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Review

CD38 as an immunotherapeutic target in multiple myeloma

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Pages 1209-1221 | Received 11 Sep 2018, Accepted 31 Oct 2018, Published online: 13 Nov 2018

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Neel R. Nabar, Christopher N. Heijjer, Chong-Shan Shi, Il-Young Hwang, Sundar Ganesan, Mikael C. I. Karlsson & John H. Kehrl. (2022) LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. Autophagy 18:1, pages 204-222.
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Yaru Feng, Xiuying Liu, Xiaorui Li, Yating Zhou, Zhiru Song, Jing Zhang, Bingjie Shi & Jianxun Wang. (2021) Novel BCMA-OR-CD38 tandem-dual chimeric antigen receptor T cells robustly control multiple myeloma. OncoImmunology 10:1.
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Luca Bertamini, Francesca Bonello, Mario Boccadoro & Sara Bringhen. (2020) New drugs in early development for treating multiple myeloma: all that glitters is not gold. Expert Opinion on Investigational Drugs 29:9, pages 989-1004.
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Pellegrino Musto & Francesco La Rocca. (2020) Monoclonal antibodies in newly diagnosed and smoldering multiple myeloma: an updated review of current clinical evidence. Expert Review of Hematology 13:5, pages 501-517.
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Pellegrino Musto & Francesco La Rocca. (2020) Monoclonal antibodies in relapsed/refractory myeloma: updated evidence from clinical trials, real-life studies, and meta-analyses. Expert Review of Hematology 13:4, pages 331-349.
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Articles from other publishers (19)

Wioletta Olejarz & Grzegorz Basak. (2023) Emerging Therapeutic Targets and Drug Resistance Mechanisms in Immunotherapy of Hematological Malignancies. Cancers 15:24, pages 5765.
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Manlio Fazio, Vittorio Del Fabro, Nunziatina Laura Parrinello, Alessandro Allegra, Uroš Markovic, Cirino Botta, Fabrizio Accardi, Iolanda Donatella Vincelli, Salvatore Leotta, Federica Elia, Benedetta Esposito, Bruno Garibaldi, Gabriele Sapuppo, Alessandra Orofino, Alessandra Romano, Giuseppe A. Palumbo, Francesco Di Raimondo & Concetta Conticello. (2023) Multiple Myeloma in 2023 Ways: From Trials to Real Life. Current Oncology 30:11, pages 9710-9733.
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Jinrong Yang, Weilin Zhou, Dan Li, Ting Niu & Wei Wang. (2023) BCMA-targeting chimeric antigen receptor T-cell therapy for multiple myeloma. Cancer Letters 553, pages 215949.
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Zehua Wang, Chen Chen, Lei Wang, Yongxu Jia & Yanru Qin. (2022) Chimeric antigen receptor T-cell therapy for multiple myeloma. Frontiers in Immunology 13.
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Irina V. Gribkova. (2022) CAR NK-сells for the treatment of hematological malignancies: A review. Journal of Modern Oncology 24:3, pages 331-335.
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Yuhan Tu, Zhiang Yao, Wenjing Yang, Shanhui Tao, Bin Li, Yun Wang, Zhijian Su & Shijun Li. (2022) Application of Nanoparticles in Tumour Targeted Drug Delivery and Vaccine. Frontiers in Nanotechnology 4.
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Peipei Yang, Ying Qu, Mengyao Wang, Bingyang Chu, Wen Chen, Yuhuan Zheng, Ting Niu & Zhiyong Qian. (2022) Pathogenesis and treatment of multiple myeloma. MedComm 3:2.
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Taewoong Choi & Yubin Kang. (2022) Chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma. Pharmacology & Therapeutics 232, pages 108007.
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Ruiting Guo, Wenyi Lu, Yi Zhang, Xinping Cao, Xin Jin & Mingfeng Zhao. (2022) Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Frontiers in Immunology 13.
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Wu Ye, Xia Wu, Xiaoyan Liu, Xue Zheng, Jili Deng & Yuping Gong. (2021) Comparison of monoclonal antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma: an indirect-comparison Meta-analysis of randomised controlled trials. BMC Cancer 21:1.
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Natalie Baum, Marie Eggers, Julia Koenigsdorf, Stephan Menzel, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas & Friedrich Koch-Nolte. (2021) Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells. Frontiers in Immunology 12.
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Hyun Tae Lee, Yujin Kim, Ui Beom Park, Tae Jun Jeong, Sang Hyung Lee & Yong-Seok Heo. (2021) Crystal structure of CD38 in complex with daratumumab, a first-in-class anti-CD38 antibody drug for treating multiple myeloma. Biochemical and Biophysical Research Communications 536, pages 26-31.
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Mattia D’Agostino, Salvatore Innorcia, Mario Boccadoro & Sara Bringhen. (2020) Monoclonal Antibodies to Treat Multiple Myeloma: A Dream Come True. International Journal of Molecular Sciences 21:21, pages 8192.
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Deming Feng & Jian Sun. (2020) Overview of anti‐BCMA CAR‐T immunotherapy for multiple myeloma and relapsed/refractory multiple myeloma. Scandinavian Journal of Immunology 92:2.
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Benjamin Motais, Sandra Charvátová, Matouš Hrdinka, Michal Šimíček, Tomáš Jelínek, Tereza Ševčíková, Zdeněk Kořístek, Roman Hájek & Juli R. Bagó. (2020) A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers. Cancers 12:5, pages 1333.
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Mattia D'Agostino, Roberto Mina & Francesca Gay. (2020) Anti-CD38 monoclonal antibodies in multiple myeloma: another cook in the kitchen?. The Lancet Haematology 7:5, pages e355-e357.
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Mattia D’Agostino & Noopur Raje. (2019) Anti-BCMA CAR T-cell therapy in multiple myeloma: can we do better?. Leukemia 34:1, pages 21-34.
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Francesca Bonello, Roberto Mina, Mario Boccadoro & Francesca Gay. (2019) Therapeutic Monoclonal Antibodies and Antibody Products: Current Practices and Development in Multiple Myeloma. Cancers 12:1, pages 15.
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Zhitao Gao, Chuan Tong, Yao Wang, Deyun Chen, Zhiqiang Wu & Weidong Han. (2019) Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells. Journal of Genetics and Genomics 46:8, pages 367-377.
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