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Journal of Toxicology and Environmental Health, Part B
Critical Reviews
Volume 21, 2018 - Issue 4
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Articles

Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance

David C. DormanDepartment of Molecular and Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USACorrespondence[email protected]
,
Weihsueh ChiuDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA
,
Barbara F. HalesDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
,
Russ HauserDepartment of Environmental Health and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
,
Kamin J. JohnsonPredictive Safety Center, The Dow Chemical Company, Midland, MI, USA
,
Ellen MantusBoard on Environmental Studies and Toxicology at the National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA
,
Susan MartelBoard on Environmental Studies and Toxicology at the National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA
,
Karen A. RobinsonDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA
,
Andrew A. RooneyOffice of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
,
Ruthann RudelSilent Spring Institute, Newton, MA, USA
,
Sheela SathyanarayanaDepartment of Pediatrics, University of Washington, Seattle Children’s Research Institute, Seattle, WA, USA
,
Susan L. SchantzDepartment of Comparative Biosciences, College of Veterinary Medicine and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA
&
Katrina M. WatersBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
 show all
Pages 207-226 | Published online: 10 Sep 2018

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Han Xiang, Shao Wang, Xiaoyan Kong, Yihang Yu, Lianju shen, Chunlan Long, Xing Liu & Guang-Hui Wei. (2021) c-Fos is upregulated in the genital tubercle of DEHP-induced hypospadiac rats and the prepuce of patients with hypospadias. Systems Biology in Reproductive Medicine 67:3, pages 193-200.
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Jerry L. Campbell$suffix/text()$suffix/text(), Rainer Otter, Warwick A. Anderson, Matthew P. Longnecker, Rebecca A. Clewell, Colin North & Harvey J. Clewell$suffix/text()$suffix/text(). (2020) Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human. Journal of Toxicology and Environmental Health, Part A 83:19-20, pages 631-648.
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Chi Rim Sung, Hyeon Gyu Kang, Ji Young Hong & Seung Jun Kwack. (2020) Citrate ester substitutes for di-2-ethylhexyl phthalate: In vivo reproductive and in vitro cytotoxicity assessments. Journal of Toxicology and Environmental Health, Part A 83:17-18, pages 589-595.
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Anna Mentor, Carl-Gustaf Bornehag, Maria Jönsson & Anna Mattsson. (2020) A suggested bisphenol A metabolite (MBP) interfered with reproductive organ development in the chicken embryo while a human-relevant mixture of phthalate monoesters had no such effects. Journal of Toxicology and Environmental Health, Part A 83:2, pages 66-81.
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Bu Young Chung, Seul Min Choi, Tae Hyun Roh, Duck Soo Lim, Mi Young Ahn, Yeon Joo Kim, Hyung Sik Kim & Byung-Mu Lee. (2019) Risk assessment of phthalates in pharmaceuticals. Journal of Toxicology and Environmental Health, Part A 82:5, pages 351-360.
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Articles from other publishers (33)

