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Pharmaceutical Biology Volume 59, 2021 - Issue 1
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Research Article

Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis

Yuan Zhoua Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaORCID Iconhttps://orcid.org/0000-0002-3820-1110View further author information
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Rong Wua Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
,
Fei-fei Caia Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
,
Wen-Jun Zhoua Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
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Yi-Yu Lua Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
,
Hui Zhanga Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
,
Qi-Long Chena Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
,
Ming-Yu Sunb Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCorrespondence[email protected]
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Shi-Bing Sua Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1003-6424View further author information
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Pages 1592-1604 | Received 05 Mar 2021, Accepted 22 Oct 2021, Published online: 22 Nov 2021

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Zheng Xu, Fan-Wei Wu, Xuan Niu, Xiao-Peng Lu, Yan-Rong Li, Shu-Ting Zhang, Jun-Zhao Ou & Xue-Mei Wang. (2022) Integrated strategy of RNA-sequencing and network pharmacology for exploring the protective mechanism of Shen-Shi-Jiang-Zhuo formula in rat with non-alcoholic fatty liver disease. Pharmaceutical Biology 60:1, pages 1819-1838.
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Articles from other publishers (10)

Lijuan Dan, Yanwei Hao, Hongfei Song, Tianyuan Wang, Jia Li, Xiaoyan He & Yue Su. (2024) Efficacy and potential mechanisms of the main active ingredients of astragalus mongholicus in animal models of liver fibrosis: A systematic review and meta-analysis. Journal of Ethnopharmacology 319, pages 117198.
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Asif Ahmad Bhat, Ahsas Goyal, Riya Thapa, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Mahaveer Singh, Suman Rohilla, Tarun Kumar Saini, Neelima Kukreti, Dhanalekshmi Unnikrishnan Meenakshi, Neeraj Kumar Fuloria, Mahendran Sekar & Gaurav Gupta. (2023) Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer. Cytokine 171, pages 156376.
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Md Sadique Hussain, Gaurav Gupta, Ahsas Goyal, Riya Thapa, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Shivkanya Fuloria, Dhanalekshmi Unnikrishnan Meenakshi, Vikas Jakhmola, Manisha Pandey, Sachin Kumar Singh & Kamal Dua. (2023) From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders. Journal of Biochemical and Molecular Toxicology 37:11.
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Yanwei LI, Yunrui LU, Mozuo NIAN, Qiuju SHENG, Chong ZHANG, Chao HAN, Xiaoguang DOU & Yang DING. (2023) Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease. Chinese Journal of Natural Medicines 21:9, pages 643-657.
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Yan Wang, Kun Shi, Jiyuan Tu, Chang Ke, Niping Chen, Bo Wang, Yanju Liu & Zhongshi Zhou. (2023) Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism. Molecules 28:14, pages 5504.
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Chenglong Cheng, Qiang Wang, Yurong Huang, Qiuyun Xue, Yuting Wang, Peng Wu, Faxue Liao & Chenggui Miao. (2023) Gandouling inhibits hepatic fibrosis in Wilson's disease through Wnt-1/β-catenin signaling pathway. Journal of Ethnopharmacology 311, pages 116445.
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Ali Hazrati, Zahra Mirsanei, Neda Heidari, Kosar Malekpour, Nasim Rahmani-Kukia, Ardeshir Abbasi & Sara Soudi. (2023) The potential application of encapsulated exosomes: A new approach to increase exosomes therapeutic efficacy. Biomedicine & Pharmacotherapy 162, pages 114615.
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Jian-Ping Deng, Xin Liu, Yue Li, Shi-Hao Ni, Shu-Ning Sun, Xiao-Lu Ou-Yang, Xiao-Han Ye, Ling-Jun Wang & Lu Lu. (2023) Drug vector representation and potential efficacy prediction based on graph representation learning and transcriptome data: Acacetin from traditional Chinese Medicine model. Journal of Ethnopharmacology 305, pages 115966.
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Zhi-yi Li, Si Lv, Jie Qiao, Si-qi Wang, Fang Ji, Dan Li, Jie Yan, Yan Wei, Lin Wu, Changzhen Gao & Miao-ling Li. (2023) Acacetin Alleviates Cardiac Fibrosis via TGF-β1/Smad and AKT/mTOR Signal Pathways in Spontaneous Hypertensive Rats. Gerontology 69:9, pages 1076-1094.
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Heming Long, Hongmei Chen, Jun Yan & Haiyan Cheng. (2022) Emodin exerts antitumor effects in ovarian cancer cell lines by preventing the development of cancer stem cells via epithelial mesenchymal transition. Oncology Letters 23:3.
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