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Expert Opinion on Pharmacotherapy Volume 20, 2019 - Issue 12
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Review

Moving beyond sodium valproate: choosing the right anti-epileptic drug in children

Ganna BalaguraPediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Opthalmology, Genetics, Maternal and Child's Health, University of Genoa, Genoa, Italy;Pediatric Neurology and Muscular Diseases Unit, “G. Gaslini” Institute, Genoa, ItalyView further author information
,
Giulia IapadreDepartment of Pediatrics, University of L’Aquila, L’Aquila, ItalyView further author information
,
Alberto VerrottiDepartment of Pediatrics, University of L’Aquila, L’Aquila, ItalyView further author information
&
Pasquale StrianoPediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Opthalmology, Genetics, Maternal and Child's Health, University of Genoa, Genoa, Italy;Pediatric Neurology and Muscular Diseases Unit, “G. Gaslini” Institute, Genoa, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6065-1476View further author information
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Pages 1449-1456 | Received 27 Sep 2018, Accepted 08 May 2019, Published online: 17 May 2019

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Xiaoyan Peng, Yin Yan, Rui Chen, Xuefeng Wang & Xin Xu. (2020) Long-term safety, tolerability, and efficacy of magnesium valproate versus sodium valproate in acute seizures. Current Medical Research and Opinion 36:2, pages 271-276.
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Wang-Tso Lee, Derrick Wei Shih Chan, Sheffali Gulati, Surachai Likasitwattanakul, Byung Chan Lim, Akihisa Okumura, Benilda Sanchez-Gan, Yi Wang & Kam Tim Liu. (2024) Role of Perampanel in the Management of Pediatric Epilepsies in Asia: Expert Opinion. Pediatric Neurology 151, pages 5-16.
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Osman Syed, Predrag Jancic, Adam B. Fink & Nebojsa Nick Knezevic. (2023) Drug Safety and Suicidality Risk of Chronic Pain Medications. Pharmaceuticals 16:10, pages 1497.
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Charles Akos Szabo & Dorothee Kasteleijn. (2023) Myoclonus as a Manifestation of Reflex Seizures. Journal of Clinical Neurophysiology 40:2, pages 109-116.
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Lara Senn, Anna-Maria Costa, Rossella Avallone, Katarzyna Socała, Piotr Wlaź & Giuseppe Biagini. (2023) Is the peroxisome proliferator-activated receptor gamma a putative target for epilepsy treatment? Current evidence and future perspectives. Pharmacology & Therapeutics 241, pages 108316.
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Song Hee Lee, Bo Young Choi, A Ra Kho, Dae Ki Hong, Beom Seok Kang, Min Kyu Park, Si Hyun Lee, Hui Chul Choi, Hong Ki Song & Sang Won Suh. (2022) Combined Treatment of Dichloroacetic Acid and Pyruvate Increased Neuronal Survival after Seizure. Nutrients 14:22, pages 4804.
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Adam Strzelczyk & Susanne Schubert-Bast. (2022) Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies. CNS Drugs 36:10, pages 1079-1111.
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R. Jover, P. Soluyanova, E. Moro-Castaño, M. Moreno-Torres, A.V. Marco-Hernández, M. Tomas-Vila & J.V. Castell. (2022) SOC-V-11 New serum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients. Toxicology Letters 368, pages S68.
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Marta Moreno-Torres, Carla Guzmán, Petar D. Petrov & Ramiro Jover. (2022) Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites. Nutrients 14:13, pages 2673.
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Yifei Zhu, Junlan Yang & Xinjian Zhu. (2022) Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis. Seizure 95, pages 17-25.
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Zhen-Ye Ji, Yi-Qian Huang & Wen-Zhen He. (2022) Sodium Valproate Combined With Topiramate vs. Sodium Valproate Alone for Refractory Epilepsy: A Systematic Review and Meta-Analysis. Frontiers in Neurology 12.
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Mohammad Radgoudarzi, Mohammad Vafaee-Shahi & Fatemeh Naderi. (2021) Effect of Sodium Valproate Treatment on the Cardiac Index in New Cases with Status Epilepticus. The Open Neurology Journal 15:1, pages 59-64.
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Meng Sun, Ran Zhou, Xin Wang & Yaying Cheng. (2021) Influence of Different Antiepileptic Drugs on Blood Ammonia and Homocysteine Levels in Children with Epilepsy. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-7.
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Bondada Venkata Mani Anirudh & Devaraj Ezhilarasan. (2020) Reactive Oxygen Species–Mediated Mitochondrial Dysfunction Triggers Sodium Valproate–Induced Cytotoxicity in Human Colorectal Adenocarcinoma Cells. Journal of Gastrointestinal Cancer 52:3, pages 899-906.
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Kumar Sannagowdara & Nadir Khan. (2021) Medical Management in Focal versus Generalized Epilepsy. Journal of Pediatric Epilepsy 10:02, pages 081-087.
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Feng Gao, Jihong Yang, Yan Geng, Bo Liu, Rui Zhang & Meng Zhang. (2021) Green synthesis of biologically important 2-aminothiophenes by the mediation of ZnO@SiO2–NH2 nanoparticle as an important anti-liver cancer alternative for valproate. Chemical Papers 75:6, pages 2647-2654.
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Miriam Kessi, Fangling Yan, Langui Pan, Baiyu Chen, Eleonore Olatoutou, Dong Li, Fang He, Tibera Rugambwa, Lifen Yang, Jing Peng & Fei Yin. (2021) Treatment for the Benign Childhood Epilepsy With Centrotemporal Spikes: A Monocentric Study. Frontiers in Neurology 12.
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Linda J. Stephen & Martin J. Brodie. (2020) Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults. CNS Drugs 34:2, pages 147-161.
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