Advanced search
Publication Cover
Expert Opinion on Investigational Drugs Volume 28, 2019 - Issue 11
Submit an article Journal homepage
1,864
Views
61
CrossRef citations to date
0
Altmetric
Drug Evaluation

Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma

Giancarlo MaroneDepartment of Public Health, University of Naples Federico II, Naples, Italy;Azienda Ospedaliera Ospedali dei Colli - Monaldi Hospital Pharmacy, Naples, ItalyView further author information
,
Giuseppe SpadaroDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, Naples, ItalyView further author information
,
Mariantonia BraileDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, Naples, ItalyView further author information
,
Remo PotoDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, Naples, ItalyView further author information
,
Gjada CriscuoloDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, Naples, ItalyView further author information
,
Hadas PahimaPharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
,
Stefania LoffredoDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, Naples, Italy;Institute of Experimental Endocrinology and Oncology “G. Salvatore” (IEOS), National Research Council (CNR), Naples, ItalyView further author information
,
Francesca Levi-SchafferPharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelView further author information
&
Gilda VarricchiDepartment of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy;WAO Center of Excellence, Naples, Italy;Institute of Experimental Endocrinology and Oncology “G. Salvatore” (IEOS), National Research Council (CNR), Naples, ItalyCorrespondence[email protected]
View further author information
 show all
Pages 931-940 | Received 29 Jul 2019, Accepted 23 Sep 2019, Published online: 10 Oct 2019

Citations (61)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Tanya M Laidlaw, Andrew Menzies-Gow, Scott Caveney, Joseph K Han, Nicole Martin, Elliot Israel, Jason K Lee, Jean-Pierre Llanos, Neil Martin, Ayman Megally, Bhavini Parikh, Sylvia Vong, Tobias Welte & Jonathan Corren. (2023) Tezepelumab Efficacy in Patients with Severe, Uncontrolled Asthma with Comorbid Nasal Polyps in NAVIGATOR. Journal of Asthma and Allergy 16, pages 915-932.
Read now
Laren D Tan, Nolan Nguyen, Abdullah Alismail & Mario Castro. (2022) Management of Uncontrolled Asthma: A Framework for Novel and Legacy Biologic Treatments. Journal of Asthma and Allergy 15, pages 875-883.
Read now
Rafael de Oliveira Resende, Vinícius José de Oliveira, Alessandro Sousa Correa, Pedro Trica de Araújo & Ernesto Akio Taketomi. (2022) COVID-19 scenario and recommendations on the continuity of immunobiological therapy in patients with atopic asthma in Brazil and Latin America. Expert Review of Respiratory Medicine 16:2, pages 211-220.
Read now
Manisha Ramphul, David K H Lo & Erol A Gaillard. (2021) Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction. Journal of Asthma and Allergy 14, pages 525-538.
Read now
Stefano Passanisi, Lucia Caminiti, Giuseppina Zirilli, Fortunato Lombardo, Giuseppe Crisafulli, Tommaso Aversa & Giovanni B Pajno. (2021) Biologics in food allergy: up-to-date. Expert Opinion on Biological Therapy 21:9, pages 1227-1235.
Read now
Evgeniya Petrova & Alain Hovnanian. (2020) Advances in understanding of Netherton syndrome and therapeutic implications. Expert Opinion on Orphan Drugs 8:11, pages 455-487.
Read now
Alessandro Vatrella, Angelantonio Maglio, Simona Pellegrino, Corrado Pelaia, Cristiana Stellato, Girolamo Pelaia & Carolina Vitale. (2020) Phenotyping severe asthma: a rationale for biologic therapy. Expert Review of Precision Medicine and Drug Development 5:4, pages 265-274.
Read now
Kim Jackson & Sami L. Bahna. (2020) Hypersensitivity and adverse reactions to biologics for asthma and allergic diseases. Expert Review of Clinical Immunology 16:3, pages 311-319.
Read now

Articles from other publishers (53)

Sylwia Smolinska, Darío Antolín-Amérigo, Florin-Dan Popescu & Marek Jutel. (2023) Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma. International Journal of Molecular Sciences 24:16, pages 12725.
Crossref
Fei Lin, Bin Yu, Bowen Deng & Rong He. (2023) The efficacy and safety of tezepelumab in the treatment of uncontrolled asthma: A systematic review and meta-analysis of randomized controlled trials. Medicine 102:32, pages e34746.
Crossref
Peer Ameen Shah & Chris Brightling. (2023) Biologics for severe asthma—Which, when and why?. Respirology 28:8, pages 709-721.
