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Pharmaceutical Biology Volume 60, 2022 - Issue 1
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Research Article

Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling

Xu Chena Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China;b Department of Cardiology, Tianjin Beichen Hospital, Tianjin, ChinaView further author information
,
Zhiyu Zhangc Tianjin Beichen Center for Disease Control and Prevention, Tianjin, ChinaView further author information
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Xiaowei Zhanga Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaView further author information
,
Zhi Jiab Department of Cardiology, Tianjin Beichen Hospital, Tianjin, ChinaView further author information
,
Jun Liub Department of Cardiology, Tianjin Beichen Hospital, Tianjin, ChinaView further author information
,
Xinpei Chena Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaView further author information
,
Aiqing Xua Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaView further author information
,
Xue Lianga Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaView further author information
&
Guangping Lia Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaCorrespondence[email protected]
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Pages 562-569 | Received 01 Jul 2020, Accepted 04 Feb 2022, Published online: 07 Mar 2022

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Chunkun Yang, Jiawen Cheng, Qinwei Zhu, Qingquan Pan, Kui Ji & Jun Li. (2023) Review of the Protective Mechanism of Paeonol on Cardiovascular Disease. Drug Design, Development and Therapy 17, pages 2193-2208.
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Articles from other publishers (11)

Zeyu Zhang, Zhihua Yang, Shuai Wang, Xianliang Wang & Jingyuan Mao. (2024) Targeting MAPK-ERK/JNK pathway: A potential intervention mechanism of myocardial fibrosis in heart failure. Biomedicine & Pharmacotherapy 173, pages 116413.
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Rui Wu, Yanfang Liu, Fang Zhang, Shu Dai, Xinyan Xue, Cheng Peng, Yan Li & Yunxia Li. (2023) Protective mechanism of Paeonol on central nervous system. Phytotherapy Research 38:2, pages 470-488.
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Atri Das, Swarnali Khan, Syamal Roy & Shantanabha Das. (2023) Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies. Exploration of Drug Science, pages 336-376.
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Magdalena Jasińska-Stroschein. (2023) Searching for Effective Treatments in HFpEF: Implications for Modeling the Disease in Rodents. Pharmaceuticals 16:10, pages 1449.
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Canzhang Liu, Xin Yi, Jie Yan, Qiang Liu, Teng Cao & Shuipeng Liu. (2023) Paeonol improves angiotensin II-induced cardiac hypertrophy by suppressing ferroptosis. Heliyon 9:9, pages e19149.
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Jincai Liu, Xiang Li, Huixin Bai, Xu Yang, Jun Mu, Ruonan Yan & Siwang Wang. (2023) Traditional uses, phytochemistry, pharmacology, and pharmacokinetics of the root bark of Paeonia x suffruticosa andrews: A comprehensive review. Journal of Ethnopharmacology 308, pages 116279.
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Mingge Ding, Rui Shi, Feng Fu, Man Li, Dema De, Yanyan Du & Zongfang Li. (2023) Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway. Journal of Advanced Research 47, pages 151-162.
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Wei Zhang, Manli Yu, Cenxi Zhang, Qing Yu, Sheng Xu, Qiongzhi Yan, Zhifu Guo & Yawei Xu. (2023) Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway. Oxidative Medicine and Cellular Longevity 2023, pages 1-14.
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Lu-lu Chen, Feng Su, Si-nan Li, Xin Yi, Yuan-yuan Luo, Dong Liang, Zhen-chuan Tang, Chao Feng, Kai Cheng & Fang Deng. (2023) Paeonol Effects on Repair of Cerebral Cortex Injury and the Expression of Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B in Postnatal Rats with Cerebral Palsy. Journal of Biomaterials and Tissue Engineering 13:2, pages 342-348.
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Huan Wang, Mei‐Lin Liu, Chu Chu, Shi‐Jiao Yu, Jing Li, Hai‐Chuan Shen, Qian Meng & Teng Zhang. (2022) Paeonol alleviates placental inflammation and apoptosis in preeclampsia by inhibiting the JAK2/STAT3 signaling pathway. The Kaohsiung Journal of Medical Sciences 38:11, pages 1103-1112.
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Cong Chen, Shuhong Liu, Gaozhen Cao, Yang Hu, Run Wang, Min Wu, Mingya Liu & Kai Hang Yiu. (2022) Cardioprotective Effect of Paeonol on Chronic Heart Failure Induced by Doxorubicin via Regulating the miR-21-5p/S-Phase Kinase-Associated Protein 2 Axis. Frontiers in Cardiovascular Medicine 9.
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