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Research Article

TGF-β signalling-related markers in cancer patients with bone metastasis

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Pages 217-236 | Received 14 May 2007, Published online: 08 Oct 2008

References

  • Akhurst RJ, Derynck R. TGF-beta signaling in cancer – a double-edged sword. Trends in Cell Biology 2001; 11: S44–S51
  • Akhurst RJ, Fee F, Balmain A. Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis. Nature 1988; 331: 363–365
  • Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR, Sun LZ. Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-{beta} type I receptor kinase inhibitor. Cancer Research 2006; 66: 6714–6721
  • Barthelemy-Brichant N, David JL, Bosquee L, Bury T, Seidel L, Albert A, Bartsch P, Baugnet-Mahieu L, Deneufbourg JM. Increased TGFbeta1 plasma level in patients with lung cancer: potential mechanisms. European Journal of Clinical Investigation 2002; 32: 193–198
  • Benjamani Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple tasting. Journal of the Royal Statistical Society B 1995; 57: 289–300
  • Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, Tobler S, Heusser C, O'Reilly T, Stolz B, Marti A, Thomas G, Lane HA. Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Research 2004; 64: 252–261
  • Buyukasik Y, Soylu B, Soylu AR, Ozcebe OI, Canbakan S, Haznedaroglu IC, Kirazli S, Baser Y, Dundar SV. In vivo platelet and T-lymphocyte activities during pulmonary tuberculosis. European Respiratory Journal 1998; 12: 1375–1379
  • Caine G, Stonelakey P, Lip G, Kehoe S. The hypercoagulable state of malignancy: pathogenesis and current debate. Neoplasia 2002; 4: 465–473
  • Dumont N, Arteaga CL. Transforming growth factor-beta and breast cancer: tumor promoting effects of transforming growth factor-beta. Breast Cancer Research 2000; 2: 125–132
  • Farrington DL, Yingling JM, Fill JA, Yan L, Qian Y-W, Shou J, Wang X, Ehsani ME, Cleverly AL, Daly TM, Lahn M, Konrad RJ, Ray CJ. Development and validation of a phosphorylated SMAD ex vivo stimulation assay. Biomarkers 2007; 12: 313–330
  • Fox E, Curt GA, Balis FM. Clinical trial design for target-based therapy. Oncologist 2002; 7: 401–409
  • Green LJ, Marder P, Ray C, Cook CA, Jaken S, Musib LC, Herbst RS, Carducci M, Britten CD, Basche M, Eckhardt SG, Thornton D. Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor. Clinical Cancer Research 2006; 12: 3408–3415
  • Jarnicki AG, Lysaght J, Todryk S, Mills KH. Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. Journal of Immunology 2006; 177: 896–904
  • Kakonen SM, Selander KS, Chirgwin JM, Yin JJ, Burns S, Rankin WA, Grubbs BG, Dallas M, Cui Y, Guise TA. Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. Journal of Biological Chemistry 2002; 277: 24571–2478
  • Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C. From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proceedings of the National Academy of Sciences USA 2001; 98: 3018–3023
  • Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massague J. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proceedings of the National Academy of Sciences USA 2005; 102: 13909–13914
  • Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C, Guise TA, Massague J. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003; 3: 537–549
  • Kowal-Bielecka O, Kowal K, Lewszuk A, Bodzenta-Lukaszyk A, Walecki J, Sierakowski S. Beta thromboglobulin and platelet factor 4 in bronchoalveolar lavage fluid of patients with systemic sclerosis. Annals of the Rheumatic Diseases 2005; 64: 484–486
  • Lahn M, Kloeker S, Berry BS. TGF-beta inhibitors for the treatment of cancer. Expert Opinions on Investigational Drugs 2005; 14: 629–643
  • Levine SP, Lindenfeld J, Ellis JB, Raymond NM, Krentz LS. Increased plasma concentrations of platelet factor 4 in coronary artery disease: a measure of in vivo platelet activation and secretion. Circulation 1981; 64: 626–632
  • Li Z-G, Yingling JM, Logothetis C, Navone NM. 2006. TGF1 receptor kinase inhibitor inhibits prostate cancer growth in bone. In: Res PAAC AACR Annual Meeting 2006. Washington, DC: American Association for Cancer Research. Abstract No. 2922.
  • Matsushita T, Dong Z, Sadler J. von Willebrand's factor and von Willebrand's disease. Current Opinion on Hematology 1994; 1: 362–368
  • O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clinical Cancer Research 2003; 9: 5465–5476
  • Rizzoli R, Thiebaud D, Bundred N, Pecherstorfer M, Herrmann Z, Huss HJ, Ruckert F, Manegold C, Tubiana-Hulin M, Steinhauer EU, Degardin M, Thurlimann B, Clemens MR, Eghbali H, Body JJ. Serum parathyroid hormone-related protein levels and response to bisphosphonate treatment in hypercalcemia of malignancy. Journal of Clinical Endocrinology & Metabolism 1999; 84: 3545–3550
  • Roberts AB, Anzano MA, Lamb LC, Smith JM, Sporn MB. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proceedings of the National Academy of Sciences USA 1981; 78: 5339–5343
  • Rohsig LM, Damin DC, Stefani SD, Castro CG, Jr, Roisenberg I, Schwartsmann G. von Willebrand factor antigen levels in plasma of patients with malignant breast disease. Brazilian Journal of Medical & Biological Research 2001; 34: 1125–1129
  • Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nature Reviews Cancer 2003; 3: 807–821
  • Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proceedings of the National Academy of Sciences USA 2003; 100: 8430–8435
  • Slungaard A. Platelet factor 4 modulation of the thrombomodulin-protein C system. Critical Care Medicine 2004; 32: S331–S335
  • Sporn MB, Roberts AB. Autocrine growth factors and cancer. Nature 1985; 313: 745–747
  • Vincent-Salomon A, Carton M, Zafrani B, Freneaux P, Nicolas A, Massemin B, Fourquet A, Clough K, Pouillart P, Sastre-Garau X. Long term outcome of small size invasive breast carcinomas independent from angiogenesis in a series of 685 cases. Cancer 2001; 92: 249–256
  • Wakefield LM, Roberts AB. TGF-beta signaling: positive and negative effects on tumorigenesis. Current Opinions on Genetic Development 2002; 12: 22–29
  • Wojtowicz-Praga S. Reversal of tumor-induced immunosuppression: a new approach to cancer therapy. Journal of Immunotherapy 1997; 20: 165–177
  • Wynendaele W, Derua R, Hoylaerts MF, Pawinski A, Waelkens E, de Bruijn EA, Paridaens R, Merlevede W, van Oosterom AT. Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo?. Annals of Oncology 1999; 10: 965–971
  • Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, Massague J, Mundy GR, Guise TA. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. Journal of Clinical Investigations 1999; 103: 197–206
  • Yingling JM, Blanchard KL, Sawyer JS. Development of TGF-beta signalling inhibitors for cancer therapy. Nature Reviews Drug Discovery 2004; 3: 1011–1022
  • Zeh HJ, Winikoff S, Landsittel DP, Gorelik E, Marrangoni AM, Velikokhatnaya L, Winans MT, Lee K, Moser A, Bartlett D, Lotze MT, Siegfried JM, Whitcomb D, Papacristou G, Slivka A, Bigbee WL, Lokshin AE. Multianalyte profiling of serum cytokines for detection of pancreatic cancer. Cancer Biomarkers 2005; 1: 259–269

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