2,957
Views
57
CrossRef citations to date
0
Altmetric
Research Paper

Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s disease

, , , , , , , , & show all
Pages 945-953 | Received 24 Mar 2017, Accepted 23 Jun 2017, Published online: 13 Jul 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Mervat Hassan, Hisham Ismail, Olfat Hammam, Abdullrahman Elsayed, Othman Othman & Sohair Aly Hassan. (2023) Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer’s rat model. Biomarkers 28:3, pages 273-288.
Read now
Kyu Hwan Shim, Niti Sharma & Seong Soo A An. (2022) Prion therapeutics: Lessons from the past. Prion 16:1, pages 265-294.
Read now
Francisco Salgado, Julio Caballero, Reinaldo Vargas, Alberto Cornejo & Carlos Areche. (2020) Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor. Natural Product Research 34:5, pages 646-650.
Read now

Articles from other publishers (54)

Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij RB Singh & Rout George Kerry. (2024) Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties. Phytomedicine 122, pages 155150.
Crossref
Jenat Pazheparambil Jerom, Sooryalekshmi Madhukumar, Raveendran Harikumaran Nair & Sunilkumar Puthenpurackal Narayanan. (2023) Anti-amyloid potential of some phytochemicals against Aβ-peptide and α-synuclein, tau, prion, and Huntingtin protein. Drug Discovery Today 28:12, pages 103802.
Crossref
Antonia González-Madrid, Camila Calfío, Andrea González, Valentina Lüttges & Ricardo B. Maccioni. (2023) Toward Prevention and Reduction of Alzheimer’s Disease. Journal of Alzheimer's Disease 96:2, pages 439-457.
Crossref
Ana Ojeda, Valentina Cofré, Francisco Melo, Leonardo Caballero, Denis Fuentealba & Alberto Cornejo. (2023) α‐Synuclein Drives Tau's Cytotoxic Aggregates Formation through Hydrophobic Interactions. ChemPlusChem 88:10.
Crossref
Lingzhi Xiang, Yanan Wang, Shenkui Liu, Beidong Liu, Xuejiao Jin & Xiuling Cao. (2023) Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases. International Journal of Molecular Sciences 24:14, pages 11275.
Crossref
Andrea González, Camila Calfio, Valentina Lüttges, Antonia González-Madrid & Cristian Guzmán. (2023) The Multifactorial Etiopathogenesis of Alzheimer’s Disease: Neuroinflammation as the Major Contributor. Journal of Alzheimer's Disease 94:1, pages 95-100.
Crossref
Pooja Ravaria, Priyanka Saxena, Shruti Laksmi BS, Vikas Ranjan, Syed Wasfi Fatma Abidi, Priyanka Saha, Siva Ramamoorthy, Faraz Ahmad & Sandeep Singh Rana. (2023) Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies. Phytotherapy Research 37:5, pages 2119-2143.
Crossref
Munazza Tamkeen Fatima, Ajaz Ahmad Bhat, Sabah Nisar, Khalid Adnan Fakhro & Ammira Sarah Al-Shabeeb Akil. (2023) The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile. Heliyon 9:1, pages e12698.
Crossref
Fatima Javed Mirza & Saadia Zahid. (2022) Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer’s disease. Frontiers in Pharmacology 13.
Crossref
Farida El Gaamouch, Fiona Chen, Lap Ho, Hsiao-Yun Lin, Chongzhen Yuan, Jean Wong & Jun Wang. (2022) Benefits of dietary polyphenols in Alzheimer’s disease. Frontiers in Aging Neuroscience 14.
Crossref
Sheena E. B. Tyler & Luke D. K. Tyler. (2022) Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease. Natural Products and Bioprospecting 12:1.
Crossref
Grover Castañeta, Nicolas Cifuentes, Beatriz Sepulveda, Daniela Bárcenas-Pérez, José Cheel & Carlos Areche. (2022) Untargeted Metabolomics by Using UHPLC–ESI–MS/MS of an Extract Obtained with Ethyl Lactate Green Solvent from Salvia rosmarinus. Separations 9:11, pages 327.
Crossref
Fatima Javed Mirza, Saadia Zahid, Sanila Amber, Sumera Sumera, Hira Jabeen, Noreen Asim & Syed Adnan Ali Shah. (2022) Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer’s Disease. Molecules 27:21, pages 7241.
Crossref
Irina Georgiana Munteanu, Vasile Robert Grădinaru & Constantin Apetrei. (2022) Sensitive Detection of Rosmarinic Acid Using Peptide-Modified Graphene Oxide Screen-Printed Carbon Electrode. Nanomaterials 12:19, pages 3292.
Crossref
S. Gayathri, Chandrashekar H. Raghu & S.M. Fayaz. (2022) Phytotherapeutics against Alzheimer’s Disease: Mechanism, Molecular Targets and Challenges for Drug Development. CNS & Neurological Disorders - Drug Targets 21:5, pages 409-426.
Crossref
Lilesh Kumar Pradhan, Pradyumna Kumar Sahoo, Santosh Chauhan & Saroj Kumar Das. (2022) Recent Advances Towards Diagnosis and Therapeutic Fingerprinting for Alzheimer’s Disease. Journal of Molecular Neuroscience 72:6, pages 1143-1165.
