shear Wet Granulation Process by Near-Infrared Spectroscopy Effect of Water Addition and Stirring Speed on Pharmaceutical Properties of the Granules. Pharmaceuticals 15:7, pages 822.
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Xingjun Wang, Quanmin Xie & Ying Huang. (2021) Study on the frequency of acoustic emission signal during crystal growth of salicylic acid. Nanotechnology Reviews 10:1, pages 596-604.
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Binbin Liu, Jiamiao Wang, Jia Zeng, Lijie Zhao, Youjie Wang, Yi Feng & Ruofei Du. (2021) A review of high shear wet granulation for better process understanding, control and product development. Powder Technology 381, pages 204-223.
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Sayantan Chattoraj, Patrick Daugherity, Todd McDermott, Angela Olsofsky, Wyatt J. Roth & Mike Tobyn. (2018) Sticking and Picking in Pharmaceutical Tablet Compression: An IQ Consortium Review. Journal of Pharmaceutical Sciences 107:9, pages 2267-2282.
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Ryoma Tanaka, Kenta Kojima, Yusuke Hattori, Kazuhide Ashizawa & Makoto Otsuka. (2018) Audible acoustic emission data analysis for active pharmaceutical ingredient concentration prediction during tableting processes. International Journal of Pharmaceutics 548:1, pages 721-727.
Crossref
P. Suresh, I. Sreedhar, R. Vaidhiswaran & A. Venugopal. (2017) A comprehensive review on process and engineering aspects of pharmaceutical wet granulation. Chemical Engineering Journal 328, pages 785-815.
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XingJun Wang & Ying Huang. (2017) An investigation of the acoustic emission generated during crystallization process of salicylic acid. Powder Technology 311, pages 350-355.
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F. Shikata, S. Kimura, Y. Hattori & M. Otsuka. (2017) Real-time monitoring of granule properties during high shear wet granulation by near-infrared spectroscopy with a chemometrics approach. RSC Advances 7:61, pages 38307-38317.
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A. Crouter & L. Briens. (2016) The effect of granule moisture on passive acoustic emissions in a V-blender. Powder Technology 299, pages 226-234.
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N.J. Watson, M.J.W. Povey, G.K. Reynolds, Y. Ding & B.H. Xu. (2016) Development of a discrete element model with moving realistic geometry to simulate particle motion in a Mi-Pro granulator. Computers & Chemical Engineering 93, pages 234-247.
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Chiya Savari, Rahmat Sotudeh-Gharebagh, Reza Zarghami & Navid Mostoufi. (2016) Non-intrusive characterization of particle size changes in fluidized beds using recurrence plots. AIChE Journal 62:10, pages 3547-3561.
Crossref
. 2016. How to Scale-Up a Wet Granulation End Point Scientifically. How to Scale-Up a Wet Granulation End Point Scientifically 67 72 .
Manuel Tramontana, Anthony Gachagan, Alison Nordon, David Littlejohn, Richard O’Leary & Anthony J. Mulholland. (2015) System modelling and device development for passive acoustic monitoring of a particulate-liquid process. Sensors and Actuators A: Physical 228, pages 159-169.
Crossref
N.J. Watson, M.J.W. Povey, G.K. Reynolds, B.H. Xu & Y. Ding. (2014) Acoustic emission monitoring from a lab scale high shear granulator—A novel approach. International Journal of Pharmaceutics 465:1-2, pages 262-274.
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Erin M. Hansuld, Lauren Briens, Amyn Sayani & Joe A.B. McCann. (2012) An investigation of the relationship between acoustic emissions and particle size. Powder Technology 219, pages 111-117.
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Ejay Nsugbe, Andrew Starr & Cristobal Ruiz Carcel. (2012) Monitoring the particle size distribution of a powder mixing process with acoustic emissions: a review. Engineering & Technology Reference 1:1.
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Zane Arp, Ben Smith, Eric Dycus & Des O'grady. (2011) Optimization of a high shear wet granulation process using focused beam reflectance measurement and particle vision microscope technologies. Journal of Pharmaceutical Sciences 100:8, pages 3431-3440.
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A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet & T. De Beer. (2011) Batch statistical process control of a fluid bed granulation process using in-line spatial filter velocimetry and product temperature measurements. European Journal of Pharmaceutical Sciences 42:5, pages 584-592.
Crossref
A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet & T. De Beer. (2010) Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation. European Journal of Pharmaceutics and Biopharmaceutics 76:1, pages 138-146.
Crossref
Jun Huang, Goldi Kaul, Julia Utz, Pedro Hernandez, Victor Wong, Daragh Bradley, Arwinder Nagi & Des O’Grady. (2010) A PAT Approach to Improve Process Understanding of High Shear Wet Granulation Through In-Line Particle Measurement Using FBRM C35. Journal of Pharmaceutical Sciences 99:7, pages 3205-3212.
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