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Research Article

Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase

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Pages 329-350 | Received 02 Feb 2006, Accepted 02 Apr 2006, Published online: 04 Oct 2008

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Read on this site (4)

Yanjun Zhang, Lu Chen, Zhonghua Wang, Yiren Zhu, Huifang Jiang, Jie Xu & Fei Xiong. (2023) Design of novel DABO derivatives as HIV-1 RT inhibitors using molecular docking, molecular dynamics simulations and ADMET properties. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-18.
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H. R. Xu, L. Fu, P. Zhan & X. Y. Liu. (2016) 3D-QSAR analysis of a series of S-DABO derivatives as anti-HIV agents by CoMFA and CoMSIA. SAR and QSAR in Environmental Research 27:12, pages 999-1014.
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Osmond J D'Cruz & Fatih M Uckun. (2014) Vaginal microbicides and their delivery platforms. Expert Opinion on Drug Delivery 11:5, pages 723-740.
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Osmond J D'Cruz, Sanjive Qazi, Seang Yiv & Fatih M Uckun. (2012) A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N′-[2-(2-thiophene)ethyl]-N′-[2-(5-bromopyridyl)] thiourea]). Expert Opinion on Investigational Drugs 21:3, pages 265-279.
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Articles from other publishers (15)

Svitlana I. Orysyk, Yurii L. Zborovskii, Viktor V. Orysyk, Liudmyla V. Garmanchuk, Polina V. Borovyk, Svitlana V. Shishkina, Olha Pavliuk, Vasyl I. Pekhnyo & Mykhailo V. Vovk. (2023) Synthesis, structural and spectral characteristics of novel n,π-chelate complexes of Pd(II) and Pt(II) with N-allylthioureas and their influence on the growth of spheroids cells MCF-7 and GGT activity. Polyhedron 231, pages 116272.
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Anastasia Khandazhinskaya, Elena Matyugina & Mikhail Novikov. 2021. Coronaviruses and other Novel Antiviral Targets. Coronaviruses and other Novel Antiviral Targets 175 238 .
Yumeng Wu, Chengrun Tang, Ruomei Rui, Liumeng Yang, Wei Ding, Jiangyuan Wang, Yiming Li, Christopher C. Lai, Yueping Wang, Ronghua Luo, Weilie Xiao, Hongbing Zhang, Yongtang Zheng & Yanping He. (2020) Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors. Acta Pharmaceutica Sinica B 10:3, pages 512-528.
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Lokendra Kumar Ojha. Mathematical modeling of tetrahydroimidazole benzodiazepine-1-one derivatives as an anti HIV agent. Mathematical modeling of tetrahydroimidazole benzodiazepine-1-one derivatives as an anti HIV agent.
Osmond D'Cruz & Fatih Uckun. 2014. Drug Delivery and Development of Anti-HIV Microbicides. Drug Delivery and Development of Anti-HIV Microbicides 1 54 .
Nagy M. Khalifa, Erik B. Pedersen, Claus Nielsen & Mohamed A. Al-Omar. (2014) Synthesis and evaluation of novel 6-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents. Russian Journal of Bioorganic Chemistry 40:5, pages 579-585.
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Peng Zhan, Xuwang Chen, Dongyue Li, Zengjun Fang, Erik De Clercq & Xinyong Liu. (2013) HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design. Medicinal Research Reviews 33:S1, pages E1-E72.
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Eugene L. Asahchop, Mark A. Wainberg, Richard D. Sloan & Cécile L. Tremblay. (2012) Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors. Antimicrobial Agents and Chemotherapy 56:10, pages 5000-5008.
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I. A. Novakov, M. Artico, A. Mai, D. Rotili, B. S. Orlinson, L. L. Brunilina & M. B. Nawrozkij. (2013) 6-(Arylmethyl)pyrimidin-4(3H)-ones: anthology and prospects of highly efficient anti-HIV agents. Russian Chemical Bulletin 61:7, pages 1399-1418.
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Marco Radi, Mafalda Pagano, Luigi Franchi, Daniele Castagnolo, Silvia Schenone, Gianni Casaluce, Claudio Zamperini, Elena Dreassi, Giovanni Maga, Alberta Samuele, Encarna Gonzalo, Bonaventura Clotet, José A. Esté & Maurizio Botta. (2012) Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors. ChemMedChem 7:5, pages 883-896.
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Mark A. Wainberg. (2012) The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance. Scientifica 2012, pages 1-28.
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Mingyan Yu, Zhenyu Li, Shuai Liu, Erkang Fan, Christophe Pannecouque, Erik De Clercq & Xinyong Liu. (2011) Synthesis and Biological Evaluation of 6-Substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as Potent HIV-1 NNRTIs. ChemMedChem 6:5, pages 826-833.
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Yan-Ping He, Jin Long, Shui-Shuan Zhang, Cong Li, Christopher Cong Lai, Chun-Sheng Zhang, Da-Xiong Li, De-Hua Zhang, Hua Wang, Qing-Qing Cai & Yong-Tang Zheng. (2011) Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl-oxopyrimidines (S-DACOs) as high active anti-HIV agents. Bioorganic & Medicinal Chemistry Letters 21:2, pages 694-697.
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Monique Araújo de BritoCarlos Rangel RodriguesJosé Jair Vianna CirinoRicardo Bicca de AlencastroHelena Carla CastroMagaly Girão Albuquerque. (2008) 3D-QSAR CoMFA of a Series of DABO Derivatives as HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors. Journal of Chemical Information and Modeling 48:8, pages 1706-1715.
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Osmond J. D'Cruz & Fatih M. Uckun. (2007) Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1. Fertility and Sterility 88:4, pages 1197-1206.
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