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Expert Opinion on Pharmacotherapy Volume 18, 2017 - Issue 6
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Editorial

How can we overcome neuropsychological adverse effects of antiepileptic drugs?

Juri-Alexander WittDepartment of Epileptology, University of Bonn Medical Center, Bonn, GermanyView further author information
&
Christoph HelmstaedterDepartment of Epileptology, University of Bonn Medical Center, Bonn, GermanyCorrespondence[email protected]
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Pages 551-554 | Received 02 Mar 2017, Accepted 16 Mar 2017, Published online: 27 Mar 2017

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Juri-Alexander Witt, Michael Rademacher, Randi von Wrede, Rainer Surges & Christoph Helmstaedter. (2022) Cognitive reawakening and improved quality of life achieved after discontinuing 16 years of anti-seizure treatment with topiramate. Neurocase 28:1, pages 102-106.
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Arne Reimers & Hanna Ljung. (2019) An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy. Expert Opinion on Pharmacotherapy 20:8, pages 909-915.
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Articles from other publishers (53)

Christoph Helmstaedter, Carolin Meschede, Sandra Mastani, Susanna Moskau-Hartmann, Michael Rademacher, Randi von Wrede & Juri-Alexander Witt. (2024) Normalization and cross-sectional validation of an extended Adverse Event Profile (E AEP) in a large cohort of patients with epilepsy. Seizure: European Journal of Epilepsy 114, pages 9-17.
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Y. A. Yakovleva, M. Y. Kissin, E. V. Gumennik & S. V. Semenova. (2023) Comorbid mental disorders with epilepsy in childhood. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY 57:4, pages 90-99.
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Francesco Pisani, Laura Rosa Pisani, Maria Antonietta Barbieri, Jose de Leon & Edoardo Spina. (2023) Optimization of Therapy in Patients with Epilepsy and Psychiatric Comorbidities: Key Points. Current Neuropharmacology 21:8, pages 1755-1766.
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Rani A. Sarkis, Alice D. Lam, Milena Pavlova, Joseph J. Locascio, Swapna Putta, Nirajan Puri, Jonathan Pham, Alison Yih, Gad A. Marshall & Robert Stickgold. (2023) Epilepsy and sleep characteristics are associated with diminished 24‐h memory retention in older adults with epilepsy. Epilepsia.
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Josefine Møller Jeppesen, Charlotte M. Sandvei, Christoph P. Beier & Joanna Gesche. (2023) Neuropsychological profile and drug treatment response in Idiopathic Generalized Epilepsy. Seizure: European Journal of Epilepsy 109, pages 12-17.
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Herpan Syafii Harahap, Astri Ferdiana, Agustine Mahardika, Ilsa Hunaifi & Setyawati Asih Putri. (2023) Higher Education Level as a Protective Factor Against Executive Dysfunction in Patients with Epilepsy in Mataram, Indonesia. Clinical Neurology and Neurosurgery, pages 107886.
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Juri‐Alexander Witt, Albert J. Becker & Christoph Helmstaedter. (2023) The multifactorial etiology of cognitive deficits in epilepsy and the neuropathology of mesial temporal lobe epilepsy beyond hyperphosphorylated tau. Alzheimer's & Dementia 19:7, pages 3231-3232.
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Anton S. Romanov & Elena F. Sharahova. (2023) Pharmacotherapy of epilepsy: new solutions to old problems. Aspirantskiy Vestnik Povolzhiya 23:2, pages 43-52.
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Joao Pizarro, Suzanne O'Sullivan & Matthew C. Walker. (2023) How accurately do adult patients report their absence seizures?. Epilepsia Open 8:2, pages 641-644.
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Sallie Baxendale. (2023) The who, what, when and why of cognitive difficulties in epilepsy. British Journal of Hospital Medicine 84:4, pages 1-8.
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Kuan‐Ying Li, Chung‐Yao Hsu & Yuan‐Han Yang. (2023) A review of cognitive and behavioral outcomes of Brivaracetam. The Kaohsiung Journal of Medical Sciences 39:2, pages 104-114.
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K.V. Voronkova, A.M. Alieva, I.G. Nikitin, G.M. Musina, E.V. Surskaya, O.S. Zaitseva, N.G. Mashkevich, L.V. Gomonova & A.S. Petrukhin. (2023) The role of the phenosanic acid in the combined treatment of patients with epilepsy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123:2, pages 151.
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Juri-Alexander Witt, Guido Widman, Niels Hansen, Randi von Wrede, Christian E. Elger & Christoph Helmstaedter. (2022) Evaluation of a Rapid Topiramate Titration Scheme for the Early Detection of Cognitive Side Effects. CNS Drugs 36:12, pages 1325-1330.
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Carina Heerwig, Hendrik Möller & Katja Brückner. (2022) Neuropsychology of epilepsy in old age – English VersionNeuropsychologie der Epilepsien im höheren Lebensalter – Englische Version. Zeitschrift für Epileptologie 35:S2, pages 73-77.
