2,201
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

, , , &
Pages 368-373 | Received 29 Jan 2016, Accepted 23 Sep 2016, Published online: 08 Dec 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Prasada Chowdari Gurram, Sairaj Satarker, Gautam Kumar, Farmiza Begum, Chetan Mehta, Usha Nayak, Jayesh Mudgal, Devinder Arora & Madhavan Nampoothiri. (2023) Avanafil mediated dual inhibition of IKKβ and TNFR1 in an experimental paradigm of Alzheimer’s disease: in silico and in vivo approach. Journal of Biomolecular Structure and Dynamics 41:20, pages 10659-10677.
Read now
Georcki Ropón-Palacios, Manuel E. Chenet-Zuta, Gustavo E. Olivos-Ramirez, Kewin Otazu, Jorge Acurio-Saavedra & Ihosvany Camps. (2020) Potential novel inhibitors against emerging zoonotic pathogen Nipah virus: a virtual screening and molecular dynamics approach. Journal of Biomolecular Structure and Dynamics 38:11, pages 3225-3234.
Read now
Monika Chaudhary, Neeraj Kumar, Ashish Baldi, Ramesh Chandra, M. Arockia Babu & Jitender Madan. (2020) 4-Bromo-4’-chloro pyrazoline analog of curcumin augmented anticancer activity against human cervical cancer, HeLa cells: in silico-guided analysis, synthesis, and in vitro cytotoxicity. Journal of Biomolecular Structure and Dynamics 38:5, pages 1335-1353.
Read now
Monika Chaudhary, Neeraj Kumar, Ashish Baldi, Ramesh Chandra, M. Arockia Babu & Jitender Madan. (2020) Chloro and bromo-pyrazole curcumin Knoevenagel condensates augmented anticancer activity against human cervical cancer cells: design, synthesis, in silico docking and in vitro cytotoxicity analysis. Journal of Biomolecular Structure and Dynamics 38:1, pages 200-218.
Read now

Articles from other publishers (24)

