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Research Article

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives

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Pages 6-12 | Received 17 Feb 2016, Accepted 22 Apr 2016, Published online: 22 May 2016

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Mohamed A Abdelgawad, Mohammad M Al-Sanea, Arafa Musa, Mohammed Elmowafy, Ashraf K El-Damasy, Amany A Azouz, Mohammed M Ghoneim & Rania B Bakr. (2022) Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds. Journal of Inflammation Research 15, pages 451-463.
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Ruba A. Alolayan, Nadia Ali Ahmed Elkanzi, Hajer Hrichi & Rania B. Bakr. (2023) Design, Synthesis, Docking Study of Pyrazolohydrazinopyrimidin‐4‐one Derivatives and Their Application as Antimicrobials. Chemistry & Biodiversity 20:5.
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Mohamed A. Mohamed Teleb, Ahmed E. M. Mekky & Sherif M. H. Sanad. (2021) 3‐Aminothieno [2,3‐ b ]pyridine‐2‐carboxylate: Effective precursor for microwave‐assisted three components synthesis of new pyrido[3′,2′:4,5]thieno[3,2‐ d ]pyrimidin‐4( 3 H )‐one hybrids . Journal of Heterocyclic Chemistry 58:9, pages 1825-1835.
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Volodymyr Ya. HorishnyPavlo V. Zadorozhnii, Ivanna V. HorishniaVasyl S. Matiychuk. (2020) Synthesis, Anti-Inflammatory Activity and Molecular Docking Studies of 1,4,5,6-Tetrahydropyrimidine-2-Carboxamides. Pharmaceutical Sciences 27:3, pages 353-365.
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Marwa F. Harras, Rehab Sabour & Omkulthom Mohamed Alkamali. (2019) Discovery of new non-acidic lonazolac analogues with COX-2 selectivity as potent anti-inflammatory agents. MedChemComm 10:10, pages 1775-1788.
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Khaled RA Abdellatif, Mohammed T El-Saadi, Shaimaa G Elzayat & Noha H Amin. (2019) New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents. Future Medicinal Chemistry 11:15, pages 1871-1882.
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Vrinda Sharma, Parth Bhatia, Ozair Alam, Mohd. Javed Naim, Farah Nawaz, Aadil Ahmad Sheikh & Mukund Jha. (2019) Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019). Bioorganic Chemistry 89, pages 103007.
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Rania B. Bakr, Amira A. Ghoneim & Amany A. Azouz. (2019) Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold. Bioorganic Chemistry 88, pages 102964.
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Noha H Amin, Mohammed T El-Saadi, Ahmed A Hefny, Ahmed H Abdelazeem, Heba AH Elshemy & Khaled RA Abdellatif. (2018) Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity. Future Medicinal Chemistry 10:21, pages 2521-2535.
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Xiaoyu Liu, Xizhong Song, Yuwen Liu, Mingjin Xie, Wei Yu, Shengjiao Yan, Jun Lin & Yi Jin. (2018) Novel 5H-[1,2,4]oxadiazolo[4,5-a]pyrimidin-5-one derivatives as antibacterial and anticancer agents: Synthesis and biological evaluation. Tetrahedron Letters 59:42, pages 3767-3772.
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Khaled R.A. Abdellatif & Rania B. Bakr. (2018) New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds. Bioorganic Chemistry 78, pages 341-357.
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Rania B. Bakr, Nadia A. A. Elkanzi, Amira A. Ghoneim & Shaima M. N. Moustafa. (2018) Synhesis, Molecular Docking Studies and in vitro Antimicrobial Evaluation of Novel Pyrimido[1,2-a]quinoxaline and Triazino[4,3-a]quinoxaline Derivatives. HETEROCYCLES 96:11, pages 1941.
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Yun-Jeong Heo & Moon-Kook Jeon. (2017) A novel solid-phase synthetic method for production of N -alkyl-4-alkylamino-1-aryl-1 H -pyrazolo[3,4- d ]pyrimidine-6-carboxamide library. Tetrahedron 73:40, pages 5959-5973.
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Mohamed A. Abdelgawad, Rania B. Bakr & Hany A. Omar. (2017) Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents. Bioorganic Chemistry 74, pages 82-90.
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Khosrow Kashfi & Pascale L. Duvalsaint. 2017. Nitric Oxide Donors. Nitric Oxide Donors 75 119 .

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