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Review

The apelin/APJ system as a therapeutic target in metabolic diseases

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Pages 215-225 | Received 07 Sep 2018, Accepted 18 Dec 2018, Published online: 10 Jan 2019

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Amir Hossein Soleimani, Aghdas Dehghani, Mehdi Abbasnejad, Saeed Esmaeili‐Mahani, Maryam Raoof & Frank Lobbezoo. (2023) Apelin signalling in the periaqueductal grey matter alleviates capsaicin‐evoked pulpal nocifensive behaviour and capsaicin‐induced spatial learning and memory impairments in rat. International Endodontic Journal 56:8, pages 968-979.
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Johnbasha Shaik, Kanumuru Balu Mahendran, Durairajan Sheela, Vudaga Krishna Murthy & Tadi Santhi. (2023) Correlation of apelin with microalbuminuria in type 2 diabetic patients. Current Issues in Pharmacy and Medical Sciences 36:1, pages 44-47.
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Huang Liu, Qingqiang Shi, Ling Tang, Hanghang Wang & Daoxin Wang. (2023) APELIN-13 AMELIORATES LPS-INDUCED ENDOTHELIAL-TO-MESENCHYMAL TRANSITION AND POST–ACUTE LUNG INJURY PULMONARY FIBROSIS BY SUPPRESSING TRANSFORMING GROWTH FACTOR-Β1 SIGNALING. Shock 59:1, pages 108-117.
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Sanju NarayananRajendra UpretyRangan MaitraScott Runyon. 2022. 2022 Medicinal Chemistry Reviews. 2022 Medicinal Chemistry Reviews 95 115 .
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Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen & Lei Chen. (2022) Neuropeptide apelin presented in the dopaminergic neurons modulates the neuronal excitability in the substantia nigra pars compacta. Neuropharmacology 219, pages 109235.
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Shuman Li, Yongjie Liu, Bin Liu, Yun-Qing Hu, Yu-Qiang Ding, Jun Zhang & Liping Feng. (2022) Maternal urban particulate matter exposure and signaling pathways in fetal brains and neurobehavioral development in offspring. Toxicology 474, pages 153225.
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Cheng Li, Hongna Cheng, Binay Kumar Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun & Yonggang Wang. (2022) The Role of Apelin–APJ System in Diabetes and Obesity. Frontiers in Endocrinology 13.
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Parvin Babaei & Rastegar Hoseini. (2022) Exercise training modulates adipokine dysregulations in metabolic syndrome. Sports Medicine and Health Science 4:1, pages 18-28.
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MervatEl Shahat El Wakeel, InassHassan Ahmad, MarwaAbdelmonim Mohammed, SallyMohamed Osama Ali, MarwaKhairy Abd El Wahab & WalaaMohamed Shipl. (2022) Correlation of serum apelin level with carotid intima–media thickness and insulin resistance in a sample of Egyptian patients with type 2 diabetes mellitus. Journal of Research in Medical Sciences 27:1, pages 13.
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Ethan S Palmer, Nigel Irwin & Finbarr PM O’Harte. (2022) Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update. Clinical Medicine Insights: Endocrinology and Diabetes 15, pages 117955142210746.
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Fiona A. Chapman, Duuamene Nyimanu, Janet J. Maguire, Anthony P. Davenport, David E. Newby & Neeraj Dhaun. (2021) The therapeutic potential of apelin in kidney disease. Nature Reviews Nephrology 17:12, pages 840-853.
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Beatrice Romier, Cédric Dray, Laetitia Vanalderwiert, Amandine Wahart, Thinhinane Hocine, Alizée Dortignac, Christian Garbar, Corinne Garbar, Camille Boulagnon, Nicole Bouland, Pascal Maurice, Amar Bennasroune, Hervé Sartelet, Laurent Martiny, Laurent Duca, Philippe Valet & Sébastien Blaise. (2021) Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall. Scientific Reports 11:1.
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Xiao Yan, Chaobin Qin, Guokun Yang, Jiali Mi & Guoxing Nie. (2021) The role of apelin in regulating glucose metabolism in common carp ( Cyprinus carpio L.) . Aquaculture Nutrition 27:5, pages 1324-1335.
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Xavier Sainsily, David Coquerel, Hugo Giguère, Lauralyne Dumont, Kien Tran, Christophe Noll, Andrei L. Ionescu, Jérôme Côté, Jean-Michel Longpré, André Carpentier, Éric Marsault, Olivier Lesur, Philippe Sarret & Mannix Auger-Messier. (2021) Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake. Frontiers in Pharmacology 12.