Crossref
Yasuo Shimizu, Chie Sugimoto & Hiroshi Wakao. (2023) Potential of MAIT cells to modulate asthma. Allergology International.
Crossref
Johnny Su, Tyler Pitre, Kairavi Desai, Jasmine Mah, Parameswaran Nair, Terence Ho & Dena Zeraatkar. (2023) Anti-epithelial-derived cytokines for severe asthma: Systematic review and meta-analysis. Journal of Allergy and Clinical Immunology 151:6, pages 1566-1576.
Crossref
Gabriel Cavalcante Lima Chagas, Débora Xavier, Lorena Gomes, Juliana Ferri-Guerra & Rafael Enrique Hernandez Oquet. (2023) Effects of Tezepelumab on Quality of Life of Patients with Moderate-to-Severe, Uncontrolled Asthma: Systematic Review and Meta-Analysis. Current Allergy and Asthma Reports 23:6, pages 287-298.
Crossref
Remo Poto, Stefania Loffredo, Gianni Marone, Antonio Di Salvatore, Amato de Paulis, John T. Schroeder & Gilda Varricchi. (2023) Basophils beyond allergic and parasitic diseases. Frontiers in Immunology 14.
Crossref
Efthymia Theofani, Aikaterini Tsitsopoulou, Ioannis Morianos & Maria Semitekolou. (2023) Severe Asthmatic Responses: The Impact of TSLP. International Journal of Molecular Sciences 24:8, pages 7581.
Crossref
Daniela Mokra, Romana Barosova & Juraj Mokry. (2023) Sex-Based Differences in Bronchial Asthma: What Are the Mechanisms behind Them?. Applied Sciences 13:4, pages 2694.
Crossref
Maria Di Cicco, Michele Ghezzi, Ahmad Kantar, Woo-Jung Song, Andrew Bush, Diego Peroni & Enza D'Auria. (2023) Pediatric obesity and severe asthma: Targeting pathways driving inflammation. Pharmacological Research 188, pages 106658.
Crossref
Nightingale  Syabbalo . (2023) Targeting thymic stromal lymphopoietin for the treatment of severe eosinophilic asthma. Journal of Lung, Pulmonary & Respiratory Research 10:1, pages 1-3.
Crossref
Yusef Eamon Badi, Barbora Salcman, Adam Taylor, Batika Rana, Nazanin Zounemat Kermani, John H. Riley, Sally Worsley, Sharon Mumby, Sven‐Eric Dahlen, David Cousins, Silvia Bulfone‐Paus, Karen Affleck, Kian Fan Chung, Stewart Bates & Ian M. Adcock. (2022) IL1RAP expression and the enrichment of IL ‐33 activation signatures in severe neutrophilic asthma . Allergy 78:1, pages 156-167.
Crossref
Petros Bakakos, Evangelia Fouka, Petros Galanakis, Konstantinos Katsoulis, Konstantinos Kostikas, Stelios Loukides, Nikolas Mathioudakis, Konstantinos Porpodis, Konstantinos Samitas, Paschalis Steiropoulos & Eleftherios Zervas. (2022) Protocol, rationale and design of the PHOLLOW cross-sectional and retrospective chart review study to assess the prevalence and characterize the patient profile, clinical features and disease burden of type-2 low severe asthma in routine care settings in Greece. Pneumon 35:4, pages 1-13.
Crossref
Gilda Varricchi, Sebastian Ferri, Jack Pepys, Remo Poto, Giuseppe Spadaro, Emanuele Nappi, Giovanni Paoletti, Johann Christian Virchow, Enrico Heffler & Walter G. Canonica. (2022) Biologics and airway remodeling in severe asthma. Allergy 77:12, pages 3538-3552.
Crossref
Rory Chan & Brian J. Lipworth. (2022) Impact of Biologic Therapy on the Small Airways Asthma Phenotype. Lung 200:6, pages 691-696.
Crossref
Remo Poto, Gjada Criscuolo, Gianni Marone, Chris E. Brightling & Gilda Varricchi. (2022) Human Lung Mast Cells: Therapeutic Implications in Asthma. International Journal of Molecular Sciences 23:22, pages 14466.
Crossref
Remo Poto, Mohamed Shamji, Gianni Marone, Stephen R. Durham, Guy W. Scadding & Gilda Varricchi. (2022) Neutrophil Extracellular Traps in Asthma: Friends or Foes?. Cells 11:21, pages 3521.
Crossref
Anil Nanda, Syed Shahzad Mustafa, Maria Castillo & Jonathan A. Bernstein. (2022) Air Pollution Effects in Allergies and Asthma. Immunology and Allergy Clinics of North America 42:4, pages 801-815.
