2,565
Views
52
CrossRef citations to date
0
Altmetric
Research Article

Hypoglycemic activity of the antioxidant saponarin, characterized as α-glucosidase inhibitor present in Tinospora cordifolia

, , &
Pages 684-690 | Received 08 Feb 2008, Accepted 23 May 2008, Published online: 01 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Vijay Kumar, Simranjeet Singh, Arjun Singh, Amit Kumar Dixit, Bhavana Srivastava, Gurpreet Kaur Sidhu, Ravindra Singh, Ajay Kumar Meena, Rajesh Pratap Singh, Varanasi Subhose & Om Prakash. (2018) Phytochemical, Antioxidant, Antimicrobial, and Protein Binding Qualities of Hydro-ethanolic Extract of Tinospora cordifolia. Journal of Biologically Active Products from Nature 8:3, pages 192-200.
Read now
Runa Masuma, Tsutomu Okuno, Mohammad Shahabuddin Kabir Choudhuri, Takeshi Saito & Masaaki Kurasaki. (2014) Effect of Tinospora cordifolia on the reduction of ultraviolet radiation‐induced cytotoxicity and DNA damage in PC12 cells. Journal of Environmental Science and Health, Part B 49:6, pages 416-421.
Read now
Abhishek Mukherjee & Subhabrata Sengupta. (2013) Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes. Journal of Enzyme Inhibition and Medicinal Chemistry 28:5, pages 900-910.
Read now
Vessela Vitcheva, Rumyana Simeonova, Ilina Krasteva, Maya Yotova, Stefan Nikolov & Mitka Mitcheva. (2011) Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. Redox Report 16:2, pages 56-61.
Read now

Articles from other publishers (48)

Vimalraj Kantharaj, Young-Eun Yoon, Keum-Ah Lee, Hyeonji Choe, Hadjer Chohra, Woo Duck Seo, Young-Nam Kim & Yong Bok Lee. (2023) Saponarin, a Di-glycosyl Flavone from Barley ( Hordeum vulgare L.): An Effective Compound for Plant Defense and Therapeutic Application . ACS Omega 8:25, pages 22285-22295.
Crossref
Richa Upadhyay, Chandrashekhar Singh, Awadhesh Kumar Mishra, Rajesh Saini, Jasmeet Singh & Kavindra Nath Tiwari. (2023) Estimation of Antioxidant Potential, Phytochemical Profiling, and In Silico Characterization of Hepatoprotective Biomarkers of Phyllanthus fraternus G.L. Webster Leaves . ChemistrySelect 8:19.
Crossref
Salome Amarachi Chime & Chika Phoebe Madumere. (2023) Herbal Medicines as Potential Immune Boosters against Coronavirus Diseases. Current Traditional Medicine 9:2.
Crossref
Nisha Pramod Gathe, Suraj Bhaskarao Rathod & Nitin B. Kohale. (2023) Tinospora Cordifolia (Giloy) : A Review. International Journal of Advanced Research in Science, Communication and Technology, pages 315-327.
Crossref
Xue-Lin Chen, Kun Zhang, Xia Zhao, Han-Lei Wang, Mei Han, Ru Li, Zhen-Nan Zhang & Yu-Mei Zhang. (2023) Triterpenoids from Kochiae Fructus: Glucose Uptake in 3T3-L1 Adipocytes and α-Glucosidase Inhibition, In Silico Molecular Docking. International Journal of Molecular Sciences 24:3, pages 2454.
Crossref
Song-Yi Choi, Hyo-Bin Chae, In-Jun Hwang, Jeong-Eun Hyun, Woo-Duck Seo & Se-Ri Kim. (2022) Effects of different drying methods and storage conditions on the reduction of Escherichia coli and the quality parameters of barley sprouts. Korean Journal of Food Preservation 29:7, pages 1047-1058.
