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Research Article

Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling

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Pages 562-569 | Received 01 Jul 2020, Accepted 04 Feb 2022, Published online: 07 Mar 2022

References

  • Asselin CY, Lam A, Cheung DYC, Eekhoudt CR, Zhu A, Mittal I, Mayba A, Solati Z, Edel A, Austria JA, et al. 2020. The cardioprotective role of flaxseed in the prevention of doxorubicin- and trastuzumab-mediated cardiotoxicity in C57bl/6 mice. J Nutr. 150(9):2353–2363.
  • Bacmeister L, Schwarzl M, Warnke S, Stoffers B, Blankenberg S, Westermann D, Lindner D. 2019. Inflammation and fibrosis in murine models of heart failure. Basic Res Cardiol. 114(3):19–756.
  • Choy KW, Murugan D, Mustafa MR. 2018. Natural products targeting ER stress pathway for the treatment of cardiovascular diseases. Pharmacol Res. 132:119–129.
  • Gao L, Wang Z, Lu D, Huang J, Liu J, Hong L. 2019. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death Dis. 10(8):609–621.
  • Jia Q, Wang L, Zhang X, Ding Y, Li H, Yang Y, Zhang A, Li Y, Lv S, Zhang J. 2020. Prevention and treatment of chronic heart failure through traditional Chinese medicine: role of the gut microbiota. Pharmacol Res. 151:1016–1041.
  • Jin X, Wang J, Xia ZM, Shang CH, Chao QL, Liu YR, Fan HY, Chen DQ, Qiu F, Zhao F. 2016. Anti-inflammatory and anti-oxidative activities of paeonol and its metabolites through blocking MAPK/ERK/p38 signaling pathway. Inflammation. 39(1):434–446.
  • Li H, Song F, Duan LR, Sheng JJ, Xie YH, Yang Q, Chen Y, Dong QQ, Zhang BL, Wang SW. 2016. Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: roles of Nrf2/Ho-1 and PI3K/Akt pathway. Sci Rep. 6:23693.
  • Lu L, Qin Y, Chen C, Guo X. 2018. Beneficial effects exerted by paeonol in the management of atherosclerosis. Oxid Med Cell Longev. 2018:1098617.
  • Martinez PF, Bonomo C, Guizoni DM, Junior SA, Damatto RL, Cezar MD, Lima AR, Pagan LU, Seiva FR, Bueno RT, et al. 2016. Modulation of MAPK and NF-954;B signaling pathways by antioxidant therapy in skeletal muscle of heart failure rats. Cell Physiol Biochem. 39(1):371–384.
  • Mei L, He M, Zhang C, Miao J, Wen Q, Liu X, Xu Q, Ye S, Ye P, Huang H, et al. 2019. Paeonol attenuates inflammation by targeting Hmgb1 through upregulating Mir-339-5p. Sci Rep. 9(1):19370–19384.
  • Okin PM, Devereux RB, Liu JE, Oikarinen L, Jern S, Kjeldsen SE, Julius S, Wachtell K, Nieminen MS, Dahlöf B. 2004. Regression of electrocardiographic left ventricular hypertrophy predicts regression of echocardiographic left ventricular mass: the life study. J Hum Hypertens. 18(6):403–409.
  • Ren J, Zhang N, Liao H, Chen S, Xu L, Li J, Yang Z, Deng W, Tang Q. 2017. Caffeic acid phenethyl ester attenuates pathological cardiac hypertrophy by regulation of MEK/ERK signaling pathway in vivo and vitro. Life Sci. 181:53–61.
  • Suematsu Y, Jing W, Nunes A, Kashyap ML, Khazaeli M, Vaziri ND, Moradi H. 2018. Lcz696 (sacubitril/valsartan), an angiotensin-receptor neprilysin inhibitor, attenuates cardiac hypertrophy, fibrosis, and vasculopathy in a rat model of chronic kidney disease. J Card Fail. 24(4):266–275.
  • Sun Y, Liu WZ, Liu T, Feng X, Yang N, Zhou HF. 2015. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 35(6):600–604.
  • Syeda MZ, Fasae MB, Yue E, Ishimwe AP, Jiang Y, Du Z, Yang B, Bai Y. 2019. Anthocyanidin attenuates myocardial ischemia induced injury via inhibition of Ros-Jnk-Bcl-2 pathway: new mechanism of anthocyanidin action. Phytother Res. 33(12):3129–3139.
  • Thabassum Akhtar Iqbal S, Tirupathi Pichiah PB, Raja S, Arunachalam S. 2020. Paeonol reverses adriamycin induced cardiac pathological remodeling through Notch1 signaling reactivation in H9c2 cells and adult zebrafish heart. Chem Res Toxicol. 33(2):312–323.
  • Wang X, Zhu G, Yang S, Wang X, Cheng H, Wang F, Li X, Li Q. 2011. Paeonol prevents excitotoxicity in rat pheochromocytoma Pc12 cells via downregulation of ERK activation and inhibition of apoptosis. Planta Med. 77(15):1695–1701.
  • Wu J, Sun C, Wang R, Li J, Zhou M, Yan M, Xue X, Wang C. 2018. Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/Akt pathway. Chem Biol Interact. 286:17–25.
  • Wu J, Xue X, Zhang B, Jiang W, Cao H, Wang R, Sun D, Guo R. 2016. The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4t1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway. Chem Biol Interact. 244:1–8.
  • Xu CN, Kong LH, Ding P, Liu Y, Fan ZG, Gao EH, Yang J, Yang LF. 2020. Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. Biochim Biophys Acta Mol Basis Dis. 1866:165848.
  • Yan X, Xun M, Wu L, Du X, Zhang F, Zheng J. 2018. DRm217 attenuates myocardial ischemia–reperfusion injury via stabilizing plasma membrane Na+–K+-ATPase, inhibiting Na+–K+-ATPase/ROS pathway and activating PI3K/Akt and ERK1/2. Toxicol Appl Pharm. 349:62–71.
  • Yang X, He T, Han S, Zhang X, Sun Y, Xing Y, Shang H. 2019. The role of traditional Chinese medicine in the regulation of oxidative stress in treating coronary heart disease. Oxid Med Cell Longev. 2019:3231424.
  • Yang ZZ, Tschopp O, Di-Poï N, Bruder E, Baudry A, Dümmler B, Wahli W, Hemmings BA. 2005. Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol. 25(23):10407–10418.
  • Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, et al. 2013. Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Br J Pharmacol. 170(7):1384–1395.
  • Zhang L, Ma C, Gu R, Zhang M, Wang X, Yang L, Liu Y, Zhou Y, He S, Zhu D. 2018. Paeonol regulates hypoxia-induced proliferation of pulmonary artery smooth muscle cells via EKR 1/2 signalling. Eur J Pharmacol. 834:257–265.
  • Zhang Y, Sun L, Zhang Y, Liang H, Li X, Cai R, Wang L, Du W, Zhang R, Li J, et al. 2013. Overexpression of microrna-1 causes atrioventricular block in rodents. Int J Biol Sci. 9(5):455–462.
  • Zhao P, Zhou WC, Li DL, Mo XT, Xu L, Li LC, Cui WH, Gao J. 2015. Total glucosides of Danggui Buxue Tang attenuate BLM-induced pulmonary fibrosis via regulating oxidative stress by inhibiting Nox4. Oxid Med Cell Longev. 2015:645814.
  • Zhao Y, Jiang Y, Chen Y, Zhang F, Zhang X, Zhu L, Yao X. 2020. Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-An decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure. J Ethnopharmacol. 248:1120–1128.