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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue sup2
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Research Article

Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents

Mahmoud M. Gamal El-DinCenter for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, ;Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea, ;Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki-Giza, Egypt,
,
Mohammed I. El-GamalDepartment of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates, ;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates, ;Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt,
,
Mohammed S. Abdel-MaksoudCenter for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, ;Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea, ;Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki-Giza, Egypt,
,
Kyung Ho YooChemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea, and
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Daejin BaekDepartment of Chemistry, Hanseo University, Seosan, Republic of Korea
,
Jungseung ChoiDepartment of Chemistry, Hanseo University, Seosan, Republic of Korea
,
Huiseong LeeDepartment of Chemistry, Hanseo University, Seosan, Republic of Korea
&
Chang-Hyun OhCenter for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, ;Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea, Correspondence[email protected]
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Pages 111-122 | Received 29 Feb 2016, Accepted 05 May 2016, Published online: 02 Jun 2016

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Nehal A. Hamdy, Mardia T. El Sayed, Hoda A. R. Hussein, Marwa M. Mounier & Manal M. Anwar. (2023) Synthesis of novel heterocyclic compounds bearing tetralin moiety of potential anticancer activity targeting the intrinsic apoptotic pathway. Synthetic Communications 53:4, pages 298-315.
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Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din & Chang Hyun Oh. (2019) Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 97-109.
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Articles from other publishers (7)

George Mihai Nitulescu, Gheorghe Stancov, Oana Cristina Seremet, Georgiana Nitulescu, Dragos Paul Mihai, Cosmina Gabriela Duta-Bratu, Stefania Felicia Barbuceanu & Octavian Tudorel Olaru. (2023) The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies. Molecules 28:14, pages 5359.
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Davinder Kumar, Navidha Aggarwal, Aakash Deep, Harsh Kumar, Hitesh Chopra, Rakesh Kumar Marwaha & Simona Cavalu. (2023) An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors. Pharmaceuticals 16:2, pages 254.
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Mohammed I. El-Gamal, Seyed-Omar Zaraei, Moustafa M. Madkour & Hanan S. Anbar. (2022) Evaluation of Substituted Pyrazole-Based Kinase Inhibitors in One Decade (2011–2020): Current Status and Future Prospects. Molecules 27:1, pages 330.
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Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Bong S. Lee, Mahmoud M. Gamal El-Din, Hong R. Jeon, Dow Kwon, Usama M. Ammar, Karim I. Mersal, Eslam M. H. Ali, Kyung-Tae Lee, Kyung Ho Yoo, Dong Keun Han, Jae Kyun Lee, Garam Kim, Hong Seok Choi, Young Jik Kwon, Kwan Hyi Lee & Chang Hyun Oh. (2021) Discovery of New Imidazo[2,1- b ]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity . Journal of Medicinal Chemistry 64:10, pages 6877-6901.
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Mohammed S. Abdel-Maksoud, Usama M. Ammar, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Karim I. Mersal, Eslam M.H. Ali, Kyung Ho Yoo, Kyung-Tae Lee & Chang-Hyun Oh. (2019) Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors. Bioorganic Chemistry 93, pages 103349.
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Runjhun Tandon, Iqubal Singh, Vijay Luxami, Nitin Tandon & Kamaldeep Paul. (2018) Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines . The Chemical Record 19:2-3, pages 362-393.
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Mohammed I. El-Gamal, Byung-Jun Park & Chang-Hyun Oh. (2018) Synthesis, in vitro antiproliferative activity, and kinase inhibitory effects of pyrazole-containing diarylureas and diarylamides. European Journal of Medicinal Chemistry 156, pages 230-239.
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