Citations (58)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Ziyan Fei, Mengyun Hu, Larry Baum, Patrick Kwan, Tao Hong & Chunbo Zhang. (2020) The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro. Xenobiotica 50:3, pages 354-362.
Read now
Read now
Romina Moavero, Laura Rosa Pisani, Francesco Pisani & Paolo Curatolo. (2018) Safety and tolerability profile of new antiepileptic drug treatment in children with epilepsy. Expert Opinion on Drug Safety 17:10, pages 1015-1028.
Read now
Read now
Iyan Younus & Doodipala Samba Reddy. (2018) A resurging boom in new drugs for epilepsy and brain disorders. Expert Review of Clinical Pharmacology 11:1, pages 27-45.
Read now
Read now
Articles from other publishers (55)
Tomáš Tvrdík, Ľubomír Melicherčík, Katarína Šebeková, Jakub Szabó, Marianna Maková, Daniel Gogola & Svatava Kašparová. (2023)
In vivo
Volumetric, DTI and
1
H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy
. Measurement Science Review 23:5, pages 237-247.
Crossref
Crossref
Xinran Guo, Yuhan Wu, Qingqing Wang, Jianbing Zhang, Xueping Sheng, Lanrong Zheng & Yule Wang. (2023) Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease. European Journal of Pharmacology 956, pages 175970.
Crossref
Crossref
Milan Malaník, Marie Čulenová, Alice Sychrová, Adrianna Skiba, Krystyna Skalicka-Woźniak & Karel Šmejkal. (2023) Treating Epilepsy with Natural Products: Nonsense or Possibility?. Pharmaceuticals 16:8, pages 1061.
Crossref
Crossref
Lai-Yang Zhou, Di Chen, Xin-Ran Guo, Yu-Qian Niu, Yong-Sai Xu, Dong-Fu Feng & Tie-Chen Li. (2023) Intravitreal injection of Huperzine A promotes retinal ganglion cells survival and axonal regeneration after optic nerve crush. Frontiers in Cellular Neuroscience 17.
Crossref
Crossref
Mingzhenlong Deng, Wanli Yan, Zhicheng Gu, Yan Li, Lei Chen & Bin He. (2023) Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease. Molecules 28:3, pages 1486.
Crossref
Crossref
Stéphanie Andrade, Débora Nunes, Meghna Dabur, Maria J. Ramalho, Maria C. Pereira & Joana A. Loureiro. (2023) Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials. Pharmaceutics 15:1, pages 212.
Crossref
Crossref
Arwa Mortada Ahmed, Basma Khalaf Mahmoud, Natalie Millán-Aguiñaga, Usama Ramadan Abdelmohsen & Mostafa Ahmed Fouad. (2023)
The endophytic
Fusarium
strains: a treasure trove of natural products
. RSC Advances 13:2, pages 1339-1369.
Crossref
Crossref
Haiyang Xia, Hamza Armghan Noushahi, Aamir Hamid Khan, Ying Liu, Andreea Cosoveanu, Lingli Cui, Jing Tang, Shehzad Iqbal & Shaohua Shu. (2022) Genome sequencing of Colletotrichum gloeosporioides ES026 reveals plausible pathway of HupA. Molecular Biology Reports 49:12, pages 11611-11622.
Crossref
Crossref
Weiwei Yao, Huihui Yang & Jinfei Yang. (2022) Small-molecule drugs development for Alzheimer's disease. Frontiers in Aging Neuroscience 14.
Crossref
Crossref
Xiaojing Zhang, Lizhen Lin, Hang Li, Wenxin Xia, Qiansong Liu, Xirong Zhou, Lin Dong & Xueyan Fu. (2022) Update on new trend and progress of the mechanism of polysaccharides in the intervention of Alzheimer's disease, based on the new understanding of relevant theories: A review. International Journal of Biological Macromolecules 218, pages 720-738.
Crossref
Crossref
Lubomir Melichercik, Tomas Tvrdik, Katarina Novakova, Marek Nemec, Michal Kalinak, Ladislav Baciak & Svatava Kasparova. (2022) Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats. Neurochemistry International 158, pages 105365.
Crossref
Crossref
Siva Prasad Panda, Yogita Dhurandhar & Mehak Agrawal. (2022) The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. Mitochondrion 66, pages 27-37.
