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Original Articles

The Potential of Selected Brominated Flame Retardants to Affect Neurological Development

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Pages 411-448 | Published online: 25 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Stéphanie Degroote, Darel Hunting, Guillaume Sébire & Larissa Takser. (2014) Autistic-like traits in Lewis rats exposed perinatally to a mixture of common endocrine disruptors. Endocrine Disruptors 2:1.
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Patricia A. Fair, Hui-Chen Stavros, Meagan A.M. Mollenhauer, Jamie C. DeWitt, Natasha Henry, Kurunthachalam Kannan, Se Hun Yun, Gregory D. Bossart, Deborah E. Keil & Margie M. Peden-Adams. (2012) Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture. Journal of Immunotoxicology 9:1, pages 96-107.
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Stéphanie Decherf & Barbara A. Demeneix. (2011) The Obesogen Hypothesis: A Shift of Focus from the Periphery to the Hypothalamus. Journal of Toxicology and Environmental Health, Part B 14:5-7, pages 423-448.
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Articles from other publishers (58)

Helmut Greim. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 971 975 .
Juan Wang & Guo-Dong Dai. (2022) Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice. Chemical Research in Toxicology 35:9, pages 1512-1518.
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Emmanuel Sunday Okeke, Bin Huang, Guanghua Mao, Yao Chen, Zeng Zhengjia, Xian Qian, Xiangyang Wu & Weiwei Feng. (2022) Review of the environmental occurrence, analytical techniques, degradation and toxicity of TBBPA and its derivatives. Environmental Research 206, pages 112594.
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Huihui Wu, Jinhang Wang, Ying Xiang, Lu Li, Hantong Qie, Meng Ren, Aijun Lin & Fangjie Qi. (2021) Effects of tetrabromobisphenol A (TBBPA) on the reproductive health of male rodents: A systematic review and meta-analysis. Science of The Total Environment 781, pages 146745.
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Chukwuebuka ThankGod Eze, Francesco Michelangeli, Adebayo Akeem Otitoloju, Obianuju Oluchukwu Eze, Omodele Ibraheem, Emeka Bright Ogbuene & Germaine Akinola Ogunwole. (2020) Occurrence of chemical pollutants in major e-waste sites in West Africa and usefulness of cytotoxicity and induction of ethoxyresorufin-O-deethylase (EROD) in determining the effects of some detected brominated flame retardants and e-waste soil-derived extracts. Environmental Science and Pollution Research 28:9, pages 10832-10846.
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Sam Kacew, Matthew S. Blais, A.Wallace Hayes, Wiebke Droege & Thomas G. Osimitz. (2020) Benefit versus risk associated with the use of brominated flame retardants. Current Opinion in Toxicology 22, pages 19-24.
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Min Zhu, Yue Niu, Yuanyuan Li, Mengqi Dong, Jinbo Li, Ran Zeng & Zhanfen Qin. (2020) Low Concentrations of Tetrabromobisphenol A Disrupt Notch Signaling and Intestinal Development in in Vitro and in Vivo Models . Chemical Research in Toxicology 33:6, pages 1418-1427.
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Sam Kacew & A. Wallace Hayes. (2019) Absence of neurotoxicity and lack of neurobehavioral consequences due to exposure to tetrabromobisphenol A (TBBPA) exposure in humans, animals and zebrafish. Archives of Toxicology 94:1, pages 59-66.
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Shaojun Liang, Hui Zhou, Nuoya Yin, Yuanping Lu & Francesco Faiola. (2019) Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity. Journal of Hazardous Materials 376, pages 223-232.
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Sam Kacew & A. Wallace Hayes. (2018) Comment on “TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways”. Environmental Science & Technology 52:22, pages 13657-13659.
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Ann M. Vuong, Kimberly Yolton, Kim N. Dietrich, Joseph M. Braun, Bruce P. Lanphear & Aimin Chen. (2018) Exposure to polybrominated diphenyl ethers (PBDEs) and child behavior: Current findings and future directions. Hormones and Behavior 101, pages 94-104.
