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Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu & Kamil Kuca. (2023) Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK). Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Aws Khalid Abushanab, Mahmoud Taysir Mousa, Mus’ab Theeb Mustafa & Rana Ahmed Qawaqzeh. (2023) The efficacy and safety of Capivasertib (AZD5363) in the treatment of patients with solid tumor: a systematic review and meta-analysis of randomized clinical trials. Expert Opinion on Drug Safety 22:9, pages 799-805.
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Fanbo Meng & Liting Dai. (2023) Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition. Growth Factors 41:2, pages 71-81.
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Xianglong Pan, Xiaotao Hou, Fan Zhang, Peiling Tang, Wanruo Wan, Zixia Su, Yeguo Yang, Wei Wei, Zhengcai Du, Jiagang Deng & Erwei Hao. (2022) Gnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells. Pharmaceutical Biology 60:1, pages 915-930.
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Katherine Shishido, Alexis Reinders & Swapna Asuthkar. (2022) Epigenetic regulation of radioresistance: insights from preclinical and clinical studies. Expert Opinion on Investigational Drugs 31:12, pages 1359-1375.
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Yu Guo, Yizhen Jin, Bingxue Qu, Yu Zhang, Jinxin Che & Xiaowu Dong. (2021) An updated patent review of Akt inhibitors (2016-present). Expert Opinion on Therapeutic Patents 31:9, pages 837-849.
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Yingchen Ji, Weiwei Hu, Yan Jin, Huiming Yu & Jin Fang. (2021) Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo. Bioengineered 12:1, pages 6070-6082.
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Lixia Cai, Yangji Xue, Jianzu Ding & Bin Zheng. (2020) Long Non-Coding RNA AC118344.1 Promotes Gastric Cancer Cell Proliferation, Invasion, and Metastasis via AKT2 and Its Downstream Molecules HK2 and MMP2. Cancer Management and Research 12, pages 12613-12621.
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Massimo Magagnoli, Carmelo Carlo-Stella & Armando Santoro. (2020) Copanlisib for the treatment of adults with relapsed follicular lymphoma. Expert Review of Clinical Pharmacology 13:8, pages 813-823.
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Articles from other publishers (114)
Wenqi Liu, Shiwen Kang, Huijian Chen, Yerlan Bahetjan, Jinyan Zhang, Rumei Lu, Ni Zheng, Guangzhong Yang & Xinzhou Yang. (2024) A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress. Journal of Ethnopharmacology 319, pages 117351.
Crossref
Crossref
Luyao Li, Zhen Lin, Junhui Yuan, Pingping Li, Qi Wang, Namki Cho, Yi Wang & Zhenlang Lin. (2024) The neuroprotective mechanisms of naringenin: Inhibition of apoptosis through the PI3K/AKT pathway after hypoxic-ischemic brain damage. Journal of Ethnopharmacology 318, pages 116941.
Crossref
Crossref
Sirinthip Klaophimai, Phisit Pouyfung, Ariyaphong Wongnoppavich & Kongthawat Chairatvit. (2023) Induction of S arrest and apoptosis in human oral cancer cells by Rhinacanthin-C extracted from Rhinacanthus nasutus via modulating Akt and p38 signaling pathways. Journal of Ethnopharmacology 317, pages 116813.
Crossref
Crossref
Mateusz Wylaź, Anna Kaczmarska, Dawid Pajor, Matthew Hryniewicki, Dorota Gil & Joanna Dulińska-Litewka. (2023) Exploring the role of PI3K/AKT/mTOR inhibitors in hormone-related cancers: A focus on breast and prostate cancer. Biomedicine & Pharmacotherapy 168, pages 115676.
Crossref
Crossref
Heena Kansal, Vishal Chopra, Kranti Garg & Siddharth Sharma. (2023) Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target. Respiratory Research 24:1.
Crossref
Crossref
Manfen Shao, Wei Zhao, Kai Shen & Huoxi Jin. (2023)
Peptides from
Harpadon nehereus
Bone Ameliorate Angiotensin II-Induced HUVEC Injury and Dysfunction through Activation of the AKT/eNOS and Nrf2 Pathway
. ACS Omega 8:44, pages 41655-41663.
Crossref
Crossref
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski & Ireneusz Majsterek. (2023) PI3K/Akt/mTOR Signaling Pathway in Blood Malignancies—New Therapeutic Possibilities. Cancers 15:21, pages 5297.
Crossref
Crossref
Ayushi Singh, Rakhi Mishra & Avijit Mazumder. (2023) Breast cancer and its therapeutic targets: A comprehensive review. Chemical Biology & Drug Design.
Crossref
Crossref
Duo Wang, Sizhen Wang, Yuanfeng Zhang, Xiaolei Cheng, Xin Huang, Yanxi Han, Zhaohui Chen, Cong Liu, Jinming Li & Rui Zhang. (2023) Validation and benchmarking of targeted panel sequencing for cancer genomic profiling. American Journal of Clinical Pathology 160:5, pages 507-523.