Crossref
Crossref
Ziqing Wei, Mingze Wei, Xiaoyu Yang, Yuming Xu, Siqi Gao & Kaidi Ren. (2022) Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity 2022, pages 1-22.
Crossref
Crossref
Zhen-Tao Deng, Xing-De Wu, Zai-Feng Yuan, Nai-Rong Yu, Yu-Fei Ou & Qin-Shi Zhao. (2022) Total synthesis of huperserratines A and B. Organic Chemistry Frontiers 9:14, pages 3664-3668.
Crossref
Crossref
Zhen‐Tao Deng, Yu‐Chen Liu, Qin‐Feng Zhu, Shuai Jiang, Xing‐De Wu & Qin‐Shi Zhao. (2022)
Hupertimines A–E, Fawcettimine‐Type
Lycopodium
Alkaloids from
Huperzia serrata
. Chemistry & Biodiversity 19:7.
Crossref
Crossref
Chongqi Wei, Ziqiang Zhu, Jia-ni Zheng, Yunqing Lu, Cheng Cao, Suchen Qu, Mengqiu Liu, Xue-er Meng, Qianyin Lou, Qingqing Wang, Jin-ao Duan, Er-xin Shang, Zhenxiang Han & Yue Zhu. (2022) Chinese Medicine, Succinum, Ameliorates Cognitive Impairment of Carotid Artery Ligation Rats and Inhibits Apoptosis of HT22 Hippocampal Cells via Regulation of the GSK3β/β-Catenin Pathway. Frontiers in Pharmacology 13.
Crossref
Crossref
Shengying Lou & Sunliang Cui. (2022) Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary
Mechanisms. Current Medicinal Chemistry 29:19, pages 3366-3391.
Crossref
Crossref
Ke Du, Miao He, Dongyi Zhao, Yuting Wang, Chao Ma, Hongyue Liang, Wuyang Wang, Dongyu Min, Lei Xue & Feng Guo. (2022) Mechanism of cell death pathways in status epilepticus and related therapeutic agents. Biomedicine & Pharmacotherapy 149, pages 112875.
Crossref
Crossref
Mayuri Shukla, Prapimpun Wongchitrat & Piyarat Govitrapong. (2022) A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis. Neurochemical Research 47:5, pages 1166-1182.
Crossref
Crossref
Zhi-Ru Chen, Jia-Bao Huang, Shu-Long Yang & Fen-Fang Hong. (2022) Role of Cholinergic Signaling in Alzheimer’s Disease. Molecules 27:6, pages 1816.
Crossref
Crossref
Siva Prasad Panda & Urvashi Soni. (2022) A review of dementia, focusing on the distinct roles of viral protein corona and MMP9 in dementia: Potential pharmacotherapeutic priorities. Ageing Research Reviews 75, pages 101560.
Crossref
Crossref
Pradeep Singh, Garima Mishra, Faheem Hyder Pottoo, Mulugeta Molla Zeleke & Amien Ewunetei. 2022. Current Thoughts on Dementia. Current Thoughts on Dementia
577
616
.
Asli Aykac & Ahmet Özer Sehirli. (2021) The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease. Global Medical Genetics 08:04, pages 149-155.
Crossref
Crossref
Worawat Niwetmarin, Rungroj Saruengkhanphasit, Chatchakorn Eurtivong & Somsak Ruchirawat. (2021)
Visible-light-mediated decarboxylative alkylation of 2-pyridone derivatives
via
a C3-selective C–H functionalization
. Organic & Biomolecular Chemistry 19:42, pages 9231-9236.
Crossref
Crossref
María Jesús Friedli & Nibaldo C. Inestrosa. (2021) Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease. Molecules 26:21, pages 6531.
Crossref
Crossref
Haoru Dong, Xiuchun Li, Mengsi Cai, Chi Zhang, Weiqi Mao, Ying Wang, Qian Xu, Mayun Chen, Liangxing Wang & Xiaoying Huang. (2021) Integrated bioinformatic analysis reveals the underlying molecular mechanism of and potential drugs for pulmonary arterial hypertension. Aging 13:10, pages 14234-14257.