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Jacek Lenart, Elzbieta Zieminska, Dominik Diamandakis & Jerzy W. Lazarewicz. (2017) Altered expression of genes involved in programmed cell death in primary cultured rat cerebellar granule cells acutely challenged with tetrabromobisphenol A. NeuroToxicology 63, pages 126-136.
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KE Pelch, JA Wignall, AE Goldstone, PK Ross, RB Blain, AJ Shapiro, SD Holmgren, J-H Hsieh, D Svoboda, SS Auerbach, FM Parham, SA Masten & KA Thayer. (2017) NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives. NTP Research Report.
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Emily W. Y. Tung, Alice Kawata, Marc Rigden, Wayne J. Bowers, Don Caldwell, Alison C. Holloway, Bernard Robaire, Barbara F. Hales & Michael G. Wade. (2017) Gestational and Lactational Exposure to an Environmentally-Relevant Mixture of Brominated Flame Retardants: Effects on Neurodevelopment and Metabolism. Birth Defects Research 109:7, pages 497-512.
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Elzbieta Zieminska, Jacek Lenart, Dominik Diamandakis & Jerzy W. Lazarewicz. (2016) The Role of Ca2+ Imbalance in the Induction of Acute Oxidative Stress and Cytotoxicity in Cultured Rat Cerebellar Granule Cells Challenged with Tetrabromobisphenol A. Neurochemical Research 42:3, pages 777-787.
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Lu Liu, Lianying Guo, Xizhe Xie, Ning Fan, Yan Li, Yachen Li & Xiuli Zhang. 2017. Taurine 10. Taurine 10 107 117 .
Thomas G Osimitz, Wiebke Droege & A Wallace Hayes. (2016) Subchronic toxicology of tetrabromobisphenol A in rats. Human & Experimental Toxicology 35:11, pages 1214-1226.
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Jiangfei Chen, Robert L. Tanguay, Yanyan Xiao, Derik E. Haggard, Xiaoqing Ge, Yinhang Jia, Yi Zheng, Qiaoxiang Dong, Changjiang Huang & Kuangfei Lin. (2016) TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental Pollution 216, pages 53-63.
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Elzbieta Zieminska, Jacek Lenart & Jerzy W. Lazarewicz. (2016) Select putative neurodevelopmental toxins modify SNAP-25 expression in primary cultures of rat cerebellar granule cells. Toxicology 370, pages 86-93.
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Jiangfei Chen, Robert L. Tanguay, Michael Simonich, Shangfei Nie, Yuxin Zhao, Lelin Li, Chenglian Bai, Qiaoxiang Dong, Changjiang Huang & Kuangfei Lin. (2016) TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish. Neurotoxicology and Teratology 56, pages 9-15.
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Christopher Leonetti, Craig M. Butt, Kate Hoffman, Marie Lynn Miranda & Heather M. Stapleton. (2016) Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues. Environment International 88, pages 23-29.
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Lucio G. Costa, Sara Tagliaferri, Pamela J. Roqué & Claudia Pellacani. (2016) Role of glutamate receptors in tetrabrominated diphenyl ether (BDE-47) neurotoxicity in mouse cerebellar granule neurons. Toxicology Letters 241, pages 159-166.
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Hester S. Hendriks, Lucas A. E. Koolen, Milou M. L. Dingemans, Henrik Viberg, Iwa Lee, Pim E. G. Leonards, Geert M. J. Ramakers & Remco H. S. Westerink. (2014) Effects of neonatal exposure to the flame retardant tetrabromobisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term potentiation and synaptic protein levels in mice. Archives of Toxicology 89:12, pages 2345-2354.
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Ewelina Honkisz & Anna K. Wójtowicz. (2015) The role of PPARγ in TBBPA-mediated endocrine disrupting effects in human choriocarcinoma JEG-3 cells. Molecular and Cellular Biochemistry 409:1-2, pages 81-91.
