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Review

An updated patent review of therapeutic applications of chalcone derivatives (2014-present)

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Pages 385-406 | Received 15 Feb 2019, Accepted 26 Apr 2019, Published online: 08 May 2019

Keep up to date with the latest research on this topic with citation updates for this article.

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Leonardo O. Aguiar, Eliane de Oliveira Silva & Jorge M. David. (2022) Biotransformation of chalcones and flavanones: An update on their bio-based derivatizations. Biocatalysis and Biotransformation 40:6, pages 393-412.
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Paloma Silva de Souza, Geysa Cristina Caldas Bibá, Evelynn Dalila do Nascimento Melo & Michelle Frazão Muzitano. (2022) Chalcones against the hallmarks of cancer: a mini-review. Natural Product Research 36:18, pages 4803-4820.
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Dana Elkhalifa, Israa Al-Hashimi, Ala-Eddin Al Moustafa & Ashraf Khalil. (2021) A comprehensive review on the antiviral activities of chalcones. Journal of Drug Targeting 29:4, pages 403-419.
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Yogeesha N. Nayak, Santosh L. Gaonkar & Mariya Sabu. (2023) Chalcones: Versatile intermediates in heterocyclic synthesis. Journal of Heterocyclic Chemistry 60:8, pages 1301-1325.
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Kibrom Mezgebe, Yadessa Melaku & Endale Mulugeta. (2023) Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N -Heterocyclic Scaffolds: A Review . ACS Omega 8:22, pages 19194-19211.
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Ahmad Zaidi Ismail, Mohanapriya Gunasekharan, Thiruventhan Karunakaran & Siti Munirah Mohd Faudzi. (2023) Crystal structure and Hirshfeld surface analysis of 3-(3-hydroxyphenyl)-1-(1 H -pyrrol-2-yl)prop-2-en-1-one hemihydrate . Acta Crystallographica Section E Crystallographic Communications 79:4, pages 287-291.
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Vivian Cordeiro Rodrigues, William Queiroz Felippe, Carla Marins Goulart, Aurea Echevarria & Ana Paula Pereira da Silva. (2022) Chalcone-thiosemicarbazone Hybrids as Inhibitors of Human Hepatocellular Carcinoma HepG2 Cells Viability and Oxygen Consumption. Current Bioactive Compounds 18:9.
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Wei-Yu Fang, Chih-Lung Lin, Wan-Hsuan Chang, Chih-Hsiang Chang, Yun-Cian Huang, Yi-Hong Tsai, Fang-Rong Chang & Yi-Ching Lo. (2022) Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide. International Journal of Molecular Sciences 23:21, pages 12929.
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D. S. Martsinkevich, K. F. Chernyavskaya, T. I. Ahramovich & V. A. Tarasevich. (2022) Synthesis and Antibacterial Activity of Novel Chalcone-derived Pyrazoles. Russian Journal of Organic Chemistry 58:5, pages 697-705.
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Qing Chen, Jiahong Lei, Jinzhe Zhou, Shaoze Ma, Qi Huang & Bujun Ge. (2021) Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in Apc Min mice . Oncology Letters 21:3.
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Pinki Yadav, Kashmiri Lal & Ashwani Kumar. (2020) Antimicrobial Screening, in Silico Studies and QSAR of Chalcone-based 1,4-disubstituted 1,2,3-triazole Hybrids. Drug Research.
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Paolo Guglielmi, Bijo Mathew, Daniela Secci & Simone Carradori. (2020) Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors. European Journal of Medicinal Chemistry 205, pages 112650.
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Ana M. L. Seca & Laila Moujir. (2020) Natural Compounds: A Dynamic Field of Applications. Applied Sciences 10:11, pages 4025.
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Carlos Diaz-Uribe, William Vallejo, Jiress Flórez, Jorge Trilleras, Margarita Gutierrez, Angela Rodriguez-Serrano, Eduardo Schott & Ximena Zarate. (2020) Furanyl chalcone derivatives as efficient singlet oxygen quenchers. An experimental and DFT/MRCI study. Tetrahedron 76:24, pages 131248.
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Della Grace Thomas Parambi, Jong Min Oh, Seung Cheol Baek, Jae Pil Lee, Anna Rita Tondo, Orazio Nicolotti, Hoon Kim & Bijo Mathew. (2019) Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors. Bioorganic Chemistry 93, pages 103335.
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