2,038
Views
46
CrossRef citations to date
0
Altmetric
Original Articles

The “Prunus mume Sieb. et Zucc” (Ume) is a Rich Natural Source of Novel Anti-Cancer Substance

, , , , , , , , , , , & show all
Pages 375-384 | Received 10 Nov 2005, Accepted 01 Jan 2006, Published online: 27 Apr 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Tiantian Tian, Hui Cao, Mohamed A. Farag, Siting Fan, Luxuan Liu, Wenjing Yang, Yuxuan Wang, Liang Zou, Ka-Wing Cheng, Mingfu Wang, Xiaolei Ze, Jesus Simal-Gandara, Chao Yang & Zhiwei Qin. (2023) Current and potential trends in the bioactive properties and health benefits of Prunus mume Sieb. Et Zucc: a comprehensive review for value maximization. Critical Reviews in Food Science and Nutrition 63:24, pages 7091-7107.
Read now
Wael S. Al-Jahdari, Hideyuki Sakurai, Yukari Yoshida, Abdulelah Mobaraki, Yoshiyuki Suzuki & Takashi Nakano. (2011) MK615, a prospective anti-proliferative agent, enhances CD4/CD8 ratio after exposure to irradiation. International Journal of Radiation Biology 87:1, pages 81-90.
Read now

Articles from other publishers (44)

Faisal Hayat, Yang Bai, Shahid Iqbal, Chengdong Ma, Muhammad Moaaz Ali, Muhammad Adnan Shahid, Mahmood Ul Hasan, Walid F. A. Mosa, Ummara Khan, Huang Xiao & Zhihong Gao. (2023) Genome-wide analysis and expression profiling of YUCCA gene family associated with plant vigor in Japanese apricot (prunus mume Sieb. Et zucc). Horticulture, Environment, and Biotechnology 64:5, pages 819-833.
Crossref
Xilei Pu, Piping Ye, Jinkui Sun, Cai Zhao, Xuewei Shi, Bin Wang & Weidong Cheng. (2023) Investigation of dynamic changes in quality of small white apricot wine during fermentation. LWT 176, pages 114536.
Crossref
EungChan Kim, Suk-Ju Hong, Sang-Yeon Kim, Chang-Hyup Lee, Sungjay Kim, Hyuck-Joo Kim & Ghiseok Kim. (2022) CNN-based object detection and growth estimation of plum fruit (Prunus mume) using RGB and depth imaging techniques. Scientific Reports 12:1.
Crossref
Jinkui Sun, Cai Zhao, Xilei Pu, Tian Li, Xuewei Shi, Bin Wang & Weidong Cheng. (2022) Flavor and Functional Analysis of Lactobacillus plantarum Fermented Apricot Juice. Fermentation 8:10, pages 533.
Crossref
Richard Moore & Kaoru Yoneda. (2022) 1029. PRUNUS MUME: Rosaceae. Curtis's Botanical Magazine 39:3, pages 409-431.
Crossref
Maryam Haroon Al-Soufi, Hussah Abdullah Alshwyeh, Haifa Alqahtani, Safa Khalil Al-Zuwaid, Fatimah Othman Al-Ahmed, Fatima Taher Al-Abdulaziz, Daniya Raed, Khaoula Hellal, Nurul Hidayah Mohd Nani, Siti Norliyana Zubaidi, Nurul Syahidah Mio Asni, Hamizah Shahirah Hamezah, Nurkhalida Kamal, Hessah Al-Muzafar & Ahmed Mediani. (2022) A Review with Updated Perspectives on Nutritional and Therapeutic Benefits of Apricot and the Industrial Application of Its Underutilized Parts. Molecules 27:15, pages 5016.
Crossref
Cai Zhao, Jinkui Sun, Xilei Pu, Xuewei Shi, Weidong Cheng & Bin Wang. (2022) Volatile Compounds Analysis and Biomarkers Identification of Four Native Apricot (Prunus armeniaca L.) Cultivars Grown in Xinjiang Region of China. Foods 11:15, pages 2297.
Crossref
Congyan Su, Tian Li, Yongqin Wang, Zhengkai Ge, Jing Xiao, Xuewei Shi & Bin Wang. (2021) Comparison of phenolic composition, vitamin C, antioxidant activity, and aromatic components in apricots from Xinjiang. Journal of Food Science 87:1, pages 231-250.
Crossref
Congyan Su, Xiaochun Zheng, Dandan Zhang, Yu Chen, Jing Xiao, Yi He, Jingren He, Bin Wang & Xuewei Shi. (2020) Investigation of sugars, organic acids, phenolic compounds, antioxidant activity and the aroma fingerprint of small white apricots grown in Xinjiang. Journal of Food Science 85:12, pages 4300-4311.
Crossref
Sajad Mohd Wani, F. A. Masoodi, Sabreena Yousuf, B. N. Dar & S. A. Rather. (2020) Phenolic compounds and antiproliferative activity of apricots: Influence of canning, freezing, and drying. Journal of Food Processing and Preservation 44:11.