Crossref
Crossref
Kaijie Qiu, Qing Xia, Hao Chen, Qiong Ye, Haixiang Mao, Mei Tian, Yichao Gan, Qinyuan Huang, Haibiao Wang & Shiwei Duan. (2023) Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study. Heliyon 9:11, pages e21851.
Crossref
Crossref
Li Chen, Yikai Lu, Mengmeng Zhao, Junfang Xu, Yan Wang, Qinghua Xu, Yajuan Cao & Haipeng Liu. (2023) A non‐canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT). The Journal of Gene Medicine.
Crossref
Crossref
Yixi Zhang, Kai Ma, Lei Jiang, Lili Xu, Yingbin Luo, Jianchun Wu & Yan Li. (2023) Revealing the Preventable Effects of Fu-Zheng-Qu-Xie Decoction against Recurrence and Metastasis of Postoperative Early-Stage Lung Adenocarcinoma Based on Network Pharmacology Coupled with Metabolomics Analysis. ACS Omega.
Crossref
Crossref
Wuyu Chen, Minghao Ruan, Minghao Zou, Fuchen Liu & Hui Liu. (2023) Clinical Significance of Non-Coding RNA Regulation of Programmed Cell Death in Hepatocellular Carcinoma. Cancers 15:16, pages 4187.
Crossref
Crossref
Hui Shao, Jingyan Chen, Ali Li, Lili Ma, Yongzhi Tang, Huazhong Chen, Yongping Chen & Junyan Liu. (2023) Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway. Applied Biochemistry and Biotechnology 195:8, pages 5217-5237.
Crossref
Crossref
Jillian O'Donnell, Ziyi Zhao, Lindsey Buckingham, Tianran Hao, Hongyan Suo, Xin Zhang, Yali Fan, Catherine John, Boer Deng, Xiaochang Shen, Wenchuan Sun, Angeles Secord, Chunxiao Zhou & Victoria Bae‑Jump. (2023)
Ipatasertib exhibits anti‑tumorigenic effects and enhances sensitivity to paclitaxel in endometrial cancer
in vitro
and
in vivo
. International Journal of Oncology 63:3.
Crossref
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Lan Yang, Jianfei Nao & Xiaoyu Dong. (2023)
The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on
In Vivo
Research Advancements
. Journal of Agricultural and Food Chemistry 71:29, pages 10932-10951.
Crossref
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Yanqing Liu, Qiong Liu, Zhe Zhang, Yaru Yang, Yazhe Zhou, Huanle Yan, Xin Wang, Xiaoru Li, Jing Zhao, Jingyan Hu, Shulin Yang, Yifan Tian, Yu Yao, Zhenye Qiu, Yanbin Song & Yang Yang. (2023) The regulatory role of PI3K in ageing-related diseases. Ageing Research Reviews 88, pages 101963.
Crossref
Crossref
Lateef O. Anifowose, Oluwatomiwa K. Paimo, Fikayo N. Adegboyega, Oludare M. Ogunyemi, Rukayat O. Akano, Sherif F. Hammad & Mohamed A. Ghazy. (2023) Molecular docking appraisal of Dysphania ambrosioides phytochemicals as potential inhibitor of a key triple-negative breast cancer driver gene. In Silico Pharmacology 11:1.
Crossref
Crossref
Binhao Chen & Weifeng Jin. (2023) A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine. Frontiers in Neuroscience 17.
Crossref
Crossref
Federica Aliquò, Aurelio Minuti, Angela Avenoso, Giuseppe Mandraffino, Giuseppe Maurizio Campo, Salvatore Campo, Angela D‘Ascola & Michele Scuruchi. (2023) Endocan Promotes Pro-Tumorigenic Signaling in Lung Cancer Cells: Modulation of Cell Proliferation, Migration and lncRNAs H19 and HULC Expression. International Journal of Molecular Sciences 24:9, pages 8178.
Crossref
Crossref
Mateen Nawaz, Moussa Gouife, Songwei Zhu, Xinyuan Yue, Kejing Huang, Rongrong Ma, Jianhu Jiang, Shan Jin, Junquan Zhu & Jiasong Xie. (2023) Transcriptome profiling and differential expression analysis of altered immune-related genes in goldfish (Carassius auratus) infected with Aeromonas hydrophila. Fish & Shellfish Immunology, pages 108789.
Crossref
Crossref
Xianren Wang, Fanrong Liu, Zhenhua Cui, Zhiwen Li & Yanfeng Lv. (2023) Carboxypeptidase A6 suppresses the proliferation and invasion of colorectal cancer cells and is negatively regulated by miR-96–3p. Archives of Biochemistry and Biophysics 740, pages 109595.
Crossref
Crossref
Mohammad Reza Amiran, Majid Taghdir & Farzane Abasi Joozdani. (2023) Investigation of the inhibitory behavior of XFE and mitoxantrone molecules in interaction with AKT1 protein: a molecular dynamics simulation study. Journal of Molecular Modeling 29:5.
Crossref
Crossref
Yiman Zhai, Tingyu Wang, Yunmei Fu, Tong Yu, Yan Ding & Hongguang Nie. (2023) Ferulic Acid: A Review of Pharmacology, Toxicology, and Therapeutic Effects on Pulmonary Diseases. International Journal of Molecular Sciences 24:9, pages 8011.
