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Research Article

Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions

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Pages 70-76 | Received 28 Jun 2007, Accepted 26 Nov 2007, Published online: 20 Oct 2008

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Read on this site (6)

Simone Giovannuzzi, Alessandro Bonardi, Paola Gratteri, Alessio Nocentini & Claudiu T. Supuran. (2023) Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Claudiu T. Supuran. (2022) Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2478-2488.
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Bilal A. Al-Jaidi, Pran Kishore Deb, Soha Taher Telfah, Abdel Naser Dakkah, Yazan A. Bataineh, Qutaiba Ahmed Al Khames Aga, Mohammad A. Al-dhoun, Ala’ Ali Ahmad Al-Subeihi, Haifa’a Marouf Odetallah, Sanaa K. Bardaweel, Raghuprasad Mailavaram, Katharigatta N. Venugopala & Anroop B. Nair. (2020) Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1483-1490.
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Ozen Ozensoy Guler, Clemente Capasso & Claudiu T. Supuran. (2016) A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 689-694.
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Clemente Capasso & Claudiu T Supuran. (2015) Bacterial, fungal and protozoan carbonic anhydrases as drug targets. Expert Opinion on Therapeutic Targets 19:12, pages 1689-1704.
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Anna-Kaisa Harju, Fatemeh Bootorabi, Marianne Kuuslahti, Claudiu T. Supuran & Seppo Parkkila. (2013) Carbonic anhydrase III: A neglected isozyme is stepping into the limelight. Journal of Enzyme Inhibition and Medicinal Chemistry 28:2, pages 231-239.
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Articles from other publishers (28)