Crossref
Ting Shi, Shahid Iqbal, Aliya Ayaz, Yang Bai, Zhenpeng Pan, Xiaopeng Ni, Faisal Hayat, Muhammad Saqib Bilal, Muhammad Khuram Razzaq & Zhihong Gao. (2020) Analyzing Differentially Expressed Genes and Pathways Associated with Pistil Abortion in Japanese Apricot via RNA-Seq. Genes 11:9, pages 1079.
Crossref
Chong Woon Cho, Young Sik Park, Xi-Tao Yan, Hyun June Kim, Young Ho Kim, Kyung Tae Kim, Chu Van Men & Jong Seong Kang. (2020) Quantitation of Phenolic Compounds Related to Antioxidant and Antiosteoporosis Activities in Ripe and Unripe Maesil ( Prunus mume ) . Journal of Food Quality 2020, pages 1-13.
Crossref
Xueyuan Han, Qi Peng, Huanyi Yang, Baowei Hu, Chi Shen & Rungang Tian. (2020) Influence of different carbohydrate sources on physicochemical properties and metabolites of fermented greengage (Prunus mume) wines. LWT 121, pages 108929.
Crossref
Christian Bailly. (2020) Anticancer properties of Prunus mume extracts (Chinese plum, Japanese apricot). Journal of Ethnopharmacology 246, pages 112215.
Crossref
Ting Shi, Wenjie Luo, Hantao Li, Xiao Huang, Zhaojun Ni, Haidong Gao, Shahid Iqbal & Zhihong Gao. (2019) Association between blooming time and climatic adaptation in Prunus mume . Ecology and Evolution 10:1, pages 292-306.
Crossref
Sabry Ali El-Naggar, Karim Samy El-Said, Adel Abd Al Hameed Albagoury, Violet Sobhy Awad & Laila Hamada Attia. (2019) Cancer-fighting Phytochemicals of Prunus armeniaca and Prunus domestica Seeds Extracts. International Journal of Cancer Research 16:1, pages 10-17.
Crossref
Hyun‐Dong Cho, Jeong‐Ho Kim, Yeong‐Seon Won, Kwang‐Deok Moon & Kwon‐Il Seo. (2019) Inhibitory Effects of Pectinase‐Treated Prunus Mume Fruit Concentrate on Colorectal Cancer Proliferation and Angiogenesis of Endothelial Cells . Journal of Food Science 84:11, pages 3284-3295.
Crossref
Zhihong Gao. 2019. The Prunus mume Genome. The Prunus mume Genome 1 3 .
Wei Luo, Silvia Tappi, Chunfang Wang, Yong Yu, Songming Zhu & Pietro Rocculi. (2018) Study and optimization of high hydrostatic pressure (HHP) to improve mass transfer and quality characteristics of candied green plums ( Prunus mume ) . Journal of Food Processing and Preservation 42:11, pages e13769.
Crossref
Wei Luo, Silvia Tappi, Chunfang Wang, Yong Yu, Songming Zhu & Pietro Rocculi. (2018) Study of the Effect of High Hydrostatic Pressure (HHP) on the Osmotic Dehydration Mechanism and Kinetics of Wumei Fruit (Prunus mume). Food and Bioprocess Technology 11:11, pages 2044-2054.
Crossref
Masashi Yanaki, Masayuki Kobayashi, Atsushi Aruga, Minoru Nomura & Makoto Ozaki. (2018) In Vivo Antitumor Effects of MK615 Led by PD-L1 Downregulation. Integrative Cancer Therapies 17:3, pages 646-653.
Crossref
Adnan KhanJeong Hoon PanSeongha ChoSojung LeeYoung Jun KimYoungja H. Park. (2017) Investigation of the Hepatoprotective Effect of Prunus mume Sieb. et Zucc Extract in a Mouse Model of Alcoholic Liver Injury Through High-Resolution Metabolomics . Journal of Medicinal Food 20:8, pages 734-743.
Crossref
Masaya Inoue, Yoshio Honma, Takeshi Urano & Junji Suzumiya. (2017) Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells. Oncology Letters 14:1, pages 792-800.
Crossref
Jeong Hoon Pan, Ki Yong Lee, Jun Ho Kim, Hyeji Shin, Jin Hyup Lee & Young Jun Kim. (2016) Prunus mume Sieb. et Zucc. fruit ameliorates alcoholic liver injury in mice by inhibiting apoptosis and inflammation through oxidative stress. Journal of Functional Foods 25, pages 135-148.
Crossref
Alberto Beretta, Roberto Accinni, Cinzia Dellanoce, Annamaria Tonini, Jean-Michel Cardot & Anthony Bussière. (2016) Efficacy of a Standardized Extract of Prunus mume in Liver Protection and Redox Homeostasis: A Randomized, Double-Blind, Placebo-Controlled Study . Phytotherapy Research 30:6, pages 949-955.
Crossref
Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara & Masayuki Tokuda. (2015) A natural therapeutic approach for the treatment of periodontitis by MK615. Medical Hypotheses 85:5, pages 618-621.
Crossref
Hye-Rim Lee, Youngsook Park, Hyun Jeong Kim, Aram Lee, Jihea Choi, Jaeho Pyee, Heonyong Park & Jongmin Kim. (2015) Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation. Journal of Life Science 25:7, pages 801-809.
