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Research Article

Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities

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Pages 1-9 | Received 19 Apr 2016, Accepted 04 Jun 2016, Published online: 22 Jun 2016

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Umit M. Kocyigit, Yakup Budak, Meliha Burcu Gürdere, Neşe Dürü, Parham Taslimi, İlhami Gülçin & Mustafa Ceylan. (2019) Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones. Monatshefte für Chemie - Chemical Monthly 150:4, pages 721-731.
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Ercan Bursal, Abdulmelik Aras, Ömer Kılıç, Parham Taslimi, Ahmet C. Gören & İlhami Gülçin. (2019) Phytochemical content, antioxidant activity, and enzyme inhibition effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes . Journal of Food Biochemistry 43:3, pages e12776.
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Adnan Cetin, Fikret Türkan, Parham Taslimi & İlhami Gulçin. (2018) Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects. Journal of Biochemical and Molecular Toxicology 33:3.
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Cuneyt Caglayan, Yeliz Demir, Sefa Kucukler, Parham Taslimi, Fatih Mehmet Kandemir & İlhami Gulçin. (2019) The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. Journal of Food Biochemistry 43:2, pages e12720.
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Aydın Aktaş, Duygu Barut Celepci, Ruya Kaya, Parham Taslimi, Yetkin Gök, Muhittin Aygün & İlhami Gülçin. (2019) Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties. Polyhedron 159, pages 345-354.
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Emre Güzel, Ümit M. Koçyiğit, Barış S. Arslan, Mehmet Ataş, Parham Taslimi, Faik Gökalp, Mehmet Nebioğlu, İlkay Şişman & İlhami Gulçin. (2019) Aminopyrazole‐substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties. Archiv der Pharmazie 352:2.
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N. Eruygur, U.M. Koçyiğit, P. Taslimi, M. Ataş, M. Tekin & İ. Gülçin. (2019) Screening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extract. South African Journal of Botany 120, pages 141-145.
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Mustafa Zengin, Hayriye Genc, Parham Taslimi, Ali Kestane, Ertugrul Guclu, Aziz Ogutlu, Oguz Karabay & İlhami Gulçin. (2018) Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors – Their antidiabetic, anticholinergic and antibacterial potentials. Bioorganic Chemistry 81, pages 119-126.
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Gunel Maharramova, Parham Taslimi, Afsun Sujayev, Vagif Farzaliyev, Lokman Durmaz & İlhami Gulçin. (2018) Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on phenylthiourea. Journal of Biochemical and Molecular Toxicology 32:12.
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Mansura Huseynova, Parham Taslimi, Ajdar Medjidov, Vagif Farzaliyev, Mahizar Aliyeva, Gulnar Gondolova, Onur Şahin, Bahattin Yalçın, Afsun Sujayev, Efe Baturhan Orman, Ali Rıza Özkaya & İlhami Gulçin. (2018) Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid. Polyhedron 155, pages 25-33.
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Shahla Daryadel, Ufuk Atmaca, Parham Taslimi, İlhami Gülçin & Murat Çelik. (2018) Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties. Archiv der Pharmazie 351:11, pages 1800209.
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Ayten Behçet, Tuba Çağlılar, Duygu Barut Celepci, Aydın Aktaş, Parham Taslimi, Yetkin Gök, Muhittin Aygün, Ruya Kaya & İlhami Gülçin. (2018) Synthesis, characterization and crystal structure of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl Substituted Benzimidazole Bromide Salts: Their inhibitory properties against carbonic anhydrase and acetylcholinesterase. Journal of Molecular Structure 1170, pages 160-169.
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Fikret Turkan, Adnan Cetin, Parham Taslimi & İlhami Gulçin. (2018) Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors. Archiv der Pharmazie 351:10.
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Gulnar Gondolova, Parham Taslimi, Ajdar Medjidov, Vagif Farzaliyev, Afsun Sujayev, Mansura Huseynova, Onur Şahin, Bahattin Yalçın, Fikret Turkan & İlhami Gulçin. (2018) Synthesis, crystal structure and biological evaluation of spectroscopic characterization of Ni(II) and Co(II) complexes with N -salicyloil- N ′-maleoil-hydrazine as anticholinergic and antidiabetic agents . Journal of Biochemical and Molecular Toxicology 32:9, pages e22197.
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Parham Taslimi, Sabiya Osmanova, Cuneyt Caglayan, Fikret Turkan, Sabira Sardarova, Vagif Farzaliyev, Afsun Sujayev, Nastaran Sadeghian & İlhami Gulçin. (2018) Novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties. Journal of Biochemical and Molecular Toxicology 32:9, pages e22191.
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Beyhan Yiğit, Murat Yiğit, Parham Taslimi, Yetkin Gök & İlhami Gülçin. (2018) Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors. Archiv der Pharmazie 351:9, pages 1800146.
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Ufuk Atmaca, Alper Yıldırım, Parham Taslimi, Seda Tuncel Çelik, İlhami Gülçin, Claudiu T. Supuran & Murat Çelik. (2018) Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes. Journal of Biochemical and Molecular Toxicology 32:8, pages e22173.
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Umit M. Kocyigit, Parham Taslimi & İlhami Gulçin. (2018) Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep. Journal of Biochemical and Molecular Toxicology 32:8, pages e22172.
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Beyhan Yiğit, Murat Yiğit, Duygu Barut Celepci, Yetkin Gök, Aydın Aktaş, Muhittin Aygün, Parham Taslimi & İlhami Gülçin. (2018) Novel Benzylic Substituted Imidazolinium, Tetrahydropyrimidinium and Tetrahydrodiazepinium Salts: Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors. ChemistrySelect 3:27, pages 7976-7982.
