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Research Article

Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents

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Pages 296-309 | Received 19 Nov 2007, Accepted 17 Mar 2008, Published online: 01 Feb 2009

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Ramesh Shingare, Yogesh Patil, Jaiprakash Sangshetti, Rajesh Patil, Dhanji Rajani & Balaji Madje. (2023) Docking Simulations and Primary Assessment of Newly Synthesized Benzene Sulfonamide Pyrazole Oxadiazole Derivatives as Potential Antimicrobial and Antitubercular Agents. Polycyclic Aromatic Compounds 43:2, pages 1799-1811.
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Prashant Aragade, R. Venkat Narayanan, Veeresh Maddi, Pankaj Patil, Prashant Shinde & Mohan Agrawal. (2012) Synthesis and antibacterial activity of a new series of 3-[3-(substituted phenyl)-1-phenyl-1H-pyrazol-5-yl]-2H-chromen-2-one derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 27:6, pages 849-853.
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Mohammad Shakirullah, Hanif Ahmad, Muhammad Raza Shah, Imtiaz Ahmad, Muhammad Ishaq, Nematullah Khan, Amir Badshah & Inamullah Khan. (2011) Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis. Journal of Enzyme Inhibition and Medicinal Chemistry 26:4, pages 468-471.
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Ajay N. Ambhore. (2021) Eco-friendly Synthesis of Some New Benzylidene-iminothiazolyl-pyrazol-3-ol Derivatives via One-Pot Multicomponent Reaction and Evaluation of Antioxidant Activities. Asian Journal of Organic & Medicinal Chemistry 6:4, pages 264-269.
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Adnan A. Bekhit, Sherry N. Nasralla, Eman J. El-Agroudy, Nahla Hamouda, Ahmed Abd El-Fattah, Salma A. Bekhit, Kikuko Amagase & Tamer M. Ibrahim. (2022) Investigation of the anti-inflammatory and analgesic activities of promising pyrazole derivative. European Journal of Pharmaceutical Sciences 168, pages 106080.
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Ismail A. Abdelhamid, Mohamed R. Shaaban & Ahmed H.M. Elwahy. 2022. 171 223 .
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Khaled R.A. Abdellatif, Eman K.A. Abdelall, Heba A.H. Elshemy, Phoebe F. Lamie, Elshaymaa Elnahaas & Dina M.E. Amin. (2021) Design, synthesis of new anti-inflammatory agents with a pyrazole core: COX-1/COX-2 inhibition assays, anti-inflammatory, ulcerogenic, histopathological, molecular Modeling, and ADME studies. Journal of Molecular Structure 1240, pages 130554.
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Mehtap Tugrak, Halise Inci Gul, Hulya Akincioglu & Ilhami Gulcin. (2021) New Chalcone Derivatives with Pyrazole and Sulfonamide Pharmacophores as Carbonic Anhydrase Inhibitors. Letters in Drug Design & Discovery 18:2, pages 191-198.
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Ramesh M. Shingare, Yogesh S. Patil, Jaiprakash N. Sangshetti, Rajesh B. Patil, Dhanji P. Rajani, Smita D. Rajani & Balaji R. Madje. (2018) Benzene sulfonamide pyrazole thio-oxadiazole hybrid as potential antimicrobial and antitubercular agents. Research on Chemical Intermediates 44:7, pages 4437-4453.
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Adnan A. Bekhit, Ahmed M. Farghaly, Ragab M. Shafik, Mona M.A. Elsemary, Alaa El-Din A. Bekhit, Aida A. Guemei, Mai S. El-Shoukrofy & Tamer M. Ibrahim. (2018) Synthesis, biological evaluation and molecular modeling of novel thienopyrimidinone and triazolothienopyrimidinone derivatives as dual anti-inflammatory antimicrobial agents. Bioorganic Chemistry 77, pages 38-46.
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Khalid Karrouchi, Smaail Radi, Youssef Ramli, Jamal Taoufik, Yahia Mabkhot, Faiz Al-aizari & M’hammed Ansar. (2018) Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review. Molecules 23:1, pages 134.