Crossref
Kaoutar Benrahou, Otman El Guourrami, Hanae Naceiri Mrabti, Yahia Cherrah & My El Abbes Faouzi. (2022) Investigation of Antioxidant, Hypoglycemic and Anti-Obesity Effects of Euphorbia Resinifera L.. Journal of Pharmacopuncture 25:3, pages 242-249.
Crossref
Yunmi Park, Soon‐ho Kwon, You Lim Jang, Doo‐Hee Lee, Seung‐Ok Yang, Hyun Ji Eo, Gwang Hun Park & Hae‐Yun Kwon. (2022) Nutritional composition and phytochemical screening in different parts of Hibiscus syriacus L. . Food Science & Nutrition 10:9, pages 3034-3042.
Crossref
Muddaser Shah, Sidra Mubin, Syed Shams ul Hassan, Priti Tagde, Obaid Ullah, Md. Habibur Rahman, Ahmed Al-Harrasi, Najeeb Ur Rehman & Waheed Murad. (2022) Phytochemical Profiling and Bio-Potentiality of Genus Scutellaria: Biomedical Approach. Biomolecules 12:7, pages 936.
Crossref
Yu Ri Kim, Sun Young Lee, So Min Lee, Insop Shim & Mi Young Lee. (2022) Effect of Hibiscus syriacus Linnaeus extract and its active constituent, saponarin, in animal models of stress-induced sleep disturbances and pentobarbital-induced sleep. Biomedicine & Pharmacotherapy 146, pages 112301.
Crossref
Jorige Archana, Akula Annapurna & Panuganti Devayani. (2022) Neuroprotective role of Tinospora cordifolia extract in streptozotocin induced neuropathic pain. Brazilian Journal of Pharmaceutical Sciences 58.
Crossref
Karuppusamy Arunachalam, Xuefei Yang & Thae Thae San. (2022) Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases. Journal of Ethnopharmacology 283, pages 114540.
Crossref
Khursheed Ahmad Shiekh, Oladipupo Odunayo Olatunde, Bin Zhang, Nurul Huda & Soottawat Benjakul. (2021) Pulsed electric field assisted process for extraction of bioactive compounds from custard apple (Annona squamosa) leaves. Food Chemistry 359, pages 129976.
Crossref
Anshika Jain, Nandita Dasgupta, Shivendu Ranjan, Vineeta Singh, Hemant Singh, Shiv Dutt Purohit, Narayan Chandra Mishra, Narayan Prasad Yadav, Shafiul Haque, Bhartendu Nath Mishra & Sujoy Kumar Samanta. (2021) Whey protein based electrosprayed nanospheres for encapsulation and controlled release of bioactive compounds from Tinospora cordifolia extract. Innovative Food Science & Emerging Technologies 69, pages 102671.
Crossref
Pradeep Kumar, Madhu Kamle, Dipendra K. Mahato, Himashree Bora, Bharti Sharma, Prasad Rasane & Vivek K. Bajpai. (2020) Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies. Current Pharmaceutical Biotechnology 21:12, pages 1165-1175.
Crossref
Chang-Won Cho, Young-Ran Song, Won-Chul Lim, Youn-Hwan Hwang, Young Kyoung Rhee, Jae Woong Choi, Kyung-Tae Lee & Hee-Do Hong. (2020) Acute Oral Toxicity and Genotoxicity of Polysaccharide Fraction from Young Barley Leaves (Hordeum vulgare L.). Foods 9:6, pages 809.
Crossref
Muhammad Saeed, Muhammad Naveed, Jakob Leskovec, Asgahr Ali kamboh, Ihsanullah Kakar, Kifayat Ullah, Fawwad Ahmad, Muhammad Sharif, Asif Javaid, Mubasher Rauf, Mohamed E. Abd El-Hack, Mervat A. Abdel-Latif & Sun Chao. (2020) Using Guduchi (Tinospora cordifolia) as an eco-friendly feed supplement in human and poultry nutrition. Poultry Science 99:2, pages 801-811.
Crossref
Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1811 1824 .