Crossref
Basharat Ahmad Bhat, Abdullah Almilaibary, Rakeeb Ahmad Mir, Badr M. Aljarallah, Wajahat R. Mir, Fuzail Ahmad & Manzoor Ahmad Mir. (2022) Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders. Frontiers in Neuroscience 16.
Crossref
Johanna Giovannini, Willy Smeralda, Marie Jouanne, Jana Sopkova-de Oliveira Santos, Marco Catto & Anne Sophie Voisin-Chiret. (2022) Tau protein aggregation: Key features to improve drug discovery screening. Drug Discovery Today 27:5, pages 1284-1297.
Crossref
Sehnaz Ferdosh, Senjuti Banerjee, Jayshree Singh & Chandana Barat. (2022) Amyloid protein‐induced sequestration of the eukaryotic ribosome: effect of stoichiometry and polyphenolic inhibitors. FEBS Letters 596:9, pages 1190-1202.
Crossref
Siva Sundara Kumar Durairajan, Karthikeyan Selvarasu, Minu Rani Bera, Kaushik Rajaram, Ashok Iyaswamy & Min Li. (2022) Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration. Current Molecular Pharmacology 15:2, pages 361-379.
Crossref
N. Salehi, A. Lohrasebi, M. Rezaeisaadaat & A. K. Bordbar. (2022) The influences of cholesterol and AC0107 inhibitor molecules on the amyloid-beta fibrils aggregation in cell membranes: molecular modeling approach. The European Physical Journal Plus 137:4.
Crossref
Saba Noor, Taj Mohammad, Malik Abdul Rub, Ali Raza, Naved Azum, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan & Abdullah M. Asiri. (2022) Biomedical features and therapeutic potential of rosmarinic acid. Archives of Pharmacal Research 45:4, pages 205-228.
Crossref
Lili Zhu & Zhenyu Qian. (2022) Recent studies of atomic‐resolution structures of tau protein and structure‐based inhibitors. Quantitative Biology 10:1, pages 17-34.
Crossref
Ancuta-Veronica Lupaescu, Monica Iavorschi & Mihai Covasa. (2022) The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer’s Disease. Pharmaceutics 14:2, pages 235.
Crossref
S.M. Hussain, A.F. Syeda, M. Alshammari, S. Alnasser, N.D. Alenzi, S.T. Alanazi & K. Nandakumar. (2022) Cognition enhancing effect of rosemary (Rosmarinus officinalis L.) in lab animal studies: a systematic review and meta-analysis. Brazilian Journal of Medical and Biological Research 55.
Crossref
Ana B. Caballero, Patrick Gamez, Raimon Sabate & Alba Espargaró. 2022. Bacterial Amyloids. Bacterial Amyloids 165 188 .
Łucja Justyna Walczak-Nowicka & Mariola Herbet. (2021) Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis. International Journal of Molecular Sciences 22:17, pages 9290.
Crossref
Chanchal Sharma & Sang Ryong Kim. (2021) Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease. Antioxidants 10:8, pages 1231.
Crossref
Mabrouka Ltaif, Manel Gargouri & Ahlem Soussi. (2021) Protective Effects of A. sativa against Oxidative Stress-Induced Liver Damage in Ovariectomized Mice. BioMed Research International 2021, pages 1-15.
Crossref
Ashim Paul, Guru KrishnaKumar Viswanathan, Adi Huber, Elad Arad, Hamutal Engel, Raz Jelinek, Ehud Gazit & Daniel Segal. (2021) Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone–Dopamine hybrid. The FEBS Journal 288:14, pages 4267-4290.
Crossref
Prajakta A. Dhage, Archana A. Sharbidre, Sarada P. Dakua & Shidin Balakrishnan. (2021) Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends. Biomedicine & Pharmacotherapy 139, pages 111634.
Crossref
Raquel Seibel, Rodolfo H. Schneider & Maria G.V. Gottlieb. (2021) Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease. Current Alzheimer Research 18:4, pages 347-357.
Crossref
Francisco Melo, Leonardo Caballero, Esteban Zamorano, Natalia Ventura, Camilo Navarro, Irving Doll, Pedro Zamorano & Alberto Cornejo. (2021) The Cytotoxic Effect of α‐Synuclein Aggregates. ChemPhysChem 22:6, pages 526-532.
Crossref
Perihan Gürbüz, Alim Hüseyin Dokumacı, Miyase Gözde Gündüz, Concepcion Perez, Fatih Göger, Mehmet Yavuz Paksoy, Mükerrem Betül Yerer & L. Ömür Demirezer. (2021) In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease. Saudi Pharmaceutical Journal 29:3, pages 236-243.
Crossref
So Yamamoto, Tomoko Kayama, Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Masahito Yamada, Keiko Abe & Shoko Kobayashi. (2021) Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. npj Science of Food 5:1.