Crossref
Marc Duchesne, Isobel Okoye & Paige Lacy. (2022) Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response. Frontiers in Immunology 13.
Crossref
Dilawar Khokhar, Sahiti Marella, Gila Idelman, Joy W. Chang, Mirna Chehade & Simon P. Hogan. (2022) Eosinophilic esophagitis: Immune mechanisms and therapeutic targets. Clinical & Experimental Allergy 52:10, pages 1142-1156.
Crossref
Jan Romantowski, Aleksandra Górska, Grażyna Moszkowska, Julia Kulczycka, Karolina Minkowska, Agata Rolewicz, Marita Nittner-Marszalska & Marek Niedoszytko. (2022) Atopy and Multisensitizations in Specific IgE Microarrays and Their Impact on Severe Asthma. Life 12:10, pages 1520.
Crossref
Alexander C. Martins, Mariana Y. Oshiro, Fernando Albericio, Beatriz G. de la Torre, Gustavo José V. Pereira & Rodrigo V. Gonzaga. (2022) Trends and Perspectives of Biological Drug Approvals by the FDA: A Review from 2015 to 2021. Biomedicines 10:9, pages 2325.
Crossref
Feng Shi, Chaoting Zhu, Tianqi Zhou & Jianhui Liu. (2022) A Novel Multidose Dry Powder Inhaler and Its Application in Patients with Asthma and COPD. Journal of Sensors 2022, pages 1-14.
Crossref
Danilo Di Bona, Federico Spataro, Palma Carlucci, Giovanni Paoletti & Giorgio W. Canonica. (2022) Severe asthma and personalized approach in the choice of biologic. Current Opinion in Allergy & Clinical Immunology 22:4, pages 268-275.
Crossref
Adriana R. Gambardella, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Fabrizio Mattei, Gilda Varricchi & Giovanna Schiavoni. (2022) Differential Effects of Alarmins on Human and Mouse Basophils. Frontiers in Immunology 13.
Crossref
Remo Poto, Stefania Loffredo, Francesco Palestra, Gianni Marone, Vincenzo Patella & Gilda Varricchi. (2022) Angiogenesis, Lymphangiogenesis, and Inflammation in Chronic Obstructive Pulmonary Disease (COPD): Few Certainties and Many Outstanding Questions. Cells 11:10, pages 1720.
Crossref
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Anna Agnese Stanziola, Cecilia Calabrese, Rosa Terracciano, Federico Longhini & Alessandro Vatrella. (2022) Novel Biological Therapies for Severe Asthma Endotypes. Biomedicines 10:5, pages 1064.
Crossref
Corrado PELAIA, Giulia PELAIA, Claudia CRIMI, Federico LONGHINI, Nicola LOMBARDO, Rocco SAVINO, Angela SCIACQUA & Alessandro VATRELLA. (2022) Biologics in severe asthma. Minerva Medica 113:1.
Crossref
Brittany Salter, Paige Lacy & Manali Mukherjee. (2022) Biologics in Asthma: A Molecular Perspective to Precision Medicine. Frontiers in Pharmacology 12.
Crossref
Soyoon Sim, Youngwoo Choi & Hae-Sim Park. (2022) Immunologic Basis of Type 2 Biologics for Severe Asthma. Immune Network 22:6.
Crossref
Laura Haidar & Carmen Panaitescu. (2022) Biologics in severe asthma – a molecular perspective. Alergologia 1:6, pages 33.
Crossref
Fabio L. M. Ricciardolo, Vitina Carriero & Francesca Bertolini. (2021) Which Therapy for Non-Type(T)2/T2-Low Asthma. Journal of Personalized Medicine 12:1, pages 10.
Crossref
Yuko Abe, Yasuhiko Suga, Kiyoharu Fukushima, Hayase Ohata, Takayuki Niitsu, Hiroshi Nabeshima, Yasuharu Nagahama, Hiroshi Kida & Atsushi Kumanogoh. (2021) Advances and Challenges of Antibody Therapeutics for Severe Bronchial Asthma. International Journal of Molecular Sciences 23:1, pages 83.
Crossref
Lorenzo Salvati, Laura Maggi, Francesco Annunziato & Lorenzo Cosmi. (2021) Thymic stromal lymphopoietin and alarmins as possible therapeutical targets for asthma. Current Opinion in Allergy & Clinical Immunology 21:6, pages 590-596.
Crossref
Michael A. Portelli, Kamini Rakkar, Sile Hu, Yike Guo & Ian M. Adcock. (2021) Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations. Frontiers in Allergy 2.