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Felix von Podewils. (2022) Weiterbehandlung von jungen Erwachsenen mit Epilepsie. Kinder- und Jugendmedizin 22:05, pages 362-368.
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Elisa Schuetz, Kathrin Wagner, Birgitta Metternich, Georgia Papadopoulou, Kristina Kravalis, Marcel Heers, Eva Martínez-Lizana, Maria Castillo-Rodriguez, Dirk-Matthias Altenmüller, Andreas Schulze-Bonhage & Martin Hirsch. (2022) Effects of cenobamate on cognitive performance of epilepsy patients. Seizure: European Journal of Epilepsy 102, pages 129-133.
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Oliver Henning, Kristin Å. Alfstad, Cecilie Johannessen Landmark, Christoph Helmstaedter, Morten I. Lossius & Annette Holth Skogan. (2022) Use of screening tools to assess comorbidities and adverse events in patients with epilepsy. A European Reference Network for Rare and Complex Epilepsies (EpiCARE) survey. Seizure 101, pages 237-243.
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Carina Heerwig, Hendrik Möller & Katja Brückner. (2022) Neuropsychologie der Epilepsien im höheren LebensalterNeuropsychology of epilepsy in old age. German version. Zeitschrift für Epileptologie 35:2, pages 135-140.
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Juri-Alexander Witt & Christoph Helmstaedter. (2022) Do executive deficits differentiate between autoimmune temporal lobe epilepsy and temporal lobe epilepsies with non-autoimmune etiologies? A critical view on recently published data. Epilepsy & Behavior 129, pages 108562.
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Christoph Baumgartner, Johannes P. Koren & Susanne Pirker. (2022) Pharmakotherapie der EpilepsiePharmacotherapy in Epilepsy. psychopraxis. neuropraxis.
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Juri-Alexander Witt & Christoph Helmstaedter. (2022) The impact of perampanel on cognition: A systematic review of studies employing standardized tests in patients with epilepsy. Seizure 94, pages 107-111.
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Christoph Helmstaedter & Juri-Alexander Witt. 2022. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 3517 3527 .
Christoph Baumgartner & Martha Britto-Arias. 2022. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 3657 3670 .
D. I. Abzalova, A. V. Prirodov & M. V. Sinkin. (2021) Symptomatic Epileptic Seizures in Patients with Brain Gliomas. Russian Sklifosovsky Journal "Emergency Medical Care" 10:3, pages 549-557.
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N. V. Pizova & A. V. Pizov. (2021) Certain risk factors for the development of cognitive impairment in persons with epilepsy and new therapeutic options. Meditsinskiy sovet = Medical Council:10, pages 86-93.
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Juri-Alexander Witt & Christoph Helmstaedter. (2021) Neuropsychological Evaluations in Limbic Encephalitis. Brain Sciences 11:5, pages 576.
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Juri-Alexander Witt, Carolin Meschede & Christoph Helmstaedter. (2021) Hazardous employment of invalid measures for cognitive outcome assessment: You only see what your test can show you. Epilepsy & Behavior 117, pages 107865.
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A.M. Teplyshova & V.K. Datieva. (2021) Alzheimer disease and epilepsy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 121:10, pages 23.
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Lasair O’Callaghan, Lysbeth Floden, Lisa Vinikoor-Imler, Tara Symonds, Kathryn Giblin, Chris Hartford & Joanna M. Zakrzewska. (2020) Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England. The Journal of Headache and Pain 21:1.
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Juri‐Alexander Witt, Robert D. Nass, Tobias Baumgartner, Randi Wrede, Christian E. Elger, Rainer Surges & Christoph Helmstaedter. (2020) Does the accumulated antiepileptic drug load in chronic epilepsy reflect disease severity?. Epilepsia 61:12, pages 2685-2695.
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Kuan-Ying Li, Ling-Chun Huang, Yang-Pei Chang & Yuan-Han Yang. (2020) The effects of lacosamide on cognitive function and psychiatric profiles in patients with epilepsy. Epilepsy & Behavior 113, pages 107580.
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Andres M. Kanner, Christoph Helmstaedter, Zahra Sadat-Hossieny & Kimford Meador. (2020) Cognitive disorders in epilepsy I: Clinical experience, real-world evidence and recommendations. Seizure 83, pages 216-222.
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C. Helmstaedter, Z. Sadat-Hossieny, A.M. Kanner & K.J. Meador. (2020) Cognitive disorders in epilepsy II: Clinical targets, indications and selection of test instruments. Seizure 83, pages 223-231.
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Sudhir Chandra Sarangi, Soumya Sucharita Pattnaik, Dipesh Joshi, P. Prarthana Chandra & Thomas Kaleekal. (2020) Adjuvant role of Ocimum sanctum hydroalcoholic extract with carbamazepine and phenytoin in experimental model of acute seizures. Saudi Pharmaceutical Journal 28:11, pages 1440-1450.
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Juri-Alexander Witt & Christoph Helmstaedter. (2020) Neuropsychologische Diagnostik bei limbischer EnzephalitisNeuropsychological diagnostics in limbic encephalitis. Zeitschrift für Epileptologie 33:4, pages 273-277.
