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Expert Opinion on Therapeutic Targets Volume 23, 2019 - Issue 2
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Review

Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases

Camila Florencia ZuccatoInstituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaORCID Iconhttp://orcid.org/0000-0002-3170-7397View further author information
ORCID Icon,
Antonela Sofia AsadInstituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaORCID Iconhttp://orcid.org/0000-0002-1234-7250View further author information
ORCID Icon,
Alejandro Javier Nicola CandiaInstituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaORCID Iconhttp://orcid.org/0000-0002-0194-560XView further author information
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María Florencia GottardoLaboratorio de Oncología Molecular, Universidad de Quilmes, Bernal, ArgentinaORCID Iconhttp://orcid.org/0000-0001-6599-5094View further author information
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Mariela Alejandra Moreno AyalaDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USAView further author information
,
María Susana TheasInstituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaView further author information
,
Adriana SeilicovichInstituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaORCID Iconhttp://orcid.org/0000-0002-2949-2921View further author information
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Marianela CandolfiInstituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaCorrespondence[email protected]
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Pages 117-126 | Received 11 Sep 2018, Accepted 11 Dec 2018, Published online: 24 Dec 2018

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Munevver Gizem Hekım, Sibel Ozcan, Mesut Yur, Nilgun Yıldırım & Mete Ozcan. (2023) Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance. Biomarkers 28:6, pages 555-561.
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Articles from other publishers (29)

