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Review

Ribosomal S6 kinase (RSK) modulators: a patent review

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Pages 1061-1078 | Received 14 Mar 2016, Accepted 11 Jul 2016, Published online: 01 Aug 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Eric B. Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A. O’Doherty & Deborah A. Lannigan. (2021) Identifying requirements for RSK2 specific inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1798-1809.
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My-my Huynh, Mary Rose Pambid, Aarthi Jayanthan, Andrew Dorr, Gerrit Los & Sandra E. Dunn. (2020) The dawn of targeted therapies for triple negative breast cancer (TNBC): a snapshot of investigational drugs in phase I and II trials. Expert Opinion on Investigational Drugs 29:11, pages 1199-1208.
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My-my Huynh, Aarthi Jayanthan, Mary Rose Pambid, Gerrit Los & Sandra E. Dunn. (2020) RSK2: a promising therapeutic target for the treatment of triple-negative breast cancer. Expert Opinion on Therapeutic Targets 24:1, pages 1-5.
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Fani Koutsougianni, Dimitra Alexopoulou, Ayca Uvez, Andromachi Lamprianidou, Evangelia Sereti, Chrisiida Tsimplouli, Elif Ilkay Armutak & Konstantinos Dimas. (2023) P90 ribosomal S6 kinases: A bona fide target for novel targeted anticancer therapies?. Biochemical Pharmacology 210, pages 115488.
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Rodrigo V.S. Bastos, Mariana S. Dorna, Fernanda Chiuso-Minicucci, Tainara F. Felix, Ana A.H. Fernandes, Paula S. Azevedo, Estefânia T. Franco, Bertha F. Polegato, Marcelo M. Rogero, Gustavo A.F. Mota, Bruna J. Quintanilha, Sergio A.R. Paiva, Leonardo A.M. Zornoff, Patricia P. Reis & Marcos F. Minicucci. (2023) Acute green tea intake attenuates circulating microRNA expression induced by a high-fat, high-saturated meal in obese women: A randomized crossover study. The Journal of Nutritional Biochemistry 112, pages 109203.
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Zhiqin Fu, Chao Ding, Wangang Gong & Chao Lu. (2023) ncRNAs mediated RPS6KA2 inhibits ovarian cancer proliferation via p38/MAPK signaling pathway. Frontiers in Oncology 13.
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Sisi Chen, Michael J. Seckl, Marc P. G. Lorentzen & Olivier E. Pardo. (2022) Differential Expression of RSK4 Transcript Isoforms in Cancer and Its Clinical Relevance. International Journal of Molecular Sciences 23:23, pages 14569.
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Deborah A Lannigan. (2022) ERK1/2-RSK2 Signaling in Regulation of ERα-Mediated Responses. Endocrinology 163:9.
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Chunmin Ma, Meng Liu, Jiong Zhang, Haiyan Cai, Yunzhao Wu, Ying Zhang, Yanjie Ji, Huizhuang Shan, Zhihui Zou, Li Yang, Ligen Liu, Hanzhang Xu, Hu Lei, Chuanxu Liu, Li Zhou, Yang Cao, Huchen Zhou & Yingli Wu. (2022) ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-κB signaling pathway. Chemico-Biological Interactions 351, pages 109770.
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Ryan Cronin, Greg N. Brooke & Filippo Prischi. (2021) The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance. Oncogene 40:22, pages 3775-3785.
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Po-Chien Chou, Swati Rajput, Xiaoyun Zhao, Chadni Patel, Danielle Albaciete, Won Jun Oh, Heineken Queen Daguplo, Nikhil Patel, Bing Su, Guy Werlen & Estela Jacinto. (2020) mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation. Cells 9:7, pages 1567.
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Yu Li, Pedro Seber, Eric B. Wright, Sharia Yasmin, Deborah A. Lannigan & George A. O'Doherty. (2020) The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C -4′-hydroxy . Chemical Communications 56:20, pages 3058-3060.
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Yu Li, Zachary M. Sandusky, Rajender Vemula, Qi Zhang, Bulan Wu, Shinji Fukuda, Mingzong Li, Deborah A. Lannigan & George A. O’Doherty. (2020) Regioselective Synthesis of a C -4′′ Carbamate, C -6′′ n -Pr Substituted Cyclitol Analogue of SL0101 . Organic Letters 22:4, pages 1448-1452.
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Xiaojuan Li, Lu Huang, Yunjun Xiao, Xiangyang Yao, Xubing Long, Fanxiu Zhu & Ersheng Kuang. (2019) Development of an ORF45-Derived Peptide To Inhibit the Sustained RSK Activation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus. Journal of Virology 93:10.
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Ling Lin, Samantha White & Kebin Hu. (2019) Role of p90RSK in Kidney and Other Diseases. International Journal of Molecular Sciences 20:4, pages 972.
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Katarzyna A. Ludwik, Oliver G. McDonald, David R. Brenin & Deborah A. Lannigan. (2018) ERα-Mediated Nuclear Sequestration of RSK2 Is Required for ER+ Breast Cancer Tumorigenesis. Cancer Research 78:8, pages 2014-2025.
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Per Hydbring, Alina Castell & Lars-Gunnar Larsson. (2017) MYC Modulation around the CDK2/p27/SKP2 Axis. Genes 8:7, pages 174.
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