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International Journal of Food Properties Volume 21, 2018 - Issue 1
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Original Article

Ethyl acetate leaf fraction of Cnidoscolus aconitifolius (Mill.) I. M. Johnst: antioxidant potential, inhibitory activities of key enzymes on carbohydrate metabolism, cholinergic, monoaminergic, purinergic, and chemical fingerprinting

Basiru Olaitan AjiboyeNutraceutical and Phytomedicine Research Laboratory, Biochemistry Programme, Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, NigeriaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5982-2322View further author information
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Oluwafemi Adeleke OjoNutraceutical and Phytomedicine Research Laboratory, Biochemistry Programme, Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, NigeriaORCID Iconhttps://orcid.org/0000-0001-9331-396XView further author information
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Mary Abiola OkesolaNutraceutical and Phytomedicine Research Laboratory, Biochemistry Programme, Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, NigeriaView further author information
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Babatunji Emmanuel OyinloyeNutraceutical and Phytomedicine Research Laboratory, Biochemistry Programme, Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria;Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaORCID Iconhttps://orcid.org/0000-0003-2165-7936View further author information
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Abidemi Paul KappoBiotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South AfricaORCID Iconhttps://orcid.org/0000-0003-2521-8957View further author information
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Pages 1697-1715 | Received 07 Jun 2018, Accepted 23 Jul 2018, Published online: 09 Aug 2018

Citations (19)

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Read on this site (4)

Reuben Samson Dangana, Reama Chinedu George & Femi Kayode Agboola. (2023) The biosynthesis of zinc oxide nanoparticles using aqueous leaf extracts of Cnidoscolus aconitifolius and their biological activities. Green Chemistry Letters and Reviews 16:1.
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Ibe Michael Usman, Samuel Sunday Adebisi, Sunday Abraham Musa, Ibrahim Abdullahi Iliya, Juma John Ochieng, Andrew Ekpeyong Ivang, Akwu Bala Peter & Akeem Ayodeji Okesina. (2022) Neurobehavioral and Immunohistochemical Studies of the Cerebral Cortex Following Treatment with Ethyl Acetate Leaf Fraction of Tamarindus indica During Prenatal Aluminum Chloride Exposure in Wistar Rats. Journal of Experimental Pharmacology 14, pages 275-289.
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Maria Lilibeth Manzanilla Valdez & Maira Rubi Segura Campos. (2021) Renal and Hepatic Disease: Cnidoscolus aconitifolius as Diet Therapy Proposal for Prevention and Treatment. Journal of the American College of Nutrition 40:7, pages 646-664.
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Faizul Azam, Honiwa Suliman Abodabos, Ismail M. Taban, Abdalla R. Rfieda, Danish Mahmood, Md Jamir Anwar, Shamshir Khan, Natalia Sizochenko, Giulio Poli, Tiziano Tuccinardi & Hamed I. Ali. (2019) Rutin as promising drug for the treatment of Parkinson’s disease: an assessment of MAO-B inhibitory potential by docking, molecular dynamics and DFT studies. Molecular Simulation 45:18, pages 1563-1571.
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Articles from other publishers (15)

