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Research Article

Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker model

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Pages 203-217 | Received 22 Sep 2004, Published online: 08 Oct 2008

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M. Ariel Geer Wallace, Tzipporah M. Kormos & Joachim D. Pleil. (2016) Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science. Journal of Toxicology and Environmental Health, Part B 19:8, pages 380-409.
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Katja T. Turunen, Vasiliki Pletsa, Panagiotis Georgiadis, John K. Triantafillidis, Dimitrios Karamanolis & Adamantini Kyriacou. (2016) Impact of β-glucan on the Fecal Water Genotoxicity of Polypectomized Patients. Nutrition and Cancer 68:4, pages 560-567.
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Michael Glei, Annett Kirmse, Nina Habermann, Christoph Persin & Beatrice L. Pool-Zobel. (2006) Bread Enriched With Green Coffee Extract Has Chemoprotective and Antigenotoxic Activities in Human Cells. Nutrition and Cancer 56:2, pages 182-192.
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Sa. Bonetta, M. Macrì, M. Acito, M. Villarini, M. Moretti, Si. Bonetta, D. Bosio, G. Mariella, V. Bellisario, E. Bergamaschi & E. Carraro. (2024) DNA damage in workers exposed to pigment grade titanium dioxide (TiO2) and association with biomarkers of oxidative stress and inflammation. Environmental Toxicology and Pharmacology 105, pages 104328.
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Miao Han, Zaifeng Zhang, Si Liu, Youying Sheng, Michael Gatheru Waigi, Xiaojie Hu, Chao Qin & Wanting Ling. (2023) Genotoxicity of organic contaminants in the soil: A review based on bibliometric analysis and methodological progress. Chemosphere 313, pages 137318.
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Rômulo Batista RodriguesMariana UczayVerônica Bidinotto BritoAntonio Cesar GodoyDinara Jaqueline MouraCarla VogelAna Carina Nogueira VasconcelosDanilo Pedro StreitJr.Jr.. (2021) Oxidative Stress and DNA Damage of Zebrafish Sperm at Different Stages of the Cryopreservation Process. Zebrafish 18:2, pages 97-109.
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Carla Russo, Mattia Acito, Cristina Fatigoni, Milena Villarini & Massimo Moretti. (2020) B-Comet Assay (Comet Assay on Buccal Cells) for the Evaluation of Primary DNA Damage in Human Biomonitoring Studies. International Journal of Environmental Research and Public Health 17:24, pages 9234.
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Natalya A. Kolbasina, Artem P. Gureev, Olga V. Serzhantova, Andrey A. Mikhailov, Ivan P. Moshurov, Anatoly A. Starkov & Vasily N. Popov. (2020) Lung cancer increases H2O2 concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa. Heliyon 6:6, pages e04303.
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Mehmet Hayta & Elif Meltem İşçimen. 2019. Flour and Breads and their Fortification in Health and Disease Prevention. Flour and Breads and their Fortification in Health and Disease Prevention 273 289 .
Armen Nersesyan, Christine Hoelzl, Franziska Ferk, Miroslav Mišík, Halh Al-Serori, Tahereh Setayesh & Siegfried Knasmueller. 2016. The Comet Assay in Toxicology. The Comet Assay in Toxicology 314 353 .
M. Glei, T. Schneider & W. Schlörmann. (2016) Comet assay: an essential tool in toxicological research. Archives of Toxicology 90:10, pages 2315-2336.
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I. Bergheim & M. Glei. (2015) Darmmikrobiom und ErnährungIntestinal microbiome and nutrition. Der Gastroenterologe 10:2, pages 116-121.
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Lisa Landgraf, Peter Ernst, Isabel Schick, Oskar Köhler, Hartmut Oehring, Wolfgang Tremel & Ingrid Hilger. (2014) Anti-oxidative effects and harmlessness of asymmetric Au@Fe3O4 Janus particles on human blood cells. Biomaterials 35:25, pages 6986-6997.
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Erba Daniela, Soldi Sara, Malavolti Marcella, Aragone Giovanni, Alexandra Meynier, Vinoy Sophie & Casiraghi M. Cristina. (2014) Fecal water genotoxicity in healthy free-living young Italian people. Food and Chemical Toxicology 64, pages 104-109.
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Andrew Collins, Gudrun Koppen, Vanessa Valdiglesias, Maria Dusinska, Marcin Kruszewski, Peter Møller, Emilio Rojas, Alok Dhawan, Iris Benzie, Erdem Coskun, Massimo Moretti, Günter Speit & Stefano Bonassi. (2014) The comet assay as a tool for human biomonitoring studies: The ComNet Project. Mutation Research/Reviews in Mutation Research 759, pages 27-39.
