Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 21, 2006 - Issue 4
Submit an article Journal homepage
817
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Homology Model of Human Retinoic Acid Metabolising Enzyme Cytochrome P450 26A1 (CYP26A1): Active Site Architecture and Ligand Binding

Mohamed Sayed Gomaa Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, U.K
,
Sook Wah Yee Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, U.K
,
Ceri Elizabeth Milbourne Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, U.K
,
Maria Chiara Barbera Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, U.K
,
Claire Simons Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, U.K
&
Andrea Brancale Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, U.K
Pages 361-369 | Received 01 Mar 2006, Accepted 31 Mar 2006, Published online: 04 Oct 2008

Citations (18)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Robert S. Foti, Philippe Diaz & Dominique Douguet. (2016) Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 148-161.
Read now
Jayne E Thatcher & Nina Isoherranen. (2009) The role of CYP26 enzymes in retinoic acid clearance. Expert Opinion on Drug Metabolism & Toxicology 5:8, pages 875-886.
Read now
Stephane Pautus, Ahmed S. Aboraia, Claire E. Bassett, Andrea Brancale, Michael P. Coogan & Claire Simons. (2009) Design and synthesis of substituted imidazole and triazole N-phenylbenzo[d]oxazolamine inhibitors of retinoic acid metabolizing enzyme CYP26. Journal of Enzyme Inhibition and Medicinal Chemistry 24:2, pages 487-498.
Read now
J.H. Ren, X.Q. Xiong, Y. Sha, M.C. Yan, B. Lin, J. Wang, Y.K. Jing, D.M. Zhao & M.S. Cheng. (2008) Structure prediction and R115866 binding study of human CYP26A1: homology modelling, fold recognition, molecular docking and MD simulations. Molecular Simulation 34:3, pages 337-346.
Read now

Articles from other publishers (14)

Nina Isoherranen & Guo Zhong. (2019) Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases. Pharmacology & Therapeutics 204, pages 107400.
Crossref
R. S. Foti, N. Isoherranen, A. Zelter, L. J. Dickmann, B. R. Buttrick, P. Diaz & D. Douguet. (2016) Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1. Journal of Pharmacology and Experimental Therapeutics 357:2, pages 281-292.
Crossref
Mohamed Awadalla, Thamir Alshammari, Leif Eriksson & Patricia Saenz-Méndez. (2016) Improved Homology Model of the Human all-trans Retinoic Acid Metabolizing Enzyme CYP26A1. Molecules 21:3, pages 351.
Crossref
Andrew Millard, David J. Scanlan, Connor Gallagher, Andrew Marsh & Paul C. Taylor. (2014) Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation. Molecular BioSystems 10:3, pages 380.
Crossref
Fengrong Li, Dongmei Zhao, Jinhong Ren, Feiyue Hao, Guyue Liu, Shengfei Jin, Yongkui Jing & Maosheng Cheng. (2013) 2-(2-Methylfuran-3-carboxamido)-3-phenylpropanoic acid, a potential CYP26A1 inhibitor to enhance all-trans retinoic acid-induced leukemia cell differentiation based on virtual screening and biological evaluation. Bioorganic & Medicinal Chemistry 21:11, pages 3256-3261.
Crossref
Jakob A. Shimshoni, Arthur G. Roberts, Michele Scian, Ariel R. Topletz, Sean A. Blankert, James R. Halpert, Wendel L. Nelson & Nina Isoherranen. (2012) Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes. Journal of Biological Chemistry 287:50, pages 42223-42232.
Crossref
Patricia Saenz-Méndez, Ali Ateia Elmabsout, Helena Sävenstrand, Mohamed Khalid Alhaj Awadalla, Åke Strid, Allan Sirsjö & Leif A. Eriksson. (2012) Homology Models of Human All-Trans Retinoic Acid Metabolizing Enzymes CYP26B1 and CYP26B1 Spliced Variant. Journal of Chemical Information and Modeling 52:10, pages 2631-2637.
Crossref
Mohamed S. Gomaa, Andrew S.T. Lim, S.C. Wilson Lau, Ann-Marie Watts, Nicola A. Illingworth, Caroline E. Bridgens, Gareth J. Veal, Christopher P.F. Redfern, Andrea Brancale, Jane L. Armstrong & Claire Simons. (2012) Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. Bioorganic & Medicinal Chemistry 20:20, pages 6080-6088.
Crossref
Puranik Purushottamachar, Jyoti B. Patel, Lalji K. Gediya, Omoshile O. Clement & Vincent C.O. Njar. (2012) First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): Identification of novel RAMBA scaffolds. European Journal of Medicinal Chemistry 47, pages 412-423.
Crossref
Mohamed S. Gomaa, Caroline E. Bridgens, Gareth J. Veal, Christopher P. F. Redfern, Andrea Brancale, Jane L. Armstrong & Claire Simons. (2011) Synthesis and Biological Evaluation of 3-(1 H -Imidazol- and Triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl Derivatives as Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26) . Journal of Medicinal Chemistry 54:19, pages 6803-6811.
Crossref
Jayne E. Thatcher, Brian Buttrick, Scott A. Shaffer, Jakob A. Shimshoni, David R. Goodlett, Wendel L. Nelson & Nina Isoherranen. (2011) Substrate Specificity and Ligand Interactions of CYP26A1, the Human Liver Retinoic Acid Hydroxylase. Molecular Pharmacology 80:2, pages 228-239.
Crossref
Mohamed S. GomaaCaroline E. BridgensAhmed S. AboraiaGareth J. VealChristopher P. F. RedfernAndrea BrancaleJane L. ArmstrongClaire Simons. (2011) Small Molecule Inhibitors of Retinoic Acid 4-Hydroxylase (CYP26): Synthesis and Biological Evaluation of Imidazole Methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. Journal of Medicinal Chemistry 54:8, pages 2778-2791.
Crossref
Mohamed Sayed Gomaa, Jane L. Armstrong, Beatrice Bobillon, Gareth J. Veal, Andrea Brancale, Christopher P.F. Redfern & Claire Simons. (2008) Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: Potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells. Bioorganic & Medicinal Chemistry 16:17, pages 8301-8313.
Crossref
Magnus Karlsson, Åke Strid, Allan Sirsjö & Leif A. Eriksson. (2008) Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1). Journal of Chemical Theory and Computation 4:6, pages 1021-1027.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.