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Roy C. Martin. (2020) AEDs and Cognition: One Small Fish in a Very Large Pond?. Epilepsy Currents 20:4, pages 196-198.
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Carolin Meschede, Juri‐Alexander Witt, Sarah Brömling, Susanna Moskau‐Hartmann, Michael Rademacher, Rainer Surges, Randi Wrede & Christoph Helmstaedter. (2020) Changes in cognition after introduction or withdrawal of zonisamide versus topiramate in epilepsy patients: A retrospective study using Bayes statistics. Epilepsia 61:7, pages 1481-1490.
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Felix von Podewils. (2020) Psychosocial outcome in juvenile myoclonic epilepsy (Janz syndrome) and other genetic generalized epilepsiesPsychosoziales Outcome bei juveniler myoklonischer Epilepsie (Janz-Syndrom) und anderen genetisch generalisierten Epilepsien. Zeitschrift für Epileptologie 33:2, pages 151-156.
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Robert J. Quon, Morgan T. Mazanec, Samantha S. Schmidt, Angeline S. Andrew, Robert M. Roth, Todd A. MacKenzie, Martha Sajatovic, Tanya Spruill & Barbara C. Jobst. (2020) Antiepileptic drug effects on subjective and objective cognition. Epilepsy & Behavior 104, pages 106906.
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Francesca Felicia Operto, Grazia Maria Giovanna Pastorino, Roberta Mazza, Marco Carotenuto, Michele Roccella, Rosa Marotta, Carlo di Bonaventura & Alberto Verrotti. (2020) Effects on executive functions of antiepileptic monotherapy in pediatric age. Epilepsy & Behavior 102, pages 106648.
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Christoph Helmstaedter & Juri-Alexander Witt. 2020. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 1 12 .
Christoph Baumgartner & Martha Britto-Arias. 2020. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 1 15 .
Christoph Helmstaedter, Philipp Durch, Christian Hoppe & Juri-Alexander Witt. (2019) Is the computerized assessment of psychomotor speed more sensitive to cognitive effects of antiepileptic pharmacotherapy than tests with a focus on higher-order cognitive processing? Implications for the choice of sensitive test parameters. European Neuropsychopharmacology.
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Christoph Helmstaedter, Juri-Alexander Witt & Christian Hoppe. (2019) Evaluating the mediating role of executive functions for antiepileptic drugs' effects on IQ in children and adolescents with epilepsy. Epilepsy & Behavior 96, pages 98-103.
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Claire S. Jacobs, Kim C. Willment & Rani A. Sarkis. (2019) Non-invasive Cognitive Enhancement in Epilepsy. Frontiers in Neurology 10.
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M. Vrinda, S. Arun, B.N. Srikumar, Bindu M. Kutty & B.S. Shankaranarayana Rao. (2019) Temporal lobe epilepsy-induced neurodegeneration and cognitive deficits: Implications for aging. Journal of Chemical Neuroanatomy 95, pages 146-153.
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Juri-Alexander Witt, Christian E. Elger & Christoph Helmstaedter. (2018) Short-term and longer-term effects of brivaracetam on cognition and behavior in a naturalistic clinical setting—Preliminary data. Seizure 62, pages 49-54.
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Christoph Helmstaedter, Ettore Beghi, Christian E. Elger, Reetta Kälviäinen, Kristina Malmgren, Theodor W. May, Emilio Perucca, Eugen Trinka & Juri-Alexander Witt. (2018) No Evidence of a Causal Role of Antiepileptic Drug Treatment with Regard to the Development of Dementia. Journal of the American Geriatrics Society 66:9, pages 1850-1852.
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Rani A. Sarkis, Yazel Goksen, Yi Mu, Bernard Rosner & Jong Woo Lee. (2018) Cognitive and fatigue side effects of anti-epileptic drugs: an analysis of phase III add-on trials. Journal of Neurology 265:9, pages 2137-2142.
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Christoph Helmstaedter, Ettore Beghi, Christian E. Elger, Reetta Kälviäinen, Kristina Malmgren, Theodor W. May, Emilio Perucca, Eugen Trinka & Juri-Alexander Witt. (2018) No proof of a causal relationship between antiepileptic drug treatment and incidence of dementia. Comment on: Use of antiepileptic drugs and dementia risk-An analysis of Finnish health register and German health insurance data. Epilepsia 59:7, pages 1303-1306.
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K. N Power, A. Gramstad, N. E. Gilhus, K. O. Hufthammer & B. A. Engelsen. (2018) Cognitive dysfunction after generalized tonic-clonic status epilepticus in adults. Acta Neurologica Scandinavica 137:4, pages 417-424.
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Yu. A. Yakovleva, A. N. Yanaeva, A. A. Spikina & E. L. Rukavitsyna. (2018) Lacosamide in treatment of patients with focal epilepsy and comorbid mental disorders. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 118:10, pages 98.
Crossref
Louise Tyvaert. 2017. Neuropsychologie des épilepsies de l'adulte. Neuropsychologie des épilepsies de l'adulte 145 174 .

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