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Review

The role of polytherapy in the management of epilepsy: suggestions for rational antiepileptic drug selection

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Pages 167-173 | Received 17 Oct 2018, Accepted 18 Dec 2019, Published online: 25 Dec 2019

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Giulia Liparoti, Beatrice Burchiani, Elisabetta Mencaroni, Domenico Tripodi, Giuseppe Di Cara & Alberto Verrotti. (2022) Individualizing doses of antiepileptic drugs. Expert Opinion on Drug Metabolism & Toxicology 18:3, pages 219-233.
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Deborah Guery & Sylvain Rheims. (2021) Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies. Neuropsychiatric Disease and Treatment 17, pages 2229-2242.
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Sara Matricardi, Francesca Felicia Operto, Giovanni Farello, Giangennaro Coppola & Alberto Verrotti. (2020) Withdrawal seizures: possible risk factors. Expert Review of Neurotherapeutics 20:7, pages 667-672.
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D. Mammadova, J. Vecko, M. Hofmann, S. C. Schüssler, L. Deiters, A. Canda, A. K. Wieland, S. Gollwitzer, H. Hamer & Regina Trollmann. (2023) A single-center observational study on long-term neurodevelopmental outcomes in children with tuberous sclerosis complex. Orphanet Journal of Rare Diseases 18:1.
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Jon Davis Perkins, Mohamed S. Abdelmoneim, Stacy Schantz Wilkins, Saadat Kamran, Boulenouar Mesraoua, Gayane Melikyan, Abdulraheem Alrabi, Ahmed El-Bardissy, Osama Elalamy & Hassan Jassim Al Hail. (2023) Dosage, time, and polytherapy dependent effects of different levetiracetam regimens on cognitive function. Epilepsy & Behavior 148, pages 109453.
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Yaroslav Winter, Katharina Sandner, Martin Glaser, Dumitru Ciolac, Viktoria Sauer, Andreas Ziebart, Ali Karakoyun, Vitalie Chiosa, Assel Saryyeva, Joachim Krauss, Florian Ringel & Sergiu Groppa. (2023) Synergistic effects of vagus nerve stimulation and antiseizure medication. Journal of Neurology 270:10, pages 4978-4984.
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Naciye Çilem Çarkı Bal, Ebru Apaydın Doğan & Yeşim Şenol. (2023) Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. Archives Of Epilepsy 29:2, pages 46-49.
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Tristan Manfred Stöber, Danylo Batulin, Jochen Triesch, Rishikesh Narayanan & Peter Jedlicka. (2023) Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair. Communications Biology 6:1.
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Ivana Damnjanović, Nastia Tsyplakova, Nikola Stefanović, Tatjana Tošić, Aleksandra Catić-Đorđević & Vangelis Karalis. (2023) Joint use of population pharmacokinetics and machine learning for optimizing antiepileptic treatment in pediatric population. Therapeutic Advances in Drug Safety 14.
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Cameron S. Metcalf, Saurabh Gagangras, Grzegorz Bulaj & H. Steve White. (2022) Synergistic effects of the galanin analog 810–2 with the antiseizure medication levetiracetam in rodent seizure models. Epilepsia 63:12, pages 3090-3099.
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Louisa G. Gordon, Thomas M. Elliott, Carmen Bennett, Georgina Hollway, Nicola Waddell & Lata Vadlamudi. (2022) Early cost–utility analysis of genetically guided therapy for patients with drug‐resistant epilepsy. Epilepsia 63:12, pages 3111-3121.
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Tommy Stödberg, Torbjörn Tomson, Britt‐Marie Anderlid, Tomas Andersson, Olivia Henry, Per Åmark & Anna Wedell. (2022) Outcome at age 7 of epilepsy presenting in the first 2 years of life. A population‐based study. Epilepsia 63:8, pages 2096-2107.
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Gianluca Dini, Eleonora Tulli, Giovanni Battista Dell’Isola, Elisabetta Mencaroni, Giuseppe Di Cara, Pasquale Striano & Alberto Verrotti. (2022) Improving Therapy of Pharmacoresistant Epilepsies: The Role of Fenfluramine. Frontiers in Pharmacology 13.
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Raziyeh Masumshah, Rosa Aghdam & Changiz Eslahchi. (2021) A neural network-based method for polypharmacy side effects prediction. BMC Bioinformatics 22:1.
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Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Marwa Abdullah AL Dhamen, Walaa Jafar Alsaeed, Mohamed S. Gomaa, Chittibabu Vatte & Mohammad N. Alomary. (2021) Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pathway. Pharmaceuticals 14:11, pages 1204.
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Hammad Ahmed, Mahtab Ahmad Khan, Syed Awais Ali Zaidi & Sajjad Muhammad. (2021) In Silico and In Vivo: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model. Frontiers in Bioengineering and Biotechnology 9.