Crossref
Crossref
Seeun Kwon, Sumin Jung & Seung Ho Baek. (2023) Combination Therapy of Radiation and Hyperthermia, Focusing on the Synergistic Anti-Cancer Effects and Research Trends. Antioxidants 12:4, pages 924.
Crossref
Crossref
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang & Ruth Nussinov. (2023) Strategy toward Kinase-Selective Drug Discovery. Journal of Chemical Theory and Computation 19:5, pages 1615-1628.
Crossref
Crossref
Korrakod Petsri, Masashi Yokoya, Satapat Racha, Sunisa Thongsom, Chorpaka Thepthanee, Bhurichaya Innets, Zin Zin Ei, Daiki Hotta, Hongbin Zou & Pithi Chanvorachote. (2023) Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells. International Journal of Molecular Sciences 24:6, pages 5345.
Crossref
Crossref
Zhe Gong, Yanqiu Zhang, Yue Yang, Yanan Yang, Jieyun Zhang, Yixuan Wang, Liqin Zhao, Nuoya Yu, Zhenhua Wu & Weijian Guo. (2023) LncRNA LINC01094 Promotes Cells Proliferation and Metastasis through the PTEN/AKT Pathway by Targeting AZGP1 in Gastric Cancer. Cancers 15:4, pages 1261.
Crossref
Crossref
An Tong, Xiangjie Di, Xia Zhao & Xiao Liang. (2023) Review the progression of ovarian clear cell carcinoma from the perspective of genomics and epigenomics. Frontiers in Genetics 14.
Crossref
Crossref
Susan Gong, Fred Gong & Abdo Kabarriti. (2023) Top 50 Most Cited Articles About OAB: A Bibliometric Analysis. Urology 172, pages 69-78.
Crossref
Crossref
Xingde Du, Haohao Liu, Zhihui Tian, Shiyu Zhang, Linjia Shi, Yongshui Wang, Xing Guo, Bingyu Zhang, Shumeng Yuan, Xin Zeng & Huizhen Zhang. (2022)
PI3K
/
AKT
/
mTOR
pathway mediated‐cell cycle dysregulation contribute to malignant proliferation of mouse spermatogonia induced by microcystin‐leucine arginine
. Environmental Toxicology 38:2, pages 343-358.
Crossref
Crossref
Yifan Ma, Yue Wang, Chen Nie & Yongzhong Lin. (2023) The efficacy of targeted therapy combined with radiotherapy and temozolomide-based chemotherapy in the treatment of glioma: A systemic review and meta-analysis of phase II/III randomized controlled trials. Frontiers in Oncology 13.
Crossref
Crossref
Yifei Wang, Yuxiao Zhao, Yizhang Zhu, Heng Xu, Wanxin Zhao, Chao Huang, Bixi Wang, Xiaoge Gao, Qing Zhang, Junnian Zheng & Shishuo Sun. (2023) DHA attenuates CAR-T cell efficacy through aggravating exhaustion and inducing apoptosis. Biologia 78:4, pages 1141-1152.
Crossref
Crossref
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Igino Simonetti, Carmine Picone, Ester Simeone, Lucia Festino, Vito Vanella, Maria Grazia Vitale, Agnese Montanino, Alessandro Morabito, Francesco Izzo, Paolo Antonio Ascierto & Antonella Petrillo. (2023) Immunotherapy Assessment: A New Paradigm for Radiologists. Diagnostics 13:2, pages 302.
Crossref
Crossref
Maria Antonietta Occhiuzzi, Gernando Lico, Giuseppina Ioele, Michele De Luca, Antonio Garofalo & Fedora Grande. (2023) Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents. European Journal of Medicinal Chemistry 246, pages 114971.
Crossref
Crossref
Guanlan Fan, Fan Wang, Yurou Chen, Qian Zheng, Jie Xiong, Qiongying Lv, Kejia Wu, Jiaqiang Xiong, Lei Wei, Dongqing Li, Jiachen Zhang, Wei Zhang & Feng Li. (2023) The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region. Cell Reports 42:1, pages 111916.
Crossref
Crossref
Sanchit Gandhi, Shruti Khanna, Shikha Kaushik, Deepali Chaudhry, Pooja Ghorawat, Jonita Chongtham & Tapasya Srivastava. 2023. Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Hypoxia in Cancer: Significance and Impact on Cancer Therapy
181
216
.
Deborah Palazzotti, Martina Fiorelli, Stefano Sabatini, Serena Massari, Maria Letizia Barreca & Andrea Astolfi. (2022) Q-raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation. Journal of Chemical Information and Modeling 62:24, pages 6309-6315.
Crossref
Crossref
Qingfang Li, Zhihui Li, Ting Luo & Huashan Shi. (2022) Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy. Molecular Biomedicine 3:1.
