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A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs

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Maria João Bessa, Fátima Brandão, Fernanda Rosário, Luciana Moreira, Ana Teresa Reis, Vanessa Valdiglesias, Blanca Laffon, Sónia Fraga & João Paulo Teixeira. (2023) Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models. Journal of Toxicology and Environmental Health, Part B 26:2, pages 67-96.
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Sreejesh Sreedharan, Georgios Zouganelis, Samantha J Drake, Gyanendra Tripathi & Ali Kermanizadeh. (2023) Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions. Journal of Toxicology and Environmental Health, Part B 26:1, pages 1-27.
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Fatma Turna Demir. (2022) Protective effects of resveratrol against genotoxicity induced by nano and bulk hydroxyapatite in Drosophila melanogaster. Journal of Toxicology and Environmental Health, Part A 85:20, pages 850-865.
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Karina Alves Feitosa, Ricardo de Oliveira Correia, Ana Carolina Maragno Fattori, Yulli Roxenne Albuquerque, Patricia Brassolatti, Genoveva Flores Luna, Joice Margareth de Almeida Rodolpho, Camila T. Nogueira, Juliana Cancino Bernardi, Carlos Speglich & Fernanda de Freitas Anibal. (2022) Toxicological effects of the mixed iron oxide nanoparticle (Fe3O4 NP) on murine fibroblasts LA-9. Journal of Toxicology and Environmental Health, Part A 85:16, pages 649-670.
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Daniel Krewski, Patrick Saunders-Hastings, Patricia Larkin, Margit Westphal, Michael G. Tyshenko, William Leiss, Maurice Dusseault, Michael Jerrett & Doug Coyle. (2022) Principles of risk decision-making. Journal of Toxicology and Environmental Health, Part B 25:5, pages 250-278.
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Ali Kermanizadeh, Nicklas R. Jacobsen, Agnieszka Mroczko, David Brown & Vicki Stone. (2021) Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures. Nanotoxicology 15:10, pages 1295-1311.
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Walter Brand, Petra C. E. van Kesteren, Ruud J. B. Peters & Agnes G. Oomen. (2021) Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure. Nanotoxicology 15:7, pages 905-933.
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Debora F. Silva, Ailime L. P. Melo, Ana F. C. Uchôa, Graziela M. A. Pereira, Alisson E. F. Alves, Maria C. Vasconcellos, Francisco H. Xavier-Júnior & Marcele F. Passos. (2023) Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review. International Journal of Molecular Sciences 24:23, pages 16719.
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Ying Liu, Meiyu Wu, Yi Liu, Jie Gao, Xiaoping Wang, Kuan Chen, Hairuo Wen, Liang Chen, Anliang Shao, Baiquan Xiao, Guanglu Ge & Liming Xie. (2023) Research progress and prospects of standardized testing and assessment for nanobiomaterials. Chinese Science Bulletin.
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Felix H. Englert, Fabrice A. Mueller, Battuja Dugershaw-Kurzer, Vera M. Kissling, Sarah Boentges, Govind S. Gupta, Gabriele A. Fontana, Sabine Diedrich, Laura Suter-Dick, Shana J. Sturla & Tina Buerki-Thurnherr. (2023) Environmentally relevant UV-light weathering of polystyrene micro- and nanoplastics promotes hepatotoxicity in a human cell line. Environmental Science: Nano 10:6, pages 1644-1659.
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Luwei Tian, Ming Guo, Haili Chen & Yanan Wu. (2023) Human health risk assessment of cinnamate UV absorbers: In vitro and in silico investigations. Environment International 171, pages 107658.
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Rachel Verdon, Vicki Stone, Fiona Murphy, Emily Christopher, Helinor Johnston, Shareen Doak, Ulla Vogel, Andrea Haase & Ali Kermanizadeh. (2022) The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment. Particle and Fibre Toxicology 19:1.
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Dhanashree Murugan, Vasanth Murugesan, Balaji Panchapakesan & Loganathan Rangasamy. (2022) Nanoparticle Enhancement of Natural Killer (NK) Cell-Based Immunotherapy. Cancers 14:21, pages 5438.
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Thi Kim Dung Doan, Masakazu Umezawa, Kyohei Okubo, Masao Kamimura, Masayuki Yamaguchi, Hirofumi Fujii & Kohei Soga. (2022) The effect of Gd-DOTA locations within PLGA- b -PEG micelle encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging . Biomaterials Science 10:21, pages 6244-6257.