Nicole B. Salvi, Akhgar Ghassabian, Sara G. Brubaker, Hongxiu Liu, Linda G. Kahn, Leonardo Trasande & Shilpi S. Mehta-Lee. (2023) Prenatal phthalate exposure and fetal penile length and width. Pediatric Research.
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Haoyang Zhang, Maohuan Ran, Liping Jiang, Xiance Sun, Tianming Qiu, Jing Li, Ningning Wang, Xiaofeng Yao, Cong Zhang, Haoyuan Deng, Shaopeng Wang & Guang Yang. (2023) Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP). Ecotoxicology and Environmental Safety 268, pages 115711.
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Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Lianju Shen, Chunlan Long, Shengde Wu & Guanghui Wei. (2023) Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway. Toxicology in Vitro 91, pages 105626.
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Pablo A. Pérez, Jonathan Toledo, Facundo Vitellini, Victoria Navall Cuello, Verónica Cantarelli, Marina Ponzio, Jorge H. Mukdsi & Silvina Gutiérrez. (2023) Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression. Journal of Molecular Histology.
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Anna-Sofia Preece, Huan Shu, Malin Knutz, Annette M. Krais & Carl-Gustaf Bornehag. (2022) Phthalate levels in prenatal and postnatal bedroom dust in the SELMA study. Environmental Research 212, pages 113429.
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Maria E Kloboves, Diana C Pacyga, Joseph C Gardiner, Jodi A Flaws, Susan L Schantz & Rita S Strakovsky. (2022) Associations of maternal anthropometrics with newborn anogenital distance and the 2:4 digit ratio. Human Reproduction 37:9, pages 2154-2166.
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Benny Neumark, Oneg Elkabets, Gabi Shefer, Assaf Buch, Naftali Stern & Aviv Amirav. (2022) Whole blood analysis for medical diagnostics by GC‐MS with Cold EI. Journal of Mass Spectrometry 57:7.
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Ling Yang, Liping Jiang, Xiance Sun, Jing Li, Ningning Wang, Xiaofang Liu, Xiaofeng Yao, Cong Zhang, Haoyuan Deng, Shaopeng Wang & Guang Yang. (2022) DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity. Food and Chemical Toxicology 164, pages 113046.
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T.S. Barton-Maclaren, M. Wade, N. Basu, S. Bayen, J. Grundy, V. Marlatt, R. Moore, L. Parent, J. Parrott, P. Grigorova, J. Pinsonnault-Cooper & V.S. Langlois. (2022) Innovation in regulatory approaches for endocrine disrupting chemicals: The journey to risk assessment modernization in Canada. Environmental Research 204, pages 112225.
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G. Delbes, M. Blázquez, J.I. Fernandino, P. Grigorova, B.F. Hales, C. Metcalfe, L. Navarro-Martín, L. Parent, B. Robaire, A. Rwigemera, G. Van Der Kraak, M. Wade & V. Marlatt. (2022) Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals. Environmental Research 204, pages 112040.
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Emily S. Barrett, Matthew Corsetti, Drew Day, Sally W. Thurston, Christine T. Loftus, Catherine J. Karr, Kurunthachalam Kannan, Kaja Z. LeWinn, Alicia K. Smith, Roger Smith, Frances A. Tylavsky, Nicole R. Bush & Sheela Sathyanarayana. (2022) Prenatal phthalate exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE cohort. Environment International 160, pages 107078.
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J. Eales, A. Bethel, T. Galloway, P. Hopkinson, K. Morrissey, R.E. Short & R. Garside. (2022) Human health impacts of exposure to phthalate plasticizers: An overview of reviews. Environment International 158, pages 106903.
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Justin M. Conley, Christy S. Lambright, Nicola Evans, Mary Cardon, Elizabeth Medlock-Kakaley, Vickie S. Wilson & L. Earl GrayJr.Jr.. (2021) A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat. Environment International 156, pages 106615.
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Anna‐Sofia Preece, Huan Shu, Malin Knutz, Annette M. Krais, Gabriel Bekö & Carl‐Gustaf Bornehag. (2021) Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study. Indoor Air 31:5, pages 1495-1508.
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Katarzyna Jędruchniewicz, Yong Sik Ok & Patryk Oleszczuk. (2021) COVID-19 discarded disposable gloves as a source and a vector of pollutants in the environment. Journal of Hazardous Materials 417, pages 125938.
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Anastasia Repouskou, Antonios Stamatakis & Efthymia Kitraki. (2021) In utero exposure to phthalates and reproductive toxicity in rodents. Best Practice & Research Clinical Endocrinology & Metabolism 35:5, pages 101512.
