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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 22, 2007 - Issue 3
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Research Article

Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors

Maria P. Giovannoni Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
,
Nicoletta Cesari Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
,
Alessia Graziano Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
,
Claudia Vergelli Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
,
Claudio Biancalani Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
,
Pierfrancesco Biagini Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
&
Vittorio Dal Piaz Dipartimento di Scienze Farmaceutiche, Via U. Schiff 6, Sesto Fiorentino, 50019, Firenze, Italy
 show all
Pages 309-318 | Received 21 Jul 2006, Accepted 16 Oct 2006, Published online: 04 Oct 2008

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David MG Halpin. (2008) ABCD of the phosphodiesterase family: interaction and differential activity in COPD. International Journal of Chronic Obstructive Pulmonary Disease 3:4, pages 543-561.
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Letizia Crocetti, Maria Paola Giovannoni, Claudia Vergelli, Gabriella Guerrini, Fabrizio Melani & Agostino Cilibrizzi. (2024) New quinoline-based PDE4 inhibitors through GSK-256066 fragment-based elaboration. Journal of Molecular Structure 1295, pages 136719.
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Xuemei Wei, Guoqi Yu, Hualiang Shen, Yanjuan Luo, Tianbo Shang, Runpu Shen, Meiyang Xi & Haopeng Sun. (2023) Targeting phosphodiesterase 4 as a therapeutic strategy for cognitive improvement. Bioorganic Chemistry 130, pages 106278.
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Xacobe C. Cambeiro. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 188 211 .
Ting Peng, Baowen Qi, Jun He, Hengming Ke & Jianyou Shi. (2020) Advances in the Development of Phosphodiesterase-4 Inhibitors. Journal of Medicinal Chemistry 63:19, pages 10594-10617.
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Masoumeh Alipour, Mehdi Khoobi, Saeed Emami, Saeed Fallah-Benakohal, Seyedeh Farnaz Ghasemi-Niri, Mohammad Abdollahi, Alireza Foroumadi & Abbas Shafiee. (2014) Antinociceptive properties of new coumarin derivatives bearing substituted 3,4-dihydro-2H-benzothiazines. DARU Journal of Pharmaceutical Sciences 22:1.
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V. I. Skvortsova, S. A. Limborskaya, I. M. Shetova, P. A. Slominskii, N. A. Shamalov, E. A. Bondarenko & D. Yu. Timofeev. (2012) Association between Polymorphisms in the Phosphodiesterase 4D (PDE4D) Gene and the Development of Cerebral Stroke in Patients in the Moscow Population. Neuroscience and Behavioral Physiology 42:8, pages 838-841.
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Maria P. Giovannoni, Alessia Graziano, Rosanna Matucci, Marta Nesi, Nicoletta Cesari, Claudia Vergelli, Claudio Biancalani, Letizia Crocetti, Agostino Cilibrizzi & Vittorio Dal Piaz. (2011) Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives. Drug Development Research 72:3, pages 274-288.
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E. A. Bondarenko, T. V. Tupitsina, P. A. Slominsky, I. M. Shetova, N. A. Shamalov, A. Yu. Botsina, V. I. Skvortsova & S. A. Limborska. (2010) Phosphodiesterase 4D (PDE4D) gene polymorphism in patients with acute stroke from Moscow. Russian Journal of Genetics 46:6, pages 765-768.
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Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, Nicoletta Cesari, Maria Paola Giovannoni, Agostino Cilibrizzi, Vittorio Dal Piaz, Claudia Vergelli, Letizia Crocetti, Maurizio Delcanale, Elisabetta Armani, Andrea Rizzi, Paola Puccini, Paola Maria Gallo, Daniele Spinabelli & Paola Caruso. (2010) Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity. Bioorganic & Medicinal Chemistry 18:10, pages 3506-3517.
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Andrew F. Donnell, Paul J. Dollings, John A. Butera, Arlene J. Dietrich, Kerri K. Lipinski, Afshin Ghavami & Warren D. Hirst. (2010) Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors. Bioorganic & Medicinal Chemistry Letters 20:7, pages 2163-2167.
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Anjana Munshi, M Sai Babu, Subhash Kaul, Gowhar Shafi, A.N. Anila, Suvarna Alladi & A. Jyothy. (2009) Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a South Indian population. Journal of the Neurological Sciences 285:1-2, pages 142-145.
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Amelia Manlove & Michael P. Groziak. 2009. A critical review of the 2007 literature preceded by two chapters on current heterocyclic topics. A critical review of the 2007 literature preceded by two chapters on current heterocyclic topics 333 363 .
George R. Uhl, Tomas Drgon, Catherine Johnson, Chuan-Yun Li, Carlo Contoreggi, Judith Hess, Daniel Naiman & Qing-Rong Liu. (2008) Molecular Genetics of Addiction and Related Heritable Phenotypes. Annals of the New York Academy of Sciences 1141:1, pages 318-381.
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Anjana Munshi & Subhash Kaul. (2008) Stroke Genetics – Focus on PDE4D Gene. International Journal of Stroke 3:3, pages 188-192.
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