Crossref
Crossref
Zhixin Jia, Lirong Liu, Cong Fang, Mingxia Pan, Shiyu Cong, Zhonghui Guo, Xiaoqin Yang, Jie Liu, Yueting Li & Hongbin Xiao. (2022) A Network-Pharmacology-Combined Integrated Pharmacokinetic Strategy to Investigate the Mechanism of Potential Liver Injury due to Polygonum multiflorum. Molecules 27:23, pages 8592.
Crossref
Crossref
Yuhua Li, Shengyu Cui, Bing Wu, Jixian Gao, Ming Li, Furong Zhang & Hao Xia. (2022) FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells. Biochemical and Biophysical Research Communications 634, pages 152-158.
Crossref
Crossref
Fang Liu, Bo Cao, Heng Zhang, Qi Zou, Guoxiong Liu, Yukun Dong, Dan Su & Dong-lin Ren. (2022) Exploring the mechanism of Tengli Kangliu Decoction in the prevention and treatment of colorectal cancer precancerous based on network pharmacology. Medicine 101:46, pages e31690.
Crossref
Crossref
Shan Gao, Tianjun Zhao, Fangchi Meng, Yinzhou Luo, Yan Li & Yong Wang. (2022) Circular RNAs in endometrial carcinoma (Review). Oncology Reports 48:6.
Crossref
Crossref
Alia Ghoneum, Daniela Gonzalez, Hesham Afify, Junjun Shu, Abigail Hegarty, Jemima Adisa, Michael Kelly, Samuel Lentz, Freddie Salsbury & Neveen Said. (2022) Compound C Inhibits Ovarian Cancer Progression via PI3K-AKT-mTOR-NFκB Pathway. Cancers 14:20, pages 5099.
Crossref
Crossref
Jakub Szymczyk, Martyna Sochacka, Patryk Chudy, Lukasz Opalinski, Jacek Otlewski & Malgorzata Zakrzewska. (2022) FGF1 protects FGFR1-overexpressing cancer cells against drugs targeting tubulin polymerization by activating AKT via two independent mechanisms. Frontiers in Oncology 12.
Crossref
Crossref
Wujun Wei, Cheng Lin, Rentong Hu, Jingjing Huang, Xiaohao Chen, Lv Zhou, Jiazhu Wei, Yi-Bin Deng & Chun-Fang Wang. (2022) LOC102553417 silencing facilitates the apoptosis of hepatic stellate cells via the miR‑30e/MTDH axis. Molecular Medicine Reports 26:5.
Crossref
Crossref
Christopher Rennie, Dylan S. Irvine, Evan Huang & Jeffrey Huang. (2022) Music Therapy as a Form of Nonpharmacologic Pain Modulation in Patients with Cancer: A Systematic Review of the Current Literature. Cancers 14:18, pages 4416.
Crossref
Crossref
Li-Tzu Huang, Chin-Ho Kuo, Lin Tseng, Yi-Syuan Li, Li-Hsin Cheng, Chin-Yun Cheng, Shane-Rong Sheu, Wen-Tsan Chang, Chien-Chin Chen & Hung-Chi Cheng. (2022) Alpha-Mangostin Reduces Pericellular Fibronectin on Suspended Tumor Cells and Therapeutically, but Not Prophylactically, Suppresses Distant Metastasis. Life 12:9, pages 1375.
Crossref
Crossref
Jie Zhang, Li Cen, Xiaofen Zhang, Chenxi Tang, Yishu Chen, Yuwei Zhang, Mengli Yu, Chao Lu, Meng Li, Sha Li, Bingru Lin, Tiantian Zhang, Xin Song, Chaohui Yu, Hao Wu & Zhe Shen. (2022) MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT. Redox Biology, pages 102469.
Crossref
Crossref
Mohsen Karami fath, Menooa Ebrahimi, Ehsan Nourbakhsh, Ahmad Zia Hazara, Ali Mirzaei, Saba Shafieyari, Azadeh Salehi, Mahsa Hoseinzadeh, Zahra Payandeh & Ghasem Barati. (2022) PI3K/Akt/mTOR signaling pathway in cancer stem cells. Pathology - Research and Practice 237, pages 154010.
Crossref
Crossref
Zuan Li, DeYong Nong, Bincai Li, Haojian Wang, Chunlin Li, Zhi Chen, Ximing Li, Guihai Huang, Junhao Lin, Nan Hao & Wei Li. (2022) Effect of AKT silence on malignant biological behavior of renal cell carcinoma cells. BMC Urology 22:1.
Crossref
Crossref
Adam Hermawan, Febri Wulandari, Naufa Hanif, Rohmad Yudi Utomo, Riris Istighfari Jenie, Muthi Ikawati & Ahmad Syauqy Tafrihani. (2022) Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study. Scientific Reports 12:1.
Crossref
Crossref
Hwan Bae, Thibault Viennet, Eunyoung Park, Nam Chu, Antonieta Salguero, Michael J Eck, Haribabu Arthanari & Philip A Cole. (2022) PH domain-mediated autoinhibition and oncogenic activation of Akt. eLife 11.
