Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue sup2
Submit an article Journal homepage
1,541
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents

Mahmoud M. Gamal El-DinCenter for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, ;Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea, ;Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki-Giza, Egypt,
,
Mohammed I. El-GamalDepartment of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates, ;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates, ;Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt,
,
Mohammed S. Abdel-MaksoudCenter for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, ;Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea, ;Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki-Giza, Egypt,
,
Kyung Ho YooChemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea, and
,
Daejin BaekDepartment of Chemistry, Hanseo University, Seosan, Republic of Korea
,
Jungseung ChoiDepartment of Chemistry, Hanseo University, Seosan, Republic of Korea
,
Huiseong LeeDepartment of Chemistry, Hanseo University, Seosan, Republic of Korea
&
Chang-Hyun OhCenter for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, ;Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea, Correspondence[email protected]
 show all
Pages 111-122 | Received 29 Feb 2016, Accepted 05 May 2016, Published online: 02 Jun 2016

Citations (9)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Nehal A. Hamdy, Mardia T. El Sayed, Hoda A. R. Hussein, Marwa M. Mounier & Manal M. Anwar. (2023) Synthesis of novel heterocyclic compounds bearing tetralin moiety of potential anticancer activity targeting the intrinsic apoptotic pathway. Synthetic Communications 53:4, pages 298-315.
Read now
Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din & Chang Hyun Oh. (2019) Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 97-109.
Read now

Articles from other publishers (7)

George Mihai Nitulescu, Gheorghe Stancov, Oana Cristina Seremet, Georgiana Nitulescu, Dragos Paul Mihai, Cosmina Gabriela Duta-Bratu, Stefania Felicia Barbuceanu & Octavian Tudorel Olaru. (2023) The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies. Molecules 28:14, pages 5359.
Crossref
Davinder Kumar, Navidha Aggarwal, Aakash Deep, Harsh Kumar, Hitesh Chopra, Rakesh Kumar Marwaha & Simona Cavalu. (2023) An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors. Pharmaceuticals 16:2, pages 254.
Crossref
Mohammed I. El-Gamal, Seyed-Omar Zaraei, Moustafa M. Madkour & Hanan S. Anbar. (2022) Evaluation of Substituted Pyrazole-Based Kinase Inhibitors in One Decade (2011–2020): Current Status and Future Prospects. Molecules 27:1, pages 330.
Crossref
Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Bong S. Lee, Mahmoud M. Gamal El-Din, Hong R. Jeon, Dow Kwon, Usama M. Ammar, Karim I. Mersal, Eslam M. H. Ali, Kyung-Tae Lee, Kyung Ho Yoo, Dong Keun Han, Jae Kyun Lee, Garam Kim, Hong Seok Choi, Young Jik Kwon, Kwan Hyi Lee & Chang Hyun Oh. (2021) Discovery of New Imidazo[2,1- b ]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity . Journal of Medicinal Chemistry 64:10, pages 6877-6901.
Crossref
Mohammed S. Abdel-Maksoud, Usama M. Ammar, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Karim I. Mersal, Eslam M.H. Ali, Kyung Ho Yoo, Kyung-Tae Lee & Chang-Hyun Oh. (2019) Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors. Bioorganic Chemistry 93, pages 103349.
Crossref
Runjhun Tandon, Iqubal Singh, Vijay Luxami, Nitin Tandon & Kamaldeep Paul. (2018) Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines . The Chemical Record 19:2-3, pages 362-393.
Crossref
Mohammed I. El-Gamal, Byung-Jun Park & Chang-Hyun Oh. (2018) Synthesis, in vitro antiproliferative activity, and kinase inhibitory effects of pyrazole-containing diarylureas and diarylamides. European Journal of Medicinal Chemistry 156, pages 230-239.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.