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Original Article

Estradiol and drospirenone for climacteric symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled study of the safety and efficacy of three dose regimens

, &
Pages 189-196 | Received 07 May 2003, Accepted 16 Nov 2003, Published online: 28 Apr 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (17)

James H Pickar, David F Archer, Risa Kagan, JoAnn V Pinkerton & Hugh S Taylor. (2017) Safety and benefit considerations for menopausal hormone therapy. Expert Opinion on Drug Safety 16:8, pages 941-954.
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C. Gerlinger, K. Gude, T. Schmelter, M. Schaefers & J. Endrikat. (2015) 0.5 vs. 1.0 mg estradiol in combination with drospirenone for the treatment of hot flushes. Climacteric 18:4, pages 512-517.
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A. R. Genazzani, T. Schmelter, M. Schaefers, C. Gerlinger & K. Gude. (2013) One-year randomized study of the endometrial safety and bleeding pattern of 0.25 mg drospirenone/0.5 mg 17β-estradiol in postmenopausal women. Climacteric 16:4, pages 490-498.
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S. M. R. R. Lima, B. F. Reis, S. S. Yamada, S. Postigo, R. M. Grande, S. R. Botogoski, A. B. Campaner, C. K. Hueb & M. A. Longo Galvão. (2011) Effects of drospirenone/estradiol on steroid receptors and Bcl-2 in the postmenopausal endometrium. Climacteric 14:5, pages 551-557.
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S-Q. Lin, L-Z. Sun, J-F. Lin, X. Yang, L-J. Zhang, J. Qiao, Z-H. Wang, Y-X. Xu, Z-A. Xiong, Y-Z. Zhou, M-L. Wang, J. Zhu, S-R. Chen, H. Su, C-S. Yang, S-H. Wang, Y-Z. Zhang & X-J. Dong. (2011) Estradiol 1 mg and drospirenone 2 mg as hormone replacement therapy in postmenopausal Chinese women. Climacteric 14:4, pages 472-481.
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M. Gambacciani, G. Rosano, B. Cappagli, A. Pepe, C. Vitale & A. R. Genazzani. (2011) Clinical and metabolic effects of drospirenone–estradiol in menopausal women: a prospective study. Climacteric 14:1, pages 18-24.
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Andrea J Rapkin & Sharon A Winer. (2007) Drospirenone: a novel progestin. Expert Opinion on Pharmacotherapy 8:7, pages 989-999.
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P. Collins, G. Rosano, C. Casey, C. Daly, M. Gambacciani, P. Hadji, R. Kaaja, T. Mikkola, S. Palacios, R. Preston, T. Simon, J. Stevenson & M. Stramba-Badiale. (2007) Management of cardiovascular risk in the perimenopausal women: a consensus statement of European cardiologists and gynecologists. Climacteric 10:6, pages 508-526.
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D. F. Archer. (2007) Drospirenone and estradiol: a new option for the postmenopausal woman. Climacteric 10:sup1, pages 3-10.
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Jean-Michel Foidart & Thomas Faustmann. (2007) Advances in hormone replacement therapy: Weight benefits of drospirenone, a 17α-spirolactone-derived progestogen. Gynecological Endocrinology 23:12, pages 692-699.
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David W. Sturdee & Alastair H. MacLennan. (2006) Not all placebos are equally pleasing. Climacteric 9:6, pages 401-403.
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R. Sitruk-Ware. (2005) Pharmacology of different progestogens: the special case of drospirenone. Climacteric 8:sup3, pages 4-12.
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Lothar A J Heinemann & J??rgen Dinger. (2004) Safety of a New Oral Contraceptive Containing Drospirenone. Drug Safety 27:13, pages 1001-1018.
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