Crossref
Crossref
Oxana V. Denisova, Joni Merisaari, Amanpreet Kaur, Laxman Yetukuri, Mikael Jumppanen, Carina von Schantz-Fant, Michael Ohlmeyer, Krister Wennerberg, Tero Aittokallio, Mikko Taipale & Jukka Westermarck. (2022) Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells. Scientific Reports 12:1.
Crossref
Crossref
Xueye Tian, Dan Liu, Xiaohang Zuo, Xiaoli Sun, Mengmin Wu, Xu Li & Yue Teng. (2022) Hexokinase 2 promoted cell motility and proliferation by activating Akt1/p-Akt1 in human ovarian cancer cells. Journal of Ovarian Research 15:1.
Crossref
Crossref
Meng Li, Wenqi Zhang, Yihan Wang, Kai Huang, Tao Sun, Zhicong Qiu, Linqi Yang, Meng Wu, Xiaolu Zhang & Wei Zhang. (2022) DDTC Suppresses Ovarian Cancer Development via the PI3K/AKT/mTOR Signaling Pathway. Disease Markers 2022, pages 1-11.
Crossref
Crossref
Cheng-Liang Zhu, Xiaomin Luo, Tian Tian, Zijian Rao, Hanlin Wang, Zhesheng Zhou, Tian Mi, Danni Chen, Yongjin Xu, Yizhe Wu, Jinxin Che, Yubo Zhou, Jia Li & Xiaowu Dong. (2022) Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader. European Journal of Medicinal Chemistry 238, pages 114459.
Crossref
Crossref
Motahareh Mortazavi, Fatemeh Moosavi, Miriam Martini, Elisa Giovannetti & Omidreza Firuzi. (2022) Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer. Critical Reviews in Oncology/Hematology 176, pages 103749.
Crossref
Crossref
Sisi Liu, Yaxin Li, Jin Wang, Xue Rui, Haobo Tian, Chenshuo Li & Chunyan Guo. (2022)
In Silico
Studies of Piperidine Derivatives as Protein Kinase B Inhibitors
through 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation
. Letters in Drug Design & Discovery 19:7, pages 591-605.
Crossref
Crossref
Li Cong, Xiaolin Xie, Sujuan Liu, Liping Xiang & Xiaohua Fu. (2022) Genistein promotes M1 macrophage apoptosis and reduces inflammatory response by disrupting miR-21/TIPE2 pathway. Saudi Pharmaceutical Journal 30:7, pages 934-945.
Crossref
Crossref
Klaudia Waszczykowska, Karolina Prażanowska, Żaneta Kałuzińska, Damian Kołat & Elżbieta Płuciennik. (2022) Discovering biomarkers for hormone-dependent tumors: in silico study on signaling pathways implicated in cell cycle and cytoskeleton regulation. Molecular Genetics and Genomics 297:4, pages 947-963.
Crossref
Crossref
Wei Hou, Bryan Bridgeman, Greg Malnassy, Xianzhong Ding, Scott J. Cotler, Asha Dhanarajan & Wei Qiu. (2022) Integrin subunit beta 8 contributes to lenvatinib resistance in HCC. Hepatology Communications 6:7, pages 1786-1802.
Crossref
Crossref
Changyou Ma, Jian Wu, Lei Wang, Xiaojun Ji, Yebin Wu, Lei Miao, Donghui Chen, Linlin Zhang, Youzhi Wu, Haiwei Feng, Ying Tang, Qiuhua Zhou, Junjie Pei, Xule Yang, Dan Xu, Qidong You & Yuan Xie. (2022) Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. Journal of Medicinal Chemistry 65:12, pages 8144-8168.
Crossref
Crossref
Leon F. McSwain, Kiran K. Parwani, Shubin W. Shahab, Dolores Hambardzumyan, Tobey J. MacDonald, Jennifer M. Spangle & Anna Marie Kenney. (2022) Medulloblastoma and the DNA Damage Response. Frontiers in Oncology 12.
Crossref
Crossref
Hui Cheng, Meng Wang, Jingjing Su, Yueyue Li, Jiao Long, Jing Chu, Xinyu Wan, Yu Cao & Qinglin Li. (2022) Lipid Metabolism and Cancer. Life 12:6, pages 784.
Crossref
Crossref
Qingying Xian & Danxia Zhu. (2022) The Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway. Journal of Oncology 2022, pages 1-11.
Crossref
Crossref
I. A. Makarov, L. B. Mitrofanova, I. B. Antonova, I. A. Danilova, A. O. Khazratov & V. S. Sidorin. (2022) Myxofibrosarcoma of the heart: case series. Journal of Arrhythmology 29:1, pages 50-57.
Crossref
Crossref
Richa Buddham, Sweety Chauhan, Priyanka Narad & Puniti Mathur. (2022) Reconstruction and Exploratory Analysis of mTORC1 Signaling Pathway and Its Applications to Various Diseases Using Network-Based Approach. Journal of Microbiology and Biotechnology 32:3, pages 365-377.
