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Research Article

Flavonoids As DNA Topoisomerase I Poisons

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Pages 25-29 | Published online: 30 Sep 2008

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Avadh Biharee, Arpita Yadav, Kailash Jangid, Yogesh Singh, Swanand Kulkarni, Devesh M. Sawant, Pradeep Kumar, Suresh Thareja & Akhlesh Kumar Jain. (2023) Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 41:16, pages 7835-7846.
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Riadh Ksouri, Wided Megdiche Ksouri, Inès Jallali, Ahmed Debez, Christian Magné, Isoda Hiroko & Chedly Abdelly. (2012) Medicinal halophytes: potent source of health promoting biomolecules with medical, nutraceutical and food applications. Critical Reviews in Biotechnology 32:4, pages 289-326.
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Ying Liang, Liuxin Wei, Zhiren Zhu, Yingming Pan, Hengshan Wang & Peizhen Liu. (2011) Isolation and Purification of Kaempferol-3,7-O-α-L-Dirhamnopyranoside from Siraitia grosvenori Leaves by High-Speed Counter-Current Chromatograph and Its Free Radical Scavenging Activity. Separation Science and Technology 46:9, pages 1528-1533.
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Marina Gálvez, Carmen Martín-Cordero & María Jesús Ayuso. (2005) Iridoids as DNA topoisomerase I poisons. Journal of Enzyme Inhibition and Medicinal Chemistry 20:4, pages 389-392.
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Carmen Martín-Cordero, Miguel López-Lázaro, Marina Gálvez & Maria Jesús Ayuso. (2003) Curcumin as a DNA Topoisomerase II Poison. Journal of Enzyme Inhibition and Medicinal Chemistry 18:6, pages 505-509.
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Articles from other publishers (20)

Minxia Fan, Guilin Chen, Baoqing Sun, Jianlin Wu, Na Li, Satyajit D. Sarker, Lutfun Nahar & Mingquan Guo. (2019) Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC–MS. Phytochemistry Reviews 19:5, pages 1231-1261.
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Fatmah M. Alqahtani, Brock A. Arivett, Zachary E. Taylor, Scott T. Handy, Anthony L. Farone & Mary B. Farone. (2019) Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound. PLOS ONE 14:12, pages e0226068.
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Mohamed A. El Raey, Ali M. El-Hagrassi, Abeer F. Osman, Khaled M. Darwish & Mahmoud Emam. (2019) Acalypha wilkesiana flowers: Phenolic profiling, cytotoxic activity of their biosynthesized silver nanoparticles and molecular docking study for its constituents as Topoisomerase-I inhibitors. Biocatalysis and Agricultural Biotechnology 20, pages 101243.
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Xiaoxia Liang, Qiang Wu, Shangxian Luan, Zhongqiong Yin, Changliang He, Lizi Yin, Yuanfeng Zou, Zhixiang Yuan, Lixia Li, Xu Song, Min He, Cheng Lv & Wei Zhang. (2019) A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade. European Journal of Medicinal Chemistry 171, pages 129-168.
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Iva Fernandes, Rosa Pérez-Gregorio, Susana Soares, Nuno Mateus & Victor de Freitas. (2017) Wine Flavonoids in Health and Disease Prevention. Molecules 22:2, pages 292.
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Vladimir A. D'yakonov, Lilya U. Dzhemileva & Usein M. Dzhemilev. 2017. 21 86 .
Marko Vidak, Damjana Rozman & Radovan Komel. (2015) Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells. Molecules 20:10, pages 19406-19432.
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M Y Sherman & V L Gabai. (2014) Hsp70 in cancer: back to the future. Oncogene 34:32, pages 4153-4161.
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Melanie Esselen & Stephan W. Barth. 2014. 123 171 .
Y. Baran, S. Zencir, Z. Cakir, E. Ozturk & Z. Topcu. (2011) Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition. Journal of Clinical Pharmacy and Therapeutics 36:6, pages 673-679.
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Maria Tselepi, Evaggelia Papachristou, Aikaterini Emmanouilidi, Apostolos Angelis, Nektarios Aligiannis, Alexios-Leandros Skaltsounis, Demetrios Kouretas & Kalliopi Liadaki. (2011) Catalytic Inhibition of Eukaryotic Topoisomerases I and II by Flavonol Glycosides Extracted from Vicia faba and Lotus edulis . Journal of Natural Products 74:11, pages 2362-2370.
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Miguel López-Lázaro, Elaine Willmore & Caroline A. Austin. (2010) The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 696:1, pages 41-47.
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Zhaofu Wang, Meng Cui, Fengrui Song, Lin Lu, Zhiqiang Liu & Shuying Liu. (2011) Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 19:7, pages 914-922.
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Sameer Urgaonkar & Jared T. Shaw. (2007) Synthesis of Kaempferitrin. The Journal of Organic Chemistry 72:12, pages 4582-4585.
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Miguel López-Lázaro, Elaine Willmore & Caroline A. Austin. (2007) Cells Lacking DNA Topoisomerase IIβ are Resistant to Genistein. Journal of Natural Products 70:5, pages 763-767.
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Diana Fridrich, Melanie Kern, Jessica Fritz, Gudrun Pahlke, Nils Köhler, Peter Winterhalter & Doris Marko. (2007) The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins. Molecular Nutrition & Food Research 51:2, pages 192-200.
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Michael HabermeyerJessica FritzHans U. BarthelmesMorten O. ChristensenMorten K. LarsenFritz BoegeDoris Marko. (2005) Anthocyanidins Modulate the Activity of Human DNA Topoisomerases I and II and Affect Cellular DNA Integrity. Chemical Research in Toxicology 18:9, pages 1395-1404.
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A. O. Prykhod'ko, O. Ya. Yakovenko, A. G. Golub, V. G. Bdzhola & S. M. Yarmoluk. (2005) Evaluation of 4H-4-chromenone derivatives as inhibitors of protein kinase CK2. Biopolymers and Cell 21:3, pages 287-292.
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A. O. Prykhod'ko, G. G. Dubinina, V. P. Khilya & S. M. Yarmoluk. (2004) Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenone derivatives against 60 human cancer cell lines. Biopolymers and Cell 20:1-2, pages 159-163.
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Marco Vinicio Ramı́rez-Mares & Elvira González de Mejı́a. (2003) Comparative study of the antioxidant effect of ardisin and epigallocatechin gallate in rat hepatocytes exposed to benomyl and 1-nitropyrene. Food and Chemical Toxicology 41:11, pages 1527-1535.
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