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Ferhat Türker, Duygu Barut Celepci, Aydın Aktaş, Parham Taslimi, Yetkin Gök, Muhittin Aygün & İlhami Gülçin. (2018) meta -Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, α-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties . Archiv der Pharmazie 351:7, pages 1800029.
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Parham Taslimi & İlhami Gulçin. (2018) Antioxidant and anticholinergic properties of olivetol. Journal of Food Biochemistry 42:3, pages e12516.
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Parham Taslimi, Cuneyt Caglayan, Vagif Farzaliyev, Oruj Nabiyev, Afsun Sujayev, Fikret Turkan, Ruya Kaya & İlhami Gulçin. (2018) Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes inhibitors: The novel N , N ′-bis-cyanomethylamine and alkoxymethylamine derivatives . Journal of Biochemical and Molecular Toxicology 32:4, pages e22042.
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Fatoş Erdemir, Duygu Barut Celepci, Aydın Aktaş, Parham Taslimi, Yetkin Gök, Hasan Karabıyık & İlhami Gülçin. (2018) 2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, α-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties. Journal of Molecular Structure 1155, pages 797-806.
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Parham Taslimi, Afsun Sujayev, Fikret Turkan, Emin Garibov, Zübeyir Huyut, Vagif Farzaliyev, Sevgi Mamedova & İlhami Gulçin. (2018) Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activities. Journal of Biochemical and Molecular Toxicology 32:2, pages e22019.
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Serdar Burmaoglu, Ali O. Yilmaz, Parham Taslimi, Oztekin Algul, Deryanur Kilic & Ilhami Gulcin. (2018) Synthesis and biological evaluation of phloroglucinol derivatives possessing α-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity. Archiv der Pharmazie 351:2, pages 1700314.
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Yakup Sarı, Aydın Aktaş, Parham Taslimi, Yetkin Gök & İlhami Gulçin. (2018) Novel N -propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes . Journal of Biochemical and Molecular Toxicology 32:1, pages e22009.
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Nilufer Bulut, Umit M. Kocyigit, Ibrahim H. Gecibesler, Taner Dastan, Huseyin Karci, Parham Taslimi, Sevgi Durna Dastan, Ilhami Gulcin & Ahmet Cetin. (2018) Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles. Journal of Biochemical and Molecular Toxicology 32:1, pages e22006.
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Ümit M. Koçyiğit, Sevgi Durna Daştan, Parham Taslimi, Taner Daştan & İlhami Gülçin. (2018) Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey. Journal of Biochemical and Molecular Toxicology 32:1, pages e22000.
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Aliye Altundas, Berna Gül, Murat Çankaya, Ali Atasever & İlhami Gülçin. (2017) Synthesis of 2-amino-3-cyanopyridine derivatives and investigation of their carbonic anhydrase inhibition effects. Journal of Biochemical and Molecular Toxicology 31:12, pages e21998.
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Parham Taslimi, Cuneyt Caglayan & İlhami Gulcin. (2017) The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study. Journal of Biochemical and Molecular Toxicology 31:12, pages e21995.
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Umit M. Kocyigit, Yakup Budak, Fikret Eligüzel, Parham Taslimi, Deryanur Kılıç, İlhami Gulçin & Mustafa Ceylan. (2017) Synthesis and Carbonic Anhydrase Inhibition of Tetrabromo Chalcone Derivatives. Archiv der Pharmazie 350:12, pages 1700198.
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Parham Taslimi, Hülya Akıncıoglu & İlhami Gülçin. (2017) Synephrine and phenylephrine act as α‐amylase, α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors. Journal of Biochemical and Molecular Toxicology 31:11.
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Taner Dastan, Umit M. Kocyigit, Sevgi Durna Dastan, Pakize Canturk Kilickaya, Parham Taslimi, Ozge Cevik, Metin Koparir, Cahit Orek, İlhami Gulçin & Ahmet Cetin. (2017) Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(α‐aminoalkyl)phosphinic acid derivatives against human breast cancer. Journal of Biochemical and Molecular Toxicology 31:11.
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Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Alessio Nocentini, Paola Gratteri, Ibrahim H. Eissa, Mohamed Fares, Omnia E. Ismael, Hazem A. Ghabbour, Mahmoud M. Elaasser, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2017) Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies. European Journal of Medicinal Chemistry 139, pages 250-262.
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Necla Öztaskın, Parham Taslimi, Ahmet Maraş, İlhami Gülcin & Süleyman Göksu. (2017) Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Bioorganic Chemistry 74, pages 104-114.
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Ümit M. KOÇYİĞİT. (2017) The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats. Cumhuriyet Science Journal 38:3, pages 450-460.
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Umit M. Kocyigit, Parham Taslimi, Hayreddin Gezegen, İlhami Gulçin & Mustafa Ceylan. (2017) Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. Journal of Biochemical and Molecular Toxicology 31:9, pages e21938.
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Parham Taslimi, Sabiya Osmanova, İlhami Gulçin, Sabira Sardarova, Vagif Farzaliyev, Afsun Sujayev, Ruya Kaya, Fatma Koc, Sukru Beydemir, Saleh H. Alwasel & Omer Irfan Kufrevioglu. (2017) Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. Journal of Biochemical and Molecular Toxicology 31:9, pages e21931.
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Parham Taslimi, Afsun Sujayev, Emin Garibov, Nazar Nazarov, Zubeyir Huyut, Saleh H. Alwasel & İlhami Gulçin. (2017) Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles. Journal of Biochemical and Molecular Toxicology 31:7, pages e21897.
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Aydın Aktaş, Parham Taslimi, İlhami Gülçin & Yetkin Gök. (2017) Novel NHC Precursors: Synthesis, Characterization, and Carbonic Anhydrase and Acetylcholinesterase Inhibitory Properties. Archiv der Pharmazie 350:6, pages e201700045.
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