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Sharon Daniel, Arin A. Balalian, Beverly J. Insel, Xinhua Liu, Robin M. Whyatt, Antonia M. Calafat, Virginia A. Rauh, Frederica P. Perera, Lori A Hoepner, Julie Herbstman & Pam Factor-Litvak. (2020) Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years. Environment International 143, pages 105894.
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Secil Ercin, Sinem Ertas, Oznur Dundar, Ozgur Oktem & Kayhan Yakin. (2020) Anogenital distance in newborn infants conceived by assisted reproduction and natural conception. Reproductive BioMedicine Online 41:3, pages 474-482.
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Richard M. Sharpe. (2020) Androgens and the masculinization programming window: human–rodent differences. Biochemical Society Transactions 48:4, pages 1725-1735.
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Zengqiang Li, Yige Yu, Yang Li, Feifei Ma, Yinghui Fang, Chaobo Ni, Keyang Wu, Peipei Pan & Ren-Shan Ge. (2020) Taxifolin attenuates the developmental testicular toxicity induced by di-n-butyl phthalate in fetal male rats. Food and Chemical Toxicology 142, pages 111482.
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Cao Yirong, Wang Shengchen, Sun Jiaxin, Wang Shuting & Zhang Ziwei. (2020) DEHP induces neutrophil extracellular traps formation and apoptosis in carp isolated from carp blood via promotion of ROS burst and autophagy. Environmental Pollution 262, pages 114295.
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Tye E. Arbuckle, Susan MacPherson, Warren G. Foster, Sheela Sathyanarayana, Mandy Fisher, Patricia Monnier, Bruce Lanphear, Gina Muckle & William D. Fraser. (2020) Prenatal perfluoroalkyl substances and newborn anogenital distance in a Canadian cohort. Reproductive Toxicology 94, pages 31-39.
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Eva J. Sugeng, Christos Symeonides, Martin O'Hely, Peter Vuillermin, Peter D. Sly, Soumini Vijayasarathy, Kristie Thompson, Angela Pezic, Jochen F. Mueller & Anne-Louise Ponsonby. (2020) Predictors with regard to ingestion, inhalation and dermal absorption of estimated phthalate daily intakes in pregnant women: The Barwon infant study. Environment International 139, pages 105700.
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Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Andrew Chesson, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Jean‐Pierre Cravedi, Cristina Fortes, Maria de Fatima Tavares Poças, Ine Waalkens‐Berendsen, Detlef Wölfle, Davide Arcella, Claudia Cascio, Anna F Castoldi, Katharina Volk & Laurence Castle. (2019) Update of the risk assessment of di‐butylphthalate (DBP), butyl‐benzyl‐phthalate (BBP), bis(2‐ethylhexyl)phthalate (DEHP), di‐isononylphthalate (DINP) and di‐isodecylphthalate (DIDP) for use in food contact materials. EFSA Journal 17:12.
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Tye E. Arbuckle, Susan MacPherson, Emily Barrett, Gina Muckle, Jean R. Séguin, Warren G. Foster, Sheela Sathyanarayana, Linda Dodds, Mandy Fisher, Amisha Agarwal, Patricia Monnier, Mark Walker & William D. Fraser. (2019) Do stressful life events during pregnancy modify associations between phthalates and anogenital distance in newborns?. Environmental Research 177, pages 108593.
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Xiaoheng Li, Jiaying Mo, Qiqi Zhu, Chaobo Ni, Yiyan Wang, Huitao Li, Zhen-kun Lin & Ren-Shan Ge. (2019) The structure–activity relationship (SAR) for phthalate-mediated developmental and reproductive toxicity in males. Chemosphere 223, pages 504-513.
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Nudrat Noor, Kelly K. Ferguson, John D. Meeker, Ellen W. Seely, Russ Hauser, Tamarra James-Todd & Thomas F. McElrath. (2019) Pregnancy phthalate metabolite concentrations and infant birth weight by gradations of maternal glucose tolerance. International Journal of Hygiene and Environmental Health 222:3, pages 395-401.
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Maryam Zarean, Mojtaba Keikha, Awat Feizi, Maryamsadat Kazemitabaee & Roya Kelishadi. (2019) The role of exposure to phthalates in variations of anogenital distance: A systematic review and meta-analysis. Environmental Pollution 247, pages 172-179.
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William Nelson, Ying-Xiong Wang, Gloria Sakwari & Yu-Bin Ding. 2020. Reviews of Environmental Contamination and Toxicology Volume 251. Reviews of Environmental Contamination and Toxicology Volume 251 131 184 .

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