Crossref
Crossref
Daniela C. dos Santos, Jamal Rafique, Sumbal Saba, Valdelúcia M. A. S. Grinevicius, Danilo W. Filho, Ariane Zamoner, Antonio L. Braga, Rozangela C. Pedrosa & Fabiana Ourique. (2022) IP-Se-06, a Selenylated Imidazo[1,2-a]pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1α and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells. Oxidative Medicine and Cellular Longevity 2022, pages 1-18.
Crossref
Crossref
Min Li, Zhiqun Zhang, Jyotsnav Joynauth, Xueqin Zhan & Lizhong Du. (2022) Intrauterine growth restriction neonates present with increased angiogenesis through the Notch1 signaling pathway. Microvascular Research 140, pages 104308.
Crossref
Crossref
Junqing Lin, Leye Yan, Xiaolong Wang, Zhengzhong Wu, Kun Ke, Xin Lin, Ning Huang & Weizhu Yang. (2022) Administration of Iodine-125 Seeds Promotes Apoptosis in Cholangiocarcinoma through the PI3K/Akt Pathway. Advances in Polymer Technology 2022, pages 1-6.
Crossref
Crossref
Xufen Yu, Jia Xu, Yudao Shen, Kaitlyn M. Cahuzac, Kwang-su Park, Brandon Dale, Jing Liu, Ramon E. Parsons & Jian Jin. (2022) Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies. Journal of Medicinal Chemistry 65:4, pages 3644-3666.
Crossref
Crossref
Salima Akter, Md. Ataur Rahman, Mohammad Nazmul Hasan, Hajara Akhter, Priya Noor, Rokibul Islam, Yoonhwa Shin, MD. Hasanur Rahman, Md. Shamim Gazi, Md Nazmul Huda, Nguyen Minh Nam, Jinwook Chung, Sunhee Han, Bonglee Kim, Insug Kang, Joohun Ha, Wonchae Choe, Tae Gyu Choi & Sung Soo Kim. (2022) Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements. Cells 11:4, pages 650.
Crossref
Crossref
Laurent Greillier, Manon Gauvrit, Elena Paillaud, Nicolas Girard, Coline Montégut, Rabia Boulahssass, Marie Wislez, Frédéric Pamoukdjian, Romain Corre, Mathilde Cabart, Philippe Caillet, Yaniss Belaroussi, Matthieu Frasca, Pernelle Noize, Pascal Wang, Soraya Mebarki, Simone Mathoulin-Pelissier & Anne-Laure Couderc. (2022) Targeted Therapy for Older Patients with Non-Small Cell Lung Cancer: Systematic Review and Guidelines from the French Society of Geriatric Oncology (SoFOG) and the French-Language Society of Pulmonology (SPLF)/French-Language Oncology Group (GOLF). Cancers 14:3, pages 769.
Crossref
Crossref
Yi Zhu, Na Xie, Yilu Chai, Yisen Nie, Ke Liu, Yufei Liu, Yang Yang, Jinsong Su & Chuantao Zhang. (2022) Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer. Frontiers in Pharmacology 13.
Crossref
Crossref
Shengyu Cui, Yuhua Li, Xutao Zhang, Bing Wu, Ming Li, Jixian Gao, Lin Xu & Hao Xia. (2022) Fibroblast growth factor 5 overexpression ameliorated lipopolysaccharide-induced apoptosis of hepatocytes through regulation of the phosphoinositide-3-kinase/protein kinase B pathway. Chinese Medical Journal 135:23, pages 2859-2868.
Crossref
Crossref
Xufen Yu, Jia Xu, Ling Xie, Li Wang, Yudao Shen, Kaitlyn M. Cahuzac, Xian Chen, Jing Liu, Ramon E. Parsons & Jian Jin. (2021) Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders. Journal of Medicinal Chemistry 64:24, pages 18054-18081.
Crossref
Crossref
Cai-Jie Zhou, Bai-Ling Xie, Hai-Yang Han, Yin Wang, Yong-Hua Wang, Jing-Yi Hong, Yi-Xia Wei, Zhi-Gang Liu, Yan Feng, Gui Yang & Ping-Chang Yang. (2021) Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells. Journal of Immunology Research 2021, pages 1-13.
Crossref
Crossref
Jakub Szymczyk, Katarzyna Sluzalska, Izabela Materla, Lukasz Opalinski, Jacek Otlewski & Malgorzata Zakrzewska. (2021) FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance. Cancers 13:22, pages 5796.
Crossref
Crossref
Jiahui Ye, Longfei Mao, Luoyijun Xie, Rongjun Zhang, Yulin Liu, Lizeng Peng, Jianxue Yang, Qingjiao Li & Miaomiao Yuan. (2021) Discovery of a Series of Theophylline Derivatives Containing 1,2,3-Triazole for Treatment of Non-Small Cell Lung Cancer. Frontiers in Pharmacology 12.
Crossref
Crossref
Huifang Chen, Andong He, Haoyang Li, Honglv Chen, Huancheng Xie, Liping Luo, Yuyi Huang, Jiaqian Chen, Jieying Guan, Qiaoling He, Jianjuan Ma, Changxing Ou, Ailin Tao & Jie Yan. (2021) TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis. Cell Death & Disease 12:10.