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A. Kumar & C. P. Singh. (2017) SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL ACTIVITYOF SOME NEWLY SYNTHESISED POLYSUBSTITUTED PYRAZOLES. INDIAN DRUGS 54:10, pages 23-29.
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Adnan A Bekhit, Ahmed M Farghaly, Ragab M Shafik, Mona MA Elsemary, Mai S El-Shoukrofy, Alaa El-Din A Bekhit & Tamer M Ibrahim. (2017) Synthesis, evaluation and modeling of some triazolothienopyrimidinones as anti-inflammatory and antimicrobial agents. Future Medicinal Chemistry 9:9, pages 881-897.
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Heba A. Abd El Razik, Mona H. Badr, Attia H. Atta, Samar M. Mouneir & Marwa M. Abu-Serie. (2017) Benzodioxole-Pyrazole Hybrids as Anti-Inflammatory and Analgesic Agents with COX-1,2/5-LOX Inhibition and Antioxidant Potential. Archiv der Pharmazie 350:5, pages 1700026.
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Chaojie Fang, Meichao Li, Xinquan Hu, Weimin Mo, Baoxiang Hu, Nan Sun, Liqun Jin & Zhenlu Shen. (2016) A Mild TEMPO-Catalyzed Aerobic Oxidative Conversion of Aldehydes into Nitriles. Advanced Synthesis & Catalysis 358:7, pages 1157-1163.
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Hayam M. A. Ashour, Ibrahim M. El-Ashmawy & Aida E. Bayad. (2015) Synthesis and pharmacological evaluation of new pyrazolyl benzenesulfonamides linked to polysubstituted pyrazoles and thiazolidinones as anti-inflammatory and analgesic agents. Monatshefte für Chemie - Chemical Monthly 147:3, pages 605-618.
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Adnan A. Bekhit, Ahmed M.M. Hassan, Heba A. Abd El Razik, Mostafa M.M. El-Miligy, Eman J. El-Agroudy & Alaa El-Din A. Bekhit. (2015) New heterocyclic hybrids of pyrazole and its bioisosteres: Design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. European Journal of Medicinal Chemistry 94, pages 30-44.
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Fatma A. El-Samahy. (2015) Synthesis of New Pyrazoles via Cycloaddition Reactions of Nitrilimines with 2-Cyclopentenone Derivatives. Journal of Heterocyclic Chemistry 52:2, pages 597-602.
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Fatma A. Ragab, Nagwa M. Abdel Gawad, Hanan H. Georgey & Mona F. Said. (2013) Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents. European Journal of Medicinal Chemistry 63, pages 645-654.
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Hayam M. Ashour, Omaima G. Shaaban, Ola H. Rizk & Ibrahim M. El-Ashmawy. (2013) Synthesis and biological evaluation of thieno [2′,3′:4,5]pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidines as anti-inflammatory and analgesic agents. European Journal of Medicinal Chemistry 62, pages 341-351.
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Rajiv Kumar Tonk, Sandhya Bawa, Gita Chawla, Girdhar Singh Deora, Suresh Kumar, Vandana Rathore, Naveen Mulakayala, Azad Rajaram, Arunasree M. Kalle & Obaid Afzal. (2012) Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents. European Journal of Medicinal Chemistry 57, pages 176-184.
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Pawan Kumar, Navneet Chandak, Pawan Kaushik, Chetan Sharma, Dhirender Kaushik, Kamal R. Aneja & Pawan K. Sharma. (2011) Synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory–antibacterial agents. Medicinal Chemistry Research 21:11, pages 3396-3405.
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Pawan K. Sharma, Navneet Chandak, Pawan Kumar, Chetan Sharma & Kamal R. Aneja. (2011) Synthesis and biological evaluation of some 4-functionalized-pyrazoles as antimicrobial agents. European Journal of Medicinal Chemistry 46:4, pages 1425-1432.
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Adnan A. Bekhit, Hesham T.Y. Fahmy, Sherif A.F. Rostom & Alaa El-Din A. Bekhit. (2010) Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents. European Journal of Medicinal Chemistry 45:12, pages 6027-6038.
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