Advanced search
Publication Cover
Biomarkers Volume 13, 2008 - Issue 2
Submit an article Journal homepage
470
Views
52
CrossRef citations to date
0
Altmetric
Research Article

TGF-β signalling-related markers in cancer patients with bone metastasis

Jose Baselga Vall d′Hebron University Hospital, 08035, Barcelona, Spain
,
Mace L. Rothenberg Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA
,
Josep Tabernero Vall d′Hebron University Hospital, 08035, Barcelona, Spain
,
Joan Seoane Vall d′Hebron University Hospital, 08035, Barcelona, Spain
,
Thomas Daly Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Ann Cleverly Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Brandi Berry Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Susanne K. Rhoades Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Chad A. Ray Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Jeffrey Fill Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Daphne L. Farrington Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Lisa Anne Wallace The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, 21205, USA
,
Jonathan M. Yingling Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Michael Lahn Eli Lilly and Company Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
,
Carlos Arteaga Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA
&
Michael Carducci The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, 21205, USA
 show all
Pages 217-236 | Received 14 May 2007, Published online: 08 Oct 2008

Citations (52)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Stephan Herbertz, J Scott Sawyer, Anja J Stauber, Ivelina Gueorguieva, Kyla E Driscoll, Shawn T Estrem, Ann L Cleverly, Durisala Desaiah, Susan C Guba, Karim A Benhadji, Christopher A Slapak & Michael M Lahn. (2015) Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Design, Development and Therapy 9, pages 4479-4499.
Read now
Peter J O’Brien, Rajeev Ramanathan, Jonathan M Yingling, Jose Baselga, Mace L Rothenberg, Michael Carducci, Thomas Daly, Dorothy Adcock & Michael Lahn. (2008) Analysis and variability of TGFβ measurements in cancer patients with skeletal metastases. Biologics: Targets and Therapy 2:3, pages 563-569.
Read now

Articles from other publishers (50)