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Ghedeir M. Alshammari, Mohamed Anwar Abdelhalim, Mohammed S. Al-Ayed, Laila Naif Al-Harbi & Mohammed Abdo Yahya. (2022) The Protective Effect of α-Lipoic Acid against Gold Nanoparticles (AuNPs)-Mediated Liver Damage Is Associated with Upregulating Nrf2 and Suppressing NF-κB. Nutrients 14:16, pages 3327.
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ChaoQun Liu, Yinquan Wang, DongLing Liu, Tao Yang & ZhanWen Tang. (2022) Analysis of Research Status and Development Trend of Nanotoxicology of Liliaceae Medicinal Plants. BioMed Research International 2022, pages 1-10.
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Tianshu Wu, Xinyu Wang, Min Chen, Xiaomeng Zhang, Jixiang Zhang, Jin Cheng, Lu Kong & Meng Tang. (2022) Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice. Food and Chemical Toxicology 163, pages 112971.
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Danielle Mulder, Cornelius Johannes Francois Taute, Mari van Wyk & Pieter J. Pretorius. (2022) A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells. Nanomaterials 12:7, pages 1126.
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Ali Kermanizadeh, Jessica Valli, Katarzyna Sanchez, Simon Hutter, Agnieszka Pawlowska, Graeme Whyte, Wolfgang Moritz & Vicki Stone. (2021) Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH. Archives of Toxicology 96:1, pages 287-303.
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Ali Kermanizadeh & Gwyndaf Roberts. 2022. Nanotoxicology in Safety Assessment of Nanomaterials. Nanotoxicology in Safety Assessment of Nanomaterials 259 273 .
Jossana A. Damasco, Tymish Y. Ohulchanskyy, Supriya Mahajan, Guanying Chen, Ajay Singh, Hilliard L. Kutscher, Haoyuan Huang, Steven G. Turowski, Joseph A. Spernyak, Anurag K. Singh, Jonathan F. Lovell, Mukund Seshadri & Paras N. Prasad. (2021) Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization. Cancer Nanotechnology 12:1.
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Vladimir V. Chrishtop, Artur Y. Prilepskii, Varvara G. Nikonorova & Vladimir A. Mironov. (2021) Nanosafety vs. nanotoxicology: adequate animal models for testing in vivo toxicity of nanoparticles. Toxicology 462, pages 152952.
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Jia-Bei Li, Wen-Song Xi, Shi-Ying Tan, Yuan-Yuan Liu, Hao Wu, Yuanfang Liu, Aoneng Cao & Haifang Wang. (2021) Effects of VO2 nanoparticles on human liver HepG2 cells: Cytotoxicity, genotoxicity, and glucose and lipid metabolism disorders. NanoImpact 24, pages 100351.
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Minakshi Prasad, Rajesh Kumar, Lukumoni Buragohain, Ankur Kumari & Mayukh Ghosh. (2021) Organoid Technology: A Reliable Developmental Biology Tool for Organ-Specific Nanotoxicity Evaluation. Frontiers in Cell and Developmental Biology 9.
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Jiani Liu, Jiayao Chen, Hongxing Liu, Ke Zhang, Qi Zeng, Shuai Yang, Zebo Jiang, Xiaoting Zhang, Tianfeng Chen, Dan Li & Hong Shan. (2021) Bi/Se-Based Nanotherapeutics Sensitize CT Image-Guided Stereotactic Body Radiotherapy through Reprogramming the Microenvironment of Hepatocellular Carcinoma. ACS Applied Materials & Interfaces 13:36, pages 42473-42485.
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Justyna Modrzynska, Alicja Mortensen, Trine Berthing, Gitte Ravn-Haren, Józef Szarek, Anne Thoustrup Saber & Ulla Vogel. (2021) Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously. Applied Nano 2:3, pages 222-241.
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Nicholas J. Braun, Rachel M. Galaska, Maggie E. Jewett & Kristen A. Krupa. (2021) Implementation of a Dynamic Co-Culture Model Abated Silver Nanoparticle Interactions and Nanotoxicological Outcomes In Vitro. Nanomaterials 11:7, pages 1807.
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Nicholas J. Hunt, Glen P. Lockwood, Sun W. S. Kang, Lara J. Westwood, Christina Limantoro, Wojciech Chrzanowski, Peter A. G. McCourt, Zdenka Kuncic, David G. Le Couteur & Victoria C. Cogger. (2021) Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano 15:3, pages 4710-4727.
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