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Judit Berta, Szilvia Török, Júlia Tárnoki-Zách, Orsolya Drozdovszky, József Tóvári, Sándor Paku, Ildikó Kovács, András Czirók, Bernard Masri, Zsolt Megyesfalvi, Henriett Oskolás, Johan Malm, Christian Ingvar, György Markó-Varga, Balázs Döme & Viktória László. (2021) Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis. Scientific Reports 11:1.
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Qinghua Wang, Shang Cheng, Fen Qin, Ailing Fu & Chen Fu. (2021) Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system. RSC Advances 11:15, pages 8505-8515.
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María Julia Barisón, Isabela Tiemy Pereira, Anny Waloski Robert & Bruno Dallagiovanna. (2021) Reorganization of Metabolism during Cardiomyogenesis Implies Time-Specific Signaling Pathway Regulation. International Journal of Molecular Sciences 22:3, pages 1330.
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Zi-Qi Shao, Shan-Shan Dou, Jun-Ge Zhu, Hui-Qing Wang, Chun-Mei Wang, Bao-Hua Cheng & Bo Bai. (2021) Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury. Neural Regeneration Research 16:6, pages 1044.
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Pamela Senesi, Livio Luzi & Ileana Terruzzi. (2020) Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions. International Journal of Molecular Sciences 21:21, pages 8372.
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Anthony B. Reed, Brian A. Lanman, Jerry Ryan Holder, Bryant H. Yang, Ji Ma, Sara C. Humphreys, Zhican Wang, Joyce C.Y. Chan, Les P. Miranda, Gayathri Swaminath & John G. Allen. (2020) Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation. Bioorganic & Medicinal Chemistry Letters 30:21, pages 127499.
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Na Li, Xiaochuan Ma, Ting Ban, Shaohua Xu, Yingli Ma, Brandon AsonLiaoyuan A. Hu. (2020) Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice. Biochemical Journal 477:17, pages 3313-3327.
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Shuangyu Lv, Xiaomei Zhang, Yuchen Zhou, Yu Feng, Yanjie Yang & Xinchun Wang. (2020) Intrathecally Administered Apelin-13 Alleviated Complete Freund’s Adjuvant-Induced Inflammatory Pain in Mice. Frontiers in Pharmacology 11.
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Flaminia Bardanzellu, Melania Puddu & Vassilios Fanos. (2020) The Human Breast Milk Metabolome in Preeclampsia, Gestational Diabetes, and Intrauterine Growth Restriction: Implications for Child Growth and Development. The Journal of Pediatrics 221, pages S20-S28.
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Isabelle Castan-Laurell, Ray El Boustany, Ophélie Pereira, Louis Potier, Michel Marre, Frédéric Fumeron, Philippe Valet, Pierre Gourdy, Gilberto Velho & Ronan Roussel. (2020) Plasma Apelin and Risk of Type 2 Diabetes in a Cohort From the Community. Diabetes Care 43:2, pages e15-e16.
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Eric Marsault, Catherine Llorens‐Cortes, Xavier Iturrioz, Hyung J. Chun, Olivier Lesur, Gavin Y. Oudit & Mannix Auger‐Messier. (2019) The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders. Annals of the New York Academy of Sciences 1455:1, pages 12-33.
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Helene Volkoff. (2019) Fish as models for understanding the vertebrate endocrine regulation of feeding and weight. Molecular and Cellular Endocrinology 497, pages 110437.
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Kannan R.R. Rengasamy, Haroon Khan, Imad Ahmad, Devina Lobine, Fawzi Mahomoodally, Shanoo Suroowan, Sherif T.S. Hassan, Suowen Xu, Seema Patel, Maria Daglia, Seyed Mohammad Nabavi & Shunmugiah Karutha Pandian. (2019) Bioactive peptides and proteins as alternative antiplatelet drugs. Medicinal Research Reviews 39:6, pages 2153-2171.
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Cai Read, Duuamene Nyimanu, Thomas L. Williams, David J. Huggins, Petra Sulentic, Robyn G. C. Macrae, Peiran Yang, Robert C. Glen, Janet J. Maguire & Anthony P. Davenport. (2019) International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand. Pharmacological Reviews 71:4, pages 467-502.
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