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Expert Opinion on Investigational Drugs Volume 26, 2017 - Issue 2
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Editorial

Thoughts on investigational hedgehog pathway inhibitors for the treatment of cancer

Tarkan JägerDepartment of Surgery, Paracelsus Medical University, Salzburger Landeskliniken (SALK), Salzburg, AustriaView further author information
,
Matthias OckerExperimental Medicine Oncology, Bayer Pharma AG, Berlin, Germany;Department of Gastroenterology CBF, Charité University Medicine Berlin, Berlin, GermanyView further author information
,
Tobias KiesslichDepartment of Internal Medicine I, Paracelsus Medical University, Salzburger Landeskliniken (SALK), Salzburg, Austria;Laboratory for Tumour Biology and Experimental Therapies (TREAT), Institute of Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, AustriaView further author information
,
Elen NeureiterFaculty of Chemistry, University of Vienna, Vienna, AustriaView further author information
&
Daniel NeureiterInstitute of Pathology, Paracelsus Medical University, Salzburger Landeskliniken (SALK), Salzburg, Austria;Cancer Cluster Salzburg (CCS), Salzburg, AustriaCorrespondence[email protected]
View further author information
Pages 133-136 | Received 29 Sep 2016, Accepted 13 Dec 2016, Published online: 27 Dec 2016

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Marla Karine Amarante, Glauco Akelinghton Freire Vitiello, Marcos Henrique Rosa, Igor Alves Mancilla & Maria Angelica Ehara Watanabe. (2018) Potential use of CXCL12/CXCR4 and sonic hedgehog pathways as therapeutic targets in medulloblastoma. Acta Oncologica 57:9, pages 1134-1142.
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Articles from other publishers (9)

Ruolan Xia, Maosen Xu, Jing Yang & Xuelei Ma. (2022) The role of Hedgehog and Notch signaling pathway in cancer. Molecular Biomedicine 3:1.
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Jian Yi Chai, Vaisnevee Sugumar, Mohammed Abdullah Alshawsh, Won Fen Wong, Aditya Arya, Pei Pei Chong & Chung Yeng Looi. (2021) The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis. Biomedicines 9:9, pages 1188.
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Jaeyoung Yoon. (2021) Vismodegib dose reduction effective when combined with itraconazole for the treatment of advanced basal cell carcinoma. JAAD Case Reports 7, pages 107-109.
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Inamul Haque, Hameem I. Kawsar, Hannah Motes, Mukut Sharma, Snigdha Banerjee, Sushanta K. Banerjee, Andrew K. Godwin & Chao H. Huang. (2020) Downregulation of miR-506-3p Facilitates EGFR-TKI Resistance through Induction of Sonic Hedgehog Signaling in Non-Small-Cell Lung Cancer Cell Lines. International Journal of Molecular Sciences 21:23, pages 9307.
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Andrew C. Flick, Carolyn A. Leverett, Hong X. Ding, Emma McInturff, Sarah J. Fink, Christopher J. Helal, Jacob C. DeForest, Peter D. Morse, Subham Mahapatra & Christopher J. O’Donnell. (2020) Synthetic Approaches to New Drugs Approved during 2018. Journal of Medicinal Chemistry 63:19, pages 10652-10704.
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Anshika N. Singh & Neeti Sharma. (2019) Epigenetic Modulators as Potential Multi-targeted Drugs Against Hedgehog Pathway for Treatment of Cancer. The Protein Journal 38:5, pages 537-550.
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Madiha Niyaz, Mosin S. Khan, Rauf A. Wani, Omar J. Shah, Syed Besina & Syed Mudassar. (2019) Nuclear localization and Overexpression of Smoothened in Pancreatic and Colorectal Cancers. Journal of Cellular Biochemistry 120:7, pages 11941-11948.
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Minhang Xin, Xinyue Ji, Ladie Kimberly De La Cruz, Suresh Thareja & Binghe Wang. (2018) Strategies to target the Hedgehog signaling pathway for cancer therapy. Medicinal Research Reviews 38:3, pages 870-913.
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Guanghai Jin, Aneesh Sivaraman & Kyeong Lee. (2017) Development of taladegib as a sonic hedgehog signaling pathway inhibitor. Archives of Pharmacal Research 40:12, pages 1390-1393.
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