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Expert Opinion on Therapeutic Patents Volume 30, 2020 - Issue 4
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Review

Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)

Deborah QuaglioDepartment of Chemistry and Technology of Drugs, Department of Excellence 2018–2022, Sapienza University of Rome, Rome, ItalyView further author information
,
Paola InfanteCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, ItalyView further author information
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Lucia Di MarcotullioDepartment of Molecular Medicine, Department of Excellence 2018–2022, Sapienza University of Rome, Rome, Italy;Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, ItalyView further author information
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Bruno BottaDepartment of Chemistry and Technology of Drugs, Department of Excellence 2018–2022, Sapienza University of Rome, Rome, ItalyORCID Iconhttps://orcid.org/0000-0001-8707-4333View further author information
ORCID Icon &
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018–2022, University of Siena, Siena, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2398-1254View further author information
ORCID Icon
Pages 235-250 | Received 30 Nov 2019, Accepted 12 Feb 2020, Published online: 19 Feb 2020

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Christopher O Dusek & M Kyle Hadden. (2021) Targeting the GLI family of transcription factors for the development of anti-cancer drugs. Expert Opinion on Drug Discovery 16:3, pages 289-302.
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Ludovica Lospinoso Severini, Francesca Ghirga, Francesca Bufalieri, Deborah Quaglio, Paola Infante & Lucia Di Marcotullio. (2020) The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma. Expert Opinion on Therapeutic Targets 24:11, pages 1159-1181.
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Zifan Feng, Shanshan Zhu, Wenrui Li, Maojun Yao, Hualong Song & Ru-Bing Wang. (2022) Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy. European Journal of Medicinal Chemistry 244, pages 114867.
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Nabin Kandel & Chunyu Wang. (2022) Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery. Frontiers in Molecular Biosciences 9.
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N Fatima, N Sheikh, AR Satoskar, BK Jha, T Akhtar, A Tayyeb & I Ashfaq. (2021) Interaction of tacrolimus through hedgehog signaling pathway: An in vitro evaluation using rat hepatocytes. Human & Experimental Toxicology 40:11, pages 1955-1961.
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Mariia Radaeva, Anh-Tien Ton, Michael Hsing, Fuqiang Ban & Artem Cherkasov. (2021) Drugging the ‘undruggable’. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods. Drug Discovery Today 26:11, pages 2660-2679.
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Chaozhong Peng, Xiao Li, Zhixue Ye & Wenqing Wu. (2021) Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer. Scientific Reports 11:1.
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Juan Wang, Yu Zhang, Wen-jing Huang, Jun Yang, Wei-guo Tang, Tao-min Huang & Wen-fu Tan. (2020) ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic. Acta Pharmacologica Sinica 42:6, pages 1005-1013.
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Annapaola Angrisani, Annamaria Di Fiore, Claudia Augusta Di Trani, Simone Fonte, Marialaura Petroni, Ludovica Lospinoso Severini, Fabio Bordin, Laura Belloni, Elisabetta Ferretti, Gianluca Canettieri, Marta Moretti & Enrico De Smaele. (2021) Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2. Frontiers in Cell and Developmental Biology 9.
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Catriona JamiesonGiovanni MartinelliCristina PapayannidisJorge E. Cortes. (2020) Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia. Blood Cancer Discovery 1:2, pages 134-145.
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Francesca Bufalieri, Ludovica Lospinoso Severini, Miriam Caimano, Paola Infante & Lucia Di Marcotullio. (2020) DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer. Cancers 12:6, pages 1518.
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