Rongrong Ge & Gavin M. Huang. (2023) Targeting transforming growth factor beta signaling in metastatic osteosarcoma. Journal of Bone Oncology 43, pages 100513.
Crossref
Aisha Al Anaz, Ravi Teja Chitturi Suryaprakash, Kate Shearston & Omar Kujan. 2023. Molecular Targets and Cancer Therapeutics (Part 1). Molecular Targets and Cancer Therapeutics (Part 1) 187 241 .
Lin Ma, Alba Gonzalez-Junca, William Chou & Mary Helen Barcellos-Hoff. 2023. Radiation Oncology and Radiotherapy Part C. Radiation Oncology and Radiotherapy Part C 49 67 .
Sharon Russo, Federica Scotto di Carlo & Fernando Gianfrancesco. (2022) The Osteoclast Traces the Route to Bone Tumors and Metastases. Frontiers in Cell and Developmental Biology 10.
Crossref
Patricia Juárez, Brenda I. Iduarte & Pierrick G.J. Fournier. 2022. Bone Cancer. Bone Cancer 253 273 .
Kamil Karolczak & Cezary Watala. (2021) Blood Platelets as an Important but Underrated Circulating Source of TGFβ. International Journal of Molecular Sciences 22:9, pages 4492.
Crossref
Manni Wang, Fan Xia, Yuquan Wei & Xiawei Wei. (2020) Molecular mechanisms and clinical management of cancer bone metastasis. Bone Research 8:1.
Crossref
Tanja Stüber, Razieh Monjezi, Lars Wallstabe, Johanna Kühnemundt, Sarah Louise Nietzer, Gudrun Dandekar, Achim Wöckel, Hermann Einsele, Jörg Wischhusen & Michael Hudecek. (2020) Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer. Journal for ImmunoTherapy of Cancer 8:1, pages e000676.
Crossref
Katie L. Owen, Natasha K. Brockwell & Belinda S. Parker. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 421 437 .
Valeria Santini, David Valcárcel, Uwe Platzbecker, Rami S. Komrokji, Ann L. Cleverly, Michael M. Lahn, Jan Janssen, Yumin Zhao, Alan Chiang, Aristoteles Giagounidis, Susan C. Guba, Ivelina Gueorguieva, Allicia C. Girvan, Mariana da Silva Ferreira, Tushar D. Bhagat, Kith Pradhan, Ulrich Steidl, Ashwin Sridharan, Britta Will & Amit Verma. (2019) Phase II Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes. Clinical Cancer Research 25:23, pages 6976-6985.
Crossref
D. Chappard, G. Mabilleau, C. Masson, A. Tahla & E. Legrand. (2018) Metaplastic woven bone in bone metastases: A Fourier-transform infrared analysis and imaging of bone quality (FTIR). Morphologie 102:337, pages 69-77.
Crossref
Cinzia Antognelli, Rodolfo Cecchetti, Francesca Riuzzi, Matthew J. Peirce & Vincenzo N. Talesa. (2018) Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control . Journal of Cellular and Molecular Medicine 22:5, pages 2865-2883.
Crossref
Jiang Jian, Yanli Pang, H. Hannah Yan, Yongfen Min, Bhagelu R. Achyut, M. Christine Hollander, P. Charles Lin, Xinhua Liang & Li Yang. (2016) Platelet factor 4 is produced by subsets of myeloid cells in premetastatic lung and inhibits tumor metastasis. Oncotarget 8:17, pages 27725-27739.
Crossref
Nan Sun, Ayumu Taguchi & Samir Hanash. (2016) Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies. Journal of Clinical Medicine 5:12, pages 109.
Crossref
Rosemary J. AkhurstRichard W. Padgett. (2015) Matters of context guide future research in TGFβ superfamily signaling. Science Signaling 8:399.
Crossref
Jordi Rodón, Michael Carducci, Juan M. Sepulveda-Sánchez, Analía Azaro, Emiliano Calvo, Joan Seoane, Irene Braña, Elisabet Sicart, Ivelina Gueorguieva, Ann Cleverly, N. Sokalingum Pillay, Durisala Desaiah, Shawn T. Estrem, Luis Paz-Ares, Matthias Holdhoff, Jaishri Blakeley, Michael M. Lahn & Jose Baselga. (2014) Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer. Investigational New Drugs 33:2, pages 357-370.
Crossref
Arseniy E. Yuzhalin & Anton G. Kutikhin. 2015. Interleukins in Cancer Biology. Interleukins in Cancer Biology 117 146 .
ALLEN COHN, MICHAEL M. LAHN, KRISTEN E. WILLIAMS, ANN L. CLEVERLY, CELINE PITOU, SUNIL K. KADAM, MARK W. FARMEN, DURISALA DESAIAH, ROBERT RAJU, PAUL CONKLING & DONALD RICHARDS. (2014) A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancer. International Journal of Oncology 45:6, pages 2221-2231.
Crossref
Ionela Daniela Popescu, Elena Codrici, Lucian Albulescu, Simona Mihai, Ana-Maria Enciu, Radu Albulescu & Cristiana Pistol Tanase. (2014) Potential serum biomarkers for glioblastoma diagnostic assessed by proteomic approaches. Proteome Science 12:1.
Crossref
Christina L Addison, Gregory R Pond, Huijun Zhao, Sasha Mazzarello, Lisa Vandermeer, Robyn Goldstein, Eitan Amir & Mark Clemons. (2014) Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastases. SpringerPlus 3:1.
Crossref
Clyde F. Phelix, Greg Villareal, Richard G. LeBaron & Dawnlee J. Roberson. (2014) Biomarkers from biosimulations: Transcriptome-to-reactome™ Technology for individualized medicine. Biomarkers from biosimulations: Transcriptome-to-reactome™ Technology for individualized medicine.
Shirly Sieh, Anna V. Taubenberger, Melanie L. Lehman, Judith A. Clements, Colleen C. Nelson & Dietmar W. Hutmacher. (2014) Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis. Bone 63, pages 121-131.
Crossref
Christina L. Addison, Nathaniel Bouganim, John Hilton, Lisa Vandermeer, Susan Dent, Eitan Amir, Sean Hopkins, Iryna Kuchuk, Roanne Segal, Xinni Song, Stan Gertler, Sasha Mazzarello, George Dranitsaris, Daylily Ooi, Gregory Pond & Mark Clemons. (2014) A phase II, multicentre trial evaluating the efficacy of de-escalated bisphosphonate therapy in metastatic breast cancer patients at low-risk of skeletal-related events. Breast Cancer Research and Treatment 144:3, pages 615-624.