Nam-Jin Chung, Jun-Young Kim, Yuna Lee, So-Hee Shin, Jeong-Sup Song, Sung Chul Shin & Beom-Tae Kim. (2019) Variations of Saponarin Content in Young Barley Leaves Illuminated with Different Light-Emitting Diodes (LEDs). Journal of Crop Science and Biotechnology 22:4, pages 317-322.
Crossref
Imen Bouhaouel, Gaëtan Richard, Marie-Laure Fauconnier, Marc Ongena, Laurent Franzil, Aurélie Gfeller, Hajer Slim Amara & Patrick du Jardin. (2019) Identification of Barley (Hordeum vulgare L. subsp. vulgare) Root Exudates Allelochemicals, Their Autoallelopathic Activity and Against Bromus diandrus Roth. Germination. Agronomy 9:7, pages 345.
Crossref
Kshirod K Ratha & Sudhanshu K Meher. (2018) An Enumeration and Review of Medicinal Plants Mentioned in Bhela Samhita . Journal of Drug Research in Ayurvedic Sciences 3:1, pages 53-62.
Crossref
Lalrinpuia Kawlni, Sachchidanand Upadhayay & Koyel Mukherjee. (2018) Comprehensive Pharmacology Review of Guduchi [ Tinospora cordifolia (Willd.) Miers] . Journal of Drug Research in Ayurvedic Sciences 3:1, pages 48-52.
Crossref
Vikas Bajpai, Sunil Kumar, Awantika Singh, Nasreen Bano, Manisha Pathak, Nikhil Kumar, Shailja Misra-Bhattacharya & Brijesh Kumar. (2017) Metabolic fingerprinting of dioecious Tinospora cordifolia (Thunb) Miers stem using DART TOF MS and differential pharmacological efficacy of its male and female plants. Industrial Crops and Products 101, pages 46-53.
Crossref
Deepika Singh & Prabir K Chaudhuri. (2017) Chemistry and Pharmacology of Tinospora cordifolia . Natural Product Communications 12:2, pages 1934578X1701200.
Crossref
Vineet Mehta & Udayabanu Malairaman. 2017. Pharmaceutical Sciences. Pharmaceutical Sciences 569 612 .
Prachi Gupta, Manju Bala, Sanjeev Gupta, Anita Dua, Rajesh Dabur, Elisha Injeti & Ashwani Mittal. (2016) Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs—A mechanistic revisit to understand their mode of action. Pharmacological Research 113, pages 636-674.
Crossref
Rakhi Chakraborty, Swarnendu Roy & Vivekananda Mandal. (2016) Assessment of traditional knowledge of the antidiabetic plants of Darjeeling and Sikkim Himalayas in the context of recent phytochemical and pharmacological advances. Journal of Integrative Medicine 14:5, pages 336-358.
Crossref
Tonmoy Ghosh, Khushbu Bhayani, Chetan Paliwal, Rahulkumar Maurya, Kaumeel Chokshi, Imran Pancha & Sandhya Mishra. (2016) Cyanobacterial Pigments as Natural Anti-Hyperglycemic Agents: An In vitro Study. Frontiers in Marine Science 3.
Crossref
Lei Chen, Hui Teng, Ting Fang & Jianbo Xiao. (2016) Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-κB in lipopolysaccharide-stimulated macrophages. Phytomedicine 23:8, pages 846-855.
Crossref
Rumyana Simeonova, Vessela Vitcheva, Ilina Krasteva, Petranka Zdraveva, Spiro Konstantinov & Iliana Ionkova. (2016) Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. Phytomedicine 23:5, pages 483-490.
Crossref
Vineet Mehta & Udayabanu Malairaman. 2016. Handbook of Research on Advancing Health Education through Technology. Handbook of Research on Advancing Health Education through Technology 286 328 .
Woo-Duck Seo, Ji Hae Lee, Yaoyao Jia, Chunyan Wu & Sung-Joon Lee. (2015) Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. Bioorganic & Medicinal Chemistry Letters 25:22, pages 5237-5242.
