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Expert Opinion on Therapeutic Patents Volume 32, 2022 - Issue 2
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Patenting perspective

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Piyusha P. Pagarea Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond VA, USAView further author information
,
Aref Rastegarb The Institute for Structural Biology, Drug Discovery, and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VAView further author information
,
Osheiza Abdulmalikc Division of Hematology, The Children’s Hospital of Philadelphia, PAView further author information
,
Abdelsattar M. Omard Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Alsulaymanyah, Jeddah, Saudi Arabia;e Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, EgyptView further author information
,
Yan Zhanga Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond VA, USAView further author information
,
Andrew Fleischmanf Illexcor Therapeutics, Richmond, VA, USAView further author information
&
Martin K. Safoa Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond VA, USA;b The Institute for Structural Biology, Drug Discovery, and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VACorrespondence[email protected]
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Pages 115-130 | Received 15 Jul 2021, Accepted 14 Oct 2021, Published online: 01 Nov 2021

Citations (5)

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Read on this site (1)

Gabriel F. Martins & N. Galamba. (2023) Protein aggregation-inhibition: a therapeutic route from Parkinson’s disease to sickle cell anemia. Critical Reviews in Biochemistry and Molecular Biology 58:1, pages 50-80.
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Articles from other publishers (4)

Glen E. Kellogg, Yana Cen, Malgorzata Dukat, Keith C. Ellis, Youzhong Guo, Jiong Li, Aaron E. May, Martin K. Safo, Shijun Zhang, Yan Zhang & Umesh R. Desai. (2023) Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular and behavioral pharmacology and computational chemistry. SLAS Discovery.
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Xiaomeng Xu, Mohini S. Ghatge, Boshi Huang, Ahmed Alghamdi, Huiqun Wang, B. Daniel Pierce, Osheiza Abdulmalik, Yan Zhang, Martin K. Safo & Jürgen Venitz. (2023) Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation. Journal of Pharmaceutical and Biomedical Analysis 223, pages 115152.
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William A. Eaton. (2022) Drug discovery by a basic research scientist. Frontiers in Molecular Biosciences 9.
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Boshi Huang, Mohini S. Ghatge, Akua K. Donkor, Faik N. Musayev, Tanvi M. Deshpande, Mohammed Al-Awadh, Rana T. Alhashimi, Hongmei Zhu, Abdelsattar M. Omar, Marilyn J. Telen, Yan Zhang, Tim J. McMahon, Osheiza Abdulmalik & Martin K. Safo. (2022) Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. Molecules 27:20, pages 6835.
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