Crossref
Anas Shamsi, Saleha Anwar, Taj Mohammad, Moyad Shahwan, Md. Imtaiyaz Hassan & Asimul Islam. 2021. Autism Spectrum Disorder and Alzheimer's Disease. Autism Spectrum Disorder and Alzheimer's Disease 111 133 .
Yang Yao, Yinglei Xu & Yong Wang. (2020) Protective roles and mechanisms of rosmarinic acid in cyclophosphamide‐induced premature ovarian failure. Journal of Biochemical and Molecular Toxicology 34:12.
Crossref
Patrizia Polverino de Laureto, Luana Palazzi & Laura Acquasaliente. 2020. Neuroprotection - New Approaches and Prospects. Neuroprotection - New Approaches and Prospects.
Antonio Dominguez-Meijide, Eftychia Vasili & Tiago Fleming Outeiro. (2020) Pharmacological Modulators of Tau Aggregation and Spreading. Brain Sciences 10:11, pages 858.
Crossref
Camila Calfio, Andrea Gonzalez, Sandeep Kumar Singh, Leonel E. Rojo & Ricardo B. Maccioni. (2020) The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer’s Disease. Journal of Alzheimer's Disease 77:1, pages 33-51.
Crossref
Víctor Andrade, Nicole Cortés, Gabriela Pastor, Andrea Gonzalez, Nicolás Ramos-Escobar, Edgar Pastene, Leonel E. Rojo & Ricardo B. Maccioni. (2020) N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer’s Disease. Journal of Alzheimer's Disease 75:4, pages 1219-1227.
Crossref
Mabrouka Ltaif, Manel Gargouri, Christian Magné, Abdelfattah Feki & Ahlem Soussi. (2020) Protective effects of Avena sativa against oxidative stress‐induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model . Journal of Food Biochemistry 44:6.
Crossref
Kadja L.C. Monteiro, Marcone G. dos S. Alcântara, Thiago M. de Aquino & Edeildo F. da Silva-Júnior. (2020) Tau Protein Aggregation in Alzheimer's Disease: Recent Advances in the Development of Novel Therapeutic Agents. Current Pharmaceutical Design 26:15, pages 1682-1692.
Crossref
Yung-Chih Kuo, Yung-I. Lou, Rajendiran Rajesh & Chang-Li Chen. (2020) Multiple-component dual-phase solid lipid nanoparticles with conjugated transferrin for formulating antioxidants and nerve growth factor against neuronal apoptosis. Journal of the Taiwan Institute of Chemical Engineers 110, pages 140-152.
Crossref
Angela De Simone, Marina Naldi, Daniele Tedesco, Manuela Bartolini, Lara Davani & Vincenza Andrisano. (2020) Advanced analytical methodologies in Alzheimer’s disease drug discovery. Journal of Pharmaceutical and Biomedical Analysis 178, pages 112899.
Crossref
Matías Silva, Valentina Caro, Camila Guzmán, George Perry, Carlos Areche & Alberto Cornejo. 2020. Bioactive Natural Products. Bioactive Natural Products 1 25 .
Perihan Gürbüz, Ana Martinez, Concepción Pérez, Loreto Martínez-González, Fatih Göger & İrem Ayran. (2019) Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ. Industrial Crops and Products 138, pages 111431.
Crossref
Qiuchen Zheng, Micheal T. Kebede, Merc M. Kemeh, Saadman Islam, Bethany Lee, Stuart D. Bleck, Liliana A. Wurfl & Noel D. Lazo. (2019) Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies. Molecules 24:12, pages 2316.
Crossref
Hedayat Karimi, Maryam Heydari Dokoohaki, Amin Reza Zolghadr & Mohammad Hadi Ghatee. (2019) The interactions of an Aβ protofibril with a cholesterol-enriched membrane and involvement of neuroprotective carbazolium-based substances. Physical Chemistry Chemical Physics 21:21, pages 11066-11078.
Crossref
Ana B. Caballero, Alba Espargaró, Caterina Pont, Maria Antònia Busquets, Joan Estelrich, Diego Muñoz-Torrero, Patrick Gamez & Raimon Sabate. (2019) Bacterial Inclusion Bodies for Anti-Amyloid Drug Discovery: Current and Future Screening Methods. Current Protein & Peptide Science 20:6, pages 563-576.
Crossref
Stephanie Andrade, Maria João Ramalho, Joana Angélica Loureiro & Maria do Carmo Pereira. (2019) Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies. International Journal of Molecular Sciences 20:9, pages 2313.
Crossref
Carlos Areche, Francisca Zapata, Mathias González, Esteban Díaz, Rubén Montecinos, Marcos Hernández, Francisco Melo & Alberto Cornejo. (2019) Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine‐Cysteine Interaction. ChemistryOpen 8:5, pages 554-559.
Crossref
Solomon Habtemariam. (2018) Molecular Pharmacology of Rosmarinic and Salvianolic Acids: Potential Seeds for Alzheimer’s and Vascular Dementia Drugs. International Journal of Molecular Sciences 19:2, pages 458.
Crossref
Aline Freyssin, Guylène Page, Bernard Fauconneau & Agnès Rioux Bilan. (2018) Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases. Neural Regeneration Research 13:6, pages 955.
Crossref