Dehua Huang, Xue Yang, Zhao Peng, Hongqiang Yin, Yongyang Liu, Yejun Zhang, Chunyan Li, Guangcun Chen & Qiangbin Wang. (2024) Multichannel-optical imaging for in vivo evaluating the safety and therapeutic efficacy of stem cells in tumor model in terms of cell tropism, proliferation and NF-κB activity. Biomaterials 307, pages 122510.
Crossref
Yingying Hu, Yan Nan, Hongzhou Lin, Qianlei Zhao, Tingting Chen, Xiaoyue Tao, Bingqing Ding, Liying Lu, Shangqin Chen, Jianghu Zhu, Xiaoling Guo & Zhenlang Lin. (2024) Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation. Pediatric Research.
Crossref
Abdalla M. Abdrabou. (2023) The Yin and Yang of IκB Kinases in Cancer. Kinases and Phosphatases 2:1, pages 9-27.
Crossref
Alessandra Cipriano, Monica Viviano, Alessandra Feoli, Ciro Milite, Giuliana Sarno, Sabrina Castellano & Gianluca Sbardella. (2023) NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors. Journal of Medicinal Chemistry 66:17, pages 11632-11655.
Crossref
Zhe Chien Khoo, Tamilselvan Kavin, Hui Jia, Govindarajan Karthivashan, Sevakumaran Vigneswari & Rameshkumar Santhanam. (2023) Drug delivery approaches to improve the efficiency of phytoderivatives against UV induced damage- A review. Journal of Drug Delivery Science and Technology 87, pages 104793.
Crossref
Di Su, Rong‐yuan Wei, Zhi‐ming Yan, Guo‐hui Zhong, Xiang‐qing Qin, Shu‐tong Huang, Juan‐yue Long, Feng‐ling Zhang, Ping He, Zhong‐ji Chen, Ya‐qian Yan, Neng Jiang & Wei‐zhong Tang. (2023) Design, synthesis, and evaluation of antitumor activity of novel C‐6 sulfhydryl‐substituted and 20‐substituted derivatives of celastrol . Chemical Biology & Drug Design 102:2, pages 316-331.
Crossref
Prasada Chowdari Gurram, Sairaj Satarker, Ajmal Nassar, Jayesh Mudgal & Madhavan Nampoothiri. (2022) Virtual structure-based docking and molecular dynamics of FDA-approved drugs for the identification of potential IKKB inhibitors possessing dopaminergic activity in Alzheimer’s disease. Chemical Papers 77:4, pages 1971-1988.
Crossref
Jiali Gan, Lin Guo, Xiaolu Zhang, Qun Yu, Qiuyue Yang, Yilin Zhang, Wenyun Zeng, Xijuan Jiang & Maojuan Guo. (2023) Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ. Journal of Inflammation 20:1.
Crossref
Yueran Cui, Xuejiao Jiang & Juan Feng. (2022) The therapeutic potential of triptolide and celastrol in neurological diseases. Frontiers in Pharmacology 13.
Crossref
Vardges Tserunyan & Stacey D. Finley. (2022) Computational analysis of 4-1BB-induced NFκB signaling suggests improvements to CAR cell design. Cell Communication and Signaling 20:1.
Crossref
Mengyuan Chen, Maozhu Liu, Ying Luo, Jun Cao, Fanning Zeng, Lu Yang, Junqing Yang, Tao Tao & Yu Jiang. (2022) Celastrol Protects against Cerebral Ischemia/Reperfusion Injury in Mice by Inhibiting Glycolysis through Targeting HIF-1α/PDK1 Axis. Oxidative Medicine and Cellular Longevity 2022, pages 1-14.
Crossref
Chenyu Zhang, Miao Zhao, Bingwei Wang, Zhijie Su, Bingbing Guo, Lihua Qin, Weiguang Zhang & Ruimao Zheng. (2021) The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease. Redox Biology 47, pages 102134.
Crossref
Xue Bai, Rui-Jia Fu, Shuo Zhang, Shi-Jun Yue, Yan-Yan Chen, Ding-Qiao Xu & Yu-Ping Tang. (2021) Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases. Biomedicine & Pharmacotherapy 139, pages 111551.
Crossref
Bo Zhang, Qi Zhong, Xuhui Chen, Xi Wu, Rong Sha, Guizhi Song, Chuanhan Zhang & Xiangdong Chen. (2020) Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway. Frontiers in Neuroscience 14.
Crossref
Sri Renukadevi Balusamy, Haribalan Perumalsamy, Karpagam Veerappan, Md. Amdadul Huq, S. Rajeshkumar, T. Lakshmi & Yeon Ju Kim. (2020) Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study . BioMed Research International 2020, pages 1-15.
Crossref
Zhu Zhang, Shiqing Zhang, Cathy Nga-Ping Lui, Peili Zhu, Zhang Zhang, Kaili Lin, Yiwu Dai & Ken Kin-Lam Yung. (2019) Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease. Journal of Neurorestoratology 7:4, pages 207-222.
Crossref
Shivaprasad H. Venkatesha & Kamal D. Moudgil. (2019) Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology. Inflammation Research 68:4, pages 285-296.
Crossref
Vinita Mishra & Chandramani Pathak. (2019) Human Toll-Like Receptor 4 (hTLR4): Structural and functional dynamics in cancer. International Journal of Biological Macromolecules 122, pages 425-451.
Crossref
Jianheng Li & Jijun Hao. (2019) Treatment of Neurodegenerative Diseases with Bioactive Components of Tripterygium wilfordii . The American Journal of Chinese Medicine 47:04, pages 769-785.
Crossref
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Tapan Mukherjee & Anupam Bishayee. (2018) Molecular targets of celastrol in cancer: Recent trends and advancements. Critical Reviews in Oncology/Hematology 128, pages 70-81.
Crossref
Mei Yi, Jing Cai, Junjun Li, Shengnan Chen, Zhaoyang Zeng, Qian Peng, Yuanyuan Ban, Ying Zhou, Xiaoling Li, Wei Xiong, Guiyuan Li & Bo Xiang. (2018) Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?. Journal of Cellular Physiology 233:8, pages 5537-5549.
Crossref
Haribalan Perumalsamy, Karuppasamy Sankarapandian, Karpagam Veerappan, Sathishkumar Natarajan, Narendran Kandaswamy, Lakshmi Thangavelu & Sri Renukadevi Balusamy. (2018) In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer. Phytomedicine 46, pages 119-130.
Crossref
Nikolay Kuzmich, Konstantin Sivak, Vladimir Chubarev, Yuri Porozov, Tatiana Savateeva-Lyubimova & Francesco Peri. (2017) TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis. Vaccines 5:4, pages 34.
Crossref
Heba A. Abdelaziz, Mohamed E. Shaker, Mohamed F. Hamed & Nariman M. Gameil. (2017) Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G. Toxicology Letters 275, pages 6-18.
Crossref