Yanyou Wu & Sen RaoYanyou Wu & Sen Rao. 2023. Root-Derived Bicarbonate Assimilation in Plants. Root-Derived Bicarbonate Assimilation in Plants 55 95 .
Ling Wang, Courtney E. Sparacino‐Watkins, Jun Wang, Nadeem Wajih, Paul Varano, Qinzi Xu, Eric Cecco, Jesús Tejero, Manoocher Soleimani, Daniel B. Kim‐Shapiro & Mark T. Gladwin. (2019) Carbonic anhydrase II does not regulate nitrite‐dependent nitric oxide formation and vasodilation. British Journal of Pharmacology 177:4, pages 898-911.
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Juan M. García Lobo, Yelina Ortiz, Candela Gonzalez-Riancho, Asunción Seoane, Beatriz Arellano-Reynoso & Félix J. Sangari. (2019) Polymorphisms in Brucella Carbonic Anhydrase II Mediate CO2 Dependence and Fitness in vivo. Frontiers in Microbiology 10.
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Claudiu T. Supuran. (2017) Bortezomib inhibits mammalian carbonic anhydrases. Bioorganic & Medicinal Chemistry 25:19, pages 5064-5067.
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Sonia Del Prete, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, William A. Donald, Jean-Yves Winum, Claudiu T. Supuran & Clemente Capasso. (2017) Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. Bioorganic & Medicinal Chemistry 25:17, pages 4800-4804.
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Sarah W. Renner, Lauren M. Walker, Lawrence J. Forsberg, Jonathan Z. Sexton & Jay E. Brenman. (2017) Carbonic anhydrase III (Car3) is not required for fatty acid synthesis and does not protect against high-fat diet induced obesity in mice. PLOS ONE 12:4, pages e0176502.
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Jekaterīna Ivanova, Agnese Balode, Raivis Žalubovskis, Janis Leitans, Andris Kazaks, Daniela Vullo, Kaspars Tars & Claudiu T. Supuran. (2017) 5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations. Bioorganic & Medicinal Chemistry 25:3, pages 857-863.
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Shihan Zhang & Yongqi Lu. (2015) Kinetic performance of CO2 absorption into a potassium carbonate solution promoted with the enzyme carbonic anhydrase: Comparison with a monoethanolamine solution. Chemical Engineering Journal 279, pages 335-343.
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Per M. Nielsen & Angela Fago. (2015) Inhibitory effects of nitrite on the reactions of bovine carbonic anhydrase II with CO2 and bicarbonate consistent with zinc-bound nitrite. Journal of Inorganic Biochemistry 149, pages 6-11.
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Viviana De Luca, Daniela Vullo, Sonia Del Prete, Vincenzo Carginale, Andrea Scozzafava, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2015) Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. Bioorganic & Medicinal Chemistry 23:15, pages 4405-4409.
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Nurcan Dedeoglu, Viviana De Luca, Semra Isik, Hatice Yildirim, Feray Kockar, Clemente Capasso & Claudiu T. Supuran. (2015) Cloning, characterization and anion inhibition study of a β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans. Bioorganic & Medicinal Chemistry 23:13, pages 2995-3001.
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Nurcan Dedeoglu, Viviana DeLuca, Semra Isik, Hatice Yildirim, Feray Kockar, Clemente Capasso & Claudiu T. Supuran. (2015) Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans. Bioorganic & Medicinal Chemistry Letters 25:11, pages 2291-2297.
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Marta Abellán-Flos, Muhammet Tanç, Claudiu T. Supuran & Stéphane P. Vincent. (2015) Exploring carbonic anhydrase inhibition with multimeric coumarins displayed on a fullerene scaffold. Organic & Biomolecular Chemistry 13:27, pages 7445-7451.
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Fabrizio Carta, Sameh M. Osman, Daniela Vullo, Zeid AlOthman & Claudiu T. Supuran. (2015) Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I–XIV. Organic & Biomolecular Chemistry 13:23, pages 6453-6457.
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Brian P. Mahon & Robert McKenna. 2015. Carbonic Anhydrases as Biocatalysts. Carbonic Anhydrases as Biocatalysts 91 108 .
Katia D’Ambrosio, Giuseppina De Simone & Claudiu T. Supuran. 2015. Carbonic Anhydrases as Biocatalysts. Carbonic Anhydrases as Biocatalysts 17 30 .
HE HUANG, HUI-MIN REN, XI-LIANG SHANG & XUE-YUAN LIU. (2014) Detection of the phosphatase activity of carbonic anhydrase III on a nitrocellulose membrane following 2D gel electrophoresis. Molecular Medicine Reports 10:4, pages 1887-1892.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Andrea Scozzafava, Zeid Alothman, Claudiu T. Supuran & Clemente Capasso. (2014) Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis. Bioorganic & Medicinal Chemistry Letters 24:18, pages 4402-4406.
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William C. FloydIIIIII, Sarah E. Baker, Carlos A. Valdez, Joshuah K. Stolaroff, Jane P. Bearinger, Joe H. SatcherJr.Jr. & Roger D. Aines. (2013) Evaluation of a Carbonic Anhydrase Mimic for Industrial Carbon Capture. Environmental Science & Technology 47:17, pages 10049-10055.
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Giuseppina De Simone & Claudiu T. Supuran. (2012) (In)organic anions as carbonic anhydrase inhibitors. Journal of Inorganic Biochemistry 111, pages 117-129.
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Fabrizio Carta, Daniela Vullo, Alfonso Maresca, Andrea Scozzafava & Claudiu T. Supuran. (2012) New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II. Bioorganic & Medicinal Chemistry Letters 22:6, pages 2182-2185.
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Emanuela Truppo, Claudiu T. Supuran, Annamaria Sandomenico, Daniela Vullo, Alessio Innocenti, Anna Di Fiore, Vincenzo Alterio, Giuseppina De Simone & Simona M. Monti. (2012) Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors. Bioorganic & Medicinal Chemistry Letters 22:4, pages 1560-1564.
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Anna Ohradanova, Daniela Vullo, Silvia Pastorekova, Jaromir Pastorek, Daniel J. Jackson, Gert Wörheide & Claudiu T. Supuran. (2012) Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana. Bioorganic & Medicinal Chemistry Letters 22:3, pages 1314-1316.
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Shyamasri Biswas, Mayank Aggarwal, Özlen Güzel, Andrea Scozzafava, Robert McKenna & Claudiu T. Supuran. (2011) Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry 19:12, pages 3732-3738.
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Claudia Temperini, Andrea Scozzafava & Claudiu T. Supuran. (2010) Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzyme. Bioorganic & Medicinal Chemistry Letters 20:2, pages 474-478.
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Alessio Innocenti, Jean-Yves Winum, Rebecca A. Hall, Fritz A. Mühlschlegel, Andrea Scozzafava & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorganic & Medicinal Chemistry Letters 19:10, pages 2642-2645.
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Jean-Yves Winum, Alessio Innocenti, Andrea Scozzafava, Jean-Louis Montero & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids. Bioorganic & Medicinal Chemistry 17:10, pages 3649-3652.
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Alessio Innocenti, Andrea Scozzafava & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorganic & Medicinal Chemistry Letters 19:7, pages 1855-1857.
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