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International Journal of Psychiatry in Clinical Practice Volume 11, 2007 - Issue 1
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ORIGINAL ARTICLE

Does long-term medication with lithium, clozapine or antidepressants prevent or attenuate dementia in bipolar and depressed patients?

Dr Jules Angst Zurich University Psychiatric Hospital, Zurich, Switzerland
,
Alex Gamma Zurich University Psychiatric Hospital, Zurich, Switzerland
,
Regina Gerber-Werder Zurich University Psychiatric Hospital, Zurich, Switzerland
,
Carlos A. Zarate Jr. Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Zurich, Switzerland
&
Husseini K. Manji Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Zurich, Switzerland
Pages 2-8 | Received 26 Sep 2005, Published online: 12 Jul 2009

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Joshua Hunsberger, Daniel R. Austin, Ioline D. Henter & Guang Chen. (2009) The neurotrophic and neuroprotective effects of psychotropic agents. Dialogues in Clinical Neuroscience 11:3, pages 333-348.
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Jules Angst. (2008) Bipolar disorder-methodological problems and future perspectives . Dialogues in Clinical Neuroscience 10:2, pages 129-139.
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Articles from other publishers (19)

L. Ronat & A. Hanganu. (2023) Neuropsychiatric and cognitive features of major depressive disorder in aging, based on the data from the US National Alzheimer's Coordinating Center (NACC). L'Encéphale.
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Alyssa L. Wiseman, Clark A. Briggs, Ariel Peritt, Nicolas Kapecki, Daniel A. Peterson, Seong S. Shim & Grace E. Stutzmann. (2023) Lithium Provides Broad Therapeutic Benefits in an Alzheimer’s Disease Mouse Model. Journal of Alzheimer's Disease 91:1, pages 273-290.
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Seong Sool Shim, Ken Berglund & Shan Ping Yu. (2023) Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer’s Disease and Related Dementia. Neurodegenerative Diseases 23:1-2, pages 1-12.
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Nobuyoshi Ishii, Takeshi Terao & Hirofumi Hirakawa. (2021) The Present State of Lithium for the Prevention of Dementia Related to Alzheimer’s Dementia in Clinical and Epidemiological Studies: A Critical Review. International Journal of Environmental Research and Public Health 18:15, pages 7756.
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Jaehyun Kim, Tae Hyon Ha, Kiwon Kim, Eun-Mi Lee, Hyekyeong Kim, Doh Kwan Kim, Hong-Hee Won, Matthew Lewis, Hyewon Lee & Woojae Myung. (2021) Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study. Journal of Alzheimer's Disease 80:1, pages 197-207.
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Lisha Wang, Bharti, Rajnish Kumar, Pavel F. Pavlov & Bengt Winblad. (2021) Small molecule therapeutics for tauopathy in Alzheimer’s disease: Walking on the path of most resistance. European Journal of Medicinal Chemistry 209, pages 112915.
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J. Velosa, A. Delgado, E. Finger, M. Berk, F. Kapczinski & T. Azevedo Cardoso. (2020) Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta‐analyses. Acta Psychiatrica Scandinavica 141:6, pages 510-521.
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Joyce Y.C. Chan, Karen K.L. Yiu, Timothy C.Y. Kwok, Samuel Y.S. Wong & Kelvin K.F. Tsoi. (2019) Depression and Antidepressants as Potential Risk Factors in Dementia: A Systematic Review and Meta-analysis of 18 Longitudinal Studies. Journal of the American Medical Directors Association 20:3, pages 279-286.e1.
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Rita Khoury & George T. Grossberg. (2018) Impact of Antidepressant Use on the Trajectory of Alzheimer’s Disease: Evidence, Mechanisms, and Therapeutic Implications. CNS Drugs 33:1, pages 17-29.
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Janusz K. Rybakowski. 2018. Alzheimer's Disease - The 21st Century Challenge. Alzheimer's Disease - The 21st Century Challenge.
John Moraros, Chijioke Nwankwo, Scott B. Patten & Darrell D. Mousseau. (2017) The association of antidepressant drug usage with cognitive impairment or dementia, including Alzheimer disease: A systematic review and meta-analysis. Depression and Anxiety 34:3, pages 217-226.
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James M. Prosser & Ronald R. Fieve. (2016) Patients receiving lithium therapy have a reduced prevalence of neurological and cardiovascular disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 71, pages 39-44.
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Sivan Mauer, Derick Vergne & S Nassir Ghaemi. (2014) Standard and trace-dose lithium: A systematic review of dementia prevention and other behavioral benefits. Australian & New Zealand Journal of Psychiatry 48:9, pages 809-818.
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Jules Angst. (2013) Bipolar disorders in DSM-5: strengths, problems and perspectives. International Journal of Bipolar Disorders 1:1.
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Vicent Balanzá-Martínez, Gabriel Selva, Anabel Martínez-Arán, Jos Prickaerts, José Salazar, Ana González-Pinto, Eduard Vieta & Rafael Tabarés-Seisdedos. (2010) Neurocognition in bipolar disorders—A closer look at comorbidities and medications. European Journal of Pharmacology 626:1, pages 87-96.
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Rodrigo Machado-Vieira, Husseini K Manji & Carlos A Zarate Jr. (2009) The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar Disorders 11, pages 92-109.
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Jules Angst. (2009) From psychoanalysis to epidemiology: autobiographical notes. Acta Psychiatrica Scandinavica 119:2, pages 87-97.
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Robert J Schloesser, Jian Huang, Peter S Klein & Husseini K Manji. (2007) Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder. Neuropsychopharmacology 33:1, pages 110-133.
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De-Maw Chuang & Husseini K. Manji. (2007) In Search of the Holy Grail for the Treatment of Neurodegenerative Disorders: Has a Simple Cation Been Overlooked?. Biological Psychiatry 62:1, pages 4-6.
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