Crossref
Xinhua Zheng, Min Zhang, Zhongxiang Fang & Yaping Liu. (2014) Effects of low frequency ultrasonic treatment on the maturation of steeped greengage wine. Food Chemistry 162, pages 264-269.
Crossref
Ernesto Quast, Isabelli Vieira, Alessandro Nogueira & Flavio Luis Schmidt. (2013) Chemical and physical characterization of mume fruit collected from different locations and at different maturity stages in São Paulo State. Food Science and Technology 33:3, pages 441-445.
Crossref
Francisco A. Tomás‐Barberán, David Ruiz, Daniel Valero, Diego Rivera, Conchita Obón, Catalina Sánchez‐Roca & María I. Gil. 2013. Bioactives in Fruit. Bioactives in Fruit 125 167 .
Miho Hattori, Koshi Kawakami, Miho Akimoto, Keizo Takenaga, Junji Suzumiya & Yoshio Honma. (2018) Antitumor Effect of Japanese Apricot Extract (MK615) on Human Cancer Cells in Vitro and in Vivo through a Reactive Oxygen Species-Dependent Mechanism . Tumori Journal 99:2, pages 239-248.
Crossref
Takashi Hoshino, Hitoshi Takagi, Atsushi Naganuma, Eri Koitabashi, Sanae Uehara, Naomi Sakamoto, Tomohiro Kudo, Ken Sato & Satoru Kakizaki. (2013) Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”. World Journal of Hepatology 5:10, pages 596.
Crossref
Ko-ichi Tada, Ko-ichi Kawahara, Shigeto Matsushita, Teruto Hashiguchi, Ikuro Maruyama & Takuro Kanekura. (2012) MK615, a Prunus mume Steb. Et Zucc (‘Ume’) Extract, Attenuates the Growth of A375 Melanoma Cells by Inhibiting the ERK1/2-Id-1 Pathway . Phytotherapy Research 26:6, pages 833-838.
Crossref
Michael A. Huffman & Andrew J. J. MacIntosh. 2012. The Monkeys of Stormy Mountain. The Monkeys of Stormy Mountain 356 432 .
Yoko Morimoto-Yamashita, Miki Matsuo, Hitoshi Komatsuzawa, Ko-ichi Kawahara, Kiyoshi Kikuchi, Mitsuo Torii & Masayuki Tokuda. (2011) MK615: A new therapeutic approach for the treatment of oral disease. Medical Hypotheses 77:2, pages 258-260.
Crossref
Jae-Wook Jeong, Pil-Woo Nam, Seung-Joo Lee & Kwang-Geun Lee. (2011) Antioxidant Activities of Korean Rice Wine Concentrates. Journal of Agricultural and Food Chemistry 59:13, pages 7039-7044.
Crossref
Su-Tze Chou, Hsiu-Hui Chan, Hsin-Yi Peng, Meei-Jen Liou & Tian-Shung Wu. (2011) Isolation of substances with antiproliferative and apoptosis-inducing activities against leukemia cells from the leaves of Zanthoxylum ailanthoides Sieb. & Zucc. Phytomedicine 18:5, pages 344-348.
Crossref
. 2010. Bioactive Foods and Extracts. Bioactive Foods and Extracts 51 56 .
Tokihiko Sawada & Keiichi Kubota. 2010. Bioactive Foods and Extracts. Bioactive Foods and Extracts 31 35 .
S. Tsubaki, Y. Ozaki & J. Azuma. (2010) Microwave-Assisted Autohydrolysis of  Prunus mume  Stone for Extraction of Polysaccharides and Phenolic Compounds . Journal of Food Science 75:2, pages C152-C159.
Crossref
SHIGETO MATSUSHITA, KO-ICHI TADA, KO-ICHI KAWAHARA, KAZUHIRO KAWAI, TERUTO HASHIGUCHI, IKURO MARUYAMA & TAKURO KANEKURA. (2010) Advanced malignant melanoma responds to Prunus mume Sieb. Et Zucc (Ume) extract: Case report and in vitro study. Experimental and Therapeutic Medicine 1:4, pages 569-574.
Crossref
Yoko Morimoto, Kiyoshi Kikuchi, Takashi Ito, Masayuki Tokuda, Takashi Matsuyama, Satoshi Noma, Teruto Hashiguchi, Mitsuo Torii, Ikuro Maruyama & Ko-ichi Kawahara. (2009) MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells. Biochemical and Biophysical Research Communications 389:1, pages 90-94.
Crossref
Hiromichi Yamai, Naruhiko Sawada, Takahiro Yoshida, Jyunichi Seike, Hiromitsu Takizawa, Koichiro Kenzaki, Takanori Miyoshi, Kazuya Kondo, Yoshimi Bando, Yoshinari Ohnishi & Akira Tangoku. (2009) Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo . International Journal of Cancer 125:4, pages 952-960.
Crossref
Toshie Okada, Tokihiko Sawada, Tatsushi Osawa, Masakazu Adachi & Keiichi Kubota. (2008) MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases. World Journal of Gastroenterology 14:9, pages 1378.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.