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Michael Glei. 2013. Biofunktionalität der Lebensmittelinhaltsstoffe. Biofunktionalität der Lebensmittelinhaltsstoffe 161 192 .
Marie-Chantal Grégoire, Frédéric Leduc & Guylain Boissonneault. 2013. Sperm Chromatin for the Researcher. Sperm Chromatin for the Researcher 201 218 .
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Stefanie Lux, Daniel Scharlau, Wiebke Schlörmann, Marc Birringer & Michael Glei. (2011) In vitro fermented nuts exhibit chemopreventive effects in HT29 colon cancer cells . British Journal of Nutrition 108:7, pages 1177-1186.
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Gemma E. Walton, Ellen G. H. M. van den Heuvel, Marit H. W. Kosters, Robert A. Rastall, Kieran M. Tuohy & Glenn R. Gibson. (2011) A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age. British Journal of Nutrition 107:10, pages 1466-1475.
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Alex Livy, Sayhean Lye, Chahil K. Jagdish, Nurul Hanis, Velapasamy Sharmila, Lian Wee Ler & Bagali Pramod. (2011) Evaluation of Quality of DNA Extracted from Buccal Swabs for Microarray Based Genotyping. Indian Journal of Clinical Biochemistry 27:1, pages 28-33.
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Karen Windey, Vicky De Preter & Kristin Verbeke. (2011) Relevance of protein fermentation to gut health. Molecular Nutrition & Food Research 56:1, pages 184-196.
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Marie-Chantal Grégoire, Frédéric Leduc & Guylain Boissonneault. 2011. Sperm Chromatin. Sperm Chromatin 307 320 .
G. K. Pot, N. Habermann, G. Majsak-Newman, L. J. Harvey, A. Geelen, K. Przybylska-Philips, F. M. Nagengast, B. J. M. Witteman, P. C. van de Meeberg, A. R. Hart, G. Schaafsma, G. Hooiveld, M. Glei, E. K. Lund, B. L. Pool-Zobel & E. Kampman. (2009) Increasing fish consumption does not affect genotoxicity markers in the colon in an intervention study. Carcinogenesis 31:6, pages 1087-1091.
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Nina Kager, Franziska Ferk, Michael Kundi, Karl-Heinz Wagner, Miroslav Mišík & Siegfried Knasmüller. (2009) Prevention of oxidative DNA damage in inner organs and lymphocytes of rats by green tea extract. European Journal of Nutrition 49:4, pages 227-234.
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Michael F Fenech. (2010) Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future. The American Journal of Clinical Nutrition 91:5, pages 1438S-1454S.
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Nina Habermann, Adrienne Schön, Elizabeth K. Lund & Michael Glei. (2010) Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. Apoptosis 15:5, pages 621-630.
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Sun Hee Lee, Hae Jin Kang, Hye-Jin Lee, Myung-Hee Kang & Yoo Kyoung Park. (2010) Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. Nutrition 26:2, pages 175-183.
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Volker Mai, Quintece M McCrary, Rashmi Sinha & Michael Glei. (2009) Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers. Nutrition Journal 8:1.
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Alok Dhawan. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Jennifer R Pearson, Chris IR Gill & Ian R Rowland. (2009) Diet, fecal water, and colon cancer - development of a biomarker. Nutrition Reviews 67:9, pages 509-526.
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Armen Nersesyan, Christine Hoelzl, Franziska Ferk, Miroslav Mišík & Siegfried Knasmueller. 2009. The Comet Assay in Toxicology. The Comet Assay in Toxicology 267 296 .
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Dorit Helbig, Andreas Wagner, Michael Glei, Samar Basu, Rainer Schubert & Gerhard Jahreis. (2009) Blackcurrant seed press residue increases tocopherol concentrations in serum and stool whilst biomarkers in stool and urine indicate increased oxidative stress in human subjects. British Journal of Nutrition 102:04, pages 554.
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Alok Dhawan, Mahima Bajpayee & Devendra Parmar. (2008) Comet assay: a reliable tool for the assessment of DNA damage in different models. Cell Biology and Toxicology 25:1, pages 5-32.
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Selvaraju Veeriah, Kamal Kumar Balavenkatraman, Frank- D. Böhmer, Kathrin Kahle, Michael Glei, Elke Richling, Wolfgang Scheppach & Beatrice L. Pool-Zobel. (2008) Intervention with cloudy apple juice results in altered biological activities of ileostomy samples collected from individual volunteers. European Journal of Nutrition 47:5, pages 226-234.