Crossref
Crossref
Naixin Kang, Jianping Zhao, Ying Zhou, Zhiru Peng, Yanli Liu, Qiongming Xu, Ikhlas A. Khan & Shilin Yang. (2021) New Dihydropyrrole-Substituted Epicatechins from Sun-Dried Dongting-Biluochun Tea Leaves and Their Inhibitory Activities on Acetylcholinesterase. ACS Food Science & Technology 1:3, pages 310-315.
Crossref
Crossref
Namrita Halder & Girdhari Lal. (2021) Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity. Frontiers in Immunology 12.
Crossref
Crossref
Lingli Cui, Hamza Armghan Noushahi, Yipeng Zhang, Jinxin Liu, Andreea Cosoveanu, Ying Liu, Ling Yan, Jing Zhang & Shaohua Shu. (2021) Endophytic Fungal Community of Huperzia serrata: Diversity and Relevance to the Production of Huperzine A by the Plant Host. Molecules 26:4, pages 892.
Crossref
Crossref
Hadi Mohsenpour, Mirko Pesce, Antonia Patruno, Azam Bahrami, Pardis Mohammadi Pour & Mohammad Hosein Farzaei. (2021) A Review of Plant Extracts and Plant-Derived Natural Compounds in the Prevention/Treatment of Neonatal Hypoxic-Ischemic Brain Injury. International Journal of Molecular Sciences 22:2, pages 833.
Crossref
Crossref
Akhlaq A. Farooqui. 2021. Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders. Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders
293
350
.
Mahin Haque, Gulzar Ahmed Rather, Ehraz Mehmood Siddiqui, Sadaf Jahan, Andleeb Khan, Hafiz Antar Makeen, Athanasios Alexiou & Ghulam Md Ashraf. 2021. Autism Spectrum Disorder and Alzheimer's Disease. Autism Spectrum Disorder and Alzheimer's Disease
239
281
.
Qing-Zhong Peng, Hua Long, Ci Du, Jing Li & De-Yu Xie. (2020) RNA-seq of aboveground sporophyte’s transcriptome of Huperzia serrata and transcriptional understanding of early steps associated with huperzine biosynthesis in forest. Current Plant Biology 24, pages 100159.
Crossref
Crossref
Xinliu Zhu, Dan Xia, Zhongbo Zhou, Saisai Xie, Zehui Shi, Guimin Chen, Lulu Wang & Ke Pan. (2020)
Lycosquarrines A–R,
Lycopodium
Alkaloids from
Phlegmariurus squarrosus
. Journal of Natural Products 83:10, pages 2831-2843.
Crossref
Crossref
Ze Wang, Chunyang He & Jing-Shan Shi. (2020) Natural Products for the Treatment of Neurodegenerative Diseases. Current Medicinal Chemistry 27:34, pages 5790-5828.
Crossref
Crossref
Xing-De Wu, Xiao-Nian Li, Li-Yan Peng & Qin-Shi Zhao. (2020)
Huperserratines A and B, Two Macrocyclic
Lycopodium
Alkaloids with an Unusual Skeleton from
Huperzia serrata
. The Journal of Organic Chemistry 85:10, pages 6803-6807.
Crossref
Crossref
Azadeh Yazdi, Mohammadmahdi Doostmohammadi, Farshid Pourhossein Majarshin & Siamak Beheshti. (2020) Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole. Epilepsy & Behavior 105, pages 106956.
Crossref
Crossref
Yongming Jia, Na Wang, Yingbo Zhang, Di Xue, Haoming Lou & Xuewei Liu. (2020) Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer’s Disease and the Clinical Significance. Aging and disease 11:2, pages 390.
Crossref
Crossref
Zheling Feng, Shixin Chen, Wei Wang, Lu Feng, Yanyan Dong, Yiping Zou, Changqiang Ke, Chunping Tang, Sheng Yao, Haiyan Zhang, Lishe Gan, Yang Ye & Ligen Lin. (2019) Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity. Fitoterapia 139, pages 104378.
Crossref
Crossref
Sebastian Meller, Claudia Brandt, Wiebke Theilmann, Jochen Klein & Wolfgang Löscher. (2019) Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy. Brain Research 1712, pages 109-123.