Crossref
Tamás Nagykálnai & László Landherr. (2014) Management of bone metastases. Orvosi Hetilap 155:6, pages 217-225.
Crossref
Nadia Rucci & Adriano Angelucci. (2014) Prostate Cancer and Bone: The Elective Affinities. BioMed Research International 2014, pages 1-14.
Crossref
Wei Yan, Bing Tu, Yun-yun Liu, Ting-yu Wang, Han Qiao, Zan-jing Zhai, Hao-wei Li & Ting-ting Tang. (2013) Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions. Bone Research 1:4, pages 362-370.
Crossref
B A Kerr, N P McCabe, W Feng & T V Byzova. (2013) Platelets govern pre-metastatic tumor communication to bone. Oncogene 32:36, pages 4319-4324.
Crossref
David G. Míguez. (2013) Network nonlinearities in drug treatment. Interdisciplinary Sciences: Computational Life Sciences 5:2, pages 85-94.
Crossref
Antonella Chiechi, David L. Waning, Keith R. Stayrook, Jeroen T. Buijs, Theresa A. Guise & Khalid S. Mohammad. (2013) Role of TGF-<i>β</i> in breast cancer bone metastases. Advances in Bioscience and Biotechnology 04:10, pages 15-30.
Crossref
David Danielpour. 2013. Prostate Cancer. Prostate Cancer 207 242 .
Elin Richardsen, Rebecca Dale Uglehus, Stein Harald Johnsen & Lill-Tove Busund. (2012) Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer. BMC Research Notes 5:1.
Crossref
Rosemary J. Akhurst & Akiko Hata. (2012) Targeting the TGFβ signalling pathway in disease. Nature Reviews Drug Discovery 11:10, pages 790-811.
Crossref
Marlous Arjaans, Thijs H. Oude Munnink, Hetty Timmer-Bosscha, Michael Reiss, Annemiek M.E. Walenkamp, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries & Carolina P. Schröder. (2012) Transforming growth factor (TGF)-β expression and activation mechanisms as potential targets for anti-tumor therapy and tumor imaging. Pharmacology & Therapeutics 135:2, pages 123-132.
Crossref
Jeroen T Buijs, Keith R Stayrook & Theresa A Guise. (2012) The role of TGF-β in bone metastasis: novel therapeutic perspectives. BoneKEy Reports 1:6.
Crossref
Loretta S. Loftus, Sophia Edwards-Bennett & Gerald H. Sokol. (2012) Systemic Therapy for Bone Metastases. Cancer Control 19:2, pages 145-153.
Crossref
Jeroen T. Buijs, Keith R. Stayrook & Theresa A. Guise. (2011) TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases. Cancer Microenvironment 4:3, pages 261-281.
Crossref
Swati Biswas, Jeffry S. Nyman, JoAnn Alvarez, Anwesa Chakrabarti, Austin Ayres, Julie Sterling, James Edwards, Tapasi Rana, Rachelle Johnson, Daniel S. Perrien, Scott Lonning, Yu Shyr, Lynn M. Matrisian & Gregory R. Mundy. (2011) Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone. PLoS ONE 6:11, pages e27090.
Crossref
Gianluigi Giannelli, Antonio Mazzocca, Emilia Fransvea, Michael Lahn & Salvatore Antonaci. (2011) Inhibiting TGF-β signaling in hepatocellular carcinoma. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1815:2, pages 214-223.
Crossref
Tomifumi Onishi, Naoki Hayashi, Richard L. Theriault, Gabriel N. Hortobagyi & Naoto T. Ueno. (2010) Future directions of bone-targeted therapy for metastatic breast cancer. Nature Reviews Clinical Oncology 7:11, pages 641-651.
Crossref
Shujie Zhao, Yubao Wang, Lin Cao, Michel M. Ouellette & James W. Freeman. (2010) Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells. International Journal of Cancer 127:9, pages 2076-2087.
Crossref
Daniel Chappard, Hélène Libouban, Erick Legrand, Norbert Ifrah, Charles Masson, Michel Felix Baslé & Maurice Audran. (2010) Computed Microtomography of Bone Specimens for Rapid Analysis of Bone Changes Associated With Malignancy. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 293:7, pages 1125-1133.
Crossref
Elin Richardsen, Rebecca Dale Uglehus, Jan Due, Christer Busch & Lill-Tove Busund. (2010) COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-β, IL-10 and Ki67. Cancer Epidemiology 34:3, pages 316-322.
Crossref
Bethany A. Kerr, Ranko Miocinovic, Armine K. Smith, Eric A. Klein & Tatiana V. Byzova. (2010) Comparison of Tumor and Microenvironment Secretomes in Plasma and in Platelets during Prostate Cancer Growth in a Xenograft Model. Neoplasia 12:5, pages 388-IN4.
Crossref
April AN Rose & Peter M Siegel. (2010) Emerging therapeutic targets in breast cancer bone metastasis. Future Oncology 6:1, pages 55-74.
Crossref
Leland W.K. Chung, Haiyen E. Zhau, John A. Petros & Mary C. Farach-Carson. 2009. Bone and Cancer. Bone and Cancer 157 166 .
Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Janet L. Stein, Irwin Leav, Andre J. van Wijnen, Zhong Jiang & Gary S. Stein. (2009) Prostate cancer regulatory networks. Journal of Cellular Biochemistry 107:5, pages 845-852.
Crossref
Antoinette R. Tan, Gabriela Alexe & Michael Reiss. (2008) Transforming growth factor-β signaling: emerging stem cell target in metastatic breast cancer?. Breast Cancer Research and Treatment 115:3, pages 453-495.
Crossref
A A Mourskaia, Z Dong, S Ng, M Banville, J C Zwaagstra, M D O'Connor-McCourt & P M Siegel. (2008) Transforming growth factor-β1 is the predominant isoform required for breast cancer cell outgrowth in bone. Oncogene 28:7, pages 1005-1015.
Crossref
Noopur Thakur, Alessandro Sorrentino, Carl–Henrik Heldin & Maréne Landström. (2009) TGF-β uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells. Future Oncology 5:1, pages 1-3.
Crossref
A Carracedo & P P Pandolfi. (2008) The PTEN–PI3K pathway: of feedbacks and cross-talks. Oncogene 27:41, pages 5527-5541.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.