Onoja Ojogbane Joel & Ugwueze Nnamdi Joachin. (2023) GC-MS Identification of Cholinesterase Inhibitory and Antioxidant Molecules from Leaves of Cnidoscolus aconitifolius (Miller) I.M. Johnston (Euphorbiaceae). Current Enzyme Inhibition 19:1, pages 19-37.
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Ibe Michael Usman, Abel Nosereme Agbon, Andrew Ekpeyong Ivang, Akwu Bala Peter, Adam Moyosore Afodun, Akeem Ayodeji Okesina, Victor Fischer, Bot Yakubu Sunday, Eric Osamu AigbogunJr.Jr., Ismail Onanuga, Caroline Asekenye, Ann Monima Lemuel & Keneth Iceland Kasozi. (2023) Ethyl acetate fraction of Tamarindus indica leaf ameliorates aluminium chloride induced neural damage in neonatal Wistar rats. Journal of Trace Elements and Minerals 3, pages 100047.
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Oluwafemi Adeleke Ojo, Damilare Emmanuel Rotimi, Adebola Busola Ojo, Akingbolabo Daniel Ogunlakin & Basiru Olaitan Ajiboye. (2023) Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats. Scientific Reports 13:1.
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Adebola Busola Ojo, Gideon Ampoma Gyebi, Olayinka Alabi, Matthew Iyobhebhe, Adedeji Benedict Kayode, Charles Obiora Nwonuma & Oluwafemi Adeleke Ojo. (2022) Syzygium aromaticum (L.) Merr. & L.M.Perry mitigates iron-mediated oxidative brain injury via in vitro, ex vivo, and in silico approaches. Journal of Molecular Structure 1268, pages 133675.
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Ibe Michael Usman, Samuel Sunday Adebisi, Sunday Abraham Musa, Ibrahim Abdullahi Iliya, Victor Bassey Archibong, Ann Monima Lemuel & Keneth Iceland Kasozi. (2022) Tamarindus indica ameliorates behavioral and cytoarchitectural changes in the cerebellar cortex following prenatal aluminum chloride exposure in Wistar rats . Anatomy & Cell Biology 55:3, pages 320-329.
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Oluwafemi Adeleke Ojo, Akingbolabo Daniel Ogunlakin, Matthew Iyobhebhe, Christopher Busayo Olowosoke, Odunayo Anthonia Taiwo, Akolade Akinola, Daniel Fadiora, Adeshina Isaiah Odugbemi, Gideon Ampoma Gyebi, Charles Obiora Nwonuma, Adebola Busola Ojo & Omolara Olajumoke Ojo. (2022) Computer aided and experimental study of cinnamic acid analog for oxidative stress treatment: The therapeutic validations. Informatics in Medicine Unlocked 35, pages 101137.
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María Lilibeth Manzanilla Valdez, Juan José Acevedo Fernández & Maira Rubi Segura Campos. (2021) Antidiabetic and hypotensive effect of Cnidoscolus aconitifolius (Mill) I.M Johnst leaves extracts. Journal of Food Measurement and Characterization 15:6, pages 5245-5255.
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Olubukola H. Oyeniran, Adedayo O. Ademiluyi & Ganiyu Oboh. (2021) Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro . Journal of Basic and Clinical Physiology and Pharmacology 32:5, pages 987-994.
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A. Anand Ganapathy, V.M. Hari Priya & Alaganandam Kumaran. (2021) Medicinal plants as a potential source of Phosphodiesterase-5 inhibitors: A review. Journal of Ethnopharmacology 267, pages 113536.
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Oluwafemi Adeleke Ojo, Mary Abiola Okesola, Lisa Ilobekemen Ekakitie, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Precious Eseose Agboinghale & Amos Sunday Onikanni. (2020) Gongronema latifolium Benth. leaf extract attenuates diabetes‐induced neuropathy via inhibition of cognitive, oxidative stress and inflammatory response . Journal of the Science of Food and Agriculture 100:12, pages 4504-4511.
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Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Bamidele Fatoba, Olakunke Bamikole Afolabi, Israel Olayide, Mary Abiola Okesola & Babatunji Emmanuel Oyinloye. (2020) In vitro antioxidant and enzyme inhibitory properties of the n -butanol fraction of Senna podocarpa (Guill. and Perr.) leaf . Journal of Basic and Clinical Physiology and Pharmacology 31:1.
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Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Omosola Olufisayo Anifowose, Ayodeji Akawa, Oluranti Esther Olaiya, Oluwaseun Ruth Olasehinde & Abidemi Paul Kappo. (2019) Ocimum gratissimum Linn. Leaves reduce the key enzymes activities relevant to erectile dysfunction in isolated penile and testicular tissues of rats. BMC Complementary and Alternative Medicine 19:1.
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Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Precious Eseose Agboinghale & Oluwafemi Adeleke Ojo. (2019) Cnidoscolus aconitifolius (Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo . Journal of Food Biochemistry 43:12.
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Oluwafemi Adeleke Ojo, Adeola Agnes Afon, Adebola Busola Ojo, Basiru Olaitan Ajiboye, Mary Abiola Okesola, Raphael Taiwo Aruleba, Tayo Alex Adekiya & Babatunji Emmanuel Oyinloye. (2019) Spondias mombim L. (Anacardiaceae): Chemical fingerprints, inhibitory activities, and molecular docking on key enzymes relevant to erectile dysfunction and Alzheimer’s diseases . Journal of Food Biochemistry 43:3, pages e12772.
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Mary Abiola Okesola, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye & Oluwafemi Adeleke Ojo. (2019) Neuromodulatory effects of ethyl acetate fraction of Zingiber officinale Roscoe extract in rats with lead-induced oxidative stress. Journal of Integrative Medicine 17:2, pages 125-131.
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