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Steffen Loft, Peter Møller, Marcus S. Cooke, Rafal Rozalski & Ryszard Olinski. (2008) Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?. European Journal of Nutrition 47:S2, pages 19-28.
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Annett Klinder, Michael Glei & Beatrice Pool-Zobel. 2008. Handbook of Prebiotics. Handbook of Prebiotics 295 328 .
Hazel L. Greetham, Sheila A. Bingham & Philip A. Burns. (2007) Adduction of Human p53 Gene by Fecal Water: An In vitro Biomarker of Mutagenesis in the Human Large Bowel . Cancer Epidemiology, Biomarkers & Prevention 16:12, pages 2681-2685.
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M.J. McCann, C.I.R. Gill, G. O’ Brien, J.R. Rao, W.C. McRoberts, P. Hughes, R. McEntee & I.R. Rowland. (2007) Anti-cancer properties of phenolics from apple waste on colon carcinogenesis in vitro. Food and Chemical Toxicology 45:7, pages 1224-1230.
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Eunju Park, Michael Glei, Yvonne Knöbel & Beatrice L. Pool-Zobel. (2007) Blood mononucleocytes are sensitive to the DNA damaging effects of iron overload—In vitro and ex vivo results with human and rat cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 619:1-2, pages 59-67.
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Jochen Kick, Balázs Hauser, Hendrik Bracht, Maura Albicini, Sükrü Öter, Florian Simon, Ulrich Ehrmann, Catherine Garrel, Jörn Sträter, Uwe B. Brückner, Xavier M. Leverve, Hubert Schelzig, Günter Speit, Peter Radermacher & Claus-Martin Muth. (2007) Effects of a cantaloupe melon extract/wheat gliadin biopolymer during aortic cross-clamping. Intensive Care Medicine 33:4, pages 694-702.
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Joseph Rafter, Michael Bennett, Giovanna Caderni, Yvonne Clune, Roisin Hughes, Pernilla C Karlsson, Annett Klinder, Micheal O'Riordan, Gerald C O'Sullivan, Beatrice Pool-Zobel, Gerhard Rechkemmer, Monika Roller, Ian Rowland, Maddalena Salvadori, Herbert Thijs, Jan Van Loo, Bernhard Watzl & John K Collins. (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. The American Journal of Clinical Nutrition 85:2, pages 488-496.
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Christiane Seidel, Volker Boehm, Heinz Vogelsang, Andreas Wagner, Christoph Persin, Michael Glei, Beatrice L. Pool-Zobel & Gerhard Jahreis. (2007) Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokers. British Journal of Nutrition 97:2, pages 349-356.
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T.E. Schmid, B. Eskenazi, A. Baumgartner, F. Marchetti, S. Young, R. Weldon, D. Anderson & A.J. Wyrobek. (2007) The effects of male age on sperm DNA damage in healthy non-smokers. Human Reproduction 22:1, pages 180-187.
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Thomas Hofmann, Ute Liegibel, Peter Winterhalter, Achim Bub, Gerhard Rechkemmer & Beatrice Louise Pool-Zobel. (2006) Intervention with polyphenol-rich fruit juices results in an elevation of glutathioneS-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers. Molecular Nutrition & Food Research 50:12, pages 1191-1200.
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Y. Knöbel, M. Glei, K. Osswald & B.L. Pool-Zobel. (2006) Ferric iron increases ROS formation, modulates cell growth and enhances genotoxic damage by 4-hydroxynonenal in human colon tumor cells. Toxicology in Vitro 20:6, pages 793-800.
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Amanda J. Cross, Hazel L. Greetham, Jim R.A. Pollock, Ian R. Rowland & Sheila A. Bingham. (2005) Variability in fecal water genotoxicity, determined using the Comet assay, is independent of endogenous N ‐Nitroso compound formation attributed to red meat consumption . Environmental and Molecular Mutagenesis 47:3, pages 179-184.
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Michael Glei, Thomas Hofmann, Katrin Küster, Jürgen Hollmann, Meinolf G. Lindhauer & Beatrice L. Pool-Zobel. (2006) Both Wheat ( Triticum aestivum ) Bran Arabinoxylans and Gut Flora-Mediated Fermentation Products Protect Human Colon Cells from Genotoxic Activities of 4-Hydroxynonenal and Hydrogen Peroxide . Journal of Agricultural and Food Chemistry 54:6, pages 2088-2095.
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Michael Glei, Stefanie Klenow, Julia Sauer, Uta Wegewitz, Konrad Richter & Beatrice L. Pool-Zobel. (2006) Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 594:1-2, pages 162-171.
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