Crossref
Crossref
Parvaneh Mohseni‐Moghaddam, Seyed Shahabeddin Sadr, Mehrdad Roghani, Somayeh Arabzadeh, Safoura Khamse, Elham Zamani, Marjan Hosseini & Fatemeh Moradi. (2019)
Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid‐induced epileptic rats by antioxidant activity and
NLRP
3/caspase‐1 pathway inhibition
. Clinical and Experimental Pharmacology and Physiology 46:4, pages 360-372.
Crossref
Crossref
Waka Nakayama, Yukio Fujiwara, Yasuhiro Kosuge, Orawan Monthakantirat, Kazumi Fujikawa, Santi Watthana, Susumu Kitanaka, Toshiaki Makino & Kan’ichiro Ishiuchi. (2019) Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development. Phytochemistry Letters 29, pages 98-103.
Crossref
Crossref
Akhlaq A. Farooqui. 2019. Molecular Mechanisms of Dementia. Molecular Mechanisms of Dementia
251
286
.
Sunil K. Deshmukh, Manish K. Gupta & Sangram K. Lenka. 2019. Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications. Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications
493
532
.
Thaiane Coelho dos Santos, Thaís Mota Gomes, Bruno Araújo Serra Pinto, Adriana Leandro Camara & Antonio Marcus de Andrade Paes. (2018) Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy. Frontiers in Pharmacology 9.
Crossref
Crossref
Xin-Yue Wang, Qian Liang, Hua-Guo Chen & Xin Zhou. (2018) Establishment of an HPLC method for testing acetylcholinesterase inhibitory activity and compared with traditional spectrophotometry. Chemical Papers 72:9, pages 2255-2264.
Crossref
Crossref
Yongrui Du, Konstantin Bagnjuk, Maralee S. Lawson, Jing Xu & Artur Mayerhofer. (2018) Acetylcholine and necroptosis are players in follicular development in primates. Scientific Reports 8:1.
Crossref
Crossref
Wei Wang, Xi-Wen Fu, Xin-Long Dai, Fang Hua, Gang-Xiu Chu, Ming-Jie Chu, Feng-Lin Hu, Tie-Jun Ling, Li-Ping Gao, Zhong-Wen Xie, Xiao-Chun Wan & Guan-Hu Bao. (2017) Novel acetylcholinesterase inhibitors from Zijuan tea and biosynthetic pathway of caffeoylated catechin in tea plant. Food Chemistry 237, pages 1172-1178.
Crossref
Crossref
Jiansong Fang, Li Gao, Huili Ma, Qihui Wu, Tian Wu, Jun Wu, Qi Wang & Feixiong Cheng. (2017) Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders. Frontiers in Pharmacology 8.
Crossref
Crossref
Lindsey R. Hamilton, Steven C. Schachter & Todd M. Myers. (2016) Time Course, Behavioral Safety, and Protective Efficacy of Centrally Active Reversible Acetylcholinesterase Inhibitors in Cynomolgus Macaques. Neurochemical Research 42:7, pages 1962-1971.
Crossref
Crossref
Lydia Giménez-Llort, Miriam Ratia, Belén Pérez, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia & M. Victoria Clos. (2017) Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer’s disease. Behavioural Pharmacology 28:2 and 3, pages 124-131.
Crossref
Crossref
Pingsheng Tang, Dehai Xiao & Bo Wang. (2017) Synthesis of 3-(aminomethyl)pyridine by traceless C3-selective umpolung of 1-amidopyridin-1-ium salts. Chemical Communications 53:12, pages 1993-1996.
Crossref
Crossref
Akhlaq A. Farooqui. 2017. Neurochemical Aspects of Alzheimer's Disease. Neurochemical Aspects of Alzheimer's Disease
279
330
.
Su-Rong Yang, Huan-Xin Sun, Zhen-Zhen Hu, Si-Heng Wang, Hui Sun, Yin-Jia Xue & Chen-Bo Ye. (2016) Repeated pre-training sleep restriction in adolescent rats impaired spatial performance. Sleep and Biological Rhythms 15:1, pages 57-65.
Crossref
Crossref
Mehmet Akif Topcuoglu & Ethem Murat Arsava. 2017. Nutrition in Neurologic Disorders. Nutrition in Neurologic Disorders
155
206
.