Crossref
Jian Chen, Sven Mangelinckx, An Adams, Zheng-tao Wang, Wei-lin Li & Norbert De Kimpe. (2015) Natural Flavonoids as Potential Herbal Medication for the Treatment of Diabetes Mellitus and its Complications. Natural Product Communications 10:1, pages 1934578X1501000.
Crossref
Rohit Sharma, Hetal Amin, Galib & Pradeep Kumar Prajapati. (2015) Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: critical appraisal and role in therapy. Asian Pacific Journal of Tropical Biomedicine 5:1, pages 68-78.
Crossref
Yung-Hung Chu, Shih-Hsiung Wu & Jung-Feng Hsieh. (2014) Isolation and characterization of α-glucosidase inhibitory constituents from Rhodiola crenulata. Food Research International 57, pages 8-14.
Crossref
Kyung Hye Seo, Mi Jin Park, Ji-Eun Ra, Sang-Ik Han, Min-Hee Nam, Jin Hyo Kim, Jin Hwan Lee & Woo Duck Seo. (2014) Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells. Food Funct. 5:11, pages 3005-3013.
Crossref
Rumyana Simeonova, Magdalena Kondeva-Burdina, Vessela Vitcheva, Ilina Krasteva, Vassil Manov & Mitka Mitcheva. (2014) Protective effects of the apigenin-O/C-diglucoside saponarin from Gypsophila trichotoma on carbone tetrachloride-induced hepatotoxicity in vitro/in vivo in rats. Phytomedicine 21:2, pages 148-154.
Crossref
Shaily Goyal, Jaya Arora & Kishan G. Ramawat. 2014. Biotechnology and Biodiversity. Biotechnology and Biodiversity 203 245 .
Rachana Mishra & Gurcharan Kaur. (2013) Aqueous Ethanolic Extract of Tinospora cordifolia as a Potential Candidate for Differentiation Based Therapy of Glioblastomas. PLoS ONE 8:10, pages e78764.
Crossref
Kazufumi Misawa, Yoshiki Gunji & Shingo Sato. (2013) Concise synthesis of flavocommelin, 7-O-methylapigenin 6-C-, 4′-O-bis-β-d-glucoside, a component of the blue supramolecular pigment from Commelina communis. Carbohydrate Research 374, pages 8-13.
Crossref
Rumyana Simeonova, Vessela Vitcheva, Magdalena Kondeva-Burdina, Ilina Krasteva, Vassil Manov & Mitka Mitcheva. (2013) Hepatoprotective and Antioxidant Effects of Saponarin, Isolated from Gypsophila trichotoma Wend. on Paracetamol-Induced Liver Damage in Rats . BioMed Research International 2013, pages 1-10.
Crossref
Hongyu Wang, Tingting Liu & Dejian Huang. 2013. 103 136 .
Mahesh Mysore Shivananjappa & Muralidhara. (2012) Abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of Tinospora cordifolia. Nutrition 28:5, pages 581-587.
Crossref
Sunil Jawla, Y Kumar & MSY Khan. (2012) Hypoglycemic activity of Bougainvillea spectabilis stem bark in normal and alloxan-induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2:2, pages S919-S923.
Crossref
Sunil Jawla, Y Kumar & MSY Khan. (2012) Antimicrobial and antihyperglycemic activities of Musa paradisiaca flowers. Asian Pacific Journal of Tropical Biomedicine 2:2, pages S914-S918.
Crossref
Vartika Jain & Surendra K. VermaVartika Jain & Surendra K. Verma. 2012. Pharmacology of Bombax ceiba Linn.. Pharmacology of Bombax ceiba Linn. 25 50 .
Raju Patil, Ravindra Patil, Bharati Ahirwar & Dheeraj Ahirwar. (2011) Current status of Indian medicinal plants with antidiabetic potential: a review. Asian Pacific Journal of Tropical Biomedicine 1:2, pages S291-S298.
Crossref
Alok Kumar Verma & Ram Pratap. (2010) The biological potential of flavones. Natural Product Reports 27:11, pages 1571.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.