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Expert Opinion on Therapeutic Targets Volume 21, 2017 - Issue 8
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Review

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

Jinwei ZhangInstitute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratory, Exeter, UKCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8683-509XView further author information
ORCID Icon,
Jason K. KarimyDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USAView further author information
,
Eric DelpireDepartment of Anesthesiolgy, Vanderbilt University School of Medicine, Nashville, TN, USAView further author information
&
Kristopher T. KahleDepartments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology; and Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT, USACorrespondence[email protected]
View further author information
Pages 795-804 | Received 10 Apr 2017, Accepted 04 Jul 2017, Published online: 12 Jul 2017

Citations (11)

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Melissa Pergakis, Neeraj Badjatia & J. Marc Simard. (2021) An update on the pharmacological management and prevention of cerebral edema: current therapeutic strategies. Expert Opinion on Pharmacotherapy 22:8, pages 1025-1037.
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Articles from other publishers (10)

Erin McMoneagle, Jin Zhou, Shiyao Zhang, Weixue Huang, Sunday Solomon Josiah, Ke Ding, Yun Wang & Jinwei Zhang. (2023) Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment. Acta Pharmacologica Sinica.
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Chih-Hao Shen, Jr-Yu Lin, Cheng-Yo Lu, Sung-Sen Yang, Chung-Kan Peng & Kun-Lun Huang. (2021) SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure. BMC Pulmonary Medicine 21:1.
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Shinya Fujii, Eriko Kikuchi, Honoka Suzuyama, Yuko Watanabe, Mari Ishigami‐Yuasa, Hiroyuki Masuno, Takayasu Mori, Kiyoshi Isobe, Shinichi Uchida & Hiroyuki Kagechika. (2021) Structural Development of Salicylanilide‐Based SPAK Inhibitors as Candidate Antihypertensive Agents. ChemMedChem 16:18, pages 2817-2822.
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Yating Gong, Muyao Wu, Fan Gao, Mengying Shi, Haiping Gu, Rong Gao, Bao-Qi Dang & Gang Chen. (2021) Inhibition of the p‑SPAK/p‑NKCC1 signaling pathway protects the blood‑brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury. Molecular Medicine Reports 24:4.
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Yucan Chen, Min Liu, Weidi Wang, Wenxiang Cai, WeiChen Song, Li Li & Guan Ning Lin. (2021) Loss of Setd2 associates with aberrant microRNA expression and contributes to inflammatory bowel disease progression in mice. Genomics 113:4, pages 2441-2454.
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Nur Farah Meor Azlan & Jinwei Zhang. (2020) Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease. Cells 9:10, pages 2293.
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Shinya Fujii, Eriko Kikuchi, Yuko Watanabe, Honoka Suzuyama, Mari Ishigami-Yuasa, Takayasu Mori, Kiyoshi Isobe, Shinichi Uchida & Hiroyuki Kagechika. (2020) Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling. Bioorganic & Medicinal Chemistry Letters 30:17, pages 127408.
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Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Jingfang Zhang, Huachen Huang, Md Nabiul Hasan, Anna E. Skrzypiec, Mariusz Mucha, Daniel Duran, Wei Huang, Robert Pawlak, Lesley M. Foley, T. Kevin Hitchens, Margaret B. Minnigh, Samuel M. Poloyac, Seth L. Alper, Bradley J. Molyneaux, Andrew J. Trevelyan, Kristopher T. Kahle, Dandan Sun & Xianming Deng. (2020) Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a. Nature Communications 11:1.
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Quentin Chevy, Clémence Simonnet, Sana Al Awabdh, Sabine Lévi & Jean Christophe Poncer. 2020. Neuronal Chloride Transporters in Health and Disease. Neuronal Chloride Transporters in Health and Disease 133 158 .
Jeannine M. C. Gregoriades, Aaron Madaris, Francisco J. Alvarez & Francisco J. Alvarez-Leefmans. (2019) Genetic and pharmacological inactivation of apical Na + -K + -2Cl − cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter . American Journal of Physiology-Cell Physiology 316:4, pages C525-C544.
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