Yang Li, Zhuozhuo Li, Yuanyuan Ren, Ying Lei, Silong Yang, Yuqi Shi, Han Peng, Weijie Yang, Tiantian Guo, Yi Yu & Yuyan Xiong. (2023) Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities. Journal of Advanced Research.
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D. S. Bug, T. F. Subbotina, A. N. Narkevich, N. V. Petukhova & A. A. Zhloba. (2023) Evolutionary Reconstruction of MT-RNR2 Gene Demonstrates a Diverse Compositional Landscape of Humanin in Vertebrates. Journal of Evolutionary Biochemistry and Physiology 59:5, pages 1566-1576.
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Jorge A. Peña Agudelo, Matías L. Pidre, Matias Garcia Fallit, Melanie Pérez Küper, Camila Zuccato, Alejandro J. Nicola Candia, Abril Marchesini, Mariana B. Vera, Emilio De Simone, Carla Giampaoli, Leslie C. Amorós Morales, Nazareno Gonzalez, Víctor Romanowski, Guillermo A. Videla-Richardson, Adriana Seilicovich & Marianela Candolfi. (2023) Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells. Cancers 15:16, pages 4061.
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Ferah Bulut, Muhammed Adam, Aslışah Özgen, Munevver Gizem Hekim, Sibel Ozcan, Sinan Canpolat & Mete Ozcan. (2023) Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis. Behavioural Brain Research 452, pages 114584.
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Junying Hua, Jianping Huang, Gang Li, Sien Lin & Liao Cui. (2023) Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms. Frontiers in Endocrinology 14.
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Ahmet Saracaloglu, Ayşe Özlem Mete, Duran Furkan Ucar, Seniz Demiryürek, Enes Erbagcı & Abdullah Tuncay Demiryürek. (2023) Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects. Current Protein & Peptide Science 24:3, pages 277-283.
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Hanlin Zhang, Xinyu Li, Wudi Fan, Sentibel Pandovski, Ye Tian & Andrew Dillin. (2023) Inter-tissue communication of mitochondrial stress and metabolic health. Life Metabolism 2:1.
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Yuanyuan Li, Haoqi Liu, Chao Tian, Na An, Ke Song, Yufei Wei, Yikun Sun, Yanwei Xing & Yonghong Gao. (2022) Targeting the multifaceted roles of mitochondria in intracerebral hemorrhage and therapeutic prospects. Biomedicine & Pharmacotherapy 148, pages 112749.
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Chrysoula Boutari, Panagiotis D Pappas, Theodoros D Theodoridis & Dimitrios Vavilis. (2022) Humanin and diabetes mellitus: A review of in vitro and in vivo studies . World Journal of Diabetes 13:3, pages 213-223.
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Ying Wu, Liankun Sun, Zhoudao Zhuang, Xiaoqing Hu & Delu Dong. (2022) Mitochondrial-Derived Peptides in Diabetes and Its Complications. Frontiers in Endocrinology 12.
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Sanoji Wijenayake & Kenneth B. Storey. (2022) The role of humanin in natural stress tolerance: An underexplored therapeutic avenue. Biochimica et Biophysica Acta (BBA) - General Subjects 1866:1, pages 130022.
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Yanhe Lue, Ronald Swerdloff, Yue Jia & Christina Wang. (2021) The emerging role of mitochondrial derived peptide humanin in the testis. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:12, pages 130009.
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Daniel L. Morris & Nico Tjandra. (2021) Inducible fold‐switching as a mechanism to fibrillate pro‐apoptotic BCL ‐2 proteins . Biopolymers 112:10.
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Siarhei A. Dabravolski, Nikita G. Nikiforov, Antonina V. Starodubova, Tatyana V. Popkova & Alexander N. Orekhov. (2021) The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets. International Journal of Molecular Sciences 22:16, pages 8770.
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Mamtaj Alam, Rajeshwar K. Yadav, Elizabeth Minj, Aarti Tiwari & Sidharth Mehan. (2021) Exploring Molecular Approaches in Amyotrophic Lateral Sclerosis: Drug Targets from Clinical and Pre-Clinical Findings. Current Molecular Pharmacology 14:3, pages 263-280.
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Valentina Bilbao-Malavé, Jorge González-Zamora, Miriam de la Puente, Sergio Recalde, Patricia Fernandez-Robredo, María Hernandez, Alfredo Garcia Layana & Manuel Saenz de Viteri. (2021) Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Age Related Macular Degeneration, Role in Pathophysiology, and Possible New Therapeutic Strategies. Antioxidants 10:8, pages 1170.
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Tarun Kapoor & Sidharth Mehan. (2021) Neuroprotective Methodologies in the Treatment of Multiple Sclerosis Current Status of Clinical and Pre-clinical Findings. Current Drug Discovery Technologies 18:1, pages 31-46.
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Abu Hazafa, Ammara Batool, Saeed Ahmad, Muhammad Amjad, Sundas Nasir Chaudhry, Jamal Asad, Hasham Feroz Ghuman, Hafiza Madeeha Khan, Muhammad Naeem & Usman Ghani. (2021) Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases. Life Sciences 264, pages 118679.
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Chaim Gilon, Agata Gitlin-Domagalska, Adi Lahiani, Shiran Yehoshua- Alshanski, Adi Shumacher-Klinger, Dan Gilon, Mahmoud Taha, Israel Sekler, Amnon Hoffman & Philip Lazarovici. (2020) Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults. Peptides 134, pages 170399.
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Sarah Atali, Sadaf Dorandish, Jonathan Devos, Asana Williams, Deanna Price, Jaylen Taylor, Jeffrey Guthrie, Deborah Heyl & Hedeel Guy Evans. (2020) Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP. FEBS Open Bio 10:12, pages 2805-2823.
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Parameswaran G. Sreekumar & Ram Kannan. (2020) Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration. Redox Biology 37, pages 101663.
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Sadaf Dorandish, Jonathan Devos, Bradley Clegg, Deanna Price, Robert Muterspaugh, Jeffrey Guthrie, Deborah L. Heyl & Hedeel Guy Evans. (2020) Biochemical determinants of the IGFBP‐3–hyaluronan interaction. FEBS Open Bio 10:8, pages 1668-1684.
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Iñaki Merino-Valverde, Emanuela Greco & María Abad. (2020) The microproteome of cancer: From invisibility to relevance. Experimental Cell Research 392:1, pages 111997.
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Deanna Price, Sadaf Dorandish, Asana Williams, Brandon Iwaniec, Alexis Stephens, Keyan Marshall, Jeffrey Guthrie, Deborah Heyl & Hedeel Guy Evans. (2020) Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3. Biochemistry 59:21, pages 1981-2002.
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Mariela A. Moreno Ayala, María Florencia Gottardo, Camila Florencia Zuccato, Matías Luis Pidre, Alejandro Javier Nicola Candia, Antonela Sofia Asad, Mercedes Imsen, Víctor Romanowski, Aldo Creton, Marina Isla Larrain, Adriana Seilicovich & Marianela Candolfi. (2020) Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer. Scientific Reports 10:1.
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Sheng-Fan Wang, Shiuan Chen, Ling-Ming Tseng & Hsin-Chen Lee. (2020) Role of the mitochondrial stress response in human cancer progression. Experimental Biology and Medicine 245:10, pages 861-878.
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Antonela Sofía Asad, Alejandro Javier Nicola Candia, Nazareno Gonzalez, Camila Florencia Zuccato, Araceli Abt, Santiago Jordi Orrillo, Yael Lastra, Emilio De Simone, Florence Boutillon, Vincent Goffin, Adriana Seilicovich, Daniel Alberto Pisera, María Jimena Ferraris & Marianela Candolfi. (2019) Prolactin and its receptor as therapeutic targets in glioblastoma multiforme. Scientific Reports 9:1.
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