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Daniele Wikoff, Chad Thompson, Camarie Perry, Matthew White, Susan Borghoff, Lauren Fitzgerald & Laurie C. Haws. (2015) Development of toxicity values and exposure estimates for tetrabromobisphenol A: application in a margin of exposure assessment. Journal of Applied Toxicology 35:11, pages 1292-1308.
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Elzbieta Zieminska, Aleksandra Stafiej, Beata Toczylowska, Jan Albrecht & Jerzy W. Lazarewicz. (2015) Role of Ryanodine and NMDA Receptors in Tetrabromobisphenol A-Induced Calcium Imbalance and Cytotoxicity in Primary Cultures of Rat Cerebellar Granule Cells. Neurotoxicity Research 28:3, pages 195-208.
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David Y. Lai, Sam Kacew & Wolfgang Dekant. (2015) Tetrabromobisphenol A (TBBPA): Possible modes of action of toxicity and carcinogenicity in rodents. Food and Chemical Toxicology 80, pages 206-214.
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Lucio G. Costa, Claudia Pellacani, Khoi Dao, Terrance J. Kavanagh & Pamela J. Roque. (2015) The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. NeuroToxicology 48, pages 68-76.
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Rhian B. Cope, Sam Kacew & Michael Dourson. (2015) A reproductive, developmental and neurobehavioral study following oral exposure of tetrabromobisphenol A on Sprague-Dawley rats. Toxicology 329, pages 49-59.
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Lucio G. Costa, Rian de Laat, Sara Tagliaferri & Claudia Pellacani. (2014) A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity. Toxicology Letters 230:2, pages 282-294.
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Julie B. Herbstman & Jennifer K. Mall. (2014) Developmental Exposure to Polybrominated Diphenyl Ethers and Neurodevelopment. Current Environmental Health Reports 1:2, pages 101-112.
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Jie Song, Zhi‐hua Li, Yu‐Tian He, Chuan‐Xin Liu, Bin Sun, Chun‐Fang Zhang, Jie Zeng, Pei‐Li Du, Hui‐li Zhang, Yan‐hong Yu & Dun‐Jin Chen. (2013) Decabrominated diphenyl ether (BDE‐209) and/or BDE‐47 exposure alters protein expression in purified neural stem/progenitor cells determined by proteomics analysis. International Journal of Developmental Neuroscience 33:1, pages 8-14.
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Miguel González-Doncel, Carlos Fernández Torija, Eulalia María Beltrán, José Enrique García-Mauriño, Salvador Sastre & Gregoria Carbonell. (2014) Limitations of waterborne exposure of fish early life stages to BDE-47. Aquatic Toxicology 148, pages 184-194.
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Svetlana Fa, Dragana Samardzija, Ljubica Odzic, Kristina Pogrmic-Majkic, Sonja Kaisarevic, Radmila Kovacevic & Nebojsa Andric. (2013) Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells. Archives of Toxicology 88:2, pages 345-354.
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Dorothea F.K. Rawn, Dean W. Gaertner, Dorcas Weber, Ivan H.A. Curran, Gerard M. Cooke & Cynthia G. Goodyer. (2014) Hexabromocyclododecane concentrations in Canadian human fetal liver and placental tissues. Science of The Total Environment 468-469, pages 622-629.
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Fawaz Al-Mousa & Francesco Michelangeli. (2014) The sarcoplasmic–endoplasmic reticulum Ca2+-ATPase (SERCA) is the likely molecular target for the acute toxicity of the brominated flame retardant hexabromocyclododecane (HBCD). Chemico-Biological Interactions 207, pages 1-6.
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Yaxian Zhao, Xianli Ruan, Yuanyuan Li, Minchan Yan & Zhanfen Qin. (2013) Polybrominated Diphenyl Ethers (PBDEs) in Aborted Human Fetuses and Placental Transfer during the First Trimester of Pregnancy. Environmental Science & Technology 47:11, pages 5939-5946.
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