Crossref
Crossref
Mu Ye, Sheng Wang, Jing-bo Qie & Pei-long Sun. (2021) SPRY4-AS1, A Novel Enhancer RNA, Is a Potential Novel Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma. Frontiers in Oncology 11.
Crossref
Crossref
Fangfang Xu, Dandan Tian, Xiaoyang Shi, Kai Sun & Yuqing Chen. (2021) Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers. Pathology and Oncology Research 27.
Crossref
Crossref
Nan-Ying Chen, Ke Lu, Jing-Mei Yuan, Xiao-Juan Li, Zi-Yu Gu, Cheng-Xue Pan, Dong-Liang Mo & Gui-Fa Su. (2021) 3-Arylamino-quinoxaline-2-carboxamides inhibit the PI3K/Akt/mTOR signaling pathways to activate P53 and induce apoptosis. Bioorganic Chemistry 114, pages 105101.
Crossref
Crossref
Christiana M. Neophytou, Ioannis P. Trougakos, Nuray Erin & Panagiotis Papageorgis. (2021) Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance. Cancers 13:17, pages 4363.
Crossref
Crossref
Jinxin Che, Xiaoyang Dai, Jian Gao, Haichao Sheng, Wenhu Zhan, Yang Lu, Dan Li, Zizheng Gao, Zegao Jin, Binhui Chen, Peihua Luo, Bo Yang, Yongzhou Hu, Qiaojun He, Qinjie Weng & Xiaowu Dong. (2021)
Discovery of
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-((3
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,4
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)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1
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-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity
. Journal of Medicinal Chemistry 64:16, pages 12163-12180.
Crossref
Crossref
Jun Lu, Qi-Feng Dong & Zhuang-Hong Shen. (2021) Effect of COPB2 expression on proliferation, migration, and invasion of gastric cancer cells. World Chinese Journal of Digestology 29:15, pages 849-857.
Crossref
Crossref
Liu Liu, Hui Yan, Maomei Ruan, Hao Yang, Lihua Wang, Bei Lei, Xiaoyan Sun, Cheng Chang, Gang Huang & Wenhui Xie. (2021) An AKT/PRMT5/SREBP1 axis in lung adenocarcinoma regulates de novo lipogenesis and tumor growth. Cancer Science 112:8, pages 3083-3098.
Crossref
Crossref
Suree Jianmongkol. 2021. Advances in Precision Medicine Oncology. Advances in Precision Medicine Oncology.
Chao-Lien Liu, Ray-Hwang Yuan & Tsui-Lien Mao. (2021) The Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer. Biomolecules 11:7, pages 998.
Crossref
Crossref
Riccardo PAMPENA, Simone MICHELINI, Michela LAI, Johanna CHESTER, Giovanni PELLACANI & Caterina LONGO. (2021) New systemic therapies for cutaneous melanoma: why, who and what. Italian Journal of Dermatology and Venereology 156:3.
Crossref
Crossref
Maryam Shariati, Kurt W. Evans, Xiaofeng Zheng, Christopher A. Bristow, Patrick Kwok-Shing Ng, Yasmeen Q. Rizvi, Coya Tapia, Fei Yang, Alessandro Carugo, Timothy P. Heffernan, Michael D. Peoples, Debu Tripathy & Funda Meric-Bernstam. (2021) Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1 mutations. Oncogene 40:26, pages 4425-4439.
Crossref
Crossref
Meng Li, Wenqi Zhang, Linqi Yang, Huibing Wang, Yihan Wang, Kai Huang & Wei Zhang. (2021) The Mechanism of Xiaoyao San in the Treatment of Ovarian Cancer by Network Pharmacology and the Effect of Stigmasterol on the PI3K/Akt Pathway. Disease Markers 2021, pages 1-10.
Crossref
Crossref
Qian Zhang, Lanyu He, Qingqing Jiang, Hongqing Zhu, Dehua Kong, Hua Zhang, Zhiqiang Cheng, Hongtao Deng, Yaxin Zheng & Xue Ying. (2021) Systems Pharmacology–Based Dissection of Anti-Cancer Mechanism of Traditional Chinese Herb Saussurea involucrata. Frontiers in Pharmacology 12.
Crossref
Crossref
Ingrid Spaan, Laura M. Timmerman, Thomas Kimman, Anne Slomp, Marta Cuenca, Niels van Nieuwenhuijzen, Laura M. Moesbergen, Monique C. Minnema, Reinier A. Raymakers & Victor Peperzak. (2021) Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma. Blood Advances 5:12, pages 2593-2607.
Crossref
Crossref
Sneha Rai, Venugopal Bhatia & Sonika Bhatnagar. (2021) Drug repurposing for hyperlipidemia associated disorders: An integrative network biology and machine learning approach. Computational Biology and Chemistry 92, pages 107505.
Crossref
Crossref
William G. Herrick, Casey L. Kilpatrick, Melinda G. Hollingshead, Dominic Esposito, Geraldine O'Sullivan Coyne, Andrea M. Gross, Barry C. Johnson, Alice P. Chen, Brigitte C. Widemann, James H. Doroshow, Ralph E. Parchment & Apurva K. Srivastava. (2021) Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies. Molecular Cancer Therapeutics 20:4, pages 749-760.