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Wolfgang Löscher. (2021) Single-Target Versus Multi-Target Drugs Versus Combinations of Drugs With Multiple Targets: Preclinical and Clinical Evidence for the Treatment or Prevention of Epilepsy. Frontiers in Pharmacology 12.
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Opeyemi Samson Osuntokun, Busayo Grace Akingboye, Gbola Olayiwola, Taiwo Adekemi Abayomi & Abiodun Oladele Ayoka. (2021) The impairment of motor coordination following chronic carbamazepine-levetiracetam combination treatment with evidence of corticocerebellar toxicity in male Wistar rats. Brain Research 1767, pages 147565.
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Valeria Venti, Maria Chiara Consentino, Pierluigi Smilari, Filippo Greco, Claudia Francesca Oliva, Agata Fiumara, Raffaele Falsaperla, Martino Ruggieri & Piero Pavone. (2021) Malformations of Cortical Development, Cognitive Involvementand Epilepsy: A Single Institution Experience in 19 Young Patients. Children 8:8, pages 637.
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K. Yu. Mukhin, E. D. Belousova, S. G. Burd, M. V. Barkhatov, N. A. Ermolenko, S. K. Zyryanov, E. I. Karpovich, E. A. Morozova & G. V. Odintsova. (2021) Perampanel in the additional therapy of focal and primary generalized tonic-clonic seizures in children 4–12 years old: clinical data, experience of use and practical recommendations. Epilepsy and paroxysmal conditions 13:2, pages 180-187.
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Jun-Sang Sunwoo, Hyunjin Jo, Kyung Wook Kang, Keun Tae Kim, Daeyoung Kim, Dong Wook Kim, Min-Jee Kim, Saeyoon Kim, Woojun Kim, Hye-Jin Moon, Ha Ree Park, Jung-Ick Byun, Jong-Geun Seo, Sung Chul Lim, Min Kyung Chu, Su-Hyun Han, Kyoung Jin Hwang & Dae-Won Seo. (2021) Survey on Antiepileptic Drug Therapy in Patients with Drug Resistant Epilepsy. Journal of Epilepsy Research 11:1, pages 72-82.
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Antonella Fattorusso, Sara Matricardi, Elisabetta Mencaroni, Giovanni Battista Dell'Isola, Giuseppe Di Cara, Pasquale Striano & Alberto Verrotti. (2021) The Pharmacoresistant Epilepsy: An Overview on Existant and New Emerging Therapies. Frontiers in Neurology 12.
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Deborah Guery & Sylvain Rheims. (2020) Is the mechanism of action of antiseizure drugs a key element in the choice of treatment?. Fundamental & Clinical Pharmacology 35:3, pages 552-563.
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William E Rosenfeld, Arkady Nisman & Louis Ferrari. (2021) Efficacy of adjunctive cenobamate based on number of concomitant antiseizure medications, seizure frequency, and epilepsy duration at baseline: A post-hoc analysis of a randomized clinical study. Epilepsy Research 172, pages 106592.
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Christian Brandt, Lynanne McGuire & Jack Uetrecht. (2021) Severe cutaneous adverse reaction associated with antiseizure medications: Diagnosis, management, and prevention. Epilepsy & Behavior 117, pages 107844.
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Jarogniew J. Łuszczki, Dominika Podgórska, Justyna Kozińska, Marek Jankiewicz, Zbigniew Plewa, Mateusz Kominek, Dorota Żółkowska & Magdalena Florek-Łuszczki. (2020) Polygonogram with isobolographic synergy for three-drug combinations of phenobarbital with second-generation antiepileptic drugs in the tonic–clonic seizure model in mice. Pharmacological Reports 73:1, pages 111-121.
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Claudia Francesca Oliva, Gloria Gangi, Silvia Marino, Lidia Marino, Giulia Messina, Sarah Sciuto, Giovanni Cacciaguerra, Mattia Comella, Raffaele Falsaperla & Piero Pavone. (2021) Single and in combination antiepileptic drug therapy in children with epilepsy: how to use it. AIMS Medical Science 8:2, pages 138-146.
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Lingyan Yu, Jianhua Feng, Zhenwei Yu & Haibin Dai. (2020) Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018. Epilepsy Research 167, pages 106448.
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Alberto Verrotti, Giulia Iapadre, Ludovica Di Francesco, Luca Zagaroli & Giovanni Farello. (2020) Diet in the Treatment of Epilepsy: What We Know So Far. Nutrients 12:9, pages 2645.
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Jonathan J. Halford & Jonathan C. Edwards. (2020) Seizure freedom as an outcome in epilepsy treatment clinical trials. Acta Neurologica Scandinavica 142:2, pages 91-107.
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Monika Mochol, Erik Taubøll, Pål Aukrust, Thor Ueland, Ole A. Andreassen & Sigrid Svalheim. (2020) Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation. Seizure 80, pages 221-225.
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Jarogniew J. Luszczki, Anna Panasiuk, Mirosław Zagaja, Sławomir Karwan, Hubert Bojar, Zbigniew Plewa & Magdalena Florek-Łuszczki. (2020) Polygonogram and isobolographic analysis of interactions between various novel antiepileptic drugs in the 6-Hz corneal stimulation-induced seizure model in mice. PLOS ONE 15:6, pages e0234070.
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