Crossref
Mariantonia Braile, Alfonso Fiorelli, Daniela Sorriento, Rosa Maria Di Crescenzo, Maria Rosaria Galdiero, Gianni Marone, Mario Santini, Gilda Varricchi & Stefania Loffredo. (2021) Human Lung-Resident Macrophages Express and Are Targets of Thymic Stromal Lymphopoietin in the Tumor Microenvironment. Cells 10:8, pages 2012.
Crossref
Gilda Varricchi, Luca Modestino, Remo Poto, Leonardo Cristinziano, Luca Gentile, Loredana Postiglione, Giuseppe Spadaro & Maria Rosaria Galdiero. (2021) Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma. Clinical and Experimental Medicine 22:2, pages 285-300.
Crossref
Uma S. Ramaswamy, Katie Melder, Vijay A. Patel & Stella E. Lee. (2021) Current Evidence for Biologic Therapy in Chronic Rhinosinusitis with Nasal Polyposis. Otolaryngologic Clinics of North America 54:4, pages 689-699.
Crossref
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Luca Gallelli, Rosa Terracciano & Alessandro Vatrella. (2021) Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma. International Journal of Molecular Sciences 22:9, pages 4369.
Crossref
Mathieu Fieldes, Chloé Bourguignon, Said Assou, Amel Nasri, Aurélie Fort, Isabelle Vachier, John De Vos, Engi Ahmed & Arnaud Bourdin. (2021) Targeted therapy in eosinophilic chronic obstructive pulmonary disease. ERJ Open Research 7:2, pages 00437-2020.
Crossref
Gilda Varricchi, Nazareno Paolocci, Felice Rivellese & Giuseppe Rengo. (2021) Editorial: Smoldering Inflammation in Cardio-Immune-Metabolic Disorders. Frontiers in Physiology 12.
Crossref
Leonardo Cristinziano, Remo Poto, Gjada Criscuolo, Anne Lise Ferrara, Maria Rosaria Galdiero, Luca Modestino, Stefania Loffredo, Amato de Paulis, Gianni Marone, Giuseppe Spadaro & Gilda Varricchi. (2021) IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors. Cells 10:1, pages 145.
Crossref
Ian Mitchell & Gaynor GoviasIan Mitchell & Gaynor Govias. 2021. Asthma Education. Asthma Education 175 221 .
Javier Checa & Josep M. Aran. (2020) Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology. International Journal of Molecular Sciences 21:23, pages 9317.
Crossref
Nightingale Syabbalo. (2020) Airway epithelial dysfunction contributes to the pathogenesis of asthma. Journal of Lung, Pulmonary & Respiratory Research 7:4, pages 101-105.
Crossref
Corrado Pelaia, Claudia Crimi, Alessandro Vatrella, Caterina Tinello, Rosa Terracciano & Girolamo Pelaia. (2020) Molecular Targets for Biological Therapies of Severe Asthma. Frontiers in Immunology 11.
Crossref
Kanwaljit K. Brar, Bruce J. Lanser, Amanda Schneider & Anna Nowak-Wegrzyn. (2020) Biologics for the Treatment of Food Allergies. Immunology and Allergy Clinics of North America 40:4, pages 575-591.
Crossref
James Walter Krempski, Christopher Dant & Kari C. Nadeau. (2020) The origins of allergy from a systems approach. Annals of Allergy, Asthma & Immunology 125:5, pages 507-516.
Crossref
Carrie-Anne Malinczak, Nicholas W. Lukacs & Wendy Fonseca. (2020) Early-Life Respiratory Syncytial Virus Infection, Trained Immunity and Subsequent Pulmonary Diseases. Viruses 12:5, pages 505.
Crossref
Polyxeni Ntontsi, Konstantinos Samitas, Eleftherion Zervas & Mina Gaga. (2020) Severe asthma: what is new in the new millennium. Current Opinion in Allergy & Clinical Immunology 20:2, pages 202-207.
Crossref
Maria Gabriella Matera, Paola Rogliani, Luigino Calzetta & Mario Cazzola. (2020) TSLP Inhibitors for Asthma: Current Status and Future Prospects. Drugs 80:5, pages 449-458.
Crossref
Riccardo Guidi, Christopher J. Wedeles & Mark S. Wilson. (2020) ncRNAs in Type-2 Immunity. Non-Coding RNA 6:1, pages 10.
Crossref
Fabrizio Mattei, Sara Andreone, Giancarlo Marone, Adriana Rosa Gambardella, Stefania Loffredo, Gilda Varricchi & Giovanna Schiavoni. 2020. Tumor Microenvironment. Tumor Microenvironment 1 28 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.