Crossref
Crossref
Md. Tariqul Islam, Fangzhi Chen & Hanchun Chen. (2021) The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics. Archives of Biochemistry and Biophysics 701, pages 108811.
Crossref
Crossref
Longtao Yang, Wenwen Zhou & Hui Lin. (2021) Posttranslational Modifications of Smurfs: Emerging Regulation in Cancer. Frontiers in Oncology 10.
Crossref
Crossref
Arthur-Quan Tran, Stephanie A. Sullivan, Leo Li-Ying Chan, Yajie Yin, Wenchuan Sun, Ziwei Fang, Sundeep Dugar, Chunxiao Zhou & Victoria Bae-Jump. (2021) SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer. Frontiers in Oncology 10.
Crossref
Crossref
Che-Fang Hsu, Pao-Chu Chen, Vaishnavi Seenan, Dah-Ching Ding & Tang-Yuan Chu. (2021) Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma. Cancers 13:3, pages 468.
Crossref
Crossref
Nikhil Rangholia, Tina M. Leisner & Stephen P. Holly. (2021) Bioactive Ether Lipids: Primordial Modulators of Cellular Signaling. Metabolites 11:1, pages 41.
Crossref
Crossref
Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Marcin Ziętek, Rafał Matkowski & Dorota Nowak. (2021) Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy. International Journal of Molecular Sciences 22:2, pages 529.
Crossref
Crossref
Thu Ha Pham, Yann Le Page, Frédéric Percevault, François Ferrière, Gilles Flouriot & Farzad Pakdel. (2021) Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling. International Journal of Molecular Sciences 22:1, pages 470.
Crossref
Crossref
Leena Abdullah, L. Benjamin Hills, Evan B. Winter & Yina H. Huang. (2021) Diverse Roles of Akt in T cells. Immunometabolism 3:1, pages e210007.
Crossref
Crossref
Leonor Fernandes, Leonor Vasconcelos de Matos, Débora Cardoso, Marlene Saraiva, Renata Medeiros-Mirra, Andreia Coelho, Helena Miranda & Ana Martins. (2020) Endocrine therapy for the treatment of leptomeningeal carcinomatosis in luminal breast cancer: a comprehensive review. CNS Oncology 9:4.
Crossref
Crossref
Ru-pin Alicia Chi, Tianyuan Wang, Chou-Long Huang, San-pin Wu, Steven L. Young, John P. Lydon & Francesco J. DeMayo. (2020) WNK1 regulates uterine homeostasis and its ability to support pregnancy. JCI Insight 5:22.
Crossref
Crossref
Surendra ChaurasiyaWanfu Wu, Anders M. Strom, Margaret WarnerJan-Åke Gustafsson. (2020) Estrogen receptor β regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3. Proceedings of the National Academy of Sciences 117:42, pages 26347-26355.
Crossref
Crossref
Baiping Mao, Tiao Bu, Dolores Mruk, Chao Li, Fei Sun & C. Yan Cheng. (2020) Modulating the Blood–Testis Barrier Towards Increasing Drug Delivery. Trends in Pharmacological Sciences 41:10, pages 690-700.
Crossref
Crossref
Rui Liu, Youwen Chen, Guangzhi Liu, Chenxi Li, Yurong Song, Zhiwen Cao, Wen Li, Jinghong Hu, Cheng Lu & Yuanyan Liu. (2020) PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death & Disease 11:9.
Crossref
Crossref
Sun-Young Hwang, Jung-Il Chae, Ah-Won Kwak, Mee-Hyun Lee & Jung-Hyun Shim. (2020) Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways. International Journal of Molecular Sciences 21:18, pages 6869.
Crossref
Crossref
Zhongying Wang, Dongmei Su, Zhaoyi Sun, Shanhe Liu, Lei sun, Qian Li, Lina Guan, Yong Liu, Xu Ma & Shanshan Hu. (2020) MDM2 phosphorylation mediates H2O2-induced lens epithelial cells apoptosis and age-related cataract. Biochemical and Biophysical Research Communications 528:1, pages 112-119.
Crossref
Crossref
Lihi Ninio-Many, Elad Hikri, Tamar Burg-Golani, Salomon M. Stemmer, Ruth Shalgi & Irit Ben-Aharon. (2020) miR-125a Induces HER2 Expression and Sensitivity to Trastuzumab in Triple-Negative Breast Cancer Lines. Frontiers in Oncology 10.
Crossref
Crossref
Cheng-Liang Zhu, Xiaomin Luo, Tian Tian, Zijian Rao, Hanlin Wang, Zhesheng Zhou, Zizheng Gao, Tian Mi, Danni Chen, Yongjin Xu, Yizhe Wu, Jinxin Che, Peihua Luo, Yubo Zhou, Jia Li & Xiaowu Dong. (2022) Structure-Based Rational Design Enables Discovery of a New Selective and Potent Akt Degrader with Improved Dermatologic Safety. SSRN Electronic Journal.
Crossref
Crossref