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Expert Opinion on Therapeutic Targets Volume 21, 2017 - Issue 3
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Editorial

Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder

Kyle A. LymanDavee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, IL, USAView further author information
,
Ye HanDavee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, IL, USAView further author information
&
Dane M. ChetkovichDavee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, IL, USACorrespondence[email protected]
View further author information
Pages 235-237 | Received 10 Aug 2016, Accepted 24 Jan 2017, Published online: 14 Feb 2017

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Chuanxi Tian, Xueping Zhu, Qiuyuan Wang, Tianyi Lv, Siyi Cheng & Daowen Yang. (2022) Bibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020). Channels 16:1, pages 49-59.
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Ye Han, Kyle A. Lyman, Kendall M. Foote & Dane M. Chetkovich. (2020) The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels. Channels 14:1, pages 110-122.
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Articles from other publishers (16)

Kyle A. Lyman. (2023) A Molecular Framework for Delirium. The Neurohospitalist.
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Paulo Pinares-Garcia, James Spyrou, Chaseley E. McKenzie, Ian C. Forster, Ming S. Soh, Erlina Mohamed Syazwan, Mohammed Atif & Christopher A. Reid. (2023) Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice. Frontiers in Pharmacology 14.
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Ye Han, Iredia D. Iyamu, Matthew R. Clutter, Rama K. Mishra, Kyle A. Lyman, Chengwen Zhou, Ioannis Michailidis, Maya Y. Xia, Horrick Sharma, Chi-Hao Luan, Gary E. Schiltz & Dane M. Chetkovich. (2022) Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons. Journal of Biological Chemistry 298:7, pages 102069.
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Chiara Piantoni, Manuel Paina, David Molla, Sheng Liu, Giorgia Bertoli, Hongmei Jiang, Yanyan Wang, Yi Wang, Yi Wang, Dario DiFrancesco, Andrea Barbuti, Annalisa Bucchi & Mirko Baruscotti. (2022) Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels. eLife 11.
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浩楠 叶. (2022) The Role of HCN Channels in Epilepsy. International Journal of Psychiatry and Neurology 11:01, pages 1-6.
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Kyle A. Lyman, Ye Han, Chengwen Zhou, Isabelle Renteria, Gai-Linn Besing, Jonathan E. Kurz & Dane M. Chetkovich. (2021) Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior. Science Translational Medicine 13:621.
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Max E. Joffe, Chiaki I. Santiago, Sheryl Anne D. Vermudez, Nicole M. Fisher, Shalini Dogra, Colleen M. Niswender & P. Jeffrey Conn. (2021) Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors. Neuropsychopharmacology 46:12, pages 2148-2157.
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Sheng-Han Kuo, Elan D. Louis, Phyllis L. Faust, Adrian Handforth, Su-youne Chang, Billur Avlar, Eric J. Lang, Ming-Kai Pan, Lauren N. Miterko, Amanda M. Brown, Roy V. Sillitoe, Collin J. Anderson, Stefan M. Pulst, Martin J. Gallagher, Kyle A. Lyman, Dane M. Chetkovich, Lorraine N. Clark, Murni Tio, Eng-King Tan & Rodger J. Elble. (2019) Current Opinions and Consensus for Studying Tremor in Animal Models. The Cerebellum 18:6, pages 1036-1063.
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Xiaoli Chang, Jun Wang, Hong Jiang, Limin Shi & Junxia Xie. (2019) Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases. Frontiers in Molecular Neuroscience 12.
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Kyle A. Lyman & Dane M. Chetkovich. (2019) CRAFTing a New Approach to Antiepileptic Drug Discovery. Epilepsy Currents 19:3, pages 182-183.
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Pan Luo, GuoFang He & Dong Liu. (2019) HCN channels: New targets for the design of an antidepressant with rapid effects. Journal of Affective Disorders 245, pages 764-770.
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Daniel W. Fisher, Ye Han, Kyle A. Lyman, Robert J. Heuermann, Linda A. Bean, Natividad Ybarra, Kendall M. Foote, Hongxin Dong, Daniel A. Nicholson & Dane M. Chetkovich. (2018) HCN channels in the hippocampus regulate active coping behavior. Journal of Neurochemistry 146:6, pages 753-766.
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Federica Frigerio, Corey Flynn, Ye Han, Kyle Lyman, Joaquin N. Lugo, Teresa Ravizza, Antoine Ghestem, Julika Pitsch, Albert Becker, Anne E. Anderson, Annamaria Vezzani, Dane Chetkovich & Christophe Bernard. (2018) Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Molecular Neurobiology 55:9, pages 7500-7511.
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Catherine Proenza. (2018) Exploiting natural regulation. eLife 7.
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Peng Zhong, Casey R Vickstrom, Xiaojie Liu, Ying Hu, Laikang Yu, Han-Gang Yu & Qing-song Liu. (2018) HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress. eLife 7.
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Kyle A. Lyman, Ye Han, Robert J. Heuermann, Xiangying Cheng, Jonathan E. Kurz, Reagan E. Lyman, Paul P. Van Veldhoven & Dane M. Chetkovich. (2017) Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. Journal of Biological Chemistry 292:43, pages 17718-17730.
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