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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 32, 2017 - Issue 1
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Short Communication

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

Ghada H. Al-AnsaryDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt; View further author information
,
Wagdy M. EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, Egypt; Correspondence[email protected]
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,
Hazem A. GhabbourDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; ;Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; View further author information
,
Sara T. A. Al-RashoodDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; View further author information
,
Khalid A. Al-RashoodDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; View further author information
,
Radwa A. EladwyDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt; View further author information
,
Abdullah Al-DhfyanStem Cell & Tissue Re-Engineering Program, Research Center, King Faisal Specialized Hospital & Research Center, MBC-03, Riyadh, Saudi Arabia; View further author information
,
Maha M. KabilDepartment of Infection Control, King Saud University Medical City, Riyadh, Saudi Arabia; View further author information
&
Hatem A. Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center, Dokki, Giza, EgyptCorrespondence[email protected]
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Pages 986-991 | Received 25 May 2017, Accepted 21 Jun 2017, Published online: 20 Jul 2017

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Wagdy M. Eldehna, Ghada S. Hassan, Sara T. Al-Rashood, Tarfah Al-Warhi, Ahmed E. Altyar, Hamad M. Alkahtani, Abdulrahman A. Almehizia & Hatem A. Abdel-Aziz. (2019) Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 322-332.
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Wagdy M. Eldehna, Dina H. EL-Naggar, Ahmed R. Hamed, Hany S. Ibrahim, Hazem A. Ghabbour & Hatem A. Abdel-Aziz. (2018) One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 309-318.
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Jiaxu Feng, Ying Zhang, Xiangdi Wang, Jing Liu, Valentina Benazzi, Kui Lu, Xia Zhao & Stefano Protti. (2023) Recent Advances in Visible‐Light‐Driven C−S Bond Formation. Advanced Synthesis & Catalysis 365:20, pages 3413-3431.
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Xue-Jun Zhao, Yuke Li, Ming Li, Ya-Ling Tian, Wen-Peng Wang, Bo-Sheng Zhang & Xi-Cun Wang. (2022) Visible light-promoted intermolecular cyclization/aromatization of chalcones and 2-mercaptobenzimidazoles via an EDA complex and a mechanism study . Organic & Biomolecular Chemistry 20:25, pages 5139-5144.
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Ziren Chen, Fei Xue, Yonghong Zhang, Weiwei Jin, Bin Wang, Yu Xia, Mengwei Xie, Ablimit Abdukader & Chenjiang Liu. (2022) Visible-Light-Promoted [3 + 2] Cyclization of Chalcones with 2-Mercaptobenzimidazoles: A Protocol for the Synthesis of Imidazo[2,1- b ]thiazoles . Organic Letters 24:17, pages 3149-3154.
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Garvit Satija, Barkha Sharma, Anish Madan, Ashif Iqubal, Mohammad Shaquiquzzaman, Mymoona Akhter, Suhel Parvez, Mohammad Ahmed Khan & Mohammad Mumtaz Alam. (2021) Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets. Journal of Heterocyclic Chemistry 59:1, pages 22-66.
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Wagdy M. Eldehna, Mahmoud A. El Hassab, Mahmoud F. Abo-Ashour, Tarfah Al-Warhi, Mahmoud M. Elaasser, Nesreen A. Safwat, Howayda Suliman, Marwa F. Ahmed, Sara T. Al-Rashood, Hatem A. Abdel-Aziz & Radwan El-Haggar. (2021) Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations. Bioorganic Chemistry 110, pages 104748.
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Ryad M. Noha, Mohammed.K. Abdelhameid, M. Mohsen Ismail, Manal.R Mohammed & Elmeligie Salwa. (2021) Design, synthesis and screening of benzimidazole containing compounds with methoxylated aryl radicals as cytotoxic molecules on (HCT-116) colon cancer cells. European Journal of Medicinal Chemistry 209, pages 112870.
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Tarfah Al-Warhi, Mohamed Said, Mahmoud El Hassab, Nada Aljaeed, Hazem Ghabour, Hadia Almahli, Wagdy Eldehna & Hatem Abdel-Aziz. (2020) Unexpected Synthesis, Single-Crystal X-ray Structure, Anticancer Activity, and Molecular Docking Studies of Certain 2–((Imidazole/Benzimidazol–2–yl)thio)–1–arylethanones. Crystals 10:6, pages 446.
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Jingxiu Xu, Renjin Deng, Jiaxi Chen, Xiaodong Tang & Jinwu Zhao. (2019) DMSO/H 2 O 2 Promoted Regioselective Synthesis of Benzoimidazo[2,1‐b]thiazoles from 2‐Mercaptobenzimidazoles and Ketones in Water . Advanced Synthesis & Catalysis 361:22, pages 5144-5148.
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Lízbeth Ayala-Domínguez, Leslie Olmedo-Nieva, J. Omar Muñoz-Bello, Adriana Contreras-Paredes, Joaquín Manzo-Merino, Imelda Martínez-Ramírez & Marcela Lizano. (2019) Mechanisms of Vasculogenic Mimicry in Ovarian Cancer. Frontiers in Oncology 9.
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Hany S. Ibrahim, Mohamed E. Albakri, Walaa R. Mahmoud, Heba Abdelrasheed Allam, Ahmed M. Reda & Hatem A. Abdel-Aziz. (2019) Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase. Bioorganic Chemistry 85, pages 337-348.
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Mohamed El-Naggar, Hadia Almahli, Hany Ibrahim, Wagdy Eldehna & Hatem Abdel-Aziz. (2018) Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation. Molecules 23:6, pages 1459.
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