Citations (49)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Lisa Chedik, Arnaud Bruyere, Astrid Bacle, Sophie Potin, Marc Le Vée & Olivier Fardel. (2018) Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity. Expert Opinion on Drug Metabolism & Toxicology 14:7, pages 739-752.
Read now
Read now
Katie Paul Friedman, Sabitha Papineni, M. Sue Marty, Kun Don Yi, Amber K. Goetz, Reza J. Rasoulpour, Pat Kwiatkowski, Douglas C. Wolf, Ann M. Blacker & Richard C. Peffer. (2016) A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study. Critical Reviews in Toxicology 46:9, pages 785-833.
Read now
Read now
Olivier Fardel, Elise Kolasa & Marc Le Vee. (2012) Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 8:1, pages 29-46.
Read now
Read now
Articles from other publishers (46)
Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung & Sigmund J. Degitz. (2023) Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo. Regulatory Toxicology and Pharmacology 144, pages 105491.
Crossref
Crossref
Christiane Wiemann, Stephanie Melching‐Kollmuss, Nina Hambruch, Lucille Wiss, Franz Stauber & Lysiane Richert. (2023) Boscalid shows increased thyroxin‐glucuronidation in rat but not in human hepatocytes in vitro. Journal of Applied Toxicology 43:6, pages 828-844.
Crossref
Crossref
Hisham El-Masri, Katie Paul Friedman, Kristin Isaacs & Barbara A. Wetmore. (2022) Advances in computational methods along the exposure to toxicological response paradigm. Toxicology and Applied Pharmacology 450, pages 116141.
Crossref
Crossref
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck & John F. Wambaugh. (2021) High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures. npj Systems Biology and Applications 7:1.
Crossref
Crossref
Nelly Guéniche, Arnaud Bruyere, Marc Le Vée & Olivier Fardel. (2019) Implication of human drug transporters to toxicokinetics and toxicity of pesticides. Pest Management Science 76:1, pages 18-25.
Crossref
Crossref
Bryan Mackowiak, Linhao Li, Caitlin Lynch, Andrew Ziman, Scott Heyward, Menghang Xia & Hongbing Wang. (2019) High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis. Biochemical Pharmacology 168, pages 224-236.
Crossref
Crossref
Pamela D. Noyes, Katie Paul Friedman, Patience Browne, Jonathan T. Haselman, Mary E. Gilbert, Michael W. Hornung, Stan BaroneJr.Jr., Kevin M. Crofton, Susan C. Laws, Tammy E. Stoker, Steven O. Simmons, Joseph E. Tietge & Sigmund J. Degitz. (2019)
Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with
in Vitro
Testing and Adverse Outcome Pathway Approaches
. Environmental Health Perspectives 127:9.
Crossref
Crossref
Linhao Li, Matthew A. Welch, Zhihui Li, Bryan Mackowiak, Scott Heyward, Peter W. Swaan & Hongbing Wang. (2019) Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. Molecular Pharmacology 96:3, pages 345-354.
Crossref
Crossref
Jon R. Sobus, John F. Wambaugh, Kristin K. Isaacs, Antony J. Williams, Andrew D. McEachran, Ann M. Richard, Christopher M. Grulke, Elin M. Ulrich, Julia E. Rager, Mark J. Strynar & Seth R. Newton. (2017) Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA. Journal of Exposure Science & Environmental Epidemiology 28:5, pages 411-426.
Crossref
Crossref
Malin Larsson, Domenico Fraccalvieri, C. David Andersson, Laura Bonati, Anna Linusson & Patrik L. Andersson. (2017) Identification of potential aryl hydrocarbon receptor ligands by virtual screening of industrial chemicals. Environmental Science and Pollution Research 25:3, pages 2436-2449.
Crossref
Crossref
Brett R. Blackwell, Gerald T. Ankley, Steven R. Corsi, Laura A. DeCicco, Keith A. Houck, Richard S. Judson, Shibin Li, Matthew T. Martin, Elizabeth Murphy, Anthony L. Schroeder, Edwin R. Smith, Joe Swintek & Daniel L. Villeneuve. (2017) An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters. Environmental Science & Technology 51:15, pages 8713-8724.
Crossref
Crossref
Maxwell C.K. Leung, Nancy C. Baker & Thomas B. Knudsen. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology
975
985
.
Richard Judson, Keith Houck, Matt Martin, Ann M. Richard, Thomas B. Knudsen, Imran Shah, Stephen Little, John Wambaugh, R. Woodrow Setzer, Parth Kothya, Jimmy Phuong, Dayne Filer, Doris Smith, David Reif, Daniel Rotroff, Nicole Kleinstreuer, Nisha Sipes, Menghang Xia, Ruili Huang, Kevin Crofton & Russell S. Thomas. (2016)
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on
In Vitro
Assay Activity Across a Diverse Chemical and Assay Space
. Toxicological Sciences 152:2, pages 323-339.
Crossref
Crossref
Kelly A. Rose, Natalie S. Holman, Angela M. Green, Melvin E. Andersen & Edward L. LeCluyse. (2016) Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. Journal of Pharmaceutical Sciences 105:2, pages 950-964.
Crossref
Crossref
Kamel Mansouri & Richard S. Judson. 2016. In Silico Methods for Predicting Drug Toxicity. In Silico Methods for Predicting Drug Toxicity
361
381
.
Robert BorotkanicsMichael TrushPaul Locke. (2015)
Analysis of ToxCast Data—
In Vitro
and Physiochemical Properties—In the Accurate Classification of Chemicals That Induce Hepatocarcinogenesis
In Vivo
. Applied In Vitro Toxicology 1:4, pages 262-275.
Crossref
Crossref
Barbara A. Wetmore, John F. Wambaugh, Brittany Allen, Stephen S. Ferguson, Mark A. Sochaski, R. Woodrow Setzer, Keith A. Houck, Cory L. Strope, Katherine Cantwell, Richard S. Judson, Edward LeCluyse, Harvey J. Clewell, Russell S. Thomas & Melvin E. Andersen. (2015)
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted
In Vitro
Bioactivity to Inform Chemical Toxicity Testing
. Toxicological Sciences 148:1, pages 121-136.
Crossref
Crossref
Hyeong-Moo Shin, Alexi Ernstoff, Jon A. Arnot, Barbara A. Wetmore, Susan A. Csiszar, Peter Fantke, Xianming Zhang, Thomas E. McKone, Olivier Jolliet & Deborah H. Bennett. (2015) Risk-Based High-Throughput Chemical Screening and Prioritization using Exposure Models and in Vitro Bioactivity Assays. Environmental Science & Technology 49:11, pages 6760-6771.
Crossref
Crossref
Barbara A. Wetmore. (2015) Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment. Toxicology 332, pages 94-101.
Crossref
Crossref
Barbara A. Wetmore, Brittany Allen, Harvey J. ClewellIIIIII, Timothy Parker, John F. Wambaugh, Lisa M. Almond, Mark A. Sochaski & Russell S. Thomas. (2014) Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. Toxicological Sciences 142:1, pages 210-224.
Crossref
Crossref
Richard Judson, Keith Houck, Matt Martin, Thomas Knudsen, Russell S. Thomas, Nisha Sipes, Imran Shah, John Wambaugh & Kevin Crofton. (2014)
In Vitro
and Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme
. Basic & Clinical Pharmacology & Toxicology 115:1, pages 69-76.
Crossref
Crossref
Falgun Shah & Nigel Greene. (2013) Analysis of Pfizer Compounds in EPA’s ToxCast Chemicals-Assay Space. Chemical Research in Toxicology 27:1, pages 86-98.
Crossref
Crossref
Russell S. Thomas, Martin A. Philbert, Scott S. Auerbach, Barbara A. Wetmore, Michael J. Devito, Ila Cote, J. Craig Rowlands, Maurice P. Whelan, Sean M. Hays, Melvin E. Andersen, M. E. (Bette) Meek, Lawrence W. Reiter, Jason C. Lambert, Harvey J. ClewellIIIIII, Martin L. Stephens, Q. Jay Zhao, Scott C. Wesselkamper, Lynn Flowers, Edward W. Carney, Timothy P. Pastoor, Dan D. Petersen, Carole L. Yauk & Andy Nong. (2013) Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework. Toxicological Sciences 136:1, pages 4-18.
Crossref
Crossref
Raymond R. Tice, Christopher P. Austin, Robert J. Kavlock & John R. Bucher. (2013) Improving the Human Hazard Characterization of Chemicals: A Tox21 Update. Environmental Health Perspectives 121:7, pages 756-765.
Crossref
Crossref
Nisha S. Sipes, Matthew T. Martin, Parth Kothiya, David M. Reif, Richard S. Judson, Ann M. Richard, Keith A. Houck, David J. Dix, Robert J. Kavlock & Thomas B. Knudsen. (2013) Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays. Chemical Research in Toxicology 26:6, pages 878-895.
Crossref
Crossref
AlberTinka J. Murk, Eddy Rijntjes, Bas J. Blaauboer, Rebecca Clewell, Kevin M. Crofton, Milou M.L. Dingemans, J. David Furlow, Robert Kavlock, Josef Köhrle, Robert Opitz, Theo Traas, Theo J. Visser, Menghang Xia & Arno C. Gutleb. (2013) Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. Toxicology in Vitro 27:4, pages 1320-1346.
Crossref
Crossref
Barbara A. Wetmore, John F. Wambaugh, Stephen S. Ferguson, Lili Li, Harvey J. ClewellIIIIII, Richard S. Judson, Kimberly Freeman, Wenjun Bao, Mark A. Sochaski, Tzu-Ming Chu, Michael B. Black, Eric Healy, Brittany Allen, Melvin E. Andersen, Russell D. Wolfinger & Russell S. Thomas. (2013) Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays. Toxicological Sciences 132:2, pages 327-346.
Crossref
Crossref
Barbara A. Wetmore & Russell S. Thomas. 2013. High‐Throughput Screening Methods in Toxicity Testing. High‐Throughput Screening Methods in Toxicity Testing
77
95
.
Nicole C. Kleinstreuer, David J. Dix, Keith A. Houck, Robert J. Kavlock, Thomas B. Knudsen, Matthew T. Martin, Katie B. Paul, David M. Reif, Kevin M. Crofton, Kerry Hamilton, Ronald Hunter, Imran Shah & Richard S. Judson. (2013) In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. Toxicological Sciences 131:1, pages 40-55.
Crossref
Crossref
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner & Stuart Creton. (2013) Novel in vitro and mathematical models for the prediction of chemical toxicity. Toxicol. Res. 2:1, pages 40-59.
Crossref
Crossref
Russell S. Thomas, Michael B. Black, Lili Li, Eric Healy, Tzu-Ming Chu, Wenjun Bao, Melvin E. Andersen & Russell D. Wolfinger. (2012) A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening. Toxicological Sciences 128:2, pages 398-417.
Crossref
Crossref
Robert Kavlock, Kelly Chandler, Keith Houck, Sid Hunter, Richard Judson, Nicole Kleinstreuer, Thomas Knudsen, Matt Martin, Stephanie Padilla, David Reif, Ann Richard, Daniel Rotroff, Nisha Sipes & David Dix. (2012) Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management. Chemical Research in Toxicology 25:7, pages 1287-1302.
Crossref
Crossref
Lauren M. Aleksunes & Curtis D. Klaassen. (2012) Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice. Drug Metabolism and Disposition 40:7, pages 1366-1379.
Crossref
Crossref
C. Magkoufopoulou, S.M.H. Claessen, M. Tsamou, D.G.J. Jennen, J.C.S. Kleinjans & J.H.M. van Delft. (2012) A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis 33:7, pages 1421-1429.
Crossref
Crossref
Richard Judson. 2010. Handbook of Green Chemistry. Handbook of Green Chemistry
21
46
.
Ivan Rusyn & J. Christopher Corton. (2012) Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutation Research/Reviews in Mutation Research 750:2, pages 141-158.
Crossref
Crossref
Sandeep Modi, Michael Hughes, Andrew Garrow & Andrew White. (2012) The value of in silico chemistry in the safety assessment of chemicals in the consumer goods and pharmaceutical industries. Drug Discovery Today 17:3-4, pages 135-142.
Crossref
Crossref
Barbara A. Wetmore, John F. Wambaugh, Stephen S. Ferguson, Mark A. Sochaski, Daniel M. Rotroff, Kimberly Freeman, Harvey J. ClewellIIIIII, David J. Dix, Melvin E. Andersen, Keith A. Houck, Brittany Allen, Richard S. Judson, Reetu Singh, Robert J. Kavlock, Ann M. Richard & Russell S. Thomas. (2012) Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment. Toxicological Sciences 125:1, pages 157-174.
Crossref
Crossref
Sandhya Kortagere, Matthew D. Krasowski & Sean Ekins. 2012. Computational Toxicology. Computational Toxicology
359
375
.
John Jack, John F Wambaugh & Imran Shah. (2011) Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles. BMC Systems Biology 5:1.
Crossref
Crossref
Nisha S. Sipes, Matthew T. Martin, David M. Reif, Nicole C. Kleinstreuer, Richard S. Judson, Amar V. Singh, Kelly J. Chandler, David J. Dix, Robert J. Kavlock & Thomas B. Knudsen. (2011) Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data. Toxicological Sciences 124:1, pages 109-127.
Crossref
Crossref
N.C. Kleinstreuer, A.M. Smith, P.R. West, K.R. Conard, B.R. Fontaine, A.M. Weir-Hauptman, J.A. Palmer, T.B. Knudsen, D.J. Dix, E.L.R. Donley & G.G. Cezar. (2011) Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics. Toxicology and Applied Pharmacology 257:1, pages 111-121.
Crossref
Crossref
Sudin Bhattacharya, Qiang Zhang, Paul L. Carmichael, Kim Boekelheide & Melvin E. Andersen. (2011) Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways. PLoS ONE 6:6, pages e20887.
Crossref
Crossref
Kelly J. Chandler, Marianne Barrier, Susan Jeffay, Harriette P. Nichols, Nicole C. Kleinstreuer, Amar V. Singh, David M. Reif, Nisha S. Sipes, Richard S. Judson, David J. Dix, Robert Kavlock, Edward S. Hunter & Thomas B. Knudsen. (2011) Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay. PLoS ONE 6:6, pages e18540.
Crossref
Crossref
Daniel KrewskiMargit WestphalMustafa Al-ZoughoolMaxine C. CroteauMelvin E. Andersen. (2011) New Directions in Toxicity Testing. Annual Review of Public Health 32:1, pages 161-178.
Crossref
Crossref
Richard S. Judson, Robert J. Kavlock, R. Woodrow Setzer, Elaine A. Cohen Hubal, Matthew T. Martin, Thomas B. Knudsen, Keith A. Houck, Russell S. Thomas, Barbara A. Wetmore & David J. Dix. (2011) Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment. Chemical Research in Toxicology 24:4, pages 451-462.
Crossref
Crossref