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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 127, 2021 - Issue 2
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Original Articles

Hepatoprotective effects of silymarin against diclofenac-induced liver toxicity in male rats based on biochemical parameters and histological study

Esfandiar HeidarianClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranView further author information
&
Ali NouriClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-2068-8493View further author information
ORCID Icon
Pages 112-118 | Received 27 Dec 2018, Accepted 14 May 2019, Published online: 05 Jun 2019

Citations (13)

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Yavuz Osman Birdane, Hülya Atik, Orkun Atik & Recep Aslan. (2022) Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation. Drug and Chemical Toxicology 0:0, pages 1-11.
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Mohsen Esmaeilzadeh, Esfandiar Heidarian, Mehrnoosh Shaghaghi, Hoshang Roshanmehr, Mohammad Najafi, Alireza Moradi & Ali Nouri. (2020) Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1β gene expression in male rats. Pharmaceutical Biology 58:1, pages 590-596.
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Articles from other publishers (11)

Rupali Choudhary, Diksha Saroch, Diljeet Kumar, Sobia Anjum, Nusrit Iqbal Andrabi, Tazeem Akram, Bhahwal Ali Shah, Sanket K. Shukla, Asha Bhagat, Gurleen Kour & Zabeer Ahmed. (2023) Anti-inflammatory and anti-arthritic potential of methotrexate in combination with BA-25, an amino analogue of β-boswellic acid in the treatment of rheumatoid arthritis. Cytokine 172, pages 156398.
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Ali Tureyen, Hasan Huseyin Demirel, Ezgi Nur Demirkapi, Azra Mila Eryavuz & Sinan Ince. (2023) Tubuloside A, a phenylethanoid glycoside, alleviates diclofenac induced hepato‐nephro oxidative injury via Nrf2/HO‐1 . Journal of Cellular and Molecular Medicine 27:21, pages 3404-3413.
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Ana Caroline dos Santos, Tauani Caroline Santos França, Larissa Venzon, Vitor Polli, Gustavo Polleti, Erica Trembulak, Sarah Freygang Mendes Pilati & Luísa Mota da Silva. (2023) Are silymarin and N‐acetylcysteine able to prevent liver damage mediated by multiple factors? Findings against ethanol plus LPS‐induced liver injury in mice. Journal of Biochemical and Molecular Toxicology.
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Funda Terzi & Mustafa Kemal Ciftci. (2022) Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity. BMC Complementary Medicine and Therapies 22:1.
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Ahmed Abdelbaset-Ismail, Abeer Tharwat, Ahmed E. Ahmed, Tarek Khamis, Ibrahim H. Abd El-Rahim, Sadeq K. Alhag & Mohamed F. Dowidar. (2022) Transplantation of adipose-derived mesenchymal stem cells ameliorates acute hepatic injury caused by nonsteroidal anti-inflammatory drug diclofenac sodium in female rats. Biomedicine & Pharmacotherapy 155, pages 113805.
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Karan Wadhwa, Rakesh Pahwa, Manish Kumar, Shobhit Kumar, Prabodh Chander Sharma, Govind Singh, Ravinder Verma, Vineet Mittal, Inderbir Singh, Deepak Kaushik & Philippe Jeandet. (2022) Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules 27:16, pages 5327.
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Gellan Alaa Mohamed Kamel, Eman Harahsheh & Shaimaa Hussein. (2022) Mechanisms underlying the hepatoprotective effect of silymarin on fluoxetine-induced liver injury in rats: the implication of peroxisome proliferator–activated receptor-gamma (PPAR-γ). Comparative Clinical Pathology 31:4, pages 689-698.
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Maggie E. Amer, Maher A. Amer, Azza I. Othman, Doaa A. Elsayed, Mohamed Amr El-Missiry & Omar A. Ammar. (2022) Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice. Molecular Biology Reports 49:6, pages 4659-4671.
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Azza El-Sheikh & Zenat Khired. (2021) Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity. Medicina 58:1, pages 46.
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Alireza Moradi, Mahdieh Abolfathi, Mahsa Javadian, Esfandiar Heidarian, Hoshang Roshanmehr, Mansoor Khaledi & Ali Nouri. (2021) Gallic Acid Exerts Nephroprotective, Anti-Oxidative Stress, and Anti-Inflammatory Effects Against Diclofenac-Induced Renal Injury in Malerats. Archives of Medical Research 52:4, pages 380-388.
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D. Faixová, G. Hrčková, T. Mačák Kubašková & D. Mudroňová. (2021) Antiparasitic effects of selected isoflavones on flatworms. Helminthologia 58:1, pages 1-16.
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