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Original Articles

Genetic Polymorphism in Cytochrome P450 2D6 (CYP2D6): Population Distribution of CYP2D6 Activity

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Pages 334-361 | Published online: 06 Oct 2009

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Crossref
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Crossref
Alexander V. LyubimovPeter L. Bullock & Olga V. Trubetskoy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
A. Serin, H. Canan, B. Alper & M. Gulmen.. (2012) The frequencies of mutated alleles of CYP2D6 gene in a Turkish population. Forensic Science International 222:1-3, pages 332-334.
Crossref
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Crossref
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Mark Walzer, Ihor Bekersky, Robert A. Blum & Dwain Tolbert. (2012) Pharmacokinetic Drug Interactions Between Clobazam and Drugs Metabolized by Cytochrome P450 Isoenzymes. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 32:4, pages 340-353.
Crossref
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Sheila Annie Peters. 2012. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations 383 399 .
Koji Chiba, Motohiro Kato, Takashi Ito, Toshio Suwa & Yuichi Sugiyama. (2012) Inter-individual Variability of In Vivo CYP2D6 Activity in Different Genotypes. Drug Metabolism and Pharmacokinetics 27:4, pages 405-413.
Crossref
Cristian Palmiere, Maria del Mar Lesta, Sara Sabatasso, Patrice Mangin, Marc Augsburger & Frank Sporkert. (2012) Usefulness of postmortem biochemistry in forensic pathology: Illustrative case reports. Legal Medicine 14:1, pages 27-35.
Crossref
V.B. Urlacher. 2012. Comprehensive Chirality. Comprehensive Chirality 275 294 .
Laura N. RiccardiRossana LanzellottoDonata LuiselliStefania CeccardiMirella FalconiCarla BiniSusi Pelotti. (2011) CYP2D6 Genotyping in Natives and Immigrants from the Emilia-Romagna Region (Italy) . Genetic Testing and Molecular Biomarkers 15:11, pages 801-806.
Crossref
Arjun Muralidharan & Maree T Smith. (2011) Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology 63:11, pages 1387-1400.
Crossref
Samuel L. C. Moors, Ann M. Vos, Maxwell D. Cummings, Herman Van Vlijmen & Arnout Ceulemans. (2011) Structure-Based Site of Metabolism Prediction for Cytochrome P450 2D6. Journal of Medicinal Chemistry 54:17, pages 6098-6105.
Crossref
Anthony Rowe, Lillian Yuan Zhang & Iqbal Ramzan. (2011) Toxicokinetics of Kava. Advances in Pharmacological